메뉴 건너뛰기




Volumn 61, Issue 11, 2012, Pages 2753-2762

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INSULIN; OXYNTOMODULIN; PROGLUCAGON;

EID: 84868013714     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-1556     Document Type: Article
Times cited : (187)

References (47)
  • 1
    • 34247899152 scopus 로고    scopus 로고
    • Gut hormones and appetite control
    • Wren AM, Bloom SR. Gut hormones and appetite control. Gastroenterology 2007;132:2116-2130
    • (2007) Gastroenterology , vol.132 , pp. 2116-2130
    • Wren, A.M.1    Bloom, S.R.2
  • 2
    • 70350619609 scopus 로고    scopus 로고
    • Effects of liraglutide in the treatment of obesity: A randomised, double-blind, placebo-controlled study
    • NN8022-1807 Study Group
    • Astrup A, Rössner S, Van Gaal L, et al.; NN8022-1807 Study Group. Effects of liraglutide in the treatment of obesity: a randomised, double-blind, placebo-controlled study. Lancet 2009;374:1606-1616
    • (2009) Lancet , vol.374 , pp. 1606-1616
    • Astrup, A.1    Rössner, S.2    Van Gaal, L.3
  • 3
    • 79960741385 scopus 로고    scopus 로고
    • Peripheral and Central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4
    • Kanoski SE, Fortin SM, Arnold M, Grill HJ, Hayes MR. Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4. Endocrinology 2011;152:3103-3112
    • (2011) Endocrinology , vol.152 , pp. 3103-3112
    • Kanoski, S.E.1    Fortin, S.M.2    Arnold, M.3    Grill, H.J.4    Hayes, M.R.5
  • 4
    • 77953724748 scopus 로고    scopus 로고
    • Glucagon regulation of energy metabolism
    • Heppner KM, Habegger KM, Day J, et al. Glucagon regulation of energy metabolism. Physiol Behav 2010;100:545-548
    • (2010) Physiol Behav , vol.100 , pp. 545-548
    • Heppner, K.M.1    Habegger, K.M.2    Day, J.3
  • 5
    • 70349644658 scopus 로고    scopus 로고
    • Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice
    • Pocai A, Carrington PE, Adams JR, et al. Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice. Diabetes 2009;58:2258-2266
    • (2009) Diabetes , vol.58 , pp. 2258-2266
    • Pocai, A.1    Carrington, P.E.2    Adams, J.R.3
  • 6
    • 70349308687 scopus 로고    scopus 로고
    • A new glucagon and GLP-1 co-agonist eliminates obesity in rodents
    • Day JW, Ottaway N, Patterson JT, et al. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 2009;5:749-757
    • (2009) Nat Chem Biol , vol.5 , pp. 749-757
    • Day, J.W.1    Ottaway, N.2    Patterson, J.T.3
  • 7
    • 4143116741 scopus 로고    scopus 로고
    • Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure
    • Baggio LL, Huang QL, Brown TJ, Drucker DJ. Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure. Gastroenterology 2004;127:546-558
    • (2004) Gastroenterology , vol.127 , pp. 546-558
    • Baggio, L.L.1    Huang, Q.L.2    Brown, T.J.3    Drucker, D.J.4
  • 9
    • 0034807498 scopus 로고    scopus 로고
    • Oxyntomodulin inhibits food intake in the rat
    • Dakin CL, Gunn I, Small CJ, et al. Oxyntomodulin inhibits food intake in the rat. Endocrinology 2001;142:4244-4250
    • (2001) Endocrinology , vol.142 , pp. 4244-4250
    • Dakin, C.L.1    Gunn, I.2    Small, C.J.3
  • 10
    • 23644443678 scopus 로고    scopus 로고
    • Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: A double-blind, randomized, controlled trial
    • Wynne K, Park AJ, Small CJ, et al. Subcutaneous oxyntomodulin reduces body weight in overweight and obese subjects: a double-blind, randomized, controlled trial. Diabetes 2005;54:2390-2395
    • (2005) Diabetes , vol.54 , pp. 2390-2395
    • Wynne, K.1    Park, A.J.2    Small, C.J.3
  • 11
    • 54349119151 scopus 로고    scopus 로고
    • The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice
    • Maida A, Lovshin JA, Baggio LL, Drucker DJ. The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice. Endocrinology 2008;149: 5670-5678
    • (2008) Endocrinology , vol.149 , pp. 5670-5678
    • Maida, A.1    Lovshin, J.A.2    Baggio, L.L.3    Drucker, D.J.4
  • 12
    • 0036889316 scopus 로고    scopus 로고
    • Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats
    • Dakin CL, Small CJ, Park AJ, Seth A, Ghatei MA, Bloom SR. Repeated ICV administration of oxyntomodulin causes a greater reduction in body weight gain than in pair-fed rats. Am J Physiol Endocrinol Metab 2002;283: E1173-E1177
    • (2002) Am J Physiol Endocrinol Metab , vol.283
    • Dakin, C.L.1    Small, C.J.2    Park, A.J.3    Seth, A.4    Ghatei, M.A.5    Bloom, S.R.6
  • 14
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 2004;84:277-359
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 15
    • 65949097938 scopus 로고    scopus 로고
    • Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    • Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci 2009;29:5916-5925
    • (2009) J Neurosci , vol.29 , pp. 5916-5925
    • Nogueiras, R.1    Pérez-Tilve, D.2    Veyrat-Durebex, C.3
  • 16
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009;360:1509-1517
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 18
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • Virtanen KA, Lidell ME, Orava J, et al. Functional brown adipose tissue in healthy adults. N Engl J Med 2009;360:1518-1525
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 19
    • 0029958404 scopus 로고    scopus 로고
    • Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene
    • Scrocchi LA, Brown TJ, MaClusky N, et al. Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene. Nat Med 1996;2:1254-1258
    • (1996) Nat Med , vol.2 , pp. 1254-1258
    • Scrocchi, L.A.1    Brown, T.J.2    MaClusky, N.3
  • 20
    • 80053159809 scopus 로고    scopus 로고
    • CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice
    • Lockie SH, Czyzyk TA, Chaudhary N, et al. CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. Endocrinology 2011;152:3661-3667
    • (2011) Endocrinology , vol.152 , pp. 3661-3667
    • Lockie, S.H.1    Czyzyk, T.A.2    Chaudhary, N.3
  • 21
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the Central regulation of feeding
    • Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69-72
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 23
    • 0013968791 scopus 로고
    • The effect of propranalol on the calorigenic response in brown adipose tissue of new-born rabbits to catecholamines, glucagon, corticotrophin and cold exposure
    • Heim T, Hull D. The effect of propranalol on the calorigenic response in brown adipose tissue of new-born rabbits to catecholamines, glucagon, corticotrophin and cold exposure. J Physiol 1966;187:271-283
    • (1966) J Physiol , vol.187 , pp. 271-283
    • Heim, T.1    Hull, D.2
  • 24
    • 0018564211 scopus 로고
    • Thermogenic responses of brown adipocytes to noradrenaline and glucagon in heat-acclimated and cold-acclimated rats
    • Kuroshima A, Yahata T. Thermogenic responses of brown adipocytes to noradrenaline and glucagon in heat-acclimated and cold-acclimated rats. Jpn J Physiol 1979;29:683-690
    • (1979) Jpn J Physiol , vol.29 , pp. 683-690
    • Kuroshima, A.1    Yahata, T.2
  • 25
    • 0031765348 scopus 로고    scopus 로고
    • Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells
    • Dicker A, Zhao J, Cannon B, Nedergaard J. Apparent thermogenic effect of injected glucagon is not due to a direct effect on brown fat cells. Am J Physiol 1998;275:R1674-R1682
    • (1998) Am J Physiol , vol.275
    • Dicker, A.1    Zhao, J.2    Cannon, B.3    Nedergaard, J.4
  • 26
    • 0021147037 scopus 로고
    • Effect of intracerebroventricularly infused glucagon on feeding behavior
    • Inokuchi A, Oomura Y, Nishimura H. Effect of intracerebroventricularly infused glucagon on feeding behavior. Physiol Behav 1984;33:397-400
    • (1984) Physiol Behav , vol.33 , pp. 397-400
    • Inokuchi, A.1    Oomura, Y.2    Nishimura, H.3
  • 27
    • 71949127251 scopus 로고    scopus 로고
    • Effects of Central administration of glucagon on feed intake and endocrine responses in sheep
    • Kurose Y, Kamisoyama H, Honda K, et al. Effects of central administration of glucagon on feed intake and endocrine responses in sheep. Anim Sci J 2009;80:686-690
    • (2009) Anim Sci J , vol.80 , pp. 686-690
    • Kurose, Y.1    Kamisoyama, H.2    Honda, K.3
  • 28
    • 0021136896 scopus 로고
    • Identification of glucagon receptors in rat brain
    • Hoosein NM, Gurd RS. Identification of glucagon receptors in rat brain. Proc Natl Acad Sci USA 1984;81:4368-4372
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 4368-4372
    • Hoosein, N.M.1    Gurd, R.S.2
  • 29
    • 0019772324 scopus 로고
    • Immunoreactive glucagon in neurons of various parts of the human brain. Demonstration by immunofluorescence technique
    • Dorn A, Rinne A, Bernstein HG, Hahn HJ, Ziegler M, Dammert K. Immunoreactive glucagon in neurons of various parts of the human brain. Demonstration by immunofluorescence technique. Acta Histochem 1981; 69:243-247
    • (1981) Acta Histochem , vol.69 , pp. 243-247
    • Dorn, A.1    Rinne, A.2    Bernstein, H.G.3    Hahn, H.J.4    Ziegler, M.5    Dammert, K.6
  • 30
    • 0023950336 scopus 로고
    • Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: An immunocytochemical study
    • Jin SLC, Han VKM, Simmons JG, Towle AC, Lauder JM, Lund PK. Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study. J Comp Neurol 1988; 271:519-532
    • (1988) J Comp Neurol , vol.271 , pp. 519-532
    • Jin, S.L.C.1    Han, V.K.M.2    Simmons, J.G.3    Towle, A.C.4    Lauder, J.M.5    Lund, P.K.6
  • 31
    • 0037349103 scopus 로고    scopus 로고
    • Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity
    • Runge S, Wulff BS, Madsen K, Bräuner-Osborne H, Knudsen LB. Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity. Br J Pharmacol 2003;138:787-794
    • (2003) Br J Pharmacol , vol.138 , pp. 787-794
    • Runge, S.1    Wulff, B.S.2    Madsen, K.3    Bräuner-Osborne, H.4    Knudsen, L.B.5
  • 32
    • 66149186747 scopus 로고    scopus 로고
    • Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors
    • Skibicka KP, Alhadeff AL, Grill HJ. Hindbrain cocaine- and amphetamine-regulated transcript induces hypothermia mediated by GLP-1 receptors. J Neurosci 2009;29:6973-6981
    • (2009) J Neurosci , vol.29 , pp. 6973-6981
    • Skibicka, K.P.1    Alhadeff, A.L.2    Grill, H.J.3
  • 33
    • 47949104953 scopus 로고    scopus 로고
    • Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation
    • Hayes MR, Skibicka KP, Grill HJ. Caudal brainstem processing is sufficient for behavioral, sympathetic, and parasympathetic responses driven by peripheral and hindbrain glucagon-like-peptide-1 receptor stimulation. Endocrinology 2008;149:4059-4068
    • (2008) Endocrinology , vol.149 , pp. 4059-4068
    • Hayes, M.R.1    Skibicka, K.P.2    Grill, H.J.3
  • 34
    • 0029963167 scopus 로고    scopus 로고
    • A role for Central glucagonlike peptide-1 in temperature regulation
    • O'Shea D, Gunn I, Chen X, Bloom S, Herbert J. A role for central glucagonlike peptide-1 in temperature regulation. Neuroreport 1996;7:830-832
    • (1996) Neuroreport , vol.7 , pp. 830-832
    • O'Shea, D.1    Gunn, I.2    Chen, X.3    Bloom, S.4    Herbert, J.5
  • 35
    • 78650507366 scopus 로고    scopus 로고
    • GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons
    • Griffioen KJ, Wan R, Okun E, et al. GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons. Cardiovasc Res 2011;89:72-78
    • (2011) Cardiovasc Res , vol.89 , pp. 72-78
    • Griffioen, K.J.1    Wan, R.2    Okun, E.3
  • 36
    • 23844446798 scopus 로고    scopus 로고
    • Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system
    • Osaka T, Endo M, Yamakawa M, Inoue S. Energy expenditure by intravenous administration of glucagon-like peptide-1 mediated by the lower brainstem and sympathoadrenal system. Peptides 2005;26:1623-1631
    • (2005) Peptides , vol.26 , pp. 1623-1631
    • Osaka, T.1    Endo, M.2    Yamakawa, M.3    Inoue, S.4
  • 38
    • 77249099832 scopus 로고    scopus 로고
    • Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat
    • Hondares E, Rosell M, Gonzalez FJ, Giralt M, Iglesias R, Villarroya F. Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab 2010;11:206-212
    • (2010) Cell Metab , vol.11 , pp. 206-212
    • Hondares, E.1    Rosell, M.2    Gonzalez, F.J.3    Giralt, M.4    Iglesias, R.5    Villarroya, F.6
  • 40
    • 79953886306 scopus 로고    scopus 로고
    • Thermogenic activation induces FGF21 expression and release in brown adipose tissue
    • Hondares E, Iglesias R, Giralt A, et al. Thermogenic activation induces FGF21 expression and release in brown adipose tissue. J Biol Chem 2011; 286:12983-12990
    • (2011) J Biol Chem , vol.286 , pp. 12983-12990
    • Hondares, E.1    Iglesias, R.2    Giralt, A.3
  • 41
    • 70349381447 scopus 로고    scopus 로고
    • Histochemical demonstration of monocarboxylate transporters in mouse brown adipose tissue
    • Iwanaga T, Kuchiiwa T, Saito M. Histochemical demonstration of monocarboxylate transporters in mouse brown adipose tissue. Biomed Res 2009;30:217-225
    • (2009) Biomed Res , vol.30 , pp. 217-225
    • Iwanaga, T.1    Kuchiiwa, T.2    Saito, M.3
  • 42
    • 79959525534 scopus 로고    scopus 로고
    • Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice
    • Gu W, Lloyd DJ, Chinookswong N, et al. Pharmacological targeting of glucagon and glucagon-like peptide 1 receptors has different effects on energy state and glucose homeostasis in diet-induced obese mice. J Pharmacol Exp Ther 2011;338:70-81
    • (2011) J Pharmacol Exp Ther , vol.338 , pp. 70-81
    • Gu, W.1    Lloyd, D.J.2    Chinookswong, N.3
  • 43
    • 79751503329 scopus 로고    scopus 로고
    • Brown adipose tissue activity controls triglyceride clearance
    • Bartelt A, Bruns OT, Reimer R, et al. Brown adipose tissue activity controls triglyceride clearance. Nat Med 2011;17:200-205
    • (2011) Nat Med , vol.17 , pp. 200-205
    • Bartelt, A.1    Bruns, O.T.2    Reimer, R.3
  • 44
    • 38949084886 scopus 로고    scopus 로고
    • Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation
    • Jakus PB, Sandor A, Janaky T, Farkas V. Cooperation between BAT and WAT of rats in thermogenesis in response to cold, and the mechanism of glycogen accumulation in BAT during reacclimation. J Lipid Res 2008;49: 332-339
    • (2008) J Lipid Res , vol.49 , pp. 332-339
    • Jakus, P.B.1    Sandor, A.2    Janaky, T.3    Farkas, V.4
  • 45
    • 0036154102 scopus 로고    scopus 로고
    • Cold elicits the simultaneous induction of fatty acid synthesis and beta-oxidation in murine brown adipose tissue: Prediction from differential gene expression and confirmation in vivo
    • Yu XX, Lewin DA, Forrest W, Adams SH. Cold elicits the simultaneous induction of fatty acid synthesis and beta-oxidation in murine brown adipose tissue: prediction from differential gene expression and confirmation in vivo. FASEB J 2002;16:155-168
    • (2002) FASEB J , vol.16 , pp. 155-168
    • Yu, X.X.1    Lewin, D.A.2    Forrest, W.3    Adams, S.H.4
  • 46
    • 0030991928 scopus 로고    scopus 로고
    • Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline
    • Thomas SA, Palmiter RD. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Nature 1997;387:94-97
    • (1997) Nature , vol.387 , pp. 94-97
    • Thomas, S.A.1    Palmiter, R.D.2
  • 47
    • 0037008157 scopus 로고    scopus 로고
    • BetaAR signaling required for diet-induced thermogenesis and obesity resistance
    • Bachman ES, Dhillon H, Zhang CY, et al. betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 2002;297:843-845
    • (2002) Science , vol.297 , pp. 843-845
    • Bachman, E.S.1    Dhillon, H.2    Zhang, C.Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.