A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

Journal of Biological Chemistry

Volumn 278, Issue 12, 2003, Pages 10297-10303

  Chavez, Jose Antonio ^a   Knotts, Trina A ^a   Wang, Li Ping ^a   Li, Guibin ^b   Dobrowsky, Rick T ^b   Florant, Gregory L ^a   Summers, Scott A ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITION; FATTY ACIDS; INSULIN; LIPIDS; METABOLITES;

FREE FATTY ACIDS (FFA);

BIOCHEMISTRY;

ACYL COENZYME A; CERAMIDE; DIACYLGLYCEROL; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PEPTIDE HORMONE; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SATURATED FATTY ACID; FATTY ACID; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; ONCOPROTEIN;

ANIMAL CELL; ARTICLE; DRUG ANTAGONISM; GLUCOSE TRANSPORT; INSULIN RESISTANCE; LIPID METABOLISM; MEDIATOR RELEASE; METABOLIC ACTIVATION; METABOLIC SYNDROME X; MITOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMALIA;

ANIMALS; CELLS, CULTURED; CERAMIDES; DIGLYCERIDES; FATTY ACIDS; FATTY ACIDS, NONESTERIFIED; GLYCOGEN SYNTHASE KINASE 3; INSULIN; MICE; MUSCLE, SKELETAL; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 0038532298     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212307200     Document Type: Article

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