메뉴 건너뛰기




Volumn 396, Issue 6712, 1998, Pages 670-679

Mice lacking melanin-concentrating hormone are hypophagic and lean

Author keywords

[No Author keywords available]

Indexed keywords

MELANIN;

EID: 0032542294     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/25341     Document Type: Article
Times cited : (1022)

References (29)
  • 1
    • 0032548825 scopus 로고    scopus 로고
    • Obesity and the hypothalamus: Novel peptides for new pathways
    • Flier, J. S. & Maratos-Flier, E. Obesity and the hypothalamus: novel peptides for new pathways. Cell 92, 437-440 (1998).
    • (1998) Cell , vol.92 , pp. 437-440
    • Flier, J.S.1    Maratos-Flier, E.2
  • 2
    • 0028228615 scopus 로고
    • Neuropeptide Yand energy balance: One way ahead for the treatment of obesity?
    • Dryden, S., Prankish, H., Wang, Q. & Williams, G. Neuropeptide Yand energy balance: one way ahead for the treatment of obesity? Eur. J. Clin. Invest. 24, 293-308 (1994).
    • (1994) Eur. J. Clin. Invest. , vol.24 , pp. 293-308
    • Dryden, S.1    Prankish, H.2    Wang, Q.3    Williams, G.4
  • 3
    • 13344279395 scopus 로고    scopus 로고
    • A role for melanin-concentrating hormone in the central regulation of feeding behaviour
    • Qu, D. et al. A role for melanin-concentrating hormone in the central regulation of feeding behaviour. Nature 380, 243-247 (1996).
    • (1996) Nature , vol.380 , pp. 243-247
    • Qu, D.1
  • 4
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior
    • Sakurai, T. et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G proteincoupled receptors that regulate feeding behavior. Cell 92, 573-585 (1998).
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1
  • 5
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea, L et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc. Natl Acad. Sci. USA 95, 322-327 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 322-327
    • De Lecea, L.1
  • 6
    • 0029946644 scopus 로고    scopus 로고
    • Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
    • Erickson, J., Clegg, K. & Palmiter, R. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415-418 (1996).
    • (1996) Nature , vol.381 , pp. 415-418
    • Erickson, J.1    Clegg, K.2    Palmiter, R.3
  • 7
    • 0028139089 scopus 로고
    • Positional cloning of the mouse ob gene and its human homologue
    • Zhang, Y. et al. Positional cloning of the mouse ob gene and its human homologue. Nature 372, 425-432 (1994).
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1
  • 8
    • 0030889192 scopus 로고    scopus 로고
    • Targeted disruption of the melanocortin-4 receptor results in obesity in mice
    • Huszar, D. et al. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141 (1997).
    • (1997) Cell , vol.88 , pp. 131-141
    • Huszar, D.1
  • 9
    • 0032488783 scopus 로고
    • Impaired locomotion and dopamine signaling in retinoid receptor mutant mice
    • Krezel, W. et al. Impaired locomotion and dopamine signaling in retinoid receptor mutant mice. Science 279, 863-867 (1993).
    • (1993) Science , vol.279 , pp. 863-867
    • Krezel, W.1
  • 10
    • 0032032575 scopus 로고    scopus 로고
    • Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and ncurocndocrine function
    • Ahima, R. S., Prabakaran, D. & Flier, J. S. Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and ncurocndocrine function. J. Clin. Invest. 101, 1020-1027 (1998).
    • (1998) J. Clin. Invest. , vol.101 , pp. 1020-1027
    • Ahima, R.S.1    Prabakaran, D.2    Flier, J.S.3
  • 11
    • 0029073613 scopus 로고
    • Weight reducing effect of the plasma protein encoded by the obese gene
    • HaIaas, J. et al. Weight reducing effect of the plasma protein encoded by the obese gene. Science 269, 543-546 (1995).
    • (1995) Science , vol.269 , pp. 543-546
    • Haiaas, J.1
  • 12
    • 0030764741 scopus 로고    scopus 로고
    • Antagonism of central melanocortin receptors in vitro and in vivo by Agoutirelated protein
    • Ollmann, M. M. et al. Antagonism of central melanocortin receptors in vitro and in vivo by Agoutirelated protein. Science 278, 135-138 (1997).
    • (1997) Science , vol.278 , pp. 135-138
    • Ollmann, M.M.1
  • 13
    • 0030893647 scopus 로고    scopus 로고
    • Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice
    • Shutter, J. R. et al. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11, 593-602 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 593-602
    • Shutter, J.R.1
  • 14
    • 0024434127 scopus 로고
    • Acetylation alters the feeding response to MSH and beta-endorphin
    • Tsujii, S. & Bray, G. A. Acetylation alters the feeding response to MSH and beta-endorphin. Brain Res. Bull 23, 165-169 (1989).
    • (1989) Brain Res. Bull , vol.23 , pp. 165-169
    • Tsujii, S.1    Bray, G.A.2
  • 15
    • 0030614331 scopus 로고    scopus 로고
    • Role of melanocortinergic neurons in feeding and the agouti obesity syndrome
    • Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J. & Cone, R. D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 385, 165-168 (1997).
    • (1997) Nature , vol.385 , pp. 165-168
    • Fan, W.1    Boston, B.A.2    Kesterson, R.A.3    Hruby, V.J.4    Cone, R.D.5
  • 16
    • 0030729210 scopus 로고    scopus 로고
    • Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice
    • Thornton, J. E., Cheung, C. C., Clifton, D. K. & Steiner, R. A. Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138, 5063-5066 (1997).
    • (1997) Endocrinology , vol.138 , pp. 5063-5066
    • Thornton, J.E.1    Cheung, C.C.2    Clifton, D.K.3    Steiner, R.A.4
  • 17
    • 0031888157 scopus 로고    scopus 로고
    • Hypothalamic pro-opiomeknocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin
    • Mizuno, T. M. et al. Hypothalamic pro-opiomeknocortin mRNA is reduced by fasting in ob/ob and db/db mice, but is stimulated by leptin. Diabetes 47, 294-297 (1998).
    • (1998) Diabetes , vol.47 , pp. 294-297
    • Mizuno, T.M.1
  • 18
    • 0029896530 scopus 로고    scopus 로고
    • Role of leptin in the neuroendocrine response to fasting
    • Ahima, R. S. et al. Role of leptin in the neuroendocrine response to fasting. Nature 382, 250-252 (1996).
    • (1996) Nature , vol.382 , pp. 250-252
    • Ahima, R.S.1
  • 19
    • 0027256843 scopus 로고
    • Diencephalic origins of melanin-concentrating hormone immunoreactive projections to medial septum/diagonal band complex and spinal cord using two retrograde fluorescent tracers
    • Bittencourt, J. C. & Elias, C. F. Diencephalic origins of melanin-concentrating hormone immunoreactive projections to medial septum/diagonal band complex and spinal cord using two retrograde fluorescent tracers. Ann. NY Acad. Sci 680, 462-465 (1993).
    • (1993) Ann. NY Acad. Sci , vol.680 , pp. 462-465
    • Bittencourt, J.C.1    Elias, C.F.2
  • 20
    • 85050956320 scopus 로고    scopus 로고
    • Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic aréa
    • in the press
    • Elias, C. F. et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic aréa. J. Comp. Ncurol. (in the press).
    • J. Comp. Ncurol.
    • Elias, C.F.1
  • 21
    • 0031838353 scopus 로고    scopus 로고
    • Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
    • Krude, H. et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genet. 19, 155-157 (1998).
    • (1998) Nature Genet. , vol.19 , pp. 155-157
    • Krude, H.1
  • 22
    • 0028153289 scopus 로고
    • The melanin-concentrating hormone: From the peptide to the gene
    • Nahon, J. L. The melanin-concentrating hormone: from the peptide to the gene. Crit. Rev. Neurobiol. 8, 221-262 (1994).
    • (1994) Crit. Rev. Neurobiol. , vol.8 , pp. 221-262
    • Nahon, J.L.1
  • 23
    • 0031023301 scopus 로고    scopus 로고
    • Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight
    • Rossi, M. et al. Melanin-concentrating hormone acutely stimulates feeding, but chronic administration has no effect on body weight. Endocrinology 138, 351-355 (1997).
    • (1997) Endocrinology , vol.138 , pp. 351-355
    • Rossi, M.1
  • 24
    • 0026766094 scopus 로고
    • The melanin-concent rating hormone system of the rat brain: An immuno- And hybridization histochemkal characterization
    • Bittencourt, J. C. et al. The melanin-concent rating hormone system of the rat brain: an immuno- and hybridization histochemkal characterization. J. Comp. Neurol. 319, 218-245 (1992).
    • (1992) J. Comp. Neurol. , vol.319 , pp. 218-245
    • Bittencourt, J.C.1
  • 25
    • 0030878110 scopus 로고    scopus 로고
    • Congenital leptin deficiency is associated with severe early-onset obesity in humans
    • Montague, C. T. et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 387, 903-908 (1997).
    • (1997) Nature , vol.387 , pp. 903-908
    • Montague, C.T.1
  • 26
    • 0027270363 scopus 로고
    • Structure and regulation of the mouse melanin concentrating hormone mRNA and gene
    • Breton, C., Presse, F., Hervieu, G. & Nahon, J. L. Structure and regulation of the mouse melanin concentrating hormone mRNA and gene. Mol. Cell Neurosci. 4, 271-284 (1993).
    • (1993) Mol. Cell Neurosci. , vol.4 , pp. 271-284
    • Breton, C.1    Presse, F.2    Hervieu, G.3    Nahon, J.L.4
  • 27
    • 0027407954 scopus 로고
    • Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoicacid receptor gene
    • Li, E., Sucov, H. M., Lee, K. F., Evans, R. M. & Jaenisch, R. Normal development and growth of mice carrying a targeted disruption of the alpha 1 retinoicacid receptor gene. Proc. Natl Acad. Sci USA 90, 1590-1594 (1993).
    • (1993) Proc. Natl Acad. Sci USA , vol.90 , pp. 1590-1594
    • Li, E.1    Sucov, H.M.2    Lee, K.F.3    Evans, R.M.4    Jaenisch, R.5
  • 28
    • 0026743005 scopus 로고
    • Simultaneous visualization of two cellular mRNA species in individual neurons by use of a new double in situ hybridization method
    • Marks, D. L. et al. Simultaneous visualization of two cellular mRNA species in individual neurons by use of a new double in situ hybridization method. Mol. Cell Neurosci. 3, 395-405 (1993).
    • (1993) Mol. Cell Neurosci. , vol.3 , pp. 395-405
    • Marks, D.L.1
  • 29
    • 0027731309 scopus 로고
    • Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
    • Lowell, B. B. et al. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 366, 740-742 (1993).
    • (1993) Nature , vol.366 , pp. 740-742
    • Lowell, B.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.