Modulating serine palmitoyl transferase (SPT)expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

Biochemical Journal

Volumn 417, Issue 3, 2009, Pages 791-801

  Watson, Maria L ^a   Coghlan, Matthew ^b   Hundal, Harinder S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Ceramide; Diacylglycerol; Insulin receptor substrate 1 (IRS1); Myriocin; Palmitate; Protein kinase B (PKB); Protein kinase C (PKC)

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; INSULIN RECEPTOR SUBSTRATE 1 (IRS1); MYRIOCIN; PALMITATE; PROTEIN KINASE B (PKB); PROTEIN KINASE C (PKC);

AMIDES; AMINO ACIDS; CELL MEMBRANES; CESIUM; ENZYMES; FATTY ACIDS; GLUCOSE; GLYCEROL; MUSCLE; NUCLEIC ACIDS; RNA; SUBSTRATES;

INSULIN;

CERAMIDE; DIACYLGLYCEROL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PALMITIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C THETA; PROTEIN P85; SERINE; SERINE PALMITOYLTRANSFERASE; SHORT HAIRPIN RNA; THERMOZYMOCIDIN; INSULIN RECEPTOR SUBSTRATE; PALMITIC ACID DERIVATIVE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL DEATH; CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; ENZYME SUBUNIT; GENE SILENCING; GENETIC TRANSFECTION; GLUCOSE TRANSPORT; HORMONAL REGULATION; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN SENSITIVITY; LIPOGENESIS; MUSCLE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; BIOPHYSICS; BIOSYNTHESIS; CELL MEMBRANE; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

RATTUS;

ANIMALS; BIOPHYSICAL PROCESSES; CELL MEMBRANE; DIGLYCERIDES; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MUSCLE, SKELETAL; PALMITATES; PHOSPHORYLATION; RATS; SERINE C-PALMITOYLTRANSFERASE; SIGNAL TRANSDUCTION;

EID: 59849098608     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20081149     Document Type: Article

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