Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

Nature

Volumn 409, Issue 6821, 2001, Pages 729-733

  Abel, E Dale ^a   Peroni, Odile ^a   Kim, Jason K ^b   Kim, Young Bum ^a   Boss, Olivier ^a   Hadro, Ed ^a   Minnemann, Timo ^a   Shulman, Gerald I ^b   Kahn, Barbara B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 4; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT DNA; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE ISOLATION; INSULIN METABOLISM; INSULIN RESISTANCE; INTRACELLULAR TRANSPORT; MALE; MOUSE; MUSCLE TISSUE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADIPOCYTES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BIOLOGICAL TRANSPORT; CROSSES, GENETIC; DIABETES MELLITUS; DOWN-REGULATION; FEMALE; GENE TARGETING; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RESISTANCE; LIVER; MALE; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL;

ANIMALIA;

EID: 0035825643     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35055575     Document Type: Article

References (25)

1. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
2. Applications of NMR spectroscopy to study muscle glycogen metabolism in man
3. Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
4. Glucose transporters and insulin action-implications for insulin resistance and diabetes mellitus
5. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
6. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
7. A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivo
8. Disruption of overlapping transcripts in the ROSA β geo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells
9. Generalized lacZ expression with the ROSA26 Cre reporter strain
10. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
11. Fiber type- and position-dependent expression of a myosin light chain- CAT transgene detected with a novel histochemical stain for CAT
12. Dietary obesity in nine inbred mouse strains
13. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
14. Leptin directly alters lipid partitioning in skeletal muscle
15. Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice
16. Tumor necrosis factor alpha: A key component of the obesity-diabetes link
17. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade
18. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
19. Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes
20. Effects of leptin on insulin sensitivity in normal rats
21. Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter
22. Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells
23. Mechanism of insulin resistance in A-ZIP/F-1 fatless mice
24. Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
25. Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid