Role of melanocortlnergic neurons in feeding and the agouti obesity syndrome

Nature

Volumn 385, Issue 6612, 1997, Pages 165-168

  Fan, Wei ^a   Boston, Bruce A ^a   Kesterson, Robert A ^a   Hruby, Victor J ^b   Cone, Roger D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b University of Arizona ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERMEDIN; RECEPTOR PROTEIN; AGOUTI PROTEIN; ALPHA INTERMEDIN; ALPHA MSH (4 10)AMIDE, AC NLE(4) CYCLO(ASP(5) PHE(7) LYS(10)); ALPHA-MSH (4-10)AMIDE, AC-NLE(4)-CYCLO(ASP(5)-PHE(7)-LYS(10))-; CORTICOTROPIN RECEPTOR; DRUG DERIVATIVE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MSH, 4 NLE 7 PHE ALPHA; MSH, 4-NLE-7-PHE-ALPHA-; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE]; NEUROPEPTIDE Y; PROTEIN; RECEPTOR; SIGNAL PEPTIDE;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ECTOPIC HORMONE PRODUCTION; FEEDING BEHAVIOR; FEMALE; HYPERPHAGIA; MALE; MELANOGENESIS; MOUSE; NERVE CELL; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN INDUCTION; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; DRUG POTENTIATION; EATING; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

AGOUTI; ANIMALIA;

ALPHA-MSH; ANIMALS; EATING; FEEDING BEHAVIOR; FEMALE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MELANOCYTE-STIMULATING HORMONES; MICE; MICE, INBRED C57BL; MICE, OBESE; NEURONS; NEUROPEPTIDE Y; OBESITY; PROTEINS; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, CORTICOTROPIN; RECEPTORS, PEPTIDE;

EID: 0030614331     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/385165a0     Document Type: Article

References (28)

1. Klebig, M. L., Wilkinson, J. E., Geisler, J. G. & Woychik, R. P. Proc. Natl Acad. Sci. USA 92, 4728-4732 (1995).
2. Bultman, S. J., Michaud, E. J. & Woychik, R. P. Cell 71, 1195-1204 (1992).
3. Kucera, G. T., Bortner, D. M. & Rosenberg, M. P. Dev. Biol. 173, 162-173 (1996).
4. Perry, W. L., Hustad, C. M., Swing, D. A., Jenkins, N. A. & Copeland, N. G. Genetics 140, 267-274 (1995).
5. Wilson, B. D. et al. Hum. Mol. Genet. 4, 223-230 (1995).
6. Miller, M. W. et al. Genes Dev. 7, 454-467 (1993).
7. Lu, D. et al. Nature 371, 799-802 (1994).
8. Gantz, I. et al. J. Biol. Chem. 268, 15174-15179 (1993).
9. Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B. & Cone, R. D. Mol. Endocrinol. 8, 1298-1308 (1994).
10. Hruby, V. J. et al. J. Med. Chem. 38, 3454-3461 (1995).
11. Gantz, I. et al. J. Biol. Chem. 268, 8246-8250 (1993).
12. Roselli-Rehfuss, L. et al. Proc. Natl Acad. Sci. USA 90, 8856-8860 (1993).
13. Wolff, G. L. Genetics 48, 1041-1058 (1963).
14. Al-Obeidi, F., Castrucci, A. M., Hadley, M. E. & Hruby, V. J. J. Med. Chem. 32, 2555-2561 (1989).
15. Watson, S. J., Akil, H., Richard, C. W. & Barchas, J. D. Nature 276, 226-228 (1978).
16. Jacobowitz, D. M. & O'Donohue, T. L. Proc. Natl Acad. Sci. USA 75, 6300-6304 (1978).
17. Huszar, D. et al. Cell (in the press).
18. Bergendahl, M., Wiemann, J. N., Clifton, D. K., Huhtaniemi, I. & Steiner, R. A. Neuroendocrinology 56, 913-920 (1992).
19. Brady, L. S., Smith, M. A., Gold, P. W. & Herkenham, M. Neuroendocrinology 52, 441-447 (1990).
20. Steiner, R. A., Kabigting, E., Lent, K. & Clifton, D. K. J. Neuroendocrinol. 6, 603-608 (1994).
21. Wilding, J. P. H. et al. Endocrinology 132, 1939-1944 (1993).
22. Erickson, J. C., Hollopeter, G. & Palmiter, R. D. Science 274, 1704-1707 (1996).
23. Stephens, T. W. et al. Nature 377, 530-532 (1995).
24. Schwartz, M. W. et al. J. Clin. Invest. 98, 1101-1106 (1996).
25. Kestersan, R. A., Huszar, D., Lynch, C. A., Sinerly, R. S. & Cone, R. D. Mol. Endocrinol. (submitted).
26. Johnson, R. A. & Salomon, Y. Methods Enzymol. 195, 3-21 (1991).
27. Chen, W., Shields, T. S., Stork, P. J. S. & Cone, R. D. Anal. Biochem. 226, 349-354 (1995).
28. Laursen, S. E. & Belknap, J. K. J. Pharmacol. Methods 16, 355-357 (1986).