Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss

American Journal of Physiology - Endocrinology and Metabolism

Volumn 293, Issue 1, 2007, Pages

  Li, Gang ^a   Zhang, Yi ^a,b   Rodrigues, Enda ^a,b   Zheng, DongHang ^a   Matheny, Michael ^a   Cheng, Kit Yan ^a,b   Scarpace, Philip J ^a,c  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF FLORIDA   (United States)

Author keywords

Adult onset obesity; Brain stem; Gene delivery; Proopiomelanocortin overexpression

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; AGOUTI RELATED PROTEIN; ALPHA INTERMEDIN; FATTY ACID; MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; MESSENGER RNA; NEUROPEPTIDE Y; PARVOVIRUS VECTOR; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANOREXIA; ARTICLE; BODY WEIGHT; BRAIN STEM; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FOOD INTAKE; GENE EXPRESSION; GENE TARGETING; GLUCOSE METABOLISM; HORMONE SYNTHESIS; HYPOTHALAMUS; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIPID METABOLISM; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RHOMBENCEPHALON; SOLEUS MUSCLE; SOLITARY TRACT NUCLEUS; TACHYPHYLAXIS; THERMOGENESIS; WEIGHT REDUCTION;

ADIPOSITY; ALPHA-MSH; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANOREXIA; APPETITE REGULATION; BODY WEIGHT; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENE THERAPY; GENE TRANSFER TECHNIQUES; LEPTIN; MALE; MELANOCORTINS; OBESITY; PRO-OPIOMELANOCORTIN; RATS; RATS, INBRED F344; SOLITARY NUCLEUS; TACHYPHYLAXIS; TIME FACTORS; WEIGHT LOSS;

EID: 34547103515     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00451.2006     Document Type: Article

References (37)

1. Bluher S, Ziotopoulou M, Bullen JW Jr, Moschos SJ, Ungsunan L, Kokkotou E, Maratos-Flier E, Mantzoros CS. Responsiveness to peripherally administered melanocortins in lean and obese mice. Diabetes 53: 82-90, 2004.
2. Broberger C, Johansen J, Johansson C, Schalling M, Hokfelt T. The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95: 15043-15048, 1998.
3. Cannon B, Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol Rev 84: 277-359, 2004.
4. Cettour-Rose P, Rohner-Jeanrenaud F. The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats. Endocrinology 143: 2277-2283, 2002.
5. Cone RD. Anatomy and regulation of the central melanocortin system. Nat Neurosci 8: 571-578, 2005.
6. Cone RD. The central melanocortin system and energy homeostasis. Trends Endocrinol Metab 10: 211-216, 1999.
7. Ellacott KL, Cone RD. The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis. Recent Prog Horm Res 59: 395-408, 2004.
8. Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385: 165-168, 1997.
9. Grill HJ, Ginsberg AB, Seeley RJ, Kaplan JM. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J Neurosci 18: 10128-10135, 1998.
10. Grill HJ, Norgren R. Chronically decerebrate rats demonstrate satiation but not bait shyness. Science 201: 267-269, 1978.
11. Joseph SA, Pilcher WH, Bennett-Clarke C. Immunocytochemical localization of ACTH perikarya in nucleus tractus solitarius: evidence for a second opiocortin neuronal system. Neurosci Lett 38: 221-225, 1983.
12. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85: 2402-2410, 2000.
13. Kim KH. Regulation of mammalian acetyl-coenzyme A carboxylase. Annu Rev Nutr 17: 77-99, 1997.
14. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, Elmquist JK. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457: 213-235, 2003.
15. Krude H, Biebermann H, Luck W, Horn R, Brabant G, Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet 19: 155-157, 1998.
16. Li G, Klein RL, Matheny M, King MA, Meyer EM, Scarpace PJ. Induction of uncoupling protein 1 by central interleukin-6 gene delivery is dependent on sympathetic innervation of brown adipose tissue and underlies one mechanism of body weight reduction in rats. Neuroscience 115: 879-889, 2002.
17. Li G, Mobbs CV, Scarpace PJ. Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats. Diabetes 52: 1951-1957, 2003.
18. Li G, Zhang Y, Wilsey JT, Scarpace PJ. Hypothalamic pro-opiomelanocortin gene delivery ameliorates obesity and glucose intolerance in aged rats. Diabetologia 48: 2376-2385, 2005.
19. Li G, Zhang Y, Wilsey JT, Scarpace PJ. Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression. J Endocrinol 182: 123-132, 2004.
20. Li H, Matheny M, Nicolson M, Tumer N, Scarpace PJ. Leptin gene expression increases with age independent of increasing adiposity in rats. Diabetes 46: 2035-2039, 1997.
21. McMinn JE, Wilkinson CW, Havel PJ, Woods SC, Schwartz MW. Effect of intracerebroventricular α-MSH on food intake, adiposity, c-Fos induction, and neuropeptide expression. Am J Physiol Regul Integr Comp Physiol 279: R695-R703, 2000.
22. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8: 1298-1308, 1994.
23. Obici S, Feng Z, Tan J, Liu L, Karkanias G, Rossetti L. Central melanocortin receptors regulate insulin action. J Clin Invest 108: 1079-1085, 2001.
24. Palkovits M, Mezey E, Eskay RL. Pro-opiomelanocortin-derived peptides (ACTH/beta-endorphin/alpha-MSH) in brainstem baroreceptor areas of the rat. Brain Res 436: 323-338, 1987.
25. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates (3rd ed.) San Diego, CA: Academic, 1997.
26. Pierroz DD, Ziotopoulou M, Ungsunan L, Moschos S, Flier JS, Mantzoros CS. Effects of acute and chronic administration of the melanocortin agonist MTII in mice with diet-induced obesity. Diabetes 51: 1337-1345, 2002.
27. Scarpace PJ, Matheny M, Zhang Y, Tumer N, Frase CD, Shek EW, Hong B, Prima V, Zolotukhin S. Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats. Neuropharmacology 42: 548-561, 2002.
28. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, Baskin DG. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46: 2119-2123, 1997.
29. Shinyama H, Masuzaki H, Fang H, Flier JS. Regulation of melanocortin-4 receptor signaling: agonist-mediated desensitization and internalization. Endocrinology 144: 1301-1314, 2003.
30. Uhler M, Herbert E. Complete amino acid sequence of mouse proopiomelanocortin derived from the nucleotide sequence of pro-opiomelanocortin cDNA. J Biol Chem 258: 257-261, 1983.
31. Wang MY, Lee Y, Unger RH. Novel form of lipolysis induced by leptin. J Biol Chem 274: 17541-17544, 1999.
32. Williams DL, Bowers RR, Bartness TJ, Kaplan JM, Grill HJ. Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology 144: 4692-4697, 2003.
33. Williams DL, Kaplan JM, Grill HJ. The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141: 1332-1337, 2000.
34. Wilson BD, Bagnol D, Kaelin CB, Ollmann MM, Gantz I, Watson SJ, Barsh GS. Physiological and anatomical circuitry between Agouti-related protein and leptin signaling. Endocrinology 140: 2387-2397, 1999.
35. Yaswen L, Diehl N, Brennan MB, Hochgeschwender U. Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5: 1066-1070, 1999.
36. Zhang Y, Matheny M, Tumer N, Scarpace PJ. Aged-obese rats exhibit robust responses to a melanocortin agonist and antagonist despite leptin resistance. Neurobiol Aging 25: 1349-1360, 2004.
37. Zheng H, Patterson LM, Phifer CB, Berthoud HR. Brain stem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol 289: R247-R258, 2005