Fibroblast growth factor-19 action in the brain reduces food intake and body weight and improves glucose tolerance in male rats

Endocrinology

Volumn 154, Issue 1, 2013, Pages 9-15

  Ryan, Karen K ^a   Kohli, Rohit ^c   Gutierrez Aguilar, Ruth ^a   Gaitonde, Shrawan G ^b   Woods, Stephen C ^b   Seeley, Randy J ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Department of Surgery ^*  (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 TERT BUTYL 3 [6 (3,5 DIMETHOXYPHENYL) 2 (4 DIETHYLAMINOBUTYLAMINO)PYRIDO[2,3 D]PYRIMIDIN 7 YL]UREA; FAT; GLUCOSE; RECOMBINANT FIBROBLAST GROWTH FACTOR 19; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIET RESTRICTION; DRUG MECHANISM; ENERGY EXPENDITURE; FOOD INTAKE; GLUCOSE HOMEOSTASIS; GLUCOSE TOLERANCE; HYPOTHALAMUS; IMPAIRED GLUCOSE TOLERANCE; LIPID DIET; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WEIGHT REDUCTION;

ANIMALS; BODY WEIGHT; BRAIN; EATING; ENERGY METABOLISM; FIBROBLAST GROWTH FACTORS; GLUCOSE; HUMANS; MALE; RATS; RATS, LONG-EVANS;

EID: 84871694003     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2012-1891     Document Type: Article

References (32)

1. Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA 2011 FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway. Cell Metab 13:729-738
2. Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA 2005 Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2:217-225
3. Choi M, Moschetta A, Bookout AL, Peng L, Umetani M, Holmstrom SR, Suino-Powell K, Xu HE, Richardson JA, Gerard RD, Mangelsdorf DJ, Kliewer SA 2006 Identification of a hormonal basis for gallbladder filling. Nat Med 12:1253-1255 (Pubitemid 44706926)
4. Jones S 2008 Mini-review: endocrine actions of fibroblast growth factor 19. Mol Pharmacol 5:42-48 (Pubitemid 351300033)
5. Itoh N 2010 Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease. Cell Tissue Res 342:1-11
6. Fu L, John LM, Adams SH, Yu XX, Tomlinson E, Renz M, Williams PM, Soriano R, Corpuz R, Moffat B, Vandlen R, Simmons L, Foster J, Stephan JP, Tsai SP, Stewart TA 2004 Fibroblast growth factor 19 increases metabolic rate and reverses dietary and leptin-deficient diabetes. Endocrinology 145:2594-2603 (Pubitemid 38686202)
7. Tomlinson E, Fu L, John L, Hultgren B, Huang X, Renz M, Stephan JP, Tsai SP, Powell-Braxton L, French D, Stewart TA 2002 Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity. Endocrinology 143:1741-1747 (Pubitemid 34415889)
8. Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ 2011 FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science 331:1621-1624
9. Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL 2007 FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes 56:2501-2510 (Pubitemid 47523257)
10. Sandoval DA, Obici S, Seeley RJ 2009 Targeting the CNS to treat type 2 diabetes. Nat Rev Drug Discov 8:386-398
11. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG 2000 Central nervous system control of food intake. Nature 404:661-671 (Pubitemid 30205071)
12. Gutierrez-Aguilar R, Kim DH, Woods SC, Seeley RJ 2012 Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology. Obesity 20:306-312
13. Clegg DJ, Gotoh K, Kemp C, Wortman MD, Benoit SC, Brown LM, D'Alessio D, Tso P, Seeley RJ, Woods SC 2011 Consumption of a high-fat diet induces central insulin resistance independent of adiposity. Physiol Behav 103:10-16
14. Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-o M 2007 Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem 282:26687-26695 (Pubitemid 47501965)
15. Fon Tacer K, Bookout AL, Ding X, Kurosu H, John GB, Wang L, Goetz R, Mohammadi M, Kuro-o M, Mangelsdorf DJ, Kliewer SA 2010 Research resource: comprehensive expression atlas of the fibroblast growth factor system in adult mouse. Mol Endocrinol 24:2050-2064
16. Matsuo A, Tooyama I, Isobe S, Oomura Y, Akiguchi I, Hanai K, Kimura J, Kimura H 1994 Immunohistochemical localization in the rat brain of an epitope corresponding to the fibroblast growth factor receptor-1. Neuroscience 60:49-66 (Pubitemid 24147607)
17. Gonzalez AM, Berry M, Maher PA, Logan A, Baird A 1995 A comprehensive analysis of the distribution of FGF-2 and FGFR1 in the rat brain. Brain Res 701:201-226
18. Ryan KK, Woods SC, Seeley RJ 2012 Central nervous system mechanisms linking the consumption of palatable high fat diets to the defense of greater adiposity. Cell Metab 15:137-149
19. Adams AC, Coskun T, Rovira AR, Schneider MA, Raches DW, Micanovic R, Bina HA, Dunbar JD, Kharitonenkov 2012 A Fundamentals of FGF19, FGF21 action in vitro and in vivo. PloS One 7:e38438
20. Sasaki K, Oomura Y, Suzuki K, Muto T, Hanai K, Tooyama I, Kimura H, Yanaihara N 1991 Effects of fibroblast growth factors and platelet-derived growth factor on food intake in rats. Brain Res Bull 27:327-332
21. Li AJ, Oomura Y, Hori T, Aou S, Sasaki K, Kimura H, Tooyama I 1996 Fibroblast growth factor receptor-1 in the lateral hypothalamic area regulates food intake. Exp Neurol 137:318-323 (Pubitemid 26081892)
22. Taylor VI JG, Cheuk AT, Tsang PS, Chung JY, Song YK, Desai K, Yu Y, Chen QR, Shah K, Youngblood V, Fang J, Kim SY, Yeung C, Helman LJ, Mendoza A, Ngo V, Staudt LM, Wei JS, Khanna C, Catchpoole D, Qualman SJ, Hewitt SM, Merlino G, Chanock SJ, Khan J 2009 Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted models. J Clin Invest 119:3395-3407
23. Pardo OE, Latigo J, Jeffery RE, Nye E, Poulsom R, Spencer-Dene B, Lemoine NR, Stamp GW, Aboagye EO, Seckl MJ 2009 The fibroblast growth factor receptor inhibitor PD173074 blocks small cell lung cancer growth in vitro and in vivo. Cancer Res 69:8645-8651
24. The gene expression nervous system altas (GENSAT) Project. NINDS Contracts 1INS02331 and HHSN271200723701C to the Rockefeller University, New York, NY
25. Barutcuoglu B, Basol G, Cakir Y, Cetinkalp S, Parildar Z, Kabaroglu C, Ozmen D, Mutaf I, Bayindir O 2011 Fibroblast growth factor-19 levels in type 2 diabetic patients with metabolic syndrome. Ann Clin Lab Sci 41:390-396
26. Strack AM, Myers RW 2004 Modulation of metabolic syndrome by fibroblast growth factor 19 (FGF19)? Endocrinology 145:2591-2593 (Pubitemid 38686201)
27. Wu X, Li Y 2011 Therapeutic utilities of fibroblast growth factor 19. Expert Opin Ther Targets 15:1307-1316
28. Long YC, Kharitonenkov A 2011 Hormone-like fibroblast growth factors and metabolic regulation. Biochim Biophys Acta 1812:791-795
29. Véniant MM, Komorowski R, Chen P, Stanislaus S, Winters K, Hager T, Zhou L, Wada R, Hecht R, Xu J 2012 Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys. Endocrinology 153:4192-4203
30. Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A 2008 Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149:6018-6027
31. Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K, Schwartz MW 2010 Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 59:1817-1824
32. Adams AC, Yang C, Coskun T, Cheng CC, Gimeno RE, Luo Y, Kharitonenkov A 27 August 2012 The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue. Mol Metab 10.1016/j.molmet.2012.08.007