-
1
-
-
0031851293
-
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
-
10.1002/(SICI)1096-9136(199807)15:7<539: AID-DIA668>3.0.CO;2-S 9686693
-
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Alberti KG, Zimmet PZ, Diabet Med 1998 15 539 553 10.1002/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S 9686693
-
(1998)
Diabet Med
, vol.15
, pp. 539-553
-
-
Alberti, K.G.1
Zimmet, P.Z.2
-
3
-
-
4444309565
-
The complex life of simple sphingolipids
-
10.1038/sj.embor.7400208 15289826
-
The complex life of simple sphingolipids. Futerman AH, Hannun YA, EMBO Rep 2004 5 777 782 10.1038/sj.embor.7400208 15289826
-
(2004)
EMBO Rep
, vol.5
, pp. 777-782
-
-
Futerman, A.H.1
Hannun, Y.A.2
-
4
-
-
66349086742
-
Bioactive sphingolipids: Metabolism and function
-
19017611
-
Bioactive sphingolipids: metabolism and function. Bartke N, Hannun YA, J Lipid Res 2009 50 91 S96 19017611
-
(2009)
J Lipid Res
, vol.50
-
-
Bartke, N.1
Hannun, Y.A.2
-
5
-
-
0035660246
-
Sphingolipids in mammalian cell signaling
-
10.1007/PL00000836 11814056
-
Sphingolipids in mammalian cell signaling. Ohanian J, Ohanian V, Cell Mol Life Sci 2001 58 2053 2068 10.1007/PL00000836 11814056
-
(2001)
Cell Mol Life Sci
, vol.58
, pp. 2053-2068
-
-
Ohanian, J.1
Ohanian, V.2
-
6
-
-
84859150636
-
Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells
-
10.1016/j.freeradbiomed.2012.02.026 22387197
-
Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells. Kizhakkayil J, Thayyullathil F, Chathoth S, Hago A, Patel M, Galadari S, Free Radic Biol Med 2012 52 1854 1864 10.1016/j.freeradbiomed.2012.02.026 22387197
-
(2012)
Free Radic Biol Med
, vol.52
, pp. 1854-1864
-
-
Kizhakkayil, J.1
Thayyullathil, F.2
Chathoth, S.3
Hago, A.4
Patel, M.5
Galadari, S.6
-
7
-
-
43049085142
-
Sphingolipid signaling in the cardiovascular system: Good, bad or both?
-
10.1016/j.ejphar.2008.02.089 18420192
-
Sphingolipid signaling in the cardiovascular system: good, bad or both? Alewijnse AE, Peters SL, Eur J Pharmacol 2008 585 292 302 10.1016/j.ejphar.2008. 02.089 18420192
-
(2008)
Eur J Pharmacol
, vol.585
, pp. 292-302
-
-
Alewijnse, A.E.1
Peters, S.L.2
-
8
-
-
74149083982
-
Deregulation of sphingolipid metabolism in Alzheimer's disease
-
10.1016/j.neurobiolaging.2008.05.010 18547682
-
Deregulation of sphingolipid metabolism in Alzheimer's disease. He X, Huang Y, Li B, Gong CX, Schuchman EH, Neurobiol Aging 2010 31 398 408 10.1016/j.neurobiolaging.2008.05.010 18547682
-
(2010)
Neurobiol Aging
, vol.31
, pp. 398-408
-
-
He, X.1
Huang, Y.2
Li, B.3
Gong, C.X.4
Schuchman, E.H.5
-
9
-
-
0028085078
-
The insulin signaling system
-
8276779
-
The insulin signaling system. White MF, Kahn CR, J Biol Chem 1994 269 1 4 8276779
-
(1994)
J Biol Chem
, vol.269
, pp. 1-4
-
-
White, M.F.1
Kahn, C.R.2
-
10
-
-
0036710280
-
IRS proteins and the common path to diabetes
-
12169433
-
IRS proteins and the common path to diabetes. White MF, Am J Physiol Endocrinol Metab 2002 283 413 E422 12169433
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
White, M.F.1
-
11
-
-
0028269980
-
Insulin signalling: The role of insulin receptor substrate 1
-
10.1016/0962-8924(94)90065-5 14731733
-
Insulin signalling: the role of insulin receptor substrate 1. Keller SR, Lienhard GE, Trends Cell Biol 1994 4 115 119 10.1016/0962-8924(94)90065-5 14731733
-
(1994)
Trends Cell Biol
, vol.4
, pp. 115-119
-
-
Keller, S.R.1
Lienhard, G.E.2
-
12
-
-
67349130083
-
Glycosphingolipids and insulin resistance
-
10.1016/j.plipres.2009.03.002 19303901
-
Glycosphingolipids and insulin resistance. Langeveld M, Aerts JM, Prog Lipid Res 2009 48 196 205 10.1016/j.plipres.2009.03.002 19303901
-
(2009)
Prog Lipid Res
, vol.48
, pp. 196-205
-
-
Langeveld, M.1
Aerts, J.M.2
-
13
-
-
29244462334
-
Insulin signaling and the regulation of glucose transport
-
16307172
-
Insulin signaling and the regulation of glucose transport. Chang L, Chiang SH, Saltiel AR, Mol Med 2004 10 65 71 16307172
-
(2004)
Mol Med
, vol.10
, pp. 65-71
-
-
Chang, L.1
Chiang, S.H.2
Saltiel, A.R.3
-
14
-
-
31644443192
-
Ceramides in insulin resistance and lipotoxicity
-
10.1016/j.plipres.2005.11.002 16445986
-
Ceramides in insulin resistance and lipotoxicity. Summers SA, Prog Lipid Res 2006 45 42 72 10.1016/j.plipres.2005.11.002 16445986
-
(2006)
Prog Lipid Res
, vol.45
, pp. 42-72
-
-
Summers, S.A.1
-
15
-
-
0033588253
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
10.1074/jbc.274.34.24202
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. Schmitz-Peiffer C, Craig DL, Biden TJ, J Biol Che 1999 274 24202 24210 10.1074/jbc.274.34.24202
-
(1999)
J Biol Che
, vol.274
, pp. 24202-24210
-
-
Schmitz-Peiffer, C.1
Craig, D.L.2
Biden, T.J.3
-
16
-
-
0035133331
-
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
-
10.1007/s001250051596 11270673
-
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Hajduch E, Balendran A, Batty IH, Litherland GJ, Blair AS, Downes CP, Hundal HS, Diabetologia 2001 44 173 183 10.1007/s001250051596 11270673
-
(2001)
Diabetologia
, vol.44
, pp. 173-183
-
-
Hajduch, E.1
Balendran, A.2
Batty, I.H.3
Litherland, G.J.4
Blair, A.S.5
Downes, C.P.6
Hundal, H.S.7
-
17
-
-
0037135536
-
De novo sphingolipid biosynthesis: A necessary, but dangerous, pathway
-
10.1074/jbc.R200009200 12011104
-
De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. Merrill AH Jr, J Biol Chem 2002 277 25843 25846 10.1074/jbc.R200009200 12011104
-
(2002)
J Biol Chem
, vol.277
, pp. 25843-25846
-
-
Merrill Jr., A.H.1
-
18
-
-
42249105215
-
The sphingolipid salvage pathway in ceramide metabolism and signaling
-
10.1016/j.cellsig.2007.12.006 18191382
-
The sphingolipid salvage pathway in ceramide metabolism and signaling. Kitatani K, Idkowiak-Baldys J, Hannun YA, Cell Signal 2008 20 1010 1018 10.1016/j.cellsig.2007.12.006 18191382
-
(2008)
Cell Signal
, vol.20
, pp. 1010-1018
-
-
Kitatani, K.1
Idkowiak-Baldys, J.2
Hannun, Y.A.3
-
19
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
10.1038/nrm2329 18216770
-
Principles of bioactive lipid signalling: lessons from sphingolipids. Hannun YA, Obeid LM, Nat Rev Mol Cell Biol 2008 9 139 150 10.1038/nrm2329 18216770
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
20
-
-
70449100846
-
Glycosphingolipids-nature, function, and pharmacological modulation
-
10.1002/anie.200902620 19862781
-
Glycosphingolipids-nature, function, and pharmacological modulation. Wennekes T, Van den Berg RJ, Boot RG, Van der Marel GA, Overkleeft HS, Aerts JM, Angew Chem Int Ed Engl 2009 48 8848 8869 10.1002/anie.200902620 19862781
-
(2009)
Angew Chem Int Ed Engl
, vol.48
, pp. 8848-8869
-
-
Wennekes, T.1
Van Den Berg, R.J.2
Boot, R.G.3
Van Der Marel, G.A.4
Overkleeft, H.S.5
Aerts, J.M.6
-
21
-
-
33845343984
-
Sphingolipid metabolism diseases
-
10.1016/j.bbamem.2006.05.027 16854371
-
Sphingolipid metabolism diseases. Kolter T, Sandhoff K, Biochim Biophys Acta 2006 1758 2057 2079 10.1016/j.bbamem.2006.05.027 16854371
-
(2006)
Biochim Biophys Acta
, vol.1758
, pp. 2057-2079
-
-
Kolter, T.1
Sandhoff, K.2
-
22
-
-
8444220527
-
Molecular mechanisms of caspase regulation during apoptosis
-
10.1038/nrm1496 15520809
-
Molecular mechanisms of caspase regulation during apoptosis. Riedl SJ, Shi Y, Nat Rev Mol Cell Biol 2004 5 897 907 10.1038/nrm1496 15520809
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 897-907
-
-
Riedl, S.J.1
Shi, Y.2
-
23
-
-
1342305497
-
Caspase-12 and ER-stress-mediated apoptosis: The story so far
-
10.1196/annals.1299.032 15033718
-
Caspase-12 and ER-stress-mediated apoptosis: the story so far. Szegezdi E, Fitzgerald U, Samali A, Ann N Y Acad Sci 2003 1010 186 194 10.1196/annals.1299.032 15033718
-
(2003)
Ann N y Acad Sci
, vol.1010
, pp. 186-194
-
-
Szegezdi, E.1
Fitzgerald, U.2
Samali, A.3
-
24
-
-
0035856952
-
Beta-Cell death during progression to diabetes
-
10.1038/414792a 11742411
-
Beta-Cell death during progression to diabetes. Mathis D, Vence L, Benoist C, Nature 2001 414 792 798 10.1038/414792a 11742411
-
(2001)
Nature
, vol.414
, pp. 792-798
-
-
Mathis, D.1
Vence, L.2
Benoist, C.3
-
25
-
-
0035128535
-
Role of apoptosis in pancreatic beta-cell death in diabetes
-
10.2337/diabetes.50.2007.S44 11272200
-
Role of apoptosis in pancreatic beta-cell death in diabetes. Chandra J, Zhivotovsky B, Zaitsev V, Juntti-Berggren L, Berggren PO, Orrenius S, Diabetes 2001 50 44 S47 10.2337/diabetes.50.2007.S44 11272200
-
(2001)
Diabetes
, vol.50
-
-
Chandra, J.1
Zhivotovsky, B.2
Zaitsev, V.3
Juntti-Berggren, L.4
Berggren, P.O.5
Orrenius, S.6
-
26
-
-
63849267286
-
Recent progress in research on beta-cell apoptosis by cytokines
-
19273093
-
Recent progress in research on beta-cell apoptosis by cytokines. Kim KA, Lee MS, Front Biosci 2009 14 657 664 19273093
-
(2009)
Front Biosci
, vol.14
, pp. 657-664
-
-
Kim, K.A.1
Lee, M.S.2
-
27
-
-
80051757598
-
Ceramide formation as a target in beta-cell survival and function
-
10.1517/14728222.2011.588209 21635197
-
Ceramide formation as a target in beta-cell survival and function. Lang F, Ullrich S, Gulbins E, Expert Opin Ther Targets 2011 15 1061 1071 10.1517/14728222.2011.588209 21635197
-
(2011)
Expert Opin Ther Targets
, vol.15
, pp. 1061-1071
-
-
Lang, F.1
Ullrich, S.2
Gulbins, E.3
-
28
-
-
13044283437
-
Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic beta cells
-
10.1016/S0026-0495(99)90234-2 10599977
-
Tumor necrosis factor alpha signaling pathway and apoptosis in pancreatic beta cells. Ishizuka N, Yagui K, Tokuyama Y, Yamada K, Suzuki Y, Miyazaki J, Hashimoto N, Makino H, Saito Y, Kanatsuka A, Metabolism 1999 48 1485 1492 10.1016/S0026-0495(99)90234-2 10599977
-
(1999)
Metabolism
, vol.48
, pp. 1485-1492
-
-
Ishizuka, N.1
Yagui, K.2
Tokuyama, Y.3
Yamada, K.4
Suzuki, Y.5
Miyazaki, J.6
Hashimoto, N.7
Makino, H.8
Saito, Y.9
Kanatsuka, A.10
-
29
-
-
0029059122
-
Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1 beta
-
10.1016/0014-5793(95)00470-T 7607324
-
Ceramide inhibits pancreatic beta-cell insulin production and mitogenesis and mimics the actions of interleukin-1 beta. Sjoholm A, FEBS Lett 1995 367 283 286 10.1016/0014-5793(95)00470-T 7607324
-
(1995)
FEBS Lett
, vol.367
, pp. 283-286
-
-
Sjoholm, A.1
-
30
-
-
0029932759
-
Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F
-
8626526
-
Interleukin-1 beta-induced ceramide and diacylglycerol generation may lead to activation of the c-Jun NH2-terminal kinase and the transcription factor ATF2 in the insulin-producing cell line RINm5F. Welsh N, J Biol Chem 1996 271 8307 8312 8626526
-
(1996)
J Biol Chem
, vol.271
, pp. 8307-8312
-
-
Welsh, N.1
-
31
-
-
0032989112
-
Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting beta-cells: Role in cytokine-induced beta-cell death
-
10.2337/diabetes.48.7.1372 10389841
-
Activation of the sphingomyelinase/ceramide signal transduction pathway in insulin-secreting beta-cells: role in cytokine-induced beta-cell death. Major CD, Gao ZY, Wolf BA, Diabetes 1999 48 1372 1380 10.2337/diabetes.48.7.1372 10389841
-
(1999)
Diabetes
, vol.48
, pp. 1372-1380
-
-
Major, C.D.1
Gao, Z.Y.2
Wolf, B.A.3
-
32
-
-
66949148332
-
Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet beta-cells
-
10.1016/j.febslet.2009.05.047 19497324
-
Acute activation of acid ceramidase affects cytokine-induced cytotoxicity in rat islet beta-cells. Zhu Q, Shan X, Miao H, Lu Y, Xu J, You N, Liu C, Liao DF, Jin J, FEBS Lett 2009 583 2136 2141 10.1016/j.febslet.2009.05.047 19497324
-
(2009)
FEBS Lett
, vol.583
, pp. 2136-2141
-
-
Zhu, Q.1
Shan, X.2
Miao, H.3
Lu, Y.4
Xu, J.5
You, N.6
Liu, C.7
Liao, D.F.8
Jin, J.9
-
33
-
-
17844364503
-
Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: Response to cytokines
-
10.2337/diabetes.54.5.1429 15855330
-
Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. Mastrandrea LD, Sessanna SM, Laychock SG, Diabetes 2005 54 1429 1436 10.2337/diabetes.54.5.1429 15855330
-
(2005)
Diabetes
, vol.54
, pp. 1429-1436
-
-
Mastrandrea, L.D.1
Sessanna, S.M.2
Laychock, S.G.3
-
34
-
-
0032478314
-
Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
-
10.1073/pnas.95.5.2498 9482914
-
Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Shimabukuro M, Zhou YT, Levi M, Unger RH, Proc Natl Acad Sci USA 1998 95 2498 2502 10.1073/pnas.95.5.2498 9482914
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2498-2502
-
-
Shimabukuro, M.1
Zhou, Y.T.2
Levi, M.3
Unger, R.H.4
-
35
-
-
0035156817
-
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
-
10.2337/diabetes.50.1.69 11147797
-
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function. Maedler K, Spinas GA, Dyntar D, Moritz W, Kaiser N, Donath MY, Diabetes 2001 50 69 76 10.2337/diabetes.50.1.69 11147797
-
(2001)
Diabetes
, vol.50
, pp. 69-76
-
-
Maedler, K.1
Spinas, G.A.2
Dyntar, D.3
Moritz, W.4
Kaiser, N.5
Donath, M.Y.6
-
36
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and proapoptotic effects on human pancreatic islets: Evidence that beta cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
10.2337/diabetes.51.5.1437 11978640
-
Prolonged exposure to free fatty acids has cytostatic and proapoptotic effects on human pancreatic islets: evidence that beta cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C, Patané G, Boggi U, Piro S, Anello M, Bergamini E, Mosca F, Di Mario U, Del Prato S, Marchetti P, Diabetes 2002 51 1437 1442 10.2337/diabetes.51.5.1437 11978640
-
(2002)
Diabetes
, vol.51
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
Del Guerra, S.4
Masini, M.5
Santangelo, C.6
Patané, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Mosca, F.12
Di Mario, U.13
Del Prato, S.14
Marchetti, P.15
-
37
-
-
0345354674
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
-
10.2337/diabetes.52.3.726 12606514
-
Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Maedler K, Oberholzer J, Bucher P, Spinas GA, Donath MY, Diabetes 2003 52 726 733 10.2337/diabetes.52.3.726 12606514
-
(2003)
Diabetes
, vol.52
, pp. 726-733
-
-
Maedler, K.1
Oberholzer, J.2
Bucher, P.3
Spinas, G.A.4
Donath, M.Y.5
-
38
-
-
0030760230
-
Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes
-
9254064
-
Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes. de Vries JE, Vork MM, Roemen TH, de Jong YF, Cleutjens JP, Van der Vusse GJ, Van Bilsen M, J Lipid Res 1997 38 1384 1394 9254064
-
(1997)
J Lipid Res
, vol.38
, pp. 1384-1394
-
-
De Vries, J.E.1
Vork, M.M.2
Roemen, T.H.3
De Jong, Y.F.4
Cleutjens, J.P.5
Van Der Vusse, G.J.6
Van Bilsen, M.7
-
39
-
-
0032484132
-
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
-
10.1074/jbc.273.49.32487 9829981
-
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. Shimabukuro M, Higa M, Zhou YT, Wang MY, Newgard CB, Unger RH, J Biol Chem 1998 273 32487 32490 10.1074/jbc.273.49. 32487 9829981
-
(1998)
J Biol Chem
, vol.273
, pp. 32487-32490
-
-
Shimabukuro, M.1
Higa, M.2
Zhou, Y.T.3
Wang, M.Y.4
Newgard, C.B.5
Unger, R.H.6
-
40
-
-
0036318319
-
Lipotoxicity in human pancreatic islets and the protective effect of metformin
-
10.2337/diabetes.51.2007.S134 11815472
-
Lipotoxicity in human pancreatic islets and the protective effect of metformin. Lupi R, Del Guerra S, Fierabracci V, Marselli L, Novelli M, Patanè G, Boggi U, Mosca F, Piro S, Del Prato S, Marchetti P, Diabetes 2002 51 134 S137 10.2337/diabetes.51.2007.S134 11815472
-
(2002)
Diabetes
, vol.51
-
-
Lupi, R.1
Del Guerra, S.2
Fierabracci, V.3
Marselli, L.4
Novelli, M.5
Patanè, G.6
Boggi, U.7
Mosca, F.8
Piro, S.9
Del Prato, S.10
Marchetti, P.11
-
41
-
-
84864396455
-
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction
-
10.4161/isl.20102 22847494
-
Roles of ceramide and sphingolipids in pancreatic β-cell function and dysfunction. Boslem E, Meikle PJ, Biden TJ, Islets 2012 4 177 187 10.4161/isl.20102 22847494
-
(2012)
Islets
, vol.4
, pp. 177-187
-
-
Boslem, E.1
Meikle, P.J.2
Biden, T.J.3
-
42
-
-
4544261024
-
Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria?
-
10.1042/BJ20031819 15144238
-
Subcellular compartmentalization of ceramide metabolism: MAM (mitochondria-associated membrane) and/or mitochondria? Bionda C, Portoukalian J, Schmitt D, Rodriguez-Lafrasse C, Ardail D, Biochem J 2004 382 527 533 10.1042/BJ20031819 15144238
-
(2004)
Biochem J
, vol.382
, pp. 527-533
-
-
Bionda, C.1
Portoukalian, J.2
Schmitt, D.3
Rodriguez-Lafrasse, C.4
Ardail, D.5
-
43
-
-
79952836464
-
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
-
10.1042/BJ20101867 21265737
-
A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking. Boslem E, MacIntosh G, Preston AM, Bartley C, Busch AK, Fuller M, Laybutt DR, Meikle PJ, Biden TJ, Biochem J 2011 435 267 276 10.1042/BJ20101867 21265737
-
(2011)
Biochem J
, vol.435
, pp. 267-276
-
-
Boslem, E.1
Macintosh, G.2
Preston, A.M.3
Bartley, C.4
Busch, A.K.5
Fuller, M.6
Laybutt, D.R.7
Meikle, P.J.8
Biden, T.J.9
-
44
-
-
79960814460
-
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells
-
10.1042/BJ20101386 21592087
-
Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells. Veret J, Coant N, Berdyshev EV, Skobeleva A, Therville N, Bailbé D, Gorshkova I, Natarajan V, Portha B, Le Stunff H, Biochem J 2011 438 177 189 10.1042/BJ20101386 21592087
-
(2011)
Biochem J
, vol.438
, pp. 177-189
-
-
Veret, J.1
Coant, N.2
Berdyshev, E.V.3
Skobeleva, A.4
Therville, N.5
Bailbé, D.6
Gorshkova, I.7
Natarajan, V.8
Portha, B.9
Le Stunff, H.10
-
45
-
-
20444430478
-
Apoptotic pathways: Ten minutes to dead
-
10.1016/j.cell.2005.05.019 15935754
-
Apoptotic pathways: ten minutes to dead. Green DR, Cell 2005 121 671 674 10.1016/j.cell.2005.05.019 15935754
-
(2005)
Cell
, vol.121
, pp. 671-674
-
-
Green, D.R.1
-
46
-
-
39749182234
-
Apoptosis: Controlled demolition at the cellular level
-
18073771
-
Apoptosis: controlled demolition at the cellular level. Taylor RC, Cullen SP, Martin SJ, Nat Rev Mol Cell Biol 2008 9 231 241 18073771
-
(2008)
Nat Rev Mol Cell Biol
, vol.9
, pp. 231-241
-
-
Taylor, R.C.1
Cullen, S.P.2
Martin, S.J.3
-
47
-
-
70449105119
-
Beta cell apoptosis in diabetes
-
10.1007/s10495-009-0339-5 19322660
-
Beta cell apoptosis in diabetes. Thomas HE, McKenzie MD, Angstetra E, Campbell PD, Kay TW, Apoptosis 2009 14 1389 1404 10.1007/s10495-009-0339-5 19322660
-
(2009)
Apoptosis
, vol.14
, pp. 1389-1404
-
-
Thomas, H.E.1
McKenzie, M.D.2
Angstetra, E.3
Campbell, P.D.4
Kay, T.W.5
-
48
-
-
34548418170
-
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models
-
10.2337/db06-1771 17563067
-
Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models. Liadis N, Salmena L, Kwan E, Tajmir P, Schroer SA, Radziszewska A, Li X, Sheu L, Eweida M, Xu S, Gaisano HY, Hakem R, Woo M, Diabetes 2007 56 2302 2311 10.2337/db06-1771 17563067
-
(2007)
Diabetes
, vol.56
, pp. 2302-2311
-
-
Liadis, N.1
Salmena, L.2
Kwan, E.3
Tajmir, P.4
Schroer, S.A.5
Radziszewska, A.6
Li, X.7
Sheu, L.8
Eweida, M.9
Xu, S.10
Gaisano, H.Y.11
Hakem, R.12
Woo, M.13
-
49
-
-
17644379373
-
Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus
-
10.1128/MCB.25.9.3620-3629.2005 15831467
-
Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus. Liadis N, Murakami K, Eweida M, Elford AR, Sheu L, Gaisano HY, Hakem R, Ohashi PS, Woo M, Mol Cell Biol 2005 25 3620 3629 10.1128/MCB.25.9.3620-3629.2005 15831467
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3620-3629
-
-
Liadis, N.1
Murakami, K.2
Eweida, M.3
Elford, A.R.4
Sheu, L.5
Gaisano, H.Y.6
Hakem, R.7
Ohashi, P.S.8
Woo, M.9
-
50
-
-
77956095537
-
Mitochondria and cell death: Outer membrane permeabilization and beyond
-
10.1038/nrm2952 20683470
-
Mitochondria and cell death: outer membrane permeabilization and beyond. Tait SW, Green DR, Nat Rev Mol Cell Biol 2010 11 621 632 10.1038/nrm2952 20683470
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 621-632
-
-
Tait, S.W.1
Green, D.R.2
-
51
-
-
18144404605
-
Positively charged ceramide is a potent inducer of mitochondrial permeabilization
-
10.1074/jbc.M411707200 15722351
-
Positively charged ceramide is a potent inducer of mitochondrial permeabilization. Novgorodov SA, Szulc ZM, Luberto C, Jones JA, Bielawski J, Bielawska A, Hannun YA, Obeid LM, J Biol Chem 2005 280 16096 16105 10.1074/jbc.M411707200 15722351
-
(2005)
J Biol Chem
, vol.280
, pp. 16096-16105
-
-
Novgorodov, S.A.1
Szulc, Z.M.2
Luberto, C.3
Jones, J.A.4
Bielawski, J.5
Bielawska, A.6
Hannun, Y.A.7
Obeid, L.M.8
-
52
-
-
0035199418
-
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis
-
10.1096/fj.01-0539com 11726543
-
Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis. Birbes H, El Bawab S, Hannun YA, Obeid LM, FASEB J 2001 15 2669 2679 10.1096/fj.01-0539com 11726543
-
(2001)
FASEB J
, vol.15
, pp. 2669-2679
-
-
Birbes, H.1
El Bawab, S.2
Hannun, Y.A.3
Obeid, L.M.4
-
53
-
-
15944425766
-
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria
-
10.1042/BJ20041627 15516208
-
A mitochondrial pool of sphingomyelin is involved in TNFalpha-induced Bax translocation to mitochondria. Birbes H, Luberto C, Hsu YT, El Bawab S, Hannun YA, Obeid LM, Biochem J 2005 386 445 451 10.1042/BJ20041627 15516208
-
(2005)
Biochem J
, vol.386
, pp. 445-451
-
-
Birbes, H.1
Luberto, C.2
Hsu, Y.T.3
El Bawab, S.4
Hannun, Y.A.5
Obeid, L.M.6
-
54
-
-
20144367155
-
Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane
-
10.1074/jbc.M410869200 15743760
-
Acid sphingomyelinase is indispensable for UV light-induced Bax conformational change at the mitochondrial membrane. Kashkar H, Wiegmann V, Yazdanpanah B, Haubert D, Kronke M, J Biol Chem 2005 280 20804 20813 10.1074/jbc.M410869200 15743760
-
(2005)
J Biol Chem
, vol.280
, pp. 20804-20813
-
-
Kashkar, H.1
Wiegmann, V.2
Yazdanpanah, B.3
Haubert, D.4
Kronke, M.5
-
55
-
-
0036375662
-
Mitochondria and ceramide: Intertwined roles in regulation of apoptosis
-
12123710
-
Mitochondria and ceramide: intertwined roles in regulation of apoptosis. Birbes H, El Bawab S, Obeid LM, Hannun YA, Adv Enzyme Regul 2002 42 113 129 12123710
-
(2002)
Adv Enzyme Regul
, vol.42
, pp. 113-129
-
-
Birbes, H.1
El Bawab, S.2
Obeid, L.M.3
Hannun, Y.A.4
-
56
-
-
0033957476
-
Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction
-
10.1093/intimm/12.1.9 10607745
-
Transgenic overexpression of human Bcl-2 in islet beta cells inhibits apoptosis but does not prevent autoimmune destruction. Allison J, Thomas H, Beck D, Brady JL, Lew AM, Elefanty A, Kosaka H, Kay TW, Huang DC, Strasser A, Int Immunol 2000 12 9 17 10.1093/intimm/12.1.9 10607745
-
(2000)
Int Immunol
, vol.12
, pp. 9-17
-
-
Allison, J.1
Thomas, H.2
Beck, D.3
Brady, J.L.4
Lew, A.M.5
Elefanty, A.6
Kosaka, H.7
Kay, T.W.8
Huang, D.C.9
Strasser, A.10
-
57
-
-
0037030465
-
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells
-
10.1038/sj.onc.1205497 12037683
-
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells. Von Haefen C, Wieder T, Gillissen B, Starck L, Graupner V, Dorken B, Daniel PT, Oncogene 2002 21 4009 4019 10.1038/sj.onc.1205497 12037683
-
(2002)
Oncogene
, vol.21
, pp. 4009-4019
-
-
Von Haefen, C.1
Wieder, T.2
Gillissen, B.3
Starck, L.4
Graupner, V.5
Dorken, B.6
Daniel, P.T.7
-
58
-
-
0037230114
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1
-
10.1210/en.2001-211282 12488362
-
Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Maestre I, Jordan J, Calvo S, Reig JA, Cena V, Soria B, Prentki M, Roche E, Endocrinology 2003 144 335 345 10.1210/en.2001-211282 12488362
-
(2003)
Endocrinology
, vol.144
, pp. 335-345
-
-
Maestre, I.1
Jordan, J.2
Calvo, S.3
Reig, J.A.4
Cena, V.5
Soria, B.6
Prentki, M.7
Roche, E.8
-
59
-
-
33745037188
-
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations
-
10.1016/j.mito.2006.03.002 16713754
-
Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations. Siskind LJ, Kolesnick RN, Colombini M, Mitochondrion 2006 6 118 125 10.1016/j.mito.2006.03.002 16713754
-
(2006)
Mitochondrion
, vol.6
, pp. 118-125
-
-
Siskind, L.J.1
Kolesnick, R.N.2
Colombini, M.3
-
60
-
-
0033758144
-
Akt mediates insulin rescue from apoptosis in brown adipocytes: Effect of ceramide
-
10.1054/ghir.2000.0165 11042022
-
Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Navarro P, Valverde AM, Rohn JL, Benito M, Lorenzo M, Growth Horm IGF Res 2000 10 256 266 10.1054/ghir.2000.0165 11042022
-
(2000)
Growth Horm IGF Res
, vol.10
, pp. 256-266
-
-
Navarro, P.1
Valverde, A.M.2
Rohn, J.L.3
Benito, M.4
Lorenzo, M.5
-
61
-
-
79651474666
-
Reactive oxygen species and insulin resistance: The good, the bad and the ugly
-
10.1016/j.tips.2010.11.006 21159388
-
Reactive oxygen species and insulin resistance: the good, the bad and the ugly. Tiganis T, Trends Pharmacol Sci 2011 32 82 89 10.1016/j.tips.2010.11.006 21159388
-
(2011)
Trends Pharmacol Sci
, vol.32
, pp. 82-89
-
-
Tiganis, T.1
-
62
-
-
12344286763
-
Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium
-
15471985
-
Endostatin uncouples NO and Ca2+ response to bradykinin through enhanced O2*- production in the intact coronary endothelium. Zhang AY, Teggatz EG, Zou AP, Campbell WB, Li PL, Am J Physiol Heart Circ Physiol 2005 288 686 H694 15471985
-
(2005)
Am J Physiol Heart Circ Physiol
, vol.288
-
-
Zhang, A.Y.1
Teggatz, E.G.2
Zou, A.P.3
Campbell, W.B.4
Li, P.L.5
-
63
-
-
1842330849
-
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
-
10.1074/jbc.272.17.11369 9111045
-
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. García-Ruiz C, Colell A, Marí M, Morales A, Fernandez-Checa JC, J Biol Chem 1997 272 11369 11377 10.1074/jbc.272.17.11369 9111045
-
(1997)
J Biol Chem
, vol.272
, pp. 11369-11377
-
-
García-Ruiz, C.1
Colell, A.2
Marí, M.3
Morales, A.4
Fernandez-Checa, J.C.5
-
64
-
-
0032584532
-
Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells
-
10.1016/S0005-2760(98)00066-6 9714807
-
Reactive oxygen species enhances the induction of inducible nitric oxide synthase by sphingomyelinase in RAW264.7 cells. Hatanaka Y, Fujii J, Fukutomi T, Watanabe T, Che W, Sanada Y, Igarashi Y, Taniguchi N, Biochim Biophys Acta 1998 1393 203 210 10.1016/S0005-2760(98)00066-6 9714807
-
(1998)
Biochim Biophys Acta
, vol.1393
, pp. 203-210
-
-
Hatanaka, Y.1
Fujii, J.2
Fukutomi, T.3
Watanabe, T.4
Che, W.5
Sanada, Y.6
Igarashi, Y.7
Taniguchi, N.8
-
65
-
-
0032539871
-
Bcl-2 expression causes redistribution of glutathione to the nucleus
-
10.1073/pnas.95.6.2956 9501197
-
Bcl-2 expression causes redistribution of glutathione to the nucleus. Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S, Meyn RE, Proc Natl Acad Sci U S A 1998 95 2956 2960 10.1073/pnas.95.6.2956 9501197
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 2956-2960
-
-
Voehringer, D.W.1
McConkey, D.J.2
McDonnell, T.J.3
Brisbay, S.4
Meyn, R.E.5
-
66
-
-
0346577312
-
NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase
-
10.1002/jcp.10464 15040013
-
NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. Pilane CM, LaBelle EF, J Cell Physiol 2004 199 310 315 10.1002/jcp.10464 15040013
-
(2004)
J Cell Physiol
, vol.199
, pp. 310-315
-
-
Pilane, C.M.1
Labelle, E.F.2
-
67
-
-
2242423614
-
Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C
-
10.1074/jbc.M204034200 12359735
-
Nitric oxide induces degradation of the neutral ceramidase in rat renal mesangial cells and is counterregulated by protein kinase C. Franzen R, Fabbro D, Aschrafi A, Pfeilschifter J, Huwiler A, J Biol Chem 2002 277 46184 46190 10.1074/jbc.M204034200 12359735
-
(2002)
J Biol Chem
, vol.277
, pp. 46184-46190
-
-
Franzen, R.1
Fabbro, D.2
Aschrafi, A.3
Pfeilschifter, J.4
Huwiler, A.5
-
68
-
-
0034612304
-
Ceramide interaction with the respiratory chain of heart mitochondria
-
10.1021/bi9924415 10828984
-
Ceramide interaction with the respiratory chain of heart mitochondria. Di Paola M, Cocco T, Lorusso M, Biochemistry 2000 39 6660 6668 10.1021/bi9924415 10828984
-
(2000)
Biochemistry
, vol.39
, pp. 6660-6668
-
-
Di Paola, M.1
Cocco, T.2
Lorusso, M.3
-
69
-
-
0030856714
-
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
-
10.1074/jbc.272.39.24154 9305864
-
Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. Gudz TI, Tserng KY, Hoppel CL, J Biol Chem 1997 272 24154 24158 10.1074/jbc.272.39.24154 9305864
-
(1997)
J Biol Chem
, vol.272
, pp. 24154-24158
-
-
Gudz, T.I.1
Tserng, K.Y.2
Hoppel, C.L.3
-
70
-
-
22844440003
-
Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis
-
10.1074/jbc.M414361200 15917250
-
Involvement of NADPH oxidase isoforms and Src family kinases in CD95-dependent hepatocyte apoptosis. Reinehr R, Becker S, Eberle A, Grether-Beck S, Haussinger D, J Biol Chem 2005 280 27179 27194 10.1074/jbc.M414361200 15917250
-
(2005)
J Biol Chem
, vol.280
, pp. 27179-27194
-
-
Reinehr, R.1
Becker, S.2
Eberle, A.3
Grether-Beck, S.4
Haussinger, D.5
-
71
-
-
66449112021
-
Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells
-
19147679
-
Association of NAD(P)H oxidase with glucose-induced insulin secretion by pancreatic beta-cells. Morgan D, Rebelato E, Abdulkader F, Graciano MF, Oliveira-Emilio HR, Hirata AE, Rocha MS, Bordin S, Curi R, Carpinelli AR, Endocrinology 2009 150 2197 2201 19147679
-
(2009)
Endocrinology
, vol.150
, pp. 2197-2201
-
-
Morgan, D.1
Rebelato, E.2
Abdulkader, F.3
Graciano, M.F.4
Oliveira-Emilio, H.R.5
Hirata, A.E.6
Rocha, M.S.7
Bordin, S.8
Curi, R.9
Carpinelli, A.R.10
-
72
-
-
0032482988
-
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression
-
10.1073/pnas.95.16.9558 9689119
-
Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Shimabukuro M, Wang MY, Zhou YT, Newgard CB, Unger RH, Proc Natl Acad Sci U S A 1998 95 9558 9561 10.1073/pnas.95.16.9558 9689119
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 9558-9561
-
-
Shimabukuro, M.1
Wang, M.Y.2
Zhou, Y.T.3
Newgard, C.B.4
Unger, R.H.5
-
73
-
-
0037203345
-
Lipoapoptosis: Its mechanism and its diseases
-
10.1016/S1388-1981(02)00342-6 12531555
-
Lipoapoptosis: its mechanism and its diseases. Unger RH, Orci L, Biochim Biophys Acta 2002 1585 202 212 10.1016/S1388-1981(02)00342-6 12531555
-
(2002)
Biochim Biophys Acta
, vol.1585
, pp. 202-212
-
-
Unger, R.H.1
Orci, L.2
-
74
-
-
0942287672
-
The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase
-
14720208
-
The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase. Won JS, Im YB, Khan M, Singh AK, Singh I, J Neurochem 2004 88 583 593 14720208
-
(2004)
J Neurochem
, vol.88
, pp. 583-593
-
-
Won, J.S.1
Im, Y.B.2
Khan, M.3
Singh, A.K.4
Singh, I.5
-
75
-
-
77957318944
-
Glucose regulation of β-cell stress in type 2 diabetes
-
21029302
-
Glucose regulation of β-cell stress in type 2 diabetes. Leibowitz G, Bachar E, Shaked M, Sinai A, Ketzinel-Gilad M, Cerasi E, Kaiser N, Diabetes Obes Metab 2010 12 66 75 21029302
-
(2010)
Diabetes Obes Metab
, vol.12
, pp. 66-75
-
-
Leibowitz, G.1
Bachar, E.2
Shaked, M.3
Sinai, A.4
Ketzinel-Gilad, M.5
Cerasi, E.6
Kaiser, N.7
-
76
-
-
43549105167
-
The unfolded protein response: A pathway that links insulin demand with beta-cell failure and diabetes
-
18436705
-
The unfolded protein response: a pathway that links insulin demand with beta-cell failure and diabetes. Scheuner D, Kaufman RJ, Endocr Rev 2008 29 317 333 18436705
-
(2008)
Endocr Rev
, vol.29
, pp. 317-333
-
-
Scheuner, D.1
Kaufman, R.J.2
-
77
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
18048764
-
The role for endoplasmic reticulum stress in diabetes mellitus. Eizirik DL, Cardozo AK, Cnop M, Endocr Rev 2008 29 42 61 18048764
-
(2008)
Endocr Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
78
-
-
70449494871
-
Endoplasmic reticulum stress in beta-cells and development of diabetes
-
10.1016/j.coph.2009.07.003 19665428
-
Endoplasmic reticulum stress in beta-cells and development of diabetes. Fonseca SG, Burcin M, Gromada J, Urano F, Curr Opin Pharmacol 2009 9 763 770 10.1016/j.coph.2009.07.003 19665428
-
(2009)
Curr Opin Pharmacol
, vol.9
, pp. 763-770
-
-
Fonseca, S.G.1
Burcin, M.2
Gromada, J.3
Urano, F.4
-
79
-
-
84855605795
-
Endoplasmic reticulum stress, obesity and diabetes
-
10.1016/j.molmed.2011.07.010 21889406
-
Endoplasmic reticulum stress, obesity and diabetes. Cnop M, Foufelle F, Velloso LA, Trends Mol Med 2012 18 59 68 10.1016/j.molmed.2011.07.010 21889406
-
(2012)
Trends Mol Med
, vol.18
, pp. 59-68
-
-
Cnop, M.1
Foufelle, F.2
Velloso, L.A.3
-
80
-
-
0036022403
-
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells
-
10.1023/A:1016175429877 12101393
-
Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells. Oyadomari S, Araki E, Mori M, Apoptosis 2002 7 335 345 10.1023/A:1016175429877 12101393
-
(2002)
Apoptosis
, vol.7
, pp. 335-345
-
-
Oyadomari, S.1
Araki, E.2
Mori, M.3
-
81
-
-
1942475176
-
The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death
-
10.1196/annals.1288.022 14679055
-
The role of endoplasmic reticulum stress in nonimmune diabetes: NOD.k iHEL, a novel model of beta cell death. Socha L, Silva D, Lesage S, Goodnow C, Petrovsky N, Ann N Y Acad Sci 2003 1005 178 183 10.1196/annals.1288.022 14679055
-
(2003)
Ann N y Acad Sci
, vol.1005
, pp. 178-183
-
-
Socha, L.1
Silva, D.2
Lesage, S.3
Goodnow, C.4
Petrovsky, N.5
-
82
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
10.1007/s00125-006-0590-z 17268797
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV, Biden TJ, Diabetologia 2007 50 752 763 10.1007/s00125-006-0590-z 17268797
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
Biankin, A.V.6
Biden, T.J.7
-
83
-
-
40449106191
-
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
-
10.1152/ajpendo.00478.2007 18198352
-
Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells. Lai E, Bikopoulos G, Wheeler MB, Rozakis-Adcock M, Volchuk A, Am J Physiol Endocrinol Metab 2008 294 540 E550 10.1152/ajpendo.00478.2007 18198352
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Lai, E.1
Bikopoulos, G.2
Wheeler, M.B.3
Rozakis-Adcock, M.4
Volchuk, A.5
-
84
-
-
77953285560
-
Group VIA Ca2 + -independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death
-
10.1016/j.biochi.2010.01.005 20083151
-
Group VIA Ca2 + -independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death. Lei X, Barbour SE, Ramanadham S, Biochimie 2010 92 627 637 10.1016/j.biochi.2010.01.005 20083151
-
(2010)
Biochimie
, vol.92
, pp. 627-637
-
-
Lei, X.1
Barbour, S.E.2
Ramanadham, S.3
-
85
-
-
66749163678
-
Disulfide formation in the ER and mitochondria: Two solutions to a common process
-
10.1126/science.1170653 19498160
-
Disulfide formation in the ER and mitochondria: two solutions to a common process. Riemer J, Bulleid N, Herrmann JM, Science 2009 324 1284 1287 10.1126/science.1170653 19498160
-
(2009)
Science
, vol.324
, pp. 1284-1287
-
-
Riemer, J.1
Bulleid, N.2
Herrmann, J.M.3
-
86
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
10.1038/sj.leu.2402824 12646949
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA, Leukemia 2003 17 590 603 10.1038/sj.leu.2402824 12646949
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, L.S.4
Shelton, J.G.5
Blalock, W.L.6
Franklin, R.A.7
McCubrey, J.A.8
-
87
-
-
0029871708
-
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine
-
10.1016/S0092-8674(00)81067-3 8601312
-
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Muslin AJ, Tanner JW, Allen PM, Shaw AS, Cell 1996 84 889 897 10.1016/S0092-8674(00)81067-3 8601312
-
(1996)
Cell
, vol.84
, pp. 889-897
-
-
Muslin, A.J.1
Tanner, J.W.2
Allen, P.M.3
Shaw, A.S.4
-
88
-
-
0031809427
-
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells)
-
10.1007/s001250050995 9686926
-
Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). Kellerer M, Mushack J, Seffer E, Mischak H, Ullrich A, Haring HU, Diabetologia 1998 41 833 838 10.1007/s001250050995 9686926
-
(1998)
Diabetologia
, vol.41
, pp. 833-838
-
-
Kellerer, M.1
Mushack, J.2
Seffer, E.3
Mischak, H.4
Ullrich, A.5
Haring, H.U.6
-
89
-
-
34250303939
-
Key role for ceramides in mediating insulin resistance in human muscle cells
-
10.1074/jbc.M611157200 17337731
-
Key role for ceramides in mediating insulin resistance in human muscle cells. Pickersgill L, Litherland GJ, Greenberg AS, Walker M, Yeaman SJ, J Biol Chem 2007 282 12583 12589 10.1074/jbc.M611157200 17337731
-
(2007)
J Biol Chem
, vol.282
, pp. 12583-12589
-
-
Pickersgill, L.1
Litherland, G.J.2
Greenberg, A.S.3
Walker, M.4
Yeaman, S.J.5
-
90
-
-
33847628837
-
Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid
-
10.1002/jcp.20922 17219404
-
Fatty acid-induced defects in insulin signalling, in myotubes derived from children, are related to ceramide production from palmitate rather than the accumulation of intramyocellular lipid. Sabin MA, Stewart CE, Crowne EC, Turner SJ, Hunt LP, Welsh GI, Grohmann MJ, Holly JM, Shield JP, J Cell Physiol 2007 211 244 252 10.1002/jcp.20922 17219404
-
(2007)
J Cell Physiol
, vol.211
, pp. 244-252
-
-
Sabin, M.A.1
Stewart, C.E.2
Crowne, E.C.3
Turner, S.J.4
Hunt, L.P.5
Welsh, G.I.6
Grohmann, M.J.7
Holly, J.M.8
Shield, J.P.9
-
91
-
-
0035515278
-
Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans
-
10.2337/diabetes.50.11.2579 11679437
-
Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Bachmann OP, Dahl DB, Brechtel K, Machann J, Haap M, Maier T, Loviscach M, Stumvoll M, Claussen CD, Schick F, Haring HU, Jacob S, Diabetes 2001 50 2579 2584 10.2337/diabetes.50.11.2579 11679437
-
(2001)
Diabetes
, vol.50
, pp. 2579-2584
-
-
Bachmann, O.P.1
Dahl, D.B.2
Brechtel, K.3
Machann, J.4
Haap, M.5
Maier, T.6
Loviscach, M.7
Stumvoll, M.8
Claussen, C.D.9
Schick, F.10
Haring, H.U.11
Jacob, S.12
-
92
-
-
0038532298
-
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
-
10.1074/jbc.M212307200 12525490
-
A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA, J Biol Chem 2003 278 10297 10303 10.1074/jbc.M212307200 12525490
-
(2003)
J Biol Chem
, vol.278
, pp. 10297-10303
-
-
Chavez, J.A.1
Knotts, T.A.2
Wang, L.P.3
Li, G.4
Dobrowsky, R.T.5
Florant, G.L.6
Summers, S.A.7
-
93
-
-
21244442275
-
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
-
10.1074/jbc.M412769200 15774472
-
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. Chavez JA, Holland WL, Bar J, Sandhoff K, Summers SA, J Biol Chem 2005 280 20148 20153 10.1074/jbc.M412769200 15774472
-
(2005)
J Biol Chem
, vol.280
, pp. 20148-20153
-
-
Chavez, J.A.1
Holland, W.L.2
Bar, J.3
Sandhoff, K.4
Summers, S.A.5
-
94
-
-
4544242908
-
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells
-
10.1042/BJ20040139 15193147
-
Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells. Powell DJ, Turban S, Gray A, Hajduch E, Hundal HS, Biochem J 2004 382 619 629 10.1042/BJ20040139 15193147
-
(2004)
Biochem J
, vol.382
, pp. 619-629
-
-
Powell, D.J.1
Turban, S.2
Gray, A.3
Hajduch, E.4
Hundal, H.S.5
-
95
-
-
14644445144
-
A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome
-
10.2337/diabetes.54.3.591 15734832
-
A role for sphingolipids in producing the common features of type 2 diabetes, metabolic syndrome X, and Cushing's syndrome. Summers SA, Nelson DH, Diabetes 2005 54 591 602 10.2337/diabetes.54.3.591 15734832
-
(2005)
Diabetes
, vol.54
, pp. 591-602
-
-
Summers, S.A.1
Nelson, D.H.2
-
96
-
-
0031841949
-
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
-
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Summers SA, Garza LA, Zhou H, Birnbaum MJ, Mol Cell Bio 1998 18 5457 5464
-
(1998)
Mol Cell Bio
, vol.18
, pp. 5457-5464
-
-
Summers, S.A.1
Garza, L.A.2
Zhou, H.3
Birnbaum, M.J.4
-
97
-
-
0031964986
-
Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes
-
10.2337/diabetes.47.1.24 9421370
-
Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes. Wang CN, O'Brien L, Brindley DN, Diabetes 1998 47 24 31 10.2337/diabetes.47.1.24 9421370
-
(1998)
Diabetes
, vol.47
, pp. 24-31
-
-
Wang, C.N.1
O'Brien, L.2
Brindley, D.N.3
-
98
-
-
0030886025
-
Fatty acid-induced insulin resistance in adipocytes
-
10.1210/en.138.10.4338 9322948
-
Fatty acid-induced insulin resistance in adipocytes. Van Epps-Fung M, Williford J, Wells A, Hardy RW, Endocrinology 1997 138 4338 4345 10.1210/en.138.10.4338 9322948
-
(1997)
Endocrinology
, vol.138
, pp. 4338-4345
-
-
Van Epps-Fung, M.1
Williford, J.2
Wells, A.3
Hardy, R.W.4
-
100
-
-
59849098608
-
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
-
10.1042/BJ20081149 18922131
-
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Watson ML, Coghlan M, Hundal HS, Biochem J 2009 417 791 801 10.1042/BJ20081149 18922131
-
(2009)
Biochem J
, vol.417
, pp. 791-801
-
-
Watson, M.L.1
Coghlan, M.2
Hundal, H.S.3
-
101
-
-
79955758735
-
Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: Implications for insulin resistance
-
10.1074/jbc.M110.186916 21454530
-
Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistance. Hu W, Ross J, Geng T, Brice SE, Cowart LA, J Biol Chem 2011 286 16596 16605 10.1074/jbc.M110.186916 21454530
-
(2011)
J Biol Chem
, vol.286
, pp. 16596-16605
-
-
Hu, W.1
Ross, J.2
Geng, T.3
Brice, S.E.4
Cowart, L.A.5
-
102
-
-
0037261135
-
Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes
-
10.1038/sj.ijo.0802183 12532151
-
Cell-permeable ceramides increase basal glucose incorporation into triacylglycerols but decrease the stimulation by insulin in 3T3-L1 adipocytes. Mei J, Wang CN, O'Brien L, Brindley DN, Int J Obes Relat Metab Disord 2003 27 31 39 10.1038/sj.ijo.0802183 12532151
-
(2003)
Int J Obes Relat Metab Disord
, vol.27
, pp. 31-39
-
-
Mei, J.1
Wang, C.N.2
O'Brien, L.3
Brindley, D.N.4
-
103
-
-
77956040410
-
Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: Reversal and improvement of glucose tolerance by lipid metabolism inhibitors
-
10.1210/en.2010-0250 20660065
-
Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors. Frangioudakis G, Garrard J, Raddatz K, Nadler JL, Mitchell TW, Schmitz-Peiffer C, Endocrinology 2010 151 4187 4196 10.1210/en.2010-0250 20660065
-
(2010)
Endocrinology
, vol.151
, pp. 4187-4196
-
-
Frangioudakis, G.1
Garrard, J.2
Raddatz, K.3
Nadler, J.L.4
Mitchell, T.W.5
Schmitz-Peiffer, C.6
-
104
-
-
67650096801
-
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
-
10.1152/ajpendo.91014.2008 19435851
-
Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome. Yang G, Badeanlou L, Bielawski J, Roberts AJ, Hannun YA, Samad F, Am J Physiol Endocrinol Metab 2009 297 211 E224 10.1152/ajpendo.91014.2008 19435851
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
-
-
Yang, G.1
Badeanlou, L.2
Bielawski, J.3
Roberts, A.J.4
Hannun, Y.A.5
Samad, F.6
-
105
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
10.1016/j.cmet.2007.01.002 17339025
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA, Cell Metab 2007 5 167 179 10.1016/j.cmet.2007.01.002 17339025
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
Hawkins, E.D.4
Sargent, K.M.5
Liu, Y.6
Narra, K.7
Hoehn, K.L.8
Knotts, T.A.9
Siesky, A.10
Nelson, D.H.11
Karathanasis, S.K.12
Fontenot, G.K.13
Birnbaum, M.J.14
Summers, S.A.15
-
106
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
-
10.2337/diabetes.51.7.2005 12086926
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Itani SI, Ruderman NB, Schmieder F, Boden G, Diabetes 2002 51 2005 2011 10.2337/diabetes.51.7.2005 12086926
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
107
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
10.1074/jbc.M200958200 12006582
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen WE, Shulman GI, J Biol Chem 2002 277 50230 50236 10.1074/jbc.M200958200 12006582
-
(2002)
J Biol Chem
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zong, H.5
Wang, Y.6
Bergeron, R.7
Kim, J.K.8
Cushman, S.W.9
Cooney, G.J.10
Atcheson, B.11
White, M.F.12
Kraegen, W.E.13
Shulman, G.I.14
-
108
-
-
0346729968
-
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans
-
14693694
-
Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Adams JM 2nd, Pratipanawatr T, Berria R, Wang E, DeFronzo RA, Sullards MC, Mandarino LJ, Diabetes 2004 53 25 31 14693694
-
(2004)
Diabetes
, vol.53
, pp. 25-31
-
-
Adams, J.M.1
Pratipanawatr, T.2
Berria, R.3
Wang, E.4
Defronzo, R.A.5
Sullards, M.C.6
Mandarino, L.J.7
-
109
-
-
2342621476
-
Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle
-
10.2337/diabetes.53.5.1215 15111489
-
Relationship between insulin sensitivity and sphingomyelin signaling pathway in human skeletal muscle. Straczkowski M, Kowalska I, Nikolajuk A, Dzienis-Straczkowska S, Kinalska I, Baranowski M, Zendzian-Piotrowska M, Brzezinska Z, Gorski J, Diabetes 2004 53 1215 1221 10.2337/diabetes.53.5.1215 15111489
-
(2004)
Diabetes
, vol.53
, pp. 1215-1221
-
-
Straczkowski, M.1
Kowalska, I.2
Nikolajuk, A.3
Dzienis-Straczkowska, S.4
Kinalska, I.5
Baranowski, M.6
Zendzian-Piotrowska, M.7
Brzezinska, Z.8
Gorski, J.9
-
110
-
-
77957327998
-
Role of PUFAs, the precursors of endocannabinoids, in human obesity and type 2 diabetes
-
Role of PUFAs, the precursors of endocannabinoids, in human obesity and type 2 diabetes. Dain A, Repossi G, Das UN, Eynard AR, Front Biosci (Elite Ed) 2010 2 1432 1447
-
(2010)
Front Biosci (Elite Ed)
, vol.2
, pp. 1432-1447
-
-
Dain, A.1
Repossi, G.2
Das, U.N.3
Eynard, A.R.4
-
111
-
-
48149101434
-
The endocannabinoid system in obesity and type 2 diabetes
-
10.1007/s00125-008-1048-2 18563385
-
The endocannabinoid system in obesity and type 2 diabetes. Di Marzo V, Diabetologia 2008 51 1356 1367 10.1007/s00125-008-1048-2 18563385
-
(2008)
Diabetologia
, vol.51
, pp. 1356-1367
-
-
Di Marzo, V.1
-
112
-
-
83855160809
-
Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors
-
10.1007/s10555-011-9308-x 22048864
-
Basic aspects of tumor cell fatty acid-regulated signaling and transcription factors. Comba A, Lin YH, Eynard AR, Valentich MA, Fernandez-Zapico ME, Pasqualini ME, Cancer Metastasis Rev 2011 30 325 342 10.1007/s10555-011-9308-x 22048864
-
(2011)
Cancer Metastasis Rev
, vol.30
, pp. 325-342
-
-
Comba, A.1
Lin, Y.H.2
Eynard, A.R.3
Valentich, M.A.4
Fernandez-Zapico, M.E.5
Pasqualini, M.E.6
-
113
-
-
79960837542
-
Eicosanoids, β-cell function, and diabetes
-
10.1016/j.prostaglandins.2011.06.001 21757024
-
Eicosanoids, β-cell function, and diabetes. Luo P, Wang MH, Prostaglandins Other Lipid Mediat 2011 95 1 4 10.1016/j.prostaglandins.2011.06. 001 21757024
-
(2011)
Prostaglandins Other Lipid Mediat
, vol.95
, pp. 1-4
-
-
Luo, P.1
Wang, M.H.2
-
114
-
-
84867867477
-
The nuclear factor kappa B signaling pathway: Integrating metabolism with inflammation
-
10.1016/j.tcb.2012.08.001 22995730
-
The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation. Tornatore L, Thotakura AK, Bennett J, Moretti M, Franzoso G, Trends Cell Biol 2012 22 557 566 10.1016/j.tcb.2012.08.001 22995730
-
(2012)
Trends Cell Biol
, vol.22
, pp. 557-566
-
-
Tornatore, L.1
Thotakura, A.K.2
Bennett, J.3
Moretti, M.4
Franzoso, G.5
-
115
-
-
77955806634
-
JNK1 and IKKβ: Molecular links between obesity and metabolic dysfunction
-
10.1096/fj.09-151340 20371626
-
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction. Solinas G, Karin M, FASEB J 2010 24 2596 2611 10.1096/fj.09-151340 20371626
-
(2010)
FASEB J
, vol.24
, pp. 2596-2611
-
-
Solinas, G.1
Karin, M.2
-
116
-
-
0028050242
-
Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation
-
10.1006/bbrc.1994.1988 8048941
-
Ceramide mediates the apoptotic response of WEHI 231 cells to anti-immunoglobulin, corticosteroids and irradiation. Quintans J, Kilkus J, McShan CL, Gottschalk AR, Dawson G, Biochem Biophys Res Commun 1994 202 710 714 10.1006/bbrc.1994.1988 8048941
-
(1994)
Biochem Biophys Res Commun
, vol.202
, pp. 710-714
-
-
Quintans, J.1
Kilkus, J.2
McShan, C.L.3
Gottschalk, A.R.4
Dawson, G.5
-
117
-
-
0035212942
-
Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption
-
10.1042/BST0290831 11709083
-
Regulation of de novo sphingolipid biosynthesis and the toxic consequences of its disruption. Linn SC, Kim HS, Keane EM, Andras LM, Wang E, Merrill AH Jr, Biochem Soc Trans 2001 29 831 835 10.1042/BST0290831 11709083
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 831-835
-
-
Linn, S.C.1
Kim, H.S.2
Keane, E.M.3
Andras, L.M.4
Wang, E.5
Merrill Jr., A.H.6
-
118
-
-
0036959692
-
Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis
-
10.1111/j.1749-6632.2002.tb04631.x 12485859
-
Involvement of sphingosine in dexamethasone-induced thymocyte apoptosis. Lepine S, Lakatos B, Maziere P, Courageot MP, Sulpice JC, Giraud F, Ann N Y Acad Sci 2002 973 190 193 10.1111/j.1749-6632.2002.tb04631.x 12485859
-
(2002)
Ann N y Acad Sci
, vol.973
, pp. 190-193
-
-
Lepine, S.1
Lakatos, B.2
Maziere, P.3
Courageot, M.P.4
Sulpice, J.C.5
Giraud, F.6
-
119
-
-
33846452968
-
Pioglitazone induces de novo ceramide synthesis in the rat heart
-
10.1016/j.prostaglandins.2006.10.004
-
Pioglitazone induces de novo ceramide synthesis in the rat heart. Baranowski M, Blachnio A, Zabielski P, Gorski J, Prostaglandins Lipid Mediat 2007 83 99 111 10.1016/j.prostaglandins.2006.10.004
-
(2007)
Prostaglandins Lipid Mediat
, vol.83
, pp. 99-111
-
-
Baranowski, M.1
Blachnio, A.2
Zabielski, P.3
Gorski, J.4
-
120
-
-
0037417725
-
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
-
10.1073/pnas.0336724100 12552126
-
A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content. Finck BN, Han X, Courtois M, Aimond F, Nerbonne JM, Kovacs A, Gross RW, Kelly DP, Proc Natl Acad Sci USA 2003 100 1226 1231 10.1073/pnas.0336724100 12552126
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 1226-1231
-
-
Finck, B.N.1
Han, X.2
Courtois, M.3
Aimond, F.4
Nerbonne, J.M.5
Kovacs, A.6
Gross, R.W.7
Kelly, D.P.8
-
121
-
-
0036255529
-
The mode of action of thiazolidinediones
-
10.1002/dmrr.249 11921433
-
The mode of action of thiazolidinediones. Hauner H, Diabetes Metab Res Rev 2002 18 10 S15 10.1002/dmrr.249 11921433
-
(2002)
Diabetes Metab Res Rev
, vol.18
-
-
Hauner, H.1
-
122
-
-
34047276087
-
Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles
-
17242494
-
Effects of pioglitazone and high-fat diet on ceramide metabolism in rat skeletal muscles. Zendzian-Piotrowska M, Baranowski M, Zabielski P, Gorski J, J Physiol Pharmacol 2006 57 101 114 17242494
-
(2006)
J Physiol Pharmacol
, vol.57
, pp. 101-114
-
-
Zendzian-Piotrowska, M.1
Baranowski, M.2
Zabielski, P.3
Gorski, J.4
-
123
-
-
15744365009
-
Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice
-
10.1016/j.bcp.2005.01.015 15794940
-
Increased Akt protein expression is associated with decreased ceramide content in skeletal muscle of troglitazone-treated mice. Planavila A, Alegret M, Sanchez RM, Rodriguez-Calvo R, Laguna JC, Vazquez-Carrera M, Biochem Pharmacol 2005 69 1195 1204 10.1016/j.bcp.2005.01.015 15794940
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 1195-1204
-
-
Planavila, A.1
Alegret, M.2
Sanchez, R.M.3
Rodriguez-Calvo, R.4
Laguna, J.C.5
Vazquez-Carrera, M.6
-
124
-
-
9444230624
-
Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle
-
10.1210/en.2004-0659 15375026
-
Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle. Lessard SJ, Lo Giudice SL, Lau W, Reid JJ, Turner N, Febbraio MA, Hawley JA, Watt MJ, Endocrinology 2004 145 5665 5670 10.1210/en.2004-0659 15375026
-
(2004)
Endocrinology
, vol.145
, pp. 5665-5670
-
-
Lessard, S.J.1
Lo Giudice, S.L.2
Lau, W.3
Reid, J.J.4
Turner, N.5
Febbraio, M.A.6
Hawley, J.A.7
Watt, M.J.8
-
125
-
-
34347208708
-
Serum retinol-binding protein: A link between obesity, insulin resistance, and type 2 diabetes
-
10.1111/j.1753-4887.2007.tb00302.x 17566551
-
Serum retinol-binding protein: a link between obesity, insulin resistance, and type 2 diabetes. Wolf G, Nutr Rev 2007 65 251 256 10.1111/j.1753-4887.2007.tb00302.x 17566551
-
(2007)
Nutr Rev
, vol.65
, pp. 251-256
-
-
Wolf, G.1
-
127
-
-
3142624494
-
Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat
-
15213354
-
Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat. Dobrzyn A, Zendzian-Piotrowska M, Gorski J, J Physiol Pharmacol 2004 55 305 313 15213354
-
(2004)
J Physiol Pharmacol
, vol.55
, pp. 305-313
-
-
Dobrzyn, A.1
Zendzian-Piotrowska, M.2
Gorski, J.3
-
128
-
-
34547131281
-
Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia
-
10.1152/ajpendo.00677.2006 17374701
-
Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia. Smith AC, Mullen KL, Junkin KA, Nickerson J, Chabowski A, Bonen A, Dyck DJ, Am J Physiol Endocrinol Metab 2007 293 172 E181 10.1152/ajpendo.00677.2006 17374701
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Smith, A.C.1
Mullen, K.L.2
Junkin, K.A.3
Nickerson, J.4
Chabowski, A.5
Bonen, A.6
Dyck, D.J.7
-
129
-
-
45549084515
-
Exercise-induced alterations in intramyocellular lipids and insulin resistance: The athlete's paradox revisited
-
10.1152/ajpendo.00769.2007 18319352
-
Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Dube JJ, Amati F, Stefanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH, Am J Physiol Endocrinol Metab 2008 294 882 E888 10.1152/ajpendo.00769.2007 18319352
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Dube, J.J.1
Amati, F.2
Stefanovic-Racic, M.3
Toledo, F.G.4
Sauers, S.E.5
Goodpaster, B.H.6
-
130
-
-
33745841299
-
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content
-
10.1152/ajpendo.00587.2005 16464906
-
Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content. Bruce CR, Thrush AB, Mertz VA, Bezaire V, Chabowski A, Heigenhauser GJ, Dyck DJ, Am J Physiol Endocrinol Metab 2006 291 99 E107 10.1152/ajpendo.00587.2005 16464906
-
(2006)
Am J Physiol Endocrinol Metab
, vol.291
-
-
Bruce, C.R.1
Thrush, A.B.2
Mertz, V.A.3
Bezaire, V.4
Chabowski, A.5
Heigenhauser, G.J.6
Dyck, D.J.7
-
131
-
-
34347390598
-
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance
-
10.2337/db06-1065 17440174
-
Tissue-specific effects of rosiglitazone and exercise in the treatment of lipid-induced insulin resistance. Lessard SJ, Rivas DA, Chen ZP, Bonen A, Febbraio MA, Reeder DW, Kemp BE, Yaspelkis BB 3rd, Hawley JA, Diabetes 2007 56 1856 1864 10.2337/db06-1065 17440174
-
(2007)
Diabetes
, vol.56
, pp. 1856-1864
-
-
Lessard, S.J.1
Rivas, D.A.2
Chen, Z.P.3
Bonen, A.4
Febbraio, M.A.5
Reeder, D.W.6
Kemp, B.E.7
Yaspelkis, B.B.8
Hawley, J.A.9
-
132
-
-
1642503772
-
Exercise and training effects on ceramide metabolism in human skeletal muscle
-
10.1113/expphysiol.2003.002605 15109217
-
Exercise and training effects on ceramide metabolism in human skeletal muscle. Helge JW, Dobrzyn A, Saltin B, Gorski J, Exp Physiol 2004 89 119 127 10.1113/expphysiol.2003.002605 15109217
-
(2004)
Exp Physiol
, vol.89
, pp. 119-127
-
-
Helge, J.W.1
Dobrzyn, A.2
Saltin, B.3
Gorski, J.4
-
133
-
-
0348222671
-
Inflammation: The link between insulin resistance, obesity and diabetes
-
10.1016/j.it.2003.10.013 14698276
-
Inflammation: the link between insulin resistance, obesity and diabetes. Dandona P, Aljada A, Bandyopadhyay A, Trends Immunol 2004 25 4 7 10.1016/j.it.2003.10.013 14698276
-
(2004)
Trends Immunol
, vol.25
, pp. 4-7
-
-
Dandona, P.1
Aljada, A.2
Bandyopadhyay, A.3
-
134
-
-
3042618753
-
Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents
-
10.1016/j.metabol.2004.02.007 15254878
-
Serum tumor necrosis factor-alpha levels and components of the metabolic syndrome in obese adolescents. Moon YS, Kim DH, Song DK, Metabolism 2004 53 863 867 10.1016/j.metabol.2004.02.007 15254878
-
(2004)
Metabolism
, vol.53
, pp. 863-867
-
-
Moon, Y.S.1
Kim, D.H.2
Song, D.K.3
-
135
-
-
41249098290
-
Aging up-regulates expression of inflammatory mediators in mouse adipose tissue
-
17878382
-
Aging up-regulates expression of inflammatory mediators in mouse adipose tissue. Wu D, Ren Z, Pae M, Guo W, Cui X, Merrill AH, Meydani SN, J Immunol 2007 179 4829 4839 17878382
-
(2007)
J Immunol
, vol.179
, pp. 4829-4839
-
-
Wu, D.1
Ren, Z.2
Pae, M.3
Guo, W.4
Cui, X.5
Merrill, A.H.6
Meydani, S.N.7
-
136
-
-
0029874429
-
Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1
-
10.1074/jbc.271.17.9895 8626623
-
Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1. Kanety H, Hemi R, Papa MZ, Karasik A, J Biol Chem 1996 271 9895 9897 10.1074/jbc.271.17.9895 8626623
-
(1996)
J Biol Chem
, vol.271
, pp. 9895-9897
-
-
Kanety, H.1
Hemi, R.2
Papa, M.Z.3
Karasik, A.4
-
137
-
-
0030669392
-
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibitstheir binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
-
10.1074/jbc.272.47.29911 9368067
-
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibitstheir binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y, J Biol Chem 1997 272 29911 29918 10.1074/jbc.272.47.29911 9368067
-
(1997)
J Biol Chem
, vol.272
, pp. 29911-29918
-
-
Paz, K.1
Hemi, R.2
Leroith, D.3
Karasik, A.4
Elhanany, E.5
Kanety, H.6
Zick, Y.7
-
138
-
-
0036924048
-
Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3
-
10.1016/S1097-2765(02)00734-7 12504027
-
Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3. Sathyanarayana P, Barthwal MK, Kundu CN, Lane ME, Bergmann A, Tzivion G, Rana A, Mol Cell 2002 10 1527 1533 10.1016/S1097-2765(02)00734-7 12504027
-
(2002)
Mol Cell
, vol.10
, pp. 1527-1533
-
-
Sathyanarayana, P.1
Barthwal, M.K.2
Kundu, C.N.3
Lane, M.E.4
Bergmann, A.5
Tzivion, G.6
Rana, A.7
-
139
-
-
0034954603
-
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis
-
10.1128/MCB.21.14.4713-4724.2001 11416147
-
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis. Xu Z, Maroney AC, Dobrzanski P, Kukekov NV, Greene LA, Mol Cell Biol 2001 21 4713 4724 10.1128/MCB.21.14.4713-4724.2001 11416147
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4713-4724
-
-
Xu, Z.1
Maroney, A.C.2
Dobrzanski, P.3
Kukekov, N.V.4
Greene, L.A.5
-
140
-
-
3142741044
-
Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells
-
10.1074/jbc.M313947200 15069087
-
Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells. Kim KY, Kim BC, Xu Z, Kim SJ, J Biol Chem 2004 279 29478 29484 10.1074/jbc.M313947200 15069087
-
(2004)
J Biol Chem
, vol.279
, pp. 29478-29484
-
-
Kim, K.Y.1
Kim, B.C.2
Xu, Z.3
Kim, S.J.4
-
141
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
10.1074/jbc.275.12.9047 10722755
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). Aguirre V, Uchida T, Yenush L, Davis R, White MF, J Biol Chem 2000 275 9047 9054 10.1074/jbc.275.12.9047 10722755
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
142
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
10.1038/nature01137 12447443
-
A central role for JNK in obesity and insulin resistance. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS, Nature 2002 420 333 336 10.1038/nature01137 12447443
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Gorgun, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.S.8
-
143
-
-
14544271905
-
Marchand-Brustel, J.F. Tanti, Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
-
10.1016/j.biochi.2004.10.019 15733744
-
Marchand-Brustel, J.F. Tanti, Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Gual P, Le Y, Biochimie 2005 87 99 109 10.1016/j.biochi.2004.10.019 15733744
-
(2005)
Biochimie
, vol.87
, pp. 99-109
-
-
Gual, P.1
Le, Y.2
-
144
-
-
0034104298
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes
-
10.1038/73523 10700186
-
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes. Waeber G, Delplanque J, Bonny C, Mooser V, Steinmann M, Widmann C, Maillard A, Miklossy J, Dina C, Hani EH, Vionnet N, Nicod P, Boutin P, Froguel P, Nat Genet 2000 24 291 295 10.1038/73523 10700186
-
(2000)
Nat Genet
, vol.24
, pp. 291-295
-
-
Waeber, G.1
Delplanque, J.2
Bonny, C.3
Mooser, V.4
Steinmann, M.5
Widmann, C.6
Maillard, A.7
Miklossy, J.8
Dina, C.9
Hani, E.H.10
Vionnet, N.11
Nicod, P.12
Boutin, P.13
Froguel, P.14
-
145
-
-
0342980927
-
Inhibition of PKB/Akt1 by C2-ceramide involves activation of
-
10.1006/mcne.1999.0813 10673324
-
Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells. Salinas M, Lopez-Valdaliso R, Martin D, Alvarez A, Cuadrado A, Mol Cell Neurosci 2000 15 156 169 10.1006/mcne.1999.0813 10673324
-
(2000)
Mol Cell Neurosci
, vol.15
, pp. 156-169
-
-
Salinas, M.1
Lopez-Valdaliso, R.2
Martin, D.3
Alvarez, A.4
Cuadrado, A.5
-
146
-
-
0034607914
-
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473
-
10.1074/jbc.275.18.13330 10788440
-
Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473. Schubert KM, Scheid MP, Duronio V, J Biol Chem 2000 275 13330 13335 10.1074/jbc.275.18.13330 10788440
-
(2000)
J Biol Chem
, vol.275
, pp. 13330-13335
-
-
Schubert, K.M.1
Scheid, M.P.2
Duronio, V.3
-
147
-
-
0035281991
-
Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation
-
10.1042/0264-6021:3540359 11171115
-
Ceramide dissociates 3′-phosphoinositide production from pleckstrin homology domain translocation. Stratford S, DeWald DB, Summers SA, Biochem J 2001 354 359 368 10.1042/0264-6021:3540359 11171115
-
(2001)
Biochem J
, vol.354
, pp. 359-368
-
-
Stratford, S.1
Dewald, D.B.2
Summers, S.A.3
-
148
-
-
0032128301
-
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
-
10.1101/gad.12.13.1941 9649498
-
Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Zundel W, Giaccia A, Genes Dev 1998 12 1941 1946 10.1101/gad.12.13.1941 9649498
-
(1998)
Genes Dev
, vol.12
, pp. 1941-1946
-
-
Zundel, W.1
Giaccia, A.2
-
149
-
-
0035513703
-
Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
-
10.2337/diabetes.50.11.2563 11679435
-
Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Teruel T, Hernandez R, Lorenzo M, Diabetes 2001 50 2563 2571 10.2337/diabetes.50.11.2563 11679435
-
(2001)
Diabetes
, vol.50
, pp. 2563-2571
-
-
Teruel, T.1
Hernandez, R.2
Lorenzo, M.3
-
150
-
-
0034816711
-
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87MG cells
-
10.1006/bbrc.2000.4248 11162641
-
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87MG cells. Zinda MJ, Vlahos CJ, Lai MT, Biochem Biophys Res Commun 2001 280 1107 1115 10.1006/bbrc.2000.4248 11162641
-
(2001)
Biochem Biophys Res Commun
, vol.280
, pp. 1107-1115
-
-
Zinda, M.J.1
Vlahos, C.J.2
Lai, M.T.3
-
151
-
-
0036479251
-
Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: Implications for growth arrest
-
10.1074/jbc.M110541200 11723139
-
Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest. Bourbon NA, Sandirasegarane L, Kester M, J Biol Chem 2002 277 3286 3292 10.1074/jbc.M110541200 11723139
-
(2002)
J Biol Chem
, vol.277
, pp. 3286-3292
-
-
Bourbon, N.A.1
Sandirasegarane, L.2
Kester, M.3
-
152
-
-
0142091454
-
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism
-
10.1128/MCB.23.21.7794-7808.2003 14560023
-
Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. Powell DJ, Hajduch E, Kular G, Hundal HS, Mol Cell Biol 2003 23 7794 7808 10.1128/MCB.23.21.7794-7808.2003 14560023
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7794-7808
-
-
Powell, D.J.1
Hajduch, E.2
Kular, G.3
Hundal, H.S.4
-
153
-
-
40449097575
-
Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide
-
10.1042/BJ20070936 17983354
-
Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide. Hajduch E, Turban S, Le Liepvre X, Le Lay S, Lipina C, Dimopoulos N, Dugail I, Hundal HS, Biochem J 2008 410 369 379 10.1042/BJ20070936 17983354
-
(2008)
Biochem J
, vol.410
, pp. 369-379
-
-
Hajduch, E.1
Turban, S.2
Le Liepvre, X.3
Le Lay, S.4
Lipina, C.5
Dimopoulos, N.6
Dugail, I.7
Hundal, H.S.8
-
154
-
-
84862798795
-
Lipid raft: A floating island of death or survival
-
10.1016/j.taap.2012.01.007 22289360
-
Lipid raft: a floating island of death or survival. George KS, Wu S, Toxicol Appl Pharmacol 2012 259 311 319 10.1016/j.taap.2012.01.007 22289360
-
(2012)
Toxicol Appl Pharmacol
, vol.259
, pp. 311-319
-
-
George, K.S.1
Wu, S.2
-
155
-
-
58149204290
-
Ceramide-enriched membrane domains-structure and function
-
10.1016/j.bbamem.2008.07.030 18786504
-
Ceramide-enriched membrane domains-structure and function. Zhang Y, Li X, Becker KA, Gulbins E, Biochim Biophys Acta 2009 1788 178 183 10.1016/j.bbamem.2008.07.030 18786504
-
(2009)
Biochim Biophys Acta
, vol.1788
, pp. 178-183
-
-
Zhang, Y.1
Li, X.2
Becker, K.A.3
Gulbins, E.4
-
156
-
-
34250742501
-
Biological aspects of ceramide-enriched membrane domains
-
10.1016/j.plipres.2007.03.002 17490747
-
Biological aspects of ceramide-enriched membrane domains. Grassme H, Riethmuller J, Gulbins E, Prog Lipid Res 2007 46 161 170 10.1016/j.plipres.2007. 03.002 17490747
-
(2007)
Prog Lipid Res
, vol.46
, pp. 161-170
-
-
Grassme, H.1
Riethmuller, J.2
Gulbins, E.3
-
157
-
-
0035968191
-
Ceramide enables fas to cap and kill
-
10.1074/jbc.M101866200 11287428
-
Ceramide enables fas to cap and kill. Cremesti A, Paris F, Grassme H, Holler N, Tschopp J, Fuks Z, Gulbins E, Kolesnick R, J Biol Chem 2001 276 23954 23961 10.1074/jbc.M101866200 11287428
-
(2001)
J Biol Chem
, vol.276
, pp. 23954-23961
-
-
Cremesti, A.1
Paris, F.2
Grassme, H.3
Holler, N.4
Tschopp, J.5
Fuks, Z.6
Gulbins, E.7
Kolesnick, R.8
-
158
-
-
0036195136
-
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes
-
10.1093/embo-reports/kvf022 11818332
-
An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. Hueber AO, Bernard AM, Herincs Z, Couzinet A, He HT, EMBO Rep 2002 3 190 196 10.1093/embo-reports/ kvf022 11818332
-
(2002)
EMBO Rep
, vol.3
, pp. 190-196
-
-
Hueber, A.O.1
Bernard, A.M.2
Herincs, Z.3
Couzinet, A.4
He, H.T.5
-
159
-
-
84859786953
-
Caveolins and caveolae, roles in insulin signalling and diabetes
-
10.1007/978-1-4614-1222-9-8 22411317
-
Caveolins and caveolae, roles in insulin signalling and diabetes. Stralfors P, Adv Exp Med Biol 2012 729 111 126 10.1007/978-1-4614-1222-9-8 22411317
-
(2012)
Adv Exp Med Biol
, vol.729
, pp. 111-126
-
-
Stralfors, P.1
-
160
-
-
24744459879
-
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines
-
10.1002/jnr.20550 15968641
-
Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines. Goswami R, Singh D, Phillips G, Kilkus J, Dawson G, J Neurosci Res 2005 81 541 550 10.1002/jnr.20550 15968641
-
(2005)
J Neurosci Res
, vol.81
, pp. 541-550
-
-
Goswami, R.1
Singh, D.2
Phillips, G.3
Kilkus, J.4
Dawson, G.5
-
161
-
-
79959746261
-
Sphingolipids: Agents provocateurs in the pathogenesis of insulin resistance
-
10.1007/s00125-011-2127-3 21468641
-
Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance. Lipina C, Hundal HS, Diabetologia 2011 54 1596 1607 10.1007/s00125-011-2127-3 21468641
-
(2011)
Diabetologia
, vol.54
, pp. 1596-1607
-
-
Lipina, C.1
Hundal, H.S.2
-
162
-
-
0035145780
-
Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids
-
10.2337/diabetes.50.2.315 11272142
-
Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids. Briaud I, Harmon JS, Kelpe CL, Segu VB, Poitout V, Diabetes 2001 50 315 321 10.2337/diabetes.50.2.315 11272142
-
(2001)
Diabetes
, vol.50
, pp. 315-321
-
-
Briaud, I.1
Harmon, J.S.2
Kelpe, C.L.3
Segu, V.B.4
Poitout, V.5
-
163
-
-
0042531617
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis
-
10.1074/jbc.M302548200 12771145
-
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis. Kelpe CL, Moore PC, Parazzoli SD, Wicksteed B, Rhodes CJ, Poitout V, J Biol Chem 2003 278 30015 30021 10.1074/jbc.M302548200 12771145
-
(2003)
J Biol Chem
, vol.278
, pp. 30015-30021
-
-
Kelpe, C.L.1
Moore, P.C.2
Parazzoli, S.D.3
Wicksteed, B.4
Rhodes, C.J.5
Poitout, V.6
-
164
-
-
77951295434
-
Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic beta-cells
-
10.1007/s11010-009-0362-4 20063116
-
Blockage of ceramide metabolism exacerbates palmitate inhibition of pro-insulin gene expression in pancreatic beta-cells. Guo J, Qian Y, Xi X, Hu X, Zhu J, Han X, Mol Cell Biochem 2010 338 283 290 10.1007/s11010-009-0362-4 20063116
-
(2010)
Mol Cell Biochem
, vol.338
, pp. 283-290
-
-
Guo, J.1
Qian, Y.2
Xi, X.3
Hu, X.4
Zhu, J.5
Han, X.6
-
165
-
-
0028174029
-
C-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control
-
8264634
-
c-jun inhibits transcriptional activation by the insulin enhancer, and the insulin control element is the target of control. Henderson E, Stein R, Mol Cell Biol 1994 14 655 662 8264634
-
(1994)
Mol Cell Biol
, vol.14
, pp. 655-662
-
-
Henderson, E.1
Stein, R.2
-
166
-
-
0037119417
-
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression
-
10.1074/jbc.M202066200 12011047
-
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. Kaneto H, Xu G, Fujii N, Kim S, Bonner-Weir S, Weir GC, J Biol Chem 2002 277 30010 30018 10.1074/jbc.M202066200 12011047
-
(2002)
J Biol Chem
, vol.277
, pp. 30010-30018
-
-
Kaneto, H.1
Xu, G.2
Fujii, N.3
Kim, S.4
Bonner-Weir, S.5
Weir, G.C.6
-
167
-
-
0034634596
-
Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex
-
10.1074/jbc.M007346200 10962008
-
Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex. Bourbon NA, Yun J, Kester M, J Biol Chem 2000 275 35617 35623 10.1074/jbc.M007346200 10962008
-
(2000)
J Biol Chem
, vol.275
, pp. 35617-35623
-
-
Bourbon, N.A.1
Yun, J.2
Kester, M.3
-
168
-
-
0032926648
-
Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulingene: DNA binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) areenhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway
-
10.1507/endocrj.46.43 10426567
-
Possible involvement of atypical protein kinase C (PKC) in glucose-sensitive expression of the human insulingene: DNA binding activity and transcriptional activity of pancreatic and duodenal homeobox gene-1 (PDX-1) areenhanced via calphostin C-sensitive but phorbol 12-myristate 13-acetate (PMA) and Go 6976-insensitive pathway. Furukawa N, Shirotani T, Araki E, Kaneko K, Todaka M, Matsumoto K, Tsuruzoe K, Motoshima H, Yoshizato K, Kishikawa H, Shichiri M, Endocr J 1999 46 43 58 10.1507/endocrj.46.43 10426567
-
(1999)
Endocr J
, vol.46
, pp. 43-58
-
-
Furukawa, N.1
Shirotani, T.2
Araki, E.3
Kaneko, K.4
Todaka, M.5
Matsumoto, K.6
Tsuruzoe, K.7
Motoshima, H.8
Yoshizato, K.9
Kishikawa, H.10
Shichiri, M.11
-
169
-
-
0029853098
-
Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
-
8870666
-
Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes. Long SD, Pekala PH, Biochem J 1996 319 179 184 8870666
-
(1996)
Biochem J
, vol.319
, pp. 179-184
-
-
Long, S.D.1
Pekala, P.H.2
-
170
-
-
34347352169
-
Diabetic cardiomyopathy revisited
-
10.1161/CIRCULATIONAHA.106.679597 17592090
-
Diabetic cardiomyopathy revisited. Boudina S, Abel ED, Circulation 2007 115 3213 3223 10.1161/CIRCULATIONAHA.106.679597 17592090
-
(2007)
Circulation
, vol.115
, pp. 3213-3223
-
-
Boudina, S.1
Abel, E.D.2
-
171
-
-
54249093047
-
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
-
10.1194/jlr.M800147-JLR200 18515784
-
Ceramide is a cardiotoxin in lipotoxic cardiomyopathy. Park TS, Hu Y, Noh HL, Drosatos K, Okajima K, Buchanan J, Tuinei J, Homma S, Jiang XC, Abel ED, Goldberg IJ, J Lipid Res 2008 49 2101 2112 10.1194/jlr.M800147-JLR200 18515784
-
(2008)
J Lipid Res
, vol.49
, pp. 2101-2112
-
-
Park, T.S.1
Hu, Y.2
Noh, H.L.3
Drosatos, K.4
Okajima, K.5
Buchanan, J.6
Tuinei, J.7
Homma, S.8
Jiang, X.C.9
Abel, E.D.10
Goldberg, I.J.11
-
172
-
-
72249100585
-
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function
-
10.1152/ajpheart.00452.2009 19801494
-
Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function. Basu R, Oudit GY, Wang X, Zhang L, Ussher JR, Lopaschuk GD, Kassiri Z, Am J Physiol Heart Circ Physiol 2009 297 2096 H2108 10.1152/ajpheart.00452.2009 19801494
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Basu, R.1
Oudit, G.Y.2
Wang, X.3
Zhang, L.4
Ussher, J.R.5
Lopaschuk, G.D.6
Kassiri, Z.7
-
173
-
-
0141563667
-
Secretory Zn2 + -dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated
-
12953170
-
Secretory Zn2 + -dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated. Gorska M, Baranczuk E, Dobrzyn A, Horm Metab Res 2003 35 506 507 12953170
-
(2003)
Horm Metab Res
, vol.35
, pp. 506-507
-
-
Gorska, M.1
Baranczuk, E.2
Dobrzyn, A.3
-
174
-
-
0029762320
-
Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins
-
10.1172/JCI118934 8823312
-
Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. Schissel SL, Tweedie-Hardman J, Rapp JH, Graham G, Williams KJ, Tabas I, J Clin Invest 1996 98 1455 1464 10.1172/JCI118934 8823312
-
(1996)
J Clin Invest
, vol.98
, pp. 1455-1464
-
-
Schissel, S.L.1
Tweedie-Hardman, J.2
Rapp, J.H.3
Graham, G.4
Williams, K.J.5
Tabas, I.6
-
175
-
-
53449098208
-
Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression
-
10.1161/ATVBAHA.108.173344 18669882
-
Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Devlin CM, Leventhal AR, Kuriakose G, Schuchman EH, Williams KJ, Tabas I, Arterioscler Thromb Vasc Biol 2008 28 1723 1730 10.1161/ATVBAHA.108.173344 18669882
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1723-1730
-
-
Devlin, C.M.1
Leventhal, A.R.2
Kuriakose, G.3
Schuchman, E.H.4
Williams, K.J.5
Tabas, I.6
-
176
-
-
20844435949
-
Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice
-
10.1161/01.CIR.0000148370.60535.22 15545514
-
Inhibition of sphingomyelin synthesis reduces atherogenesis in apolipoprotein E-knockout mice. Park TS, Panek RL, Mueller SB, Hanselman JC, Rosebury WS, Robertson AW, Kindt EK, Homan R, Karathanasis SK, Rekhter MD, Circulation 2004 110 3465 3471 10.1161/01.CIR.0000148370.60535.22 15545514
-
(2004)
Circulation
, vol.110
, pp. 3465-3471
-
-
Park, T.S.1
Panek, R.L.2
Mueller, S.B.3
Hanselman, J.C.4
Rosebury, W.S.5
Robertson, A.W.6
Kindt, E.K.7
Homan, R.8
Karathanasis, S.K.9
Rekhter, M.D.10
-
177
-
-
79955581245
-
Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effectsof rapamycin
-
10.1093/ndt/gfq633 20961887
-
Evaluation of sphingolipid metabolism in renal cortex of rats with streptozotocin-induced diabetes and the effectsof rapamycin. Liu G, Han F, Yang Y, Xie Y, Jiang H, Mao Y, Wang H, Wang M, Chen R, Yang J, Chen J, Nephrol Dial Transplant 2011 26 1493 1502 10.1093/ndt/gfq633 20961887
-
(2011)
Nephrol Dial Transplant
, vol.26
, pp. 1493-1502
-
-
Liu, G.1
Han, F.2
Yang, Y.3
Xie, Y.4
Jiang, H.5
Mao, Y.6
Wang, H.7
Wang, M.8
Chen, R.9
Yang, J.10
Chen, J.11
-
178
-
-
33644641640
-
Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury
-
10.1038/sj.ki.5000057 16408118
-
Involvement of de novo ceramide synthesis in radiocontrast-induced renal tubular cell injury. Itoh Y, Yano T, Sendo T, Sueyasu M, Hirano K, Kanaide H, Oishi R, Kidney Int 2006 69 288 297 10.1038/sj.ki.5000057 16408118
-
(2006)
Kidney Int
, vol.69
, pp. 288-297
-
-
Itoh, Y.1
Yano, T.2
Sendo, T.3
Sueyasu, M.4
Hirano, K.5
Kanaide, H.6
Oishi, R.7
-
179
-
-
12144252951
-
Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation
-
15479855
-
Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation. Basnakian AG, Ueda N, Hong X, Galitovsky VE, Yin X, Shah SV, Am J Physiol Renal Physiol 2005 288 308 F314 15479855
-
(2005)
Am J Physiol Renal Physiol
, vol.288
-
-
Basnakian, A.G.1
Ueda, N.2
Hong, X.3
Galitovsky, V.E.4
Yin, X.5
Shah, S.V.6
-
180
-
-
79851508128
-
Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways
-
21145948
-
Palmitate induces apoptosis in Schwann cells via both ceramide-dependent and independent pathways. Suzuki J, Akahane K, Nakamura J, Naruse K, Kamiya H, Himeno T, Nakamura N, Shibata T, Kondo M, Nagasaki H, Fujiya A, Oiso Y, Hamada Y, Neuroscience 2011 176 188 198 21145948
-
(2011)
Neuroscience
, vol.176
, pp. 188-198
-
-
Suzuki, J.1
Akahane, K.2
Nakamura, J.3
Naruse, K.4
Kamiya, H.5
Himeno, T.6
Nakamura, N.7
Shibata, T.8
Kondo, M.9
Nagasaki, H.10
Fujiya, A.11
Oiso, Y.12
Hamada, Y.13
-
181
-
-
0041743753
-
Diabetic retinopathy
-
10.2337/diacare.26.1.226 12502685
-
Diabetic retinopathy. Fong DS, Aiello L, Gardner TW, King GL, Blankenship G, Cavallerano JD, Ferris FL, Klein R, Diabetes Care 2003 26 226 229 10.2337/diacare.26.1.226 12502685
-
(2003)
Diabetes Care
, vol.26
, pp. 226-229
-
-
Fong, D.S.1
Aiello, L.2
Gardner, T.W.3
King, G.L.4
Blankenship, G.5
Cavallerano, J.D.6
Ferris, F.L.7
Klein, R.8
-
182
-
-
20044386906
-
Palmitate-induced apoptosis in cultured bovine retinal pericytes: Roles of NAD(P)H oxidase, oxidant stress, and ceramide
-
10.2337/diabetes.54.6.1838 15919807
-
Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y, Diabetes 2005 54 1838 1845 10.2337/diabetes.54.6. 1838 15919807
-
(2005)
Diabetes
, vol.54
, pp. 1838-1845
-
-
Cacicedo, J.M.1
Benjachareowong, S.2
Chou, E.3
Ruderman, N.B.4
Ido, Y.5
-
183
-
-
0037098871
-
Advanced glycation endproducts induce apoptosis of bovine retinal pericytes in culture: Involvement ofdiacylglycerol/ceramide production and oxidative stress induction
-
10.1016/S0891-5849(02)00879-1 12106819
-
Advanced glycation endproducts induce apoptosis of bovine retinal pericytes in culture: involvement ofdiacylglycerol/ceramide production and oxidative stress induction. Denis U, Lecomte M, Paget C, Ruggiero D, Wiernsperger N, Lagarde M, Free Radic Biol Med 2002 33 236 247 10.1016/S0891-5849(02)00879-1 12106819
-
(2002)
Free Radic Biol Med
, vol.33
, pp. 236-247
-
-
Denis, U.1
Lecomte, M.2
Paget, C.3
Ruggiero, D.4
Wiernsperger, N.5
Lagarde, M.6
-
184
-
-
12144266206
-
A series a series gangliosides mediate the effects of advanced glycation end products on pericyte and mesangial cell proliferation: A common mediator for retinal and renal microangiopathy?
-
10.2337/diabetes.54.1.220 15616032
-
A series a series gangliosides mediate the effects of advanced glycation end products on pericyte and mesangial cell proliferation: a common mediator for retinal and renal microangiopathy? Masson E, Troncy L, Ruggiero D, Wiernsperger N, Lagarde M, El Bawab S, Diabetes 2005 54 220 227 10.2337/diabetes.54.1.220 15616032
-
(2005)
Diabetes
, vol.54
, pp. 220-227
-
-
Masson, E.1
Troncy, L.2
Ruggiero, D.3
Wiernsperger, N.4
Lagarde, M.5
El Bawab, S.6
-
185
-
-
33845547166
-
Diabetes alters sphingolipid metabolism in the retina: A potential mechanism of cell death in diabetic retinopathy
-
10.2337/db06-0539 17130506
-
Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy. Fox TE, Han X, Kelly S, Merrill AH 2nd, Martin RE, Anderson RE, Gardner TW, Kester M, Diabetes 2006 55 3573 3580 10.2337/db06-0539 17130506
-
(2006)
Diabetes
, vol.55
, pp. 3573-3580
-
-
Fox, T.E.1
Han, X.2
Kelly, S.3
Merrill, A.H.4
Martin, R.E.5
Anderson, R.E.6
Gardner, T.W.7
Kester, M.8
|