Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity

Molecular Endocrinology

Volumn 24, Issue 12, 2010, Pages 2366-2381

  Ghamari Langroudi, Masoud ^a   Vella, Kristen R ^b   Srisai, Dollada ^c   Sugrue, Michelle L ^b   Hollenberg, Anthony N ^b   Cone, Roger D ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c KASETSART UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; LEPTIN; PROTIRELIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; HYPOTHALAMUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THALAMUS MIDLINE NUCLEUS;

ADIPOSITY; ALPHA-MSH; ANIMALS; ARCUATE NUCLEUS; FASTING; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; LEPTIN; MELANOCORTINS; MICE; MICE, TRANSGENIC; NEURONS; NEUROPEPTIDE Y; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; PITUITARY GLAND; RATS; THYROID GLAND; THYROID HORMONES; THYROTROPIN-RELEASING HORMONE;

MUS;

EID: 78649413249     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2010-0203     Document Type: Article

References (51)

1. Lechan RM, Fekete C 2006 The TRH neuron: a hypothalamic integrator of energy metabolism. Prog Brain Res 153:209-235 (Pubitemid 44107417)
2. Segerson TP, Kauer J, Wolfe HC, Mobtaker H, Wu P, Jackson IM, Lechan RM 1987 Thyroid hormone regulates TRH biosynthesis in the paraventricular nucleus of the rat hypothalamus. Science 238:78-80
3. Kakucska I, Rand W, Lechan RM 1992 Thyrotropin-releasing hormone gene expression in the hypothalamic paraventricular nucleus is dependent on feedback regulation by both triiodothyronine and thyroxine. Endocrinology 130:2845-2850
4. Tapia-Arancibia L, Arancibia S, Astier H 1985 Evidence for α1-adrenergic stimulatory control of in vitro release of immunoreactive thyrotropin-releasing hormone from rat median eminence: in vivo corroboration. Endocrinology 116:2314-2319
5. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjøorbaek C, Elmquist JK, Flier JS, Hollenberg AN 2001 Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 107:111-120 (Pubitemid 32047420)
6. Fekete C, Mihály E, Luo LG, Kelly J, Clausen JT, Mao Q, Rand WM, Moss LG, Kuhar M, Emerson CH, Jackson IM, Lechan RM 2000 Association of cocaine- and amphetamine-regulated transcript-immunoreactive elements with thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and its role in the regulation of the hypothalamic-pituitary-thyroid axis during fasting. J Neurosci 20:9224-9234
7. Perello M, Stuart RC, Nillni EA 2006 The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 147:3296-3306
8. Toni R, Jackson IM, Lechan RM 1990 Neuropeptide-Y-immunoreactive innervation of thyrotropin-releasing hormone-synthesizing neurons in the rat hypothalamic paraventricular nucleus. Endocrinology 126:2444-2453 (Pubitemid 20173032)
9. Fekete C, Légrádi G, Mihály E, Huang QH, Tatro JB, Rand WM, Emerson CH, Lechan RM 2000 α-Melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J Neurosci 20:1550-1558
10. Shioda S, Nakai Y, Sato A, Sunayama S, Shimoda Y 1986 Electron-microscopic cytochemistry of the catecholaminergic innervation of TRH neurons in the rat hypothalamus. Cell Tissue Res 245:247-252 (Pubitemid 16059005)
11. Sawchenko PE, Swanson LW, Grzanna R, Howe PR, Bloom SR, Polak JM 1985 Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241:138-153
12. ter Horst GJ, Luiten PG 1986 The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res Bull 16:231-248
13. Keys A, Brozek J, Henschel J 1950 The biology of human starvation. Minneapolis: University of Minnesota Press
14. Bray GA, Fisler J, York DA 1990 Neuroendocrine control of the development of obesity: understanding gained from studies of experimental animal models. Front Neuroendocrinol 11:128-181
15. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos- Flier E, Flier JS 1996 Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252 (Pubitemid 26251358)
16. Légrádi G, Emerson CH, Ahima RS, Flier JS, Lechan RM 1997 Leptin prevents fasting induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 138:2569-2576
17. Welt CK, Chan JL, Bullen J, Murphy R, Smith P, DePaoli AM, Karalis A, Mantzoros CS 2004 Recombinant human leptin in women with hypothalamic amenorrhea. N Engl J Med 351:987-997
18. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S, Gallagher D, Mayer L, Murphy E, Leibel RL 2005 Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. The J Clin Invest 115:3579-3586 (Pubitemid 43121846)
19. Fekete C, Marks DL, Sarkar S, Emerson CH, Rand WM, Cone RD, Lechan RM 2004 Effect of agouti-related protein in regulation of the hypothalamic- pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse. Endocrinology 145:4816-4821
20. Elmquist JK, Bjørbaek C, Ahima RS, Flier JS, Saper CB 1998 Distribution of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 395:535-547 (Pubitemid 28226097)
21. Bates SH, Dundon TA, Seifert M, Carlson M, Maratos-Flier E, Myers Jr MG 2004 LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53:3067-3073
22. Hübschle T, Thom E, Watson A, Roth J, Klaus S, Meyerhof W 2001 Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci 21:2413-2424 (Pubitemid 32240538)
23. Legradi G, Emerson CH, Ahima RS, Rand WM, Flier JS, Lechan RM 1998 Arcuate nucleus ablation prevents fasting-induced suppression of proTRH mRNA in the hypothalamic paraventricular nucleus. Neuroendocrinology 68:89-97
24. Sarkar S, Légrádi G, Lechan RM 2002 Intracerebroventricular administration of α-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus. Brain Res 945:50-59
25. Fekete C, Kelly J, Mihaly E, Sarkar S, Rand WM, Légrádi G, Emerson CH, Lechan RM 2001 Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis. Endocrinology 142:2606-2613 (Pubitemid 32473117)
26. Farooqi IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, Butler G, Cheetham T, O'Rahilly S 2000 Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 106:271-279
27. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Grüters A 1998 Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19:155-157
28. Erickson JC, Ahima RS, Hollopeter G, Flier JS, Palmiter RD 1997 Endocrine function of neuropeptide Y knockout mice. Regul Pept 70:199-202 (Pubitemid 27362313)
29. Challis BG, Coll AP, Yeo GS, Pinnock SB, Dickson SL, Thresher RR, Dixon J, Zahn D, Rochford JJ, White A, Oliver RL, Millington G, Aparicio SA, Colledge WH, Russ AP, Carlton MB, O'Rahilly S 2004 Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY(3-36). Proc Natl Acad Sci USA 101:4695-4700
30. Martin NM, Small CJ, Sajedi A, Liao XH, Weiss RE, Gardiner JV, Ghatei MA, Bloom SR 2004 Abnormalities of the hypothalamo-pituitary-thyroid axis in the pro-opiomelanocortin deficient mouse. Regul Pept 122:169-172
31. Wortley KE, Anderson KD, Yasenchak J, Murphy A, Valenzuela D, Diano S, Yancopoulos GD, Wiegand SJ, Sleeman MW 2005 Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab 2:421-427
32. Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjørbak C, Flier JS 2000 Leptin regulates prothyrotropin-releasing hormone biosynthesis. J Biol Chem 275:36124-36133
33. Guo F, Bakal K, Minokoshi Y, Hollenberg AN 2004 Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology 145:2221-2227 (Pubitemid 38535051)
34. Sugrue ML, Vella KR, Morales C, Lopez ME, Hollenberg AN 2010 The thyrotropin-releasing hormone gene is regulated by thyroid hormone at the level of transcription in vivo. Endocrinology 151:793-801
35. Swanson LW, Kuypers HG 1980 The paraventricular nucleus of the hypothalamus: cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J Comp Neurol 194:555-570
36. Lechan RM, Jackson IMD 1982 Immunohistochemical localization of thyrotropin-releasing hormone in the rat hypothalamus and pituitary. Endocrinology 111:55-65
37. Bern H, Knowles F 1966 Neurosecretion. In: Martini L, Ganong W, eds. Neuroendocrinology. New York: Academic; 139-186
38. Merchenthaler I 1991 Neurons with access to the general circulation in the central nervous system of the rat: a retrograde tracing study with fluoro-gold. Neuroscience 44:655-662
39. Luther JA, Daftary SS, Boudaba C, Gould GC, Halmos KC, Tasker JG 2002 Neurosecretory and non-neurosecretory parvocellular neurones of the hypothalamic paraventricular nucleus express distinct electrophysiological properties. J Neuroendocrinol 14:929-932
40. Stern JE 2001 Electrophysiological and morphological properties of pre-autonomic neurones in the rat hypothalamic paraventricular nucleus. J Physiol 537:161-177
41. Tasker JG, Dudek FE 1991 Electrophysiological properties of neurones in the region of the paraventricular nucleus in slices of rat hypothalamus. J Physiol 434:271-293
42. Luther JA, Tasker JG 2000 Voltage-gated currents distinguish parvocellular from magnocellular neurones in the rat hypothalamic paraventricular nucleus. J Physiol 523:193-209
43. Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, Elmquist JK 2003 Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23:7143-7154 (Pubitemid 36975878)
44. Smith MA, Hisadome K, Al-Qassab H, Heffron H, Withers DJ, Ashford ML 2007 Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. J Physiol 578(Pt 2):425-438
45. Fong TM, Van der Ploeg LHT 2000 A melanocortin agonist reduces neuronal firing rate in rat hypothalamic slices. Neurosci Lett 283:5-8
46. Schiöth HB, Mutulis F, Muceniece R, Prusis P, Wikberg JE 1998 Discovery of novel melanocortin4 receptor selective MSH analogues. Br J Pharmacol 124:75-82
47. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD 1999 Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: Evidence of a cellular basis for the adipostat. Neuron 24:155-163
48. Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ 2001 Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 411:480-484 (Pubitemid 32494394)
49. Powis JE, Bains JS, Ferguson AV 1998 Leptin depolarizes rat hypothalamic paraventricular nucleus neurons. Am J Physiol Regul Integr Comp Physiol 274:R1468-R1472
50. Ben-Barak Y, Russell JT, Whitnall MH, Ozato K, Gainer H 1985 Neurophysin in the hypothalamo-neurohypophysial system. I. Production and characterization of monoclonal antibodies. J Neurosci 5:81-97 (Pubitemid 15155673)
51. Satoh T, Yamada M, Monden T, Iizuka M, Mori M 1992 Cloning of the mouse hypothalamic preprothyrotropin-releasing hormone (TRH) cDNA and tissue distribution of its mRNA. Brain Res Mol Brain Res 14:131-135