Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons

Cell

Volumn 152, Issue 3, 2013, Pages 612-619

  Sohn, Jong Woo ^a   Harris, Louise E ^c   Berglund, Eric D ^a   Liu, Tiemin ^a   Vong, Linh ^d   Lowell, Bradford B ^d   Balthasar, Nina ^c   Williams, Kevin W ^a   Elmquist, Joel K ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE RECEPTOR STIMULATING AGENT; INSULIN; MELANOCORTIN 4 RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CHOLINERGIC ACTIVITY; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE DELETION; HYPERTENSION; INHIBITION KINETICS; MOUSE; NONHUMAN; OBESITY; PARASYMPATHETIC NERVE CELL; PREGANGLIONIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD; SYMPATHETIC NERVE CELL;

EID: 84873301711     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2012.12.022     Document Type: Article

References (29)

1. C. Acuna-Goycolea, and A. van den Pol Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal J. Neurosci. 24 2004 8141 8152
2. N. Balthasar, L.T. Dalgaard, C.E. Lee, J. Yu, H. Funahashi, T. Williams, M. Ferreira, V. Tang, R.A. McGovern, and C.D. Kenny Divergence of melanocortin pathways in the control of food intake and energy expenditure Cell 123 2005 493 505
3. R.D. Cone Anatomy and regulation of the central melanocortin system Nat. Neurosci. 8 2005 571 578
4. M.J. Diógenes, C.C. Fernandes, A.M. Sebastião, and J.A. Ribeiro Activation of adenosine A2A receptor facilitates brain-derived neurotrophic factor modulation of synaptic transmission in hippocampal slices J. Neurosci. 24 2004 2905 2913
5. W. Fan, B.A. Boston, R.A. Kesterson, V.J. Hruby, and R.D. Cone Role of melanocortinergic neurons in feeding and the agouti obesity syndrome Nature 385 1997 165 168
6. W. Fan, D.M. Dinulescu, A.A. Butler, J. Zhou, D.L. Marks, and R.D. Cone The central melanocortin system can directly regulate serum insulin levels Endocrinology 141 2000 3072 3079
7. I.S. Farooqi, J.M. Keogh, G.S. Yeo, E.J. Lank, T. Cheetham, and S. O'Rahilly Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene N. Engl. J. Med. 348 2003 1085 1095
8. T.P. Flagg, D. Enkvetchakul, J.C. Koster, and C.G. Nichols Muscle KATP channels: recent insights to energy sensing and myoprotection Physiol. Rev. 90 2010 799 829
9. J.R. Greenfield, J.W. Miller, J.M. Keogh, E. Henning, J.H. Satterwhite, G.S. Cameron, B. Astruc, J.P. Mayer, S. Brage, and T.C. See Modulation of blood pressure by central melanocortinergic pathways N. Engl. J. Med. 360 2009 44 52
10. J.W. Hill, K.W. Williams, C. Ye, J. Luo, N. Balthasar, R. Coppari, M.A. Cowley, L.C. Cantley, B.B. Lowell, and J.K. Elmquist Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice J. Clin. Invest. 118 2008 1796 1805
11. D. Huszar, C.A. Lynch, V. Fairchild-Huntress, J.H. Dunmore, Q. Fang, L.R. Berkemeier, W. Gu, R.A. Kesterson, B.A. Boston, and R.D. Cone Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell 88 1997 131 141
12. J.J. Kuo, A.A. da Silva, L.S. Tallam, and J.E. Hall Role of adrenergic activity in pressor responses to chronic melanocortin receptor activation Hypertension 43 2004 370 375
13. Y.W. Lin, M.Y. Min, T.H. Chiu, and H.W. Yang Enhancement of associative long-term potentiation by activation of beta-adrenergic receptors at CA1 synapses in rat hippocampal slices J. Neurosci. 23 2003 4173 4181
14. H. Liu, T. Kishi, A.G. Roseberry, X. Cai, C.E. Lee, J.M. Montez, J.M. Friedman, and J.K. Elmquist Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter J. Neurosci. 23 2003 7143 7154
15. K.G. Mountjoy, M.T. Mortrud, M.J. Low, R.B. Simerly, and R.D. Cone Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain Mol. Endocrinol. 8 1994 1298 1308
16. X.P. Ni, A.A. Butler, R.D. Cone, and M.H. Humphreys Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones J. Hypertens. 24 2006 2239 2246
17. S. Obici, Z. Feng, J. Tan, L. Liu, G. Karkanias, and L. Rossetti Central melanocortin receptors regulate insulin action J. Clin. Invest. 108 2001 1079 1085
18. V. Pascoli, M. Turiault, and C. Lüscher Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour Nature 481 2012 71 75
19. K.V. Quinn, J.P. Giblin, and A. Tinker Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel Circ. Res. 94 2004 1359 1366
20. J. Rossi, N. Balthasar, D. Olson, M. Scott, E. Berglund, C.E. Lee, M.J. Choi, D. Lauzon, B.B. Lowell, and J.K. Elmquist Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis Cell Metab. 13 2011 195 204
21. M.A. Smith, K. Hisadome, H. Al-Qassab, H. Heffron, D.J. Withers, and M.L. Ashford Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances J. Physiol. 578 2007 425 438
22. L.S. Tallam, D.E. Stec, M.A. Willis, A.A. da Silva, and J.E. Hall Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia Hypertension 46 2005 326 332
23. C. Vaisse, K. Clement, B. Guy-Grand, and P. Froguel A frameshift mutation in human MC4R is associated with a dominant form of obesity Nat. Genet. 20 1998 113 114
24. S. Wan, F.H. Coleman, and R.A. Travagli Glucagon-like peptide-1 excites pancreas-projecting preganglionic vagal motoneurons Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 G1474 G1482
25. S. Wan, K.N. Browning, F.H. Coleman, G. Sutton, H. Zheng, A. Butler, H.R. Berthoud, and R.A. Travagli Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons J. Neurosci. 28 2008 4957 4966
26. L. Wang, E. Spary, J. Deuchars, and S.A. Deuchars Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control J. Neurosci. 28 2008 12445 12452
27. K.W. Williams, and B.N. Smith Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour J. Physiol. 573 2006 395 412
28. K.W. Williams, A. Zsombok, and B.N. Smith Rapid inhibition of neurons in the dorsal motor nucleus of the vagus by leptin Endocrinology 148 2007 1868 1881
29. G.S. Yeo, I.S. Farooqi, S. Aminian, D.J. Halsall, R.G. Stanhope, and S. O'Rahilly A frameshift mutation in MC4R associated with dominantly inherited human obesity Nat. Genet. 20 1998 111 112