Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

Journal of Clinical Investigation

Volumn 121, Issue 4, 2011, Pages 1424-1428

  Krashes, Michael J ^a   Koda, Shuichi ^a,b   Ye, ChianPing ^a   Rogan, Sarah C ^c   Adams, Andrew C ^a   Cusher, Daniel S ^a   Maratos Flier, Eleftheria ^a   Roth, Bryan L ^c   Lowell, Bradford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DAIICHI SANKYO CO   (Japan)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGOUTI RELATED PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; ENERGY EXPENDITURE; FEEDING BEHAVIOR; FOOD INTAKE; LIPID STORAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

AGOUTI-RELATED PROTEIN; ANIMALS; ARCUATE NUCLEUS; BRAIN; CLOZAPINE; EATING; ENERGY METABOLISM; FEEDING BEHAVIOR; FEMALE; MALE; MICE; MICE, TRANSGENIC; NEURONS; WEIGHT GAIN;

EID: 79953307878     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46229     Document Type: Article

References (22)

1. Saper CB, Chou TC, Elmquist JK. The need to feed: homeostatic and hedonic control of eating. Neuron. 2002;36(2):199-211. (Pubitemid 35217887)
2. Flier JS. AgRP in energy balance: Will the real AgRP please stand up? Cell Metab. 2006;3(2):83-85.
3. Ollmann MM, et al. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 1997;278(5335):135-138. (Pubitemid 27446294)
4. Tong Q, Ye C, Jones JE, Elmquist JK, Lowell BB. Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008;11(9):998-1000.
5. Wu Q, Boyle MP, Palmiter RD. Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation. Cell. 2009;137(7):1225-1234.
6. Qian S, et al. Neither agouti-related protein nor neuropeptide Y is critically required for the regulation of energy homeostasis in mice. Mol Cell Biol. 2002;22(14):5027-5035. (Pubitemid 34700694)
7. Luquet S, Perez FA, Hnasko TS, Palmiter RD. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science. 2005;310(5748):683-685. (Pubitemid 41528162)
8. Gropp E, et al. Agouti-related peptide-expressing neurons are mandatory for feeding. Nat Neurosci. 2005;8(10):1289-1291. (Pubitemid 41630413)
9. Xu AW, et al. Effects of hypothalamic neurodegeneration on energy balance. PLoS Biol. 2005;3(12):e415.
10. Ferguson SM, et al. Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci. 2011;14(1):22-24.
11. Alexander GM, et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron. 2009;63(1):27-39.
12. Atasoy D, Aponte Y, Su HH, Sternson SM. A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J Neurosci. 2008;28(28):7025-7030.
13. Keesey RE, Powley TL. Body energy homeostasis. Appetite. 2008;51(3):442-445.
14. Armbruster BN, Li X, Pausch MJ, Herlitze S, Roth BL. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A. 2007; 104(12):5163-5168. (Pubitemid 47186193)
15. Shin AC, Zheng H, Berthoud HR. An expanded view of energy homeostasis: neural integration of metabolic, cognitive, and emotional drives to eat. Physiol Behav. 2009;97(5):572-580.
16. Brunzell DH, Chang JR, Schneider B, Olausson P, Taylor JR, Picciotto MR. beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice. Psychopharmacology. 2006;184(3-4):328-338. (Pubitemid 43255849)
17. Pissios P, et al. Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice. Biol Psychiatry. 2008;64(3):184-191.
18. Shu X, Shaner NC, Yarbrough CA, Tsien RY, Remington SJ. Novel chromophores and buried charges control color in mFruits. Biochemistry. 2006;45(32):9639-9647. (Pubitemid 44257411)
19. Cardin JA, et al. Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature. 2009;459(7247):663-667.
20. Cardin JA, et al. Targeted optogenetic stimulation and recording of neurons in vivo using cell-typespecific expression of Channelrhodopsin-2. Nat protoc. 2010;5(2):247-254.
21. Balthasar N, et al. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005;123(3):493-505. (Pubitemid 41546678)
22. Dhillon H, et al. Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron. 2006;49(2):191-203. (Pubitemid 43089637)