-
1
-
-
0024948256
-
Genetic and environmental influences on obesity assessed by the adoption method
-
Sorensen TI, (1989) Genetic and environmental influences on obesity assessed by the adoption method. Rev Epidemiol Sante Publique 37: 525-531.
-
(1989)
Rev Epidemiol Sante Publique
, vol.37
, pp. 525-531
-
-
Sorensen, T.I.1
-
2
-
-
0025293894
-
The body-mass index of twins who have been reared apart
-
Stunkard AJ, Harris JR, Pedersen NL, McClearn GE, (1990) The body-mass index of twins who have been reared apart. N Engl J Med 322: 1483-1487.
-
(1990)
N Engl J Med
, vol.322
, pp. 1483-1487
-
-
Stunkard, A.J.1
Harris, J.R.2
Pedersen, N.L.3
McClearn, G.E.4
-
3
-
-
0030843960
-
Genetic and environmental factors in relative body weight and human adiposity
-
Maes HH, Neale MC, Eaves LJ, (1997) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27: 325-351.
-
(1997)
Behav Genet
, vol.27
, pp. 325-351
-
-
Maes, H.H.1
Neale, M.C.2
Eaves, L.J.3
-
4
-
-
33645825830
-
A common genetic variant is associated with adult and childhood obesity
-
Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, et al. (2006) A common genetic variant is associated with adult and childhood obesity. Science 312: 279-283.
-
(2006)
Science
, vol.312
, pp. 279-283
-
-
Herbert, A.1
Gerry, N.P.2
McQueen, M.B.3
Heid, I.M.4
Pfeufer, A.5
-
5
-
-
34248594090
-
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
-
Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
-
(2007)
Science
, vol.316
, pp. 889-894
-
-
Frayling, T.M.1
Timpson, N.J.2
Weedon, M.N.3
Zeggini, E.4
Freathy, R.M.5
-
6
-
-
34547625955
-
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits
-
Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115.
-
(2007)
PLoS Genet
, vol.3
-
-
Scuteri, A.1
Sanna, S.2
Chen, W.M.3
Uda, M.4
Albai, G.5
-
7
-
-
44849086097
-
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity
-
Liu YJ, Liu XG, Wang L, Dina C, Yan H, et al. (2008) Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Hum Mol Genet 17: 1803-1813.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 1803-1813
-
-
Liu, Y.J.1
Liu, X.G.2
Wang, L.3
Dina, C.4
Yan, H.5
-
8
-
-
41749090524
-
Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants
-
Hinney A, Nguyen TT, Scherag A, Friedel S, Brönner G, et al. (2007) Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2: e1361.
-
(2007)
PLoS One
, vol.2
-
-
Hinney, A.1
Nguyen, T.T.2
Scherag, A.3
Friedel, S.4
Brönner, G.5
-
9
-
-
38449098674
-
Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation
-
Andreasen CH, Stender-Petersen KL, Mogensen MS, Torekov SS, Wegner L, et al. (2008) Low physical activity accentuates the effect of the FTO rs9939609 polymorphism on body fat accumulation. Diabetes 57: 95-101.
-
(2008)
Diabetes
, vol.57
, pp. 95-101
-
-
Andreasen, C.H.1
Stender-Petersen, K.L.2
Mogensen, M.S.3
Torekov, S.S.4
Wegner, L.5
-
10
-
-
40749094439
-
Variants in the FTO gene are associated with common obesity in the Belgian population
-
Peeters A, Beckers S, Verrijken A, Roevens P, Peeters P, et al. (2008) Variants in the FTO gene are associated with common obesity in the Belgian population. Mol Genet Metab 93: 481-484.
-
(2008)
Mol Genet Metab
, vol.93
, pp. 481-484
-
-
Peeters, A.1
Beckers, S.2
Verrijken, A.3
Roevens, P.4
Peeters, P.5
-
11
-
-
58149528039
-
Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G×E) interaction
-
Cornes BK, Lind PA, Medland SE, Montgomery GW, Nyholt DR, et al. (2009) Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G×E) interaction. Int J Obes 33: 75-79.
-
(2009)
Int J Obes
, vol.33
, pp. 75-79
-
-
Cornes, B.K.1
Lind, P.A.2
Medland, S.E.3
Montgomery, G.W.4
Nyholt, D.R.5
-
12
-
-
44349166252
-
Common genetic variation near MC4R is associated with waist circumference and insulin resistance
-
Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40: 716-718.
-
(2008)
Nat Genet
, vol.40
, pp. 716-718
-
-
Chambers, J.C.1
Elliott, P.2
Zabaneh, D.3
Zhang, W.4
Li, Y.5
-
13
-
-
44349142294
-
Common variants near MC4R are associated with fat mass, weight and risk of obesity
-
Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
-
(2008)
Nat Genet
, vol.40
, pp. 768-775
-
-
Loos, R.J.1
Lindgren, C.M.2
Li, S.3
Wheeler, E.4
Zhao, J.H.5
-
14
-
-
62749100569
-
Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes
-
Zobel DP, Andreasen CH, Grarup N, Eiberg H, Sørensen TI, et al. (2009) Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. Diabetes 58: 757-764.
-
(2009)
Diabetes
, vol.58
, pp. 757-764
-
-
Zobel, D.P.1
Andreasen, C.H.2
Grarup, N.3
Eiberg, H.4
Sørensen, T.I.5
-
15
-
-
74249117319
-
Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure
-
Kring SI, Holst C, Toubro S, Astrup A, Hansen T, et al. (2010) Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure. Int J Obes 34: 182-189.
-
(2010)
Int J Obes
, vol.34
, pp. 182-189
-
-
Kring, S.I.1
Holst, C.2
Toubro, S.3
Astrup, A.4
Hansen, T.5
-
16
-
-
48349113289
-
Common nonsynonymous variants in PCSK1 confer risk of obesity
-
Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, et al. (2008) Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet 40: 943-945.
-
(2008)
Nat Genet
, vol.40
, pp. 943-945
-
-
Benzinou, M.1
Creemers, J.W.2
Choquet, H.3
Lobbens, S.4
Dina, C.5
-
17
-
-
77954277206
-
Combined analyses of 20 common obesity susceptibility variants
-
Sandholt CH, Sparso T, Grarup N, Albrechtsen A, Almind K, et al. (2010) Combined analyses of 20 common obesity susceptibility variants. Diabetes 59: 1667-1673.
-
(2010)
Diabetes
, vol.59
, pp. 1667-1673
-
-
Sandholt, C.H.1
Sparso, T.2
Grarup, N.3
Albrechtsen, A.4
Almind, K.5
-
18
-
-
69449093447
-
Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study
-
Kilpelainen TO, Bingham SA, Khaw KT, Wareham NJ, Loos RJ, (2009) Association of variants in the PCSK1 gene with obesity in the EPIC-Norfolk study. Hum Mol Genet 18: 3496-3501.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 3496-3501
-
-
Kilpelainen, T.O.1
Bingham, S.A.2
Khaw, K.T.3
Wareham, N.J.4
Loos, R.J.5
-
19
-
-
58149163141
-
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
-
2009
-
Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24, 2009.
-
(2009)
Nat Genet
, vol.41
, pp. 18-24
-
-
Thorleifsson, G.1
Walters, G.B.2
Gudbjartsson, D.F.3
Steinthorsdottir, V.4
Sulem, P.5
-
20
-
-
58149163142
-
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
-
Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
-
(2009)
Nat Genet
, vol.41
, pp. 25-34
-
-
Willer, C.J.1
Speliotes, E.K.2
Loos, R.J.3
Li, S.4
Lindgren, C.M.5
-
21
-
-
59149097625
-
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
-
Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens C, et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41: 157-159.
-
(2009)
Nat Genet
, vol.41
, pp. 157-159
-
-
Meyre, D.1
Delplanque, J.2
Chevre, J.C.3
Lecoeur, C.4
Lobbens, C.5
-
22
-
-
59149105634
-
A supersized list of obesity genes
-
Hofker M, Wijmenga C, (2009) A supersized list of obesity genes. Nat Genet 41: 139-140.
-
(2009)
Nat Genet
, vol.41
, pp. 139-140
-
-
Hofker, M.1
Wijmenga, C.2
-
23
-
-
77952288486
-
The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
-
Almen MS, Jacobsson JA, Shaik JH, Olszewski PK, Cedernaes J, et al. (2010) The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children. BMC Med Genet 11: 58.
-
(2010)
BMC Med Genet
, vol.11
, pp. 58
-
-
Almen, M.S.1
Jacobsson, J.A.2
Shaik, J.H.3
Olszewski, P.K.4
Cedernaes, J.5
-
24
-
-
77952956214
-
Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study
-
Haupt A, Thamer C, Heni M, Machicao F, Machann J, et al. (2009) Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study. Obesity 18: 1212-1217.
-
(2009)
Obesity
, vol.18
, pp. 1212-1217
-
-
Haupt, A.1
Thamer, C.2
Heni, M.3
Machicao, F.4
Machann, J.5
-
25
-
-
73649136827
-
Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
-
Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, et al. (2009) Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. J Hum Genet 54: 727-731.
-
(2009)
J Hum Genet
, vol.54
, pp. 727-731
-
-
Hotta, K.1
Nakamura, M.2
Nakamura, T.3
Matsuo, T.4
Nakata, Y.5
-
26
-
-
77957912843
-
Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA
-
Holzapfel C, Grallert H, Huth C, Wahl S, Fischer B, et al. (2010) Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA. Int J Obes 18: 1538-1545.
-
(2010)
Int J Obes
, vol.18
, pp. 1538-1545
-
-
Holzapfel, C.1
Grallert, H.2
Huth, C.3
Wahl, S.4
Fischer, B.5
-
27
-
-
77952405825
-
Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for early-Onset Extreme Obesity in French and German Study Groups
-
Scherag A, Dina C, Hinney A, Vatin V, Scherag S, et al. (2010) Two New Loci for Body-Weight Regulation Identified in a Joint Analysis of Genome-Wide Association Studies for early-Onset Extreme Obesity in French and German Study Groups. PLoS Gen 4: e1000916.
-
(2010)
PLoS Gen
, vol.4
-
-
Scherag, A.1
Dina, C.2
Hinney, A.3
Vatin, V.4
Scherag, S.5
-
28
-
-
64549158008
-
Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
-
Renstrom F, Payne F, Nordstrom A, Brito EC, Rolandsson O, et al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 18: 1489-1496.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 1489-1496
-
-
Renstrom, F.1
Payne, F.2
Nordstrom, A.3
Brito, E.C.4
Rolandsson, O.5
-
29
-
-
70349783304
-
Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference
-
Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, et al. (2009) Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr 90: 951-959.
-
(2009)
Am J Clin Nutr
, vol.90
, pp. 951-959
-
-
Bauer, F.1
Elbers, C.C.2
Adan, R.A.3
Loos, R.J.4
Onland-Moret, N.C.5
-
30
-
-
77952746932
-
Implication of Genetic Variants Near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with Obesity and Type 2 Diabetes in 7705 Chinese
-
Ng MC, Tam CH, So WY, Ho JS, Chan AW, et al. (2010) Implication of Genetic Variants Near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with Obesity and Type 2 Diabetes in 7705 Chinese. J Clin Endocrinol Metab 95: 2418-2425.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2418-2425
-
-
Ng, M.C.1
Tam, C.H.2
So, W.Y.3
Ho, J.S.4
Chan, A.W.5
-
31
-
-
33845663497
-
SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other
-
Maures TJ, Kurzer JH, Carter-Su C, (2007) SH2B1 (SH2-B) and JAK2: a multifunctional adaptor protein and kinase made for each other. Trends Endocrinol Metab 18: 38-45.
-
(2007)
Trends Endocrinol Metab
, vol.18
, pp. 38-45
-
-
Maures, T.J.1
Kurzer, J.H.2
Carter-Su, C.3
-
32
-
-
4344581405
-
Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance
-
Duan C, Yang H, White MF, Rui L, (2004) Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Mol Cell Biol 24: 7435-7443.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 7435-7443
-
-
Duan, C.1
Yang, H.2
White, M.F.3
Rui, L.4
-
33
-
-
33645891474
-
Differential role of SH2-B and APS in regulating energy and glucose homeostasis
-
Li M, Ren D, Iseki M, Takaki S, Rui L, (2006) Differential role of SH2-B and APS in regulating energy and glucose homeostasis. Endocrinology 147: 2163-2170.
-
(2006)
Endocrinology
, vol.147
, pp. 2163-2170
-
-
Li, M.1
Ren, D.2
Iseki, M.3
Takaki, S.4
Rui, L.5
-
34
-
-
33846822094
-
Neuronal SH2B1 is essential for controlling energy and glucose homeostasis
-
Ren D, Zhou Y, Morris D, Li M, Li Z, et al. (2007) Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. J Clin Invest 117: 397-406.
-
(2007)
J Clin Invest
, vol.117
, pp. 397-406
-
-
Ren, D.1
Zhou, Y.2
Morris, D.3
Li, M.4
Li, Z.5
-
35
-
-
70349086181
-
SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins
-
Morris DL, Cho KW, Zhou Y, Rui L, (2009) SH2B1 enhances insulin sensitivity by both stimulating the insulin receptor and inhibiting tyrosine dephosphorylation of insulin receptor substrate proteins. Diabetes 58: 2039-2047.
-
(2009)
Diabetes
, vol.58
, pp. 2039-2047
-
-
Morris, D.L.1
Cho, K.W.2
Zhou, Y.3
Rui, L.4
-
36
-
-
0038392755
-
Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor
-
Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, et al. (2003) Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci 6: 736-742.
-
(2003)
Nat Neurosci
, vol.6
, pp. 736-742
-
-
Xu, B.1
Goulding, E.H.2
Zang, K.3
Cepoi, D.4
Cone, R.D.5
-
37
-
-
18144435678
-
Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice
-
Nakagawa T, Tsuchida A, Itakura Y, Nonomura T, Ono M, et al. (2000) Brain-derived neurotrophic factor regulates glucose metabolism by modulating energy balance in diabetic mice. Diabetes 49: 436-444.
-
(2000)
Diabetes
, vol.49
, pp. 436-444
-
-
Nakagawa, T.1
Tsuchida, A.2
Itakura, Y.3
Nonomura, T.4
Ono, M.5
-
38
-
-
0031577526
-
Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice
-
Ono M, Ichihara J, Nonomura T, Itakura Y, Taiji M, et al. (1997) Brain-derived neurotrophic factor reduces blood glucose level in obese diabetic mice but not in normal mice. Biochem Biophys Res Commun 238: 633-637.
-
(1997)
Biochem Biophys Res Commun
, vol.238
, pp. 633-637
-
-
Ono, M.1
Ichihara, J.2
Nonomura, T.3
Itakura, Y.4
Taiji, M.5
-
39
-
-
34447127251
-
Brain-derived neurotrophic factor (BDNF) and type 2 diabetes
-
Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, et al. (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50: 431-438.
-
(2007)
Diabetologia
, vol.50
, pp. 431-438
-
-
Krabbe, K.S.1
Nielsen, A.R.2
Krogh-Madsen, R.3
Plomgaard, P.4
Rasmussen, P.5
-
40
-
-
20144370557
-
Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease
-
Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, et al. (2005) Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet 134B: 93-103.
-
(2005)
Am J Med Genet B Neuropsychiatr Genet
, vol.134 B
, pp. 93-103
-
-
Liu, Q.R.1
Walther, D.2
Drgon, T.3
Polesskaya, O.4
Lesnick, T.G.5
-
41
-
-
34547499702
-
Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters
-
Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T, (2007) Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics 90: 397-406.
-
(2007)
Genomics
, vol.90
, pp. 397-406
-
-
Pruunsild, P.1
Kazantseva, A.2
Aid, T.3
Palm, K.4
Timmusk, T.5
-
42
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat genet 42: 937-948.
-
(2010)
Nat Genet
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
Willer, C.J.2
Berndt, S.I.3
Monda, K.L.4
Thorleifsson, G.5
-
43
-
-
0346394178
-
A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99
-
Jorgensen T, Borch-Johnsen K, Thomsen TF, Ibsen H, Glumer C, et al. (2003) A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99. Eur J Cardiovasc Prev Rehabil 10: 377-386.
-
(2003)
Eur J Cardiovasc Prev Rehabil
, vol.10
, pp. 377-386
-
-
Jorgensen, T.1
Borch-Johnsen, K.2
Thomsen, T.F.3
Ibsen, H.4
Glumer, C.5
-
44
-
-
0033808127
-
The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening
-
Lauritzen T, Griffin S, Borch-Johnsen K, Wareham NJ, Wolffenbuttel BH, et al. (2000) The ADDITION study: proposed trial of the cost-effectiveness of an intensive multifactorial intervention on morbidity and mortality among people with Type 2 diabetes detected by screening. Int J Obes Relat Metab Disord 24 (Suppl 3): S6-11.
-
(2000)
Int J Obes Relat Metab Disord
, vol.24
, Issue.SUPPL. 3
-
-
Lauritzen, T.1
Griffin, S.2
Borch-Johnsen, K.3
Wareham, N.J.4
Wolffenbuttel, B.H.5
|