Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection

Neuron

Volumn 42, Issue 4, 2004, Pages 635-652

  Van Den Pol, Anthony N ^a   Acuna Goycolea, Claudio ^a   Clark, K Reed ^b   Ghosh, Prabhat K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN CONCENTRATING HORMONE; MUSCARINE; NEUROPEPTIDE Y; NORADRENALIN; OREXIN; SEROTONIN;

ANIMAL CELL; ANIMAL TISSUE; AROUSAL; ARTICLE; BRAIN CELL; CELL FUNCTION; CELL MEMBRANE; CYTOMEGALOVIRUS; ENERGY BALANCE; ENERGY CONSERVATION; GENE EXPRESSION; HORMONE SYNTHESIS; HYPOTHALAMUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SYNAPTIC TRANSMISSION; VIRUS INFECTION;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; AROUSAL; CARRIER PROTEINS; CYTOMEGALOVIRUS; DEPENDOVIRUS; ENERGY METABOLISM; EXCITATORY POSTSYNAPTIC POTENTIALS; GENE EXPRESSION REGULATION; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HYPOTHALAMIC HORMONES; HYPOTHALAMUS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUMINESCENT PROTEINS; MELANINS; MEMBRANE POTENTIALS; MICE; MUSCARINE; NEURAL INHIBITION; NEURONS; NEUROPEPTIDE Y; NEUROPEPTIDES; PITUITARY HORMONES; PROMOTER REGIONS (GENETICS); SEROTONIN; SYNAPSES;

EID: 2442538044     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(04)00251-X     Document Type: Article

References (56)

1. Bittencourt J.C., Presse F., Arias C., Peto C., Vaughan J., Nahon J.-L., Vale W., Sawchenko P.E. The melanin-concentrating hormone system of the rat brain. an immuno- and hybridization histochemical characterization J. Comp. Neurol. 319:1992;218-245
2. Borowsky B., Durkin M.M., Ogozalek K., Marzabadi M.R., DeLeon J., Lagu B., Heurich R., Lichtblau H., Shaposhnik Z., Daniewska I., et al. Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist. Nat. Med. 8:2002;825-830
3. Broberger C., De Lecea L., Sutcliffe J.G., Hökfelt T. Hypocretin/orexin and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus. relationship to the neuropeptide Y and Agouti gene-related protein systems J. Comp. Neurol. 402:1998;460-474
4. Burlet S., Tyler C.J., Leonard C.S. Direct and indirect excitation of laterodorsal tegmental neurons by hypocretin/orexin peptides. implications for wakefulness and narcolepsy J. Neurosci. 22:2002;2862-2872
5. Chambers J., Ames R.S., Bergsma D., Muir A., Fitzgerald L.R., Hervieu G., Dytko G.M., Foley J.J., Martin J., Liu W.S., et al. Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1. Nature. 400:1999;261-265
6. Clark K.R., Liu X., McGrath J.P., Johnson P.R. Highly purified recombinant adeno-associated virus vectors are biologically active and free of detectable helper and wild-type viruses. Hum. Gene Ther. 10:1999;1031-1039
7. Cowley M.A., Smart J.L., Rubinstein M., Cerdan M.G., Diano S., Horvath T.L., Cone R.D., Low M.J. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411:2001;480-484
8. Cowley M.A., Pronchuk N., Fan W., Dinulescu D.M., Colmers W.F., Cone R.D. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus. evidence of a cellular basis for the adipostat Neuron. 124:1999;155-163
9. de Lecea L., Kilduff T.S., Peyron C., Gao X.-B., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L.F., Gautvik V.T., Bartlett F.S. II, et al. The hypocretins. hypothalamus-specific peptides with neuroexcitatory activity Proc. Natl. Acad. Sci. USA. 95:1998;322-327
10. During M.J., Leone P. Adeno-associated virus vectors for gene therapy of neurodegenerative disorders. Clin. Neurosci. 3:1995;292-300
11. Eggermann E., Bayer L., Serafin M., Saint-Mleux B., Bernheim L., Machard D., Jones B.E., Muhlethaler M. The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization. J. Neurosci. 23:2003;1557-1562
12. Ehlers C.L., Somes C., Lopez A., Kirby D., Rivier J.E. Electrophysiological actions of neuropeptide Y and its analogs. new measures for anxiolytic therapy? Neuropsychopharmacology. 17:1997;34-43
13. Elias C.F., Saper C.B., Maratos-Flier E., Tritos N.A., Lee C., Kelly J., Tatro J.B., Hoffman G.E., Ollmann M.M., Barsh G.S., et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J. Comp. Neurol. 402:1998;442-459
14. Elias C.F., Lee C.E., Kelly J.F., Ahima R.S., Kuhar M., Saper C.B., Elmquist J.K. Characterization of CART neurons in the rat and human hypothalamus. J. Comp. Neurol. 432:2001;1-19
15. Fulton S., Woodside B., Shizgal P. Modulation of brain reward circuitry by leptin. Science. 287:2000;125-128
16. Gallopin T., Fort P., Eggermann E., Cauli B., Luppi P.H., Rossier J., Audinat E., Muhlethaler M., Serafin M. Identification of sleep-promoting neurons in vitro. Nature. 404:2000;992-995
17. Gao X.-B., van den Pol A.N. Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus. J. Physiol. 533:2001;237-252
18. Gao X.-B., Ghosh P.K., van den Pol A.N. Neurons synthesizing melanin concentrating hormone identified by selective reporter gene expression after transfection in vitro. J. Neurophysiol. 90:2003;3978-3985
19. Guan J.L., Uehara K., Lu S., Wang Q.P., Funahashi H., Sakurai T., Yanagizawa M., Shioda S. Reciprocal synaptic relationships between orexin- and melanin-concentrating hormone-containing neurons in the rat lateral hypothalamus. a novel circuit implicated in feeding regulation Int. J. Obes. Relat. Metab. Disord. 26:2002;1523-1532
20. ob mice. Neuroendocrinology. 69:1999;145-153
21. Li Y., Gao X.-B., Sakurai T., van den Pol A.N. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - a potential mechanism for orchestrating the hypothalamic arousal system. Neuron. 36:2002;1169-1181
22. Lin L., Faraco J., Li H., Kadotani R., Rogers W., Lin X., Qui X., deJong P.J., Nishino S., Mignot E. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 98:1999;365-376
23. Liu R.J., van den Pol A.N., Aghajanian G.K. Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J. Neurosci. 22:2002;9453-9464
24. Liu H., Kishi T., Roseberry A.G., Cai X., Lee C.E., Montez J.M., Friedman J.M., Elmquist J.K. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J. Neurosci. 23:2003;7143-7154
25. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J. Comp. Neurol. 435:2001;6-25
26. Marsh D.J., Weingarth D.T., Novi D.E., Chen H.Y., Trumbauer M.E., Chen A.S., Guan X.M., Jiang M.M., Feng Y., Camacho R.E., et al. Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism. Proc. Natl. Acad. Sci. USA. 99:2002;3240-3245
27. Mochizuki T., Scammell T.E. Orexin/hypocretin. wired for wakefulness Curr. Biol. 13:2003;R563-R564
28. Naveilhan P., Canals J.M., Valjakka A., Vartiainen J., Arenas E., Ernfors P. Neuropeptide Y alters sedation through a hypothalamic Y1-mediated mechanism. Eur. J. Neurosci. 13:2001;2241-2246
29. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J. Neurosci. 18:1998;9996-10008
30. Peyron C., Faraco J., Rogers W., Ripley B., Overeem S., Charnay Y., Nevsimalova S., Aldrich M., Reynolds D., Albin R., et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med. 6:2000;991-997
31. Qu D., Ludwig D.S., Gammeltoft S., Piper M., Pelleymounter M.A., Cullen M.J., Mathes W.F., Przypek J., Kanarek R., Maratos-Flier E. A role of melanin-concentrating hormone in the central regulation of feeding behavior. Nature. 380:1996;243-247
32. Rhim H., Kinney G.A., Emmerson P.J., Miller R.J. Regulation of neurotransmission in the arcuate nucleus of the rat by different neuropeptide Y receptors. J. Neurosci. 17:1997;2980-2989
33. Rolls E.T. The neurophysiology of feeding. Int. J. Obes. Suppl. 8:1984;139-150
34. Rolls E.T., Kelley P.H. Neural basis of stimulus-bound locomotor behavior in the rat. J. Comp. Physiol. Psychol. 81:1972;173-182
35. Rosin D.L., Weston M.C., Sevigny C.P., Stornetta R.L., Guyenet P.G. Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2. J. Comp. Neurol. 465:2003;593-603
36. Saito Y., Nothacker H.P., Wang Z.W., Lin S.H.S., Leslie F., Civelli O. Molecular characterization of the melanin-concentrating-hormone receptor. Nature. 400:1999;265-269
37. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., et al. Orexins and orexin receptors. A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior Cell. 92:1998;573-585
38. Samulski R.J. Expanding the AAV package. Nat. Biotechnol. 18:2000;497-498
39. Sawchenko P.E. Toward a new neurobiology of energy balance, appetite, and obesity. The anatomists weigh in J. Comp. Neurol. 402:1998;435-441
40. Schwartz M.W., Gelling R.W. Rats lighten up with MCH antagonist. Nat. Med. 8:2002;779-780
41. Schwartz M.W., Woods S.C., Porte D. Jr., Seeley R.J., Baskin D.G. Central nervous system control of food intake. Nature. 404:2000;661-671
42. Segal-Lieberman G., Bradley R.L., Kokkotou E., Carlson M., Trombly D.J., Wang X., Bates S., Myers M.G. Jr., Flier J.S., Maratos-Flier E. Melanin-concentrating hormone is a critical mediator of the leptin-deficient phenotype. Proc. Natl. Acad. Sci. USA. 100:2003;10085-10090
43. Sherin J.E., Shiromani P.J., McCarley R.W., Saper C.B. Activation of ventrolateral preoptic neurons during sleep. Science. 271:1996;216-219
44. Shimada M., Tritos N.A., Lowell B.B., Flier L.S., Maratos-Flier E. Mice lacking melanin-concentrating hormone are hypophagic and lean. Nature. 396:1998;670-674
45. Thannickal R., Moore R.Y., Nienhuis R., Ramanathan L., Gulyani S., Aldrich M., Cornford M., Siegel J.M. Reduced number of hypocretin neurons in human epilepsy. Neuron. 27:2000;469-474
46. Thompson R.C., Watson S.J. Nucleotide sequences and tissue-specific expression of the rat melanin concentrating hormone gene. DNA Cell Biol. 9:1990;637-645
47. Torrealba F., Yanagisawa M., Saper C.B. Colocalization of orexin a and glutamate immunoreactivity in axon terminals in the tuberomammillary nucleus in rats. Neuroscience. 119:2003;1033-1044
48. Valenstein E.S., Campbell J.F. Medial forebrain bundle-lateral hypothalamic area and reinforcing brain stimulation. Am. J. Physiol. 210:1966;270-274
49. van den Pol A.N. Hypothalamic hypocretin (orexin). robust innervation of the spinal cord J. Neurosci. 19:1999;3171-3182
50. van den Pol A.N., Ghosh P.K. Selective neuronal expression of green fluorescent protein with cytomegalovirus promoter reveals entire neuronal arbor in transgenic mice. J. Neurosci. 18:1998;10640-10651
51. van den Pol A.N., Obrietan K., Chen G., Belousov A.B. Neuropeptide Y-mediated long-term depression of excitatory activity in suprachiasmatic nucleus neurons. J. Neurosci. 16:1996;5883-5895
52. van den Pol A.N., Gao X.-B., Obrietan K., Kilduff T., Belousov A. Pre- and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J. Neurosci. 18:1998;7962-7971
53. van den Pol A.N., Mocarski E., Saederup N., Vierira J., Meier T.J. Cytomegalovirus cell tropism, replication, and gene transfer in brain. J. Neurosci. 19:1999;10948-10965
54. van den Pol A.N., Ghosh P.K., Liu R.J., Li Y., Aghajanian G.K., Gao X.-B. Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J. Physiol. 541:2002;169-185
55. Verret L., Goutagny R., Fort P., Cagnon L., Salvert D., Leger L., Boissard R., Salin P., Peyron C., Luppi P.H. A role of melanin-concentrating hormone producing neurons in the central regulation of paradoxical sleep. BMC Neurosci. 4:2003;19.. Published online September 9, 2003
56. Yamanaka A., Beuckmann C.T., Willie J.T., Hara J., Tsujino N., Mieda M., Tominaga M., Yagami K., Sugiyama F., Goto K., et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron. 38:2003;701-713