Ablation of Sim1 neurons causes obesity through hyperphagia and reduced energy expenditure

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Xi, Dong ^a   Gandhi, Nilay ^a   Lai, Meizan ^a   Kublaoui, Bassil M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; DIPHTHERIA TOXIN RECEPTOR; RECEPTOR; SINGLE MINDED 1 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 1; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; NEUROPEPTIDE; REPRESSOR PROTEIN; SIGNAL PEPTIDE; SIM1 PROTEIN, MOUSE;

ADULT ANIMAL; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENERGY EXPENDITURE; FEEDING BEHAVIOR; FEMALE; FOOD INTAKE; GENE; GENE EXPRESSION; HOMOZYGOTE; HYPERPHAGIA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; MOUSE; NEUROMODULATION; NONHUMAN; OBESITY; OXYTOCIN GENE; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN EXPRESSION; SIM1 GENE; THERMOGENESIS; THYROTROPIN RELEASING HORMONE GENE; ANIMAL; BODY WEIGHT; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; TRANSGENIC MOUSE;

MUS; SIMIAE;

ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BODY WEIGHT; DIPHTHERIA TOXIN; ENERGY METABOLISM; FEEDING BEHAVIOR; FEMALE; GENE EXPRESSION REGULATION; HYPERPHAGIA; HYPOTHALAMUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NEURONS; NEUROPEPTIDES; OBESITY; REPRESSOR PROTEINS; THERMOGENESIS;

EID: 84860476819     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036453     Document Type: Article

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