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Volumn 61, Issue 6, 2012, Pages 1455-1462

Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84861918690     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db11-0390     Document Type: Article
Times cited : (177)

References (33)
  • 1
    • 0036312905 scopus 로고    scopus 로고
    • Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
    • Seppälä-Lindroos A, Vehkavaara S, Häkkinen AM, et al. Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 2002;87:3023-3028
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 3023-3028
    • Seppälä-Lindroos, A.1    Vehkavaara, S.2    Häkkinen, A.M.3
  • 2
    • 33845490856 scopus 로고    scopus 로고
    • Review: The role of insulin resistance in nonalcoholic fatty liver disease
    • DOI 10.1210/jc.2006-0587
    • Utzschneider KM, Kahn SE. Review: the role of insulin resistance in nonalcoholic fatty liver disease. J Clin Endocrinol Metab 2006;91:4753-4761 (Pubitemid 44917301)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.12 , pp. 4753-4761
    • Utzschneider, K.M.1    Kahn, S.E.2
  • 3
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • Saltiel AR, Kahn CR. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 2001;414:799-806 (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 4
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • DOI 10.1038/nature05485, PII NATURE05485
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006;444: 860-867 (Pubitemid 46024993)
    • (2006) Nature , vol.444 , Issue.7121 , pp. 860-867
    • Hotamisligil, G.S.1
  • 6
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz M, Hébrard S, Leclerc J, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010;120:2355-2369
    • (2010) J Clin Invest , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hébrard, S.2    Leclerc, J.3
  • 8
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • DOI 10.1038/nm1072
    • Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjørbaek C, Flier JS. Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004;10:734-738 (Pubitemid 38937639)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjoorbaek, C.5    Flier, J.S.6
  • 9
    • 52949096557 scopus 로고    scopus 로고
    • Hypothalamic IKKbeta/ NF-kappaB and ER stress link overnutrition to energy imbalance and obesity
    • Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D. Hypothalamic IKKbeta/ NF-kappaB and ER stress link overnutrition to energy imbalance and obesity. Cell 2008;135:61-73
    • (2008) Cell , vol.135 , pp. 61-73
    • Zhang, X.1    Zhang, G.2    Zhang, H.3    Karin, M.4    Bai, H.5    Cai, D.6
  • 10
    • 58849149821 scopus 로고    scopus 로고
    • Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
    • Milanski M, Degasperi G, Coope A, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 2009;29:359-370
    • (2009) J Neurosci , vol.29 , pp. 359-370
    • Milanski, M.1    Degasperi, G.2    Coope, A.3
  • 11
    • 64549104642 scopus 로고    scopus 로고
    • High-fat diet induces apoptosis of hypothalamic neurons
    • Moraes JC, Coope A, Morari J, et al. High-fat diet induces apoptosis of hypothalamic neurons. PLoS ONE 2009;4:e5045
    • (2009) PLoS ONE , vol.4
    • Moraes, J.C.1    Coope, A.2    Morari, J.3
  • 14
    • 73649128543 scopus 로고    scopus 로고
    • AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance
    • Dzamko N, van Denderen BJ, Hevener AL, et al. AMPK beta1 deletion reduces appetite, preventing obesity and hepatic insulin resistance. J Biol Chem 2010;285:115-122
    • (2010) J Biol Chem , vol.285 , pp. 115-122
    • Dzamko, N.1    Van Denderen, B.J.2    Hevener, A.L.3
  • 15
    • 79952595599 scopus 로고    scopus 로고
    • Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress
    • Purkayastha S, Zhang H, Zhang G, Ahmed Z, Wang Y, Cai D. Neural dysregulation of peripheral insulin action and blood pressure by brain endoplasmic reticulum stress. Proc Natl Acad Sci USA 2011;108:2939-2944
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 2939-2944
    • Purkayastha, S.1    Zhang, H.2    Zhang, G.3    Ahmed, Z.4    Wang, Y.5    Cai, D.6
  • 16
    • 67650914230 scopus 로고    scopus 로고
    • AMPK in health and disease
    • Steinberg GR, Kemp BE. AMPK in health and disease. Physiol Rev 2009;89: 1025-1078
    • (2009) Physiol Rev , vol.89 , pp. 1025-1078
    • Steinberg, G.R.1    Kemp, B.E.2
  • 17
    • 73649094118 scopus 로고    scopus 로고
    • Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
    • Romanatto T, Roman EA, Arruda AP, et al. Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis. J Biol Chem 2009;284:36213-36222
    • (2009) J Biol Chem , vol.284 , pp. 36213-36222
    • Romanatto, T.1    Roman, E.A.2    Arruda, A.P.3
  • 19
    • 0027258140 scopus 로고
    • Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
    • Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 1993; 92:883-893 (Pubitemid 23262411)
    • (1993) Journal of Clinical Investigation , vol.92 , Issue.2 , pp. 883-893
    • Ishibashi, S.1    Brown, M.S.2    Goldstein, J.L.3    Gerard, R.D.4    Hammer, R.E.5    Herz, J.6
  • 20
    • 34247511618 scopus 로고    scopus 로고
    • TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient-Effects on leptin and insulin signaling pathways
    • DOI 10.1016/j.peptides.2007.03.006, PII S0196978107001039
    • Romanatto T, Cesquini M, Amaral ME, et al. TNF-alpha acts in the hypothalamus inhibiting food intake and increasing the respiratory quotient: effects on leptin and insulin signaling pathways. Peptides 2007;28:1050-1058 (Pubitemid 46654450)
    • (2007) Peptides , vol.28 , Issue.5 , pp. 1050-1058
    • Romanatto, T.1    Cesquini, M.2    Amaral, M.E.3    Roman, E.A.4    Moraes, J.C.5    Torsoni, M.A.6    Cruz-Neto, A.P.7    Velloso, L.A.8
  • 24
    • 84861911461 scopus 로고    scopus 로고
    • Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels
    • 6 October Epub ahead of print
    • Weston-Green K, Huang XF, Lian J, Deng C. Effects of olanzapine on muscarinic M3 receptor binding density in the brain relates to weight gain, plasma insulin and metabolic hormone levels. Eur Neuropsychopharmacol 6 October 2011 [Epub ahead of print]
    • (2011) Eur Neuropsychopharmacol
    • Weston-Green, K.1    Huang, X.F.2    Lian, J.3    Deng, C.4
  • 25
    • 79953889813 scopus 로고    scopus 로고
    • Inflammation of the hypothalamus leads to defective pancreatic islet function
    • Calegari VC, Torsoni AS, Vanzela EC, et al. Inflammation of the hypothalamus leads to defective pancreatic islet function. J Biol Chem 2011; 286:12870-12880
    • (2011) J Biol Chem , vol.286 , pp. 12870-12880
    • Calegari, V.C.1    Torsoni, A.S.2    Vanzela, E.C.3
  • 27
    • 70349337472 scopus 로고    scopus 로고
    • Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve
    • German J, Kim F, Schwartz GJ, et al. Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve. Endocrinology 2009;150:4502-4511
    • (2009) Endocrinology , vol.150 , pp. 4502-4511
    • German, J.1    Kim, F.2    Schwartz, G.J.3
  • 28
    • 78649753017 scopus 로고    scopus 로고
    • Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity
    • Koch C, Augustine RA, Steger J, et al. Leptin rapidly improves glucose homeostasis in obese mice by increasing hypothalamic insulin sensitivity. J Neurosci 2010;30:16180-16187
    • (2010) J Neurosci , vol.30 , pp. 16180-16187
    • Koch, C.1    Augustine, R.A.2    Steger, J.3
  • 29
    • 77956013253 scopus 로고    scopus 로고
    • Minireview: Inflammation and obesity pathogenesis: The hypothalamus heats up
    • Thaler JP, Schwartz MW. Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up. Endocrinology 2010;151:4109-4115
    • (2010) Endocrinology , vol.151 , pp. 4109-4115
    • Thaler, J.P.1    Schwartz, M.W.2
  • 30
    • 84856450553 scopus 로고    scopus 로고
    • Altered hypothalamic function in diet-induced obesity
    • Lond
    • Velloso LA, Schwartz MW. Altered hypothalamic function in diet-induced obesity. Int J Obes (Lond) 2011;35:1455-1465
    • (2011) Int J Obes , vol.35 , pp. 1455-1465
    • Velloso, L.A.1    Schwartz, M.W.2
  • 31
    • 70350203976 scopus 로고    scopus 로고
    • Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism
    • Roman EA, Reis D, Romanatto T, et al. Central leptin action improves skeletal muscle AKT, AMPK, and PGC1 alpha activation by hypothalamic PI3K-dependent mechanism. Mol Cell Endocrinol 2010;314:62-69
    • (2010) Mol Cell Endocrinol , vol.314 , pp. 62-69
    • Roman, E.A.1    Reis, D.2    Romanatto, T.3
  • 32
    • 56549124437 scopus 로고    scopus 로고
    • Hypothalamic control of hepatic glucose production and its potential role in insulin resistance
    • Buettner C, Camacho RC. Hypothalamic control of hepatic glucose production and its potential role in insulin resistance. Endocrinol Metab Clin North Am 2008;37:825-840
    • (2008) Endocrinol Metab Clin North Am , vol.37 , pp. 825-840
    • Buettner, C.1    Camacho, R.C.2
  • 33
    • 0344512367 scopus 로고    scopus 로고
    • Minireview: Nutrient Sensing and the Regulation of Insulin Action and Energy Balance
    • DOI 10.1210/en.2003-0999
    • Obici S, Rossetti L. Minireview: nutrient sensing and the regulation of insulin action and energy balance. Endocrinology 2003;144:5172-5178 (Pubitemid 37476043)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5172-5178
    • Obici, S.1    Rossetti, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.