Steroidogenic factor 1 directs programs regulating diet-induced thermogenesis and leptin action in the ventral medial hypothalamic nucleus

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 26, 2011, Pages 10673-10678

  Kim, Ki Woo ^a,b   Zhao, Liping ^b   Donato Jr , Jose ^a   Kohno, Daisuke ^a,b   Xu, Yong ^a,b   Eliasa, Carol F ^a,b   Lee, Charlotte ^a,b   Parker, Keith L ^c   Elmquist, Joel K ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; STEROIDOGENIC FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE INACTIVATION; HYPOTHALAMUS NUCLEUS; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; THERMOGENESIS;

ANIMALS; DIETARY FATS; ENERGY INTAKE; HOMEOSTASIS; LEPTIN; MICE; MICE, KNOCKOUT; STEROIDOGENIC FACTOR 1; THERMOGENESIS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

MUS;

EID: 79960617185     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1102364108     Document Type: Article

References (47)

1. Parker KL, et al. (2002) Steroidogenic factor 1: An essential mediator of endocrine development. Recent Prog Horm Res 57:19-36.
2. King BM (2006) The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight. Physiol Behav 87:221-244.
3. Majdic G, et al. (2002) Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity. Endocrinology 143:607-614. (Pubitemid 34107215)
4. Ikeda Y, Luo X, Abbud R, Nilson JH, Parker KL (1995) The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Mol Endocrinol 9:478-486.
5. Achermann JC, Ito M, Ito M, Hindmarsh PC, Jameson JL (1999) A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet 22:125-126. (Pubitemid 29264799)
6. Correa RV, et al. (2004) A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency. J Clin Endocrinol Metab 89:1767-1772. (Pubitemid 38507932)
7. Hasegawa T, et al. (2004) Testicular dysgenesis without adrenal insufficiency in a 46, XY patient with a heterozygous inactive mutation of steroidogenic factor-1. J Clin Endocrinol Metab 89:5930-5935. (Pubitemid 39628395)
8. Liu W, Liu M, Fan W, Nawata H, Yanase T (2006) The Gly146Ala variation in human SF-1 gene: Its association with insulin resistance and type 2 diabetes in Chinese. Diabetes Res Clin Pract 73:322-328. (Pubitemid 44429895)
9. Bingham NC, Anderson KK, Reuter AL, Stallings NR, Parker KL (2008) Selective loss of leptin receptors in the ventromedial hypothalamic nucleus results in increased adiposity and a metabolic syndrome. Endocrinology 149:2138-2148. (Pubitemid 351574486)
10. Dhillon H, et al. (2006) Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis. Neuron 49:191-203. (Pubitemid 43089637)
11. Xu Y, et al. (2010) PI3K signaling in the ventromedial hypothalamic nucleus is required for normal energy homeostasis. Cell Metab 12:88-95.
12. Tong Q, et al. (2007) Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia. Cell Metab 5:383-393. (Pubitemid 46667758)
13. Zhang R, et al. (2008) Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight. Endocrinology 149:5654-5661.
14. Briancon N, McNay DE, Maratos-Flier E, Flier JS (2010) Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes 59:3074-3084.
15. Stallings NR, et al. (2002) Development of a transgenic green fluorescent protein lineage marker for steroidogenic factor 1. Mol Endocrinol 16:2360-2370. (Pubitemid 35155546)
16. Davis AM, et al. (2004) Loss of steroidogenic factor 1 alters cellular topography in the mouse ventromedial nucleus of the hypothalamus. J Neurobiol 60:424-436. (Pubitemid 39108883)
17. Zhao L, et al. (2008) Central nervous system-specific knockout of steroidogenic factor 1 results in increased anxiety-like behavior. Mol Endocrinol 22:1403-1415. (Pubitemid 351787000)
18. Tolson KP, et al. (2010) Postnatal Sim1 deficiency causes hyperphagic obesity and reduced Mc4r and oxytocin expression. J Neurosci 30:3803-3812.
19. Rios M, et al. (2001) Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol Endocrinol 15:1748-1757. (Pubitemid 32939305)
20. Oku J, Bray GA, Fisler JS, Schemmel R (1984) Ventromedial hypothalamic knife-cut lesions in rats resistant to dietary obesity. Am J Physiol 246:R943-R948. (Pubitemid 14076645)
21. Sakaguchi T, Arase K, Bray GA (1988) Sympathetic activity and food intake of rats with ventromedial hypothalamic lesions. Int J Obes 12:285-291.
22. Sakaguchi T, Bray GA, Eddlestone G (1988) Sympathetic activity following paraventricular or ventromedial hypothalamic lesions in rats. Brain Res Bull 20:461-465. (Pubitemid 19266439)
23. Hamann A, Flier JS, Lowell BB (1996) Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia. Endocrinology 137:21-29. (Pubitemid 26004968)
24. Sell H, Deshaies Y, Richard D (2004) The brown adipocyte: Update on its metabolic role. Int J Biochem Cell Biol 36:2098-2104. (Pubitemid 39094431)
25. Mori H, et al. (2004) Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med 10:739-743. (Pubitemid 38937640)
26. Scott MM, et al. (2009) Leptin targets in the mouse brain. J Comp Neurol 514:518-532.
27. Münzberg H, Flier JS, Bjørbaek C (2004) Region-specific leptin resistance within the hypothalamus of diet-induced obese mice. Endocrinology 145:4880-4889.
28. Hetherington AW, Ranson SW (1940) Hypothalamic lesions and adiposity in th rat. Anat Rec 78:149-172.
29. Gold RM (1973) Hypothalamic obesity: The myth of the ventromedial nucleus. Science 182:488-490.
30. Powley TL (1977) The ventromedial hypothalamic syndrome, satiety, and a cephalic phase hypothesis. Psychol Rev 84:89-126.
31. Rabin BM (1974) Independence of food intake and obesity following ventromedial hypothalamic lesions in the rat. Physiol Behav 13:769-772.
32. Lowell BB, Spiegelman BM (2000) Towards a molecular understanding of adaptive thermogenesis. Nature 404:652-660. (Pubitemid 30205070)
33. Bachman ES, et al. (2002) betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science 297:843-845. (Pubitemid 34839635)
34. Shimazu T (1981) Central nervous system regulation of liver and adipose tissue metabolism. Diabetologia 20(Suppl):343-356.
35. Rohner-Jeanrenaud F, et al. (1982-1983) Defective diet-induced but normal cold-induced brown adipose tissue adaptation in hypothalamic obesity in rats. J Physiol (Paris) 78:833-837.
36. Niijima A, Rohner-Jeanrenaud F, Jeanrenaud B (1984) Role of ventromedial hypothalamus on sympathetic efferents of brown adipose tissue. Am J Physiol 247:R650-R654. (Pubitemid 15200520)
37. Hogan S, Himms-Hagen J, Coscina DV (1985) Lack of diet-induced thermogenesis in brown adipose tissue of obese medial hypothalamic-lesioned rats. Physiol Behav 35:287-294. (Pubitemid 16249568)
38. Shimazu T, Takahashi A (1980) Stimulation of hypothalamic nuclei has differential effects on lipid synthesis in brown and white adipose tissue. Nature 284:62-63. (Pubitemid 10098767)
39. Saito M, Minokoshi Y, Shimazu T (1985) Brown adipose tissue after ventromedial hypothalamic lesions in rats. Am J Physiol 248:E20-E25. (Pubitemid 15125527)
40. Huang XF, et al. (2008) Ventromedial hypothalamic NPY Y2 receptor in the maintenance of body weight in diet-induced obesity in mice. Neurochem Res 33:1881-1888.
41. Irani BG, Dunn-Meynell AA, Levin BE (2007) Altered hypothalamic leptin, insulin, and melanocortin binding associated with moderate-fat diet and predisposition to obesity. Endocrinology 148:310-316. (Pubitemid 46021463)
42. Musatov S, et al. (2007) Silencing of estrogen receptor alpha in the ventromedial nucleus of hypothalamus leads to metabolic syndrome. Proc Natl Acad Sci USA 104:2501-2506. (Pubitemid 46391425)
43. Minokoshi Y, Saito M, Shimazu T (1986) Sympathetic denervation impairs responses of brown adipose tissue to VMH stimulation. Am J Physiol 251:R1005-R1008.
44. Kim KW, et al. (2008) Steroidogenic factor 1 regulates expression of the cannabinoid receptor 1 in the ventromedial hypothalamic nucleus. Mol Endocrinol 22:1950-1961.
45. Tran PV, et al. (2006) Diminished hypothalamic bdnf expression and impaired VMH function are associated with reduced SF-1 gene dosage. J Comp Neurol 498:637-648. (Pubitemid 44350355)
46. Unger TJ, Calderon GA, Bradley LC, Sena-Esteves M, Rios M (2007) Selective deletion of Bdnf in the ventromedial and dorsomedial hypothalamus of adult mice results in hyperphagic behavior and obesity. J Neurosci 27:14265-14274.
47. Jamshidi N, Taylor DA (2001) Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats. Br J Pharmacol 134:1151-1154. (Pubitemid 33097243)