메뉴 건너뛰기




Volumn 297, Issue 1, 2009, Pages

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

Author keywords

Insulin resistance; Leptin resistance; Monocyte chemoattactant protein 1; Plasminogen activator inhibitor 1; Sphingolipids; Suppressor of cytokine signaling 3; Tumor necrosis factor

Indexed keywords

CERAMIDE; INSULIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; MYRISTIC ACID; PLASMINOGEN ACTIVATOR INHIBITOR 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA; UNCOUPLING PROTEIN 3;

EID: 67650096801     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.91014.2008     Document Type: Article
Times cited : (252)

References (59)
  • 1
    • 11844278218 scopus 로고    scopus 로고
    • Adipose tissue and its relation to inflammation: The role of adipokines
    • Axelsson J, Heimburger O, Lindholm B, Stenvinkel P. Adipose tissue and its relation to inflammation: the role of adipokines. J Ren Nutr 15: 131-136, 2005.
    • (2005) J Ren Nutr , vol.15 , pp. 131-136
    • Axelsson, J.1    Heimburger, O.2    Lindholm, B.3    Stenvinkel, P.4
  • 2
    • 33746271951 scopus 로고    scopus 로고
    • Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry
    • Bielawski J, Szulc ZM, Hannun YA, Bielawska A. Simultaneous quantitative analysis of bioactive sphingolipids by high-performance liquid chromatography-tandem mass spectrometry. Methods 39: 82-91, 2006.
    • (2006) Methods , vol.39 , pp. 82-91
    • Bielawski, J.1    Szulc, Z.M.2    Hannun, Y.A.3    Bielawska, A.4
  • 3
    • 41549123672 scopus 로고    scopus 로고
    • Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity
    • Cernkovich ER, Deng J, Bond MC, Combs TP, Harp JB. Adipose-specific disruption of signal transducer and activator of transcription 3 increases body weight and adiposity. Endocrinology 149: 1581-1590, 2008.
    • (2008) Endocrinology , vol.149 , pp. 1581-1590
    • Cernkovich, E.R.1    Deng, J.2    Bond, M.C.3    Combs, T.P.4    Harp, J.B.5
  • 4
    • 29244462334 scopus 로고    scopus 로고
    • Insulin signaling and the regulation of glucose transport
    • Chang L, Chiang SH, Saltiel AR. Insulin signaling and the regulation of glucose transport. Mol Med 10: 65-71, 2004.
    • (2004) Mol Med , vol.10 , pp. 65-71
    • Chang, L.1    Chiang, S.H.2    Saltiel, A.R.3
  • 5
    • 15044365690 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1: A common denominator in obesity, diabetes and cardiovascular disease
    • De TB, Smith LH, Vaughan DE. Plasminogen activator inhibitor-1: a common denominator in obesity, diabetes and cardiovascular disease. Curr Opin Pharmacol 5: 149-154, 2005.
    • (2005) Curr Opin Pharmacol , vol.5 , pp. 149-154
    • TB, D.1    Smith, L.H.2    Vaughan, D.E.3
  • 6
    • 16844377832 scopus 로고    scopus 로고
    • Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease
    • Dellas C, Loskutoff DJ. Historical analysis of PAI-1 from its discovery to its potential role in cell motility and disease. Thromb Haemost 93: 631-640, 2005.
    • (2005) Thromb Haemost , vol.93 , pp. 631-640
    • Dellas, C.1    Loskutoff, D.J.2
  • 7
    • 0035930605 scopus 로고    scopus 로고
    • Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van OE. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 276: 47944-47949, 2001.
    • Emanuelli B, Peraldi P, Filloux C, Chavey C, Freidinger K, Hilton DJ, Hotamisligil GS, Van OE. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J Biol Chem 276: 47944-47949, 2001.
  • 8
    • 38449106913 scopus 로고    scopus 로고
    • Lipid raft proteomics: More than just detergent-resistant membranes
    • Foster LJ, Chan QW. Lipid raft proteomics: more than just detergent-resistant membranes. Subcell Biochem 43: 35-47, 2007.
    • (2007) Subcell Biochem , vol.43 , pp. 35-47
    • Foster, L.J.1    Chan, Q.W.2
  • 9
    • 0037122801 scopus 로고    scopus 로고
    • Fat in all the wrong places
    • Friedman J. Fat in all the wrong places. Nature 415: 268-269, 2002.
    • (2002) Nature , vol.415 , pp. 268-269
    • Friedman, J.1
  • 10
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 395: 763-770, 1998.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 11
    • 0026518215 scopus 로고
    • Tackling a weighty problem
    • Friedman JM, Leibel RL. Tackling a weighty problem. Cell 69: 217-220, 1992.
    • (1992) Cell , vol.69 , pp. 217-220
    • Friedman, J.M.1    Leibel, R.L.2
  • 13
    • 0032134003 scopus 로고    scopus 로고
    • Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    • Gu L, Okada Y, Clinton SK, Gerard C, Sukhova GK, Libby P, Rollins BJ. Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell 2: 275-281, 1998.
    • (1998) Mol Cell , vol.2 , pp. 275-281
    • Gu, L.1    Okada, Y.2    Clinton, S.K.3    Gerard, C.4    Sukhova, G.K.5    Libby, P.6    Rollins, B.J.7
  • 14
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun YA, Obeid LM. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J Biol Chem 277: 25847-25850, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 25847-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 16
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 17
    • 33750153292 scopus 로고    scopus 로고
    • Attenuation of leptin and insulin signaling by SOCS proteins
    • Howard JK, Flier JS. Attenuation of leptin and insulin signaling by SOCS proteins. Trends Endocrinol Metab 17: 365-371, 2006.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 365-371
    • Howard, J.K.1    Flier, J.S.2
  • 18
    • 27744556268 scopus 로고    scopus 로고
    • Lipid microdomains and insulin resistance: Is there a connection?
    • Ikonen E, Vainio S. Lipid microdomains and insulin resistance: is there a connection? Sci STKE 2005: e3, 2005.
    • (2005) Sci STKE , vol.2005
    • Ikonen, E.1    Vainio, S.2
  • 19
    • 0141832847 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk
    • Juhan-Vague I, Alessi MC, Mavri A, Morange PE. Plasminogen activator inhibitor-1, inflammation, obesity, insulin resistance and vascular risk. J Thromb Haemost 1: 1575-1579, 2003.
    • (2003) J Thromb Haemost , vol.1 , pp. 1575-1579
    • Juhan-Vague, I.1    Alessi, M.C.2    Mavri, A.3    Morange, P.E.4
  • 21
    • 33847364944 scopus 로고    scopus 로고
    • Effects of pioglitazone on suppressor of cytokine signaling 3 expression: Potential mechanisms for its effects on insulin sensitivity and adiponectin expression
    • Kanatani Y, Usui I, Ishizuka K, Bukhari A, Fujisaka S, Urakaze M, Haruta T, Kishimoto T, Naka T, Kobayashi M. Effects of pioglitazone on suppressor of cytokine signaling 3 expression: potential mechanisms for its effects on insulin sensitivity and adiponectin expression. Diabetes 56: 795-803, 2007.
    • (2007) Diabetes , vol.56 , pp. 795-803
    • Kanatani, Y.1    Usui, I.2    Ishizuka, K.3    Bukhari, A.4    Fujisaka, S.5    Urakaze, M.6    Haruta, T.7    Kishimoto, T.8    Naka, T.9    Kobayashi, M.10
  • 24
    • 0033834808 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in energy expenditure
    • Kozak LP, Harper ME. Mitochondrial uncoupling proteins in energy expenditure. Annu Rev Nutr 20: 339-363, 2000.
    • (2000) Annu Rev Nutr , vol.20 , pp. 339-363
    • Kozak, L.P.1    Harper, M.E.2
  • 25
    • 0034975220 scopus 로고    scopus 로고
    • The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity
    • Kraegen EW, Cooney GJ, Ye JM, Thompson AL, Furler SM. The role of lipids in the pathogenesis of muscle insulin resistance and beta cell failure in type II diabetes and obesity. Exp Clin Endocrinol Diabetes 109, Suppl 2: S189-S201, 2001.
    • (2001) Exp Clin Endocrinol Diabetes , vol.109 , Issue.SUPPL. 2
    • Kraegen, E.W.1    Cooney, G.J.2    Ye, J.M.3    Thompson, A.L.4    Furler, S.M.5
  • 27
    • 37249093922 scopus 로고    scopus 로고
    • SOCS proteins causing trouble in insulin action
    • Lebrun P, Van OE. SOCS proteins causing trouble in insulin action. Acta Physiol (Oxf) 192: 29-36, 2008.
    • (2008) Acta Physiol (Oxf) , vol.192 , pp. 29-36
    • Lebrun, P.1    Van, O.E.2
  • 28
    • 12444334643 scopus 로고    scopus 로고
    • Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation
    • Lelliott C, Vidal-Puig AJ. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 28, Suppl 4: S22-S28, 2004.
    • (2004) Int J Obes Relat Metab Disord , vol.28 , Issue.SUPPL. 4
    • Lelliott, C.1    Vidal-Puig, A.J.2
  • 29
    • 0031963703 scopus 로고    scopus 로고
    • The adipocyte and hemostatic balance in obesity: Studies of PAI-1
    • Loskutoff DJ, Samad F. The adipocyte and hemostatic balance in obesity: Studies of PAI-1. Arterioscler Thromb Vasc Biol 18: 1-6, 1998.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1-6
    • Loskutoff, D.J.1    Samad, F.2
  • 30
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 31
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during dietinduced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during dietinduced obesity. Diabetes 56: 16-23, 2007.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 32
    • 0036092239 scopus 로고    scopus 로고
    • Banting lecture 2001. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD. Banting lecture 2001. Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51: 7-18, 2002.
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 34
    • 0026075699 scopus 로고
    • Monocyte chemoattractant protein-1 in human atheromatous plaques
    • Nelken NA, Coughlin SR, Gordon D, Wilcox JN. Monocyte chemoattractant protein-1 in human atheromatous plaques. J Clin Invest 88: 1121-1127, 1991.
    • (1991) J Clin Invest , vol.88 , pp. 1121-1127
    • Nelken, N.A.1    Coughlin, S.R.2    Gordon, D.3    Wilcox, J.N.4
  • 35
    • 0021322138 scopus 로고
    • Thermogenic mechanisms in brown fat
    • Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiol Rev 64: 1-64, 1984.
    • (1984) Physiol Rev , vol.64 , pp. 1-64
    • Nicholls, D.G.1    Locke, R.M.2
  • 36
    • 0035660246 scopus 로고    scopus 로고
    • Sphingolipids in mammalian cell signalling
    • Ohanian J, Ohanian V. Sphingolipids in mammalian cell signalling. Cell Mol Life Sci 58: 2053-2068, 2001.
    • (2001) Cell Mol Life Sci , vol.58 , pp. 2053-2068
    • Ohanian, J.1    Ohanian, V.2
  • 38
    • 0345505667 scopus 로고    scopus 로고
    • Divergent roles for p55 and p75 TNF-α receptors in the induction of plasminogen activator inhibitor-1
    • Pandey M, Tuncman G, Hotamisligil GS, Samad F. Divergent roles for p55 and p75 TNF-α receptors in the induction of plasminogen activator inhibitor-1. Am J Pathol 162: 933-941, 2003.
    • (2003) Am J Pathol , vol.162 , pp. 933-941
    • Pandey, M.1    Tuncman, G.2    Hotamisligil, G.S.3    Samad, F.4
  • 39
    • 33748746334 scopus 로고    scopus 로고
    • When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis
    • Pewzner-Jung Y, Ben-Dor S, Futerman AH. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: insights into the regulation of ceramide synthesis. J Biol Chem 281: 25001-25005, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 25001-25005
    • Pewzner-Jung, Y.1    Ben-Dor, S.2    Futerman, A.H.3
  • 40
    • 0037401894 scopus 로고    scopus 로고
    • Intracellular signal transduction pathways activated by ceramide and its metabolites
    • Ruvolo PP. Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol Res 47: 383-392, 2003.
    • (2003) Pharmacol Res , vol.47 , pp. 383-392
    • Ruvolo, P.P.1
  • 41
    • 37549038241 scopus 로고    scopus 로고
    • Contribution of sphingolipids to the pathogenesis of obesity
    • Samad F. Contribution of sphingolipids to the pathogenesis of obesity. Future Lipidol 2: 625-639, 2008.
    • (2008) Future Lipidol , vol.2 , pp. 625-639
    • Samad, F.1
  • 42
    • 33750590489 scopus 로고    scopus 로고
    • Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk
    • Samad F, Hester KD, Yang G, Hannun YA, Bielawski J. Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 55: 2579-2587, 2006.
    • (2006) Diabetes , vol.55 , pp. 2579-2587
    • Samad, F.1    Hester, K.D.2    Yang, G.3    Hannun, Y.A.4    Bielawski, J.5
  • 43
    • 0030050952 scopus 로고    scopus 로고
    • Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: Induction by tumor necrosis factor-α and lipopolysaccharide
    • Samad F, Yamamoto K, Loskutoff DJ. Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo: Induction by tumor necrosis factor-α and lipopolysaccharide. J Clin Invest 97: 37-46, 1996.
    • (1996) J Clin Invest , vol.97 , pp. 37-46
    • Samad, F.1    Yamamoto, K.2    Loskutoff, D.J.3
  • 44
    • 37549038241 scopus 로고    scopus 로고
    • Contribution of sphingolipids to the pathogenesis of obesity
    • Samad F. Contribution of sphingolipids to the pathogenesis of obesity. Future Lipidology 2: 625-639, 2007.
    • (2007) Future Lipidology , vol.2 , pp. 625-639
    • Samad, F.1
  • 45
    • 0034598978 scopus 로고    scopus 로고
    • Characterisation of receptor-specific TNFα functions in adipocyte cell lines lacking type 1 and 2 TNF receptors
    • Sethi JK, Xu H, Uysal KT, Wiesbrock SM, Scheja L, Hotamisligil GS. Characterisation of receptor-specific TNFα functions in adipocyte cell lines lacking type 1 and 2 TNF receptors. FEBS Lett 469: 77-82, 2000.
    • (2000) FEBS Lett , vol.469 , pp. 77-82
    • Sethi, J.K.1    Xu, H.2    Uysal, K.T.3    Wiesbrock, S.M.4    Scheja, L.5    Hotamisligil, G.S.6
  • 46
    • 46649108016 scopus 로고    scopus 로고
    • Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1
    • Shah C, Yang G, Lee I, Bielawski J, Hannun YA, Samad F. Protection from high fat diet-induced increase in ceramide in mice lacking plasminogen activator inhibitor 1. J Biol Chem 283: 13538-13548, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 13538-13548
    • Shah, C.1    Yang, G.2    Lee, I.3    Bielawski, J.4    Hannun, Y.A.5    Samad, F.6
  • 47
    • 0028895009 scopus 로고
    • Sphingomyelinase and cell-permeable ceramide analogs increase the release of plasminogen activator inhibitor-1 from cultured endothelial cells
    • Soeda S, Honda O, Shimeno H, Nagamatsu A. Sphingomyelinase and cell-permeable ceramide analogs increase the release of plasminogen activator inhibitor-1 from cultured endothelial cells. Thromb Res 80: 509-518, 1995.
    • (1995) Thromb Res , vol.80 , pp. 509-518
    • Soeda, S.1    Honda, O.2    Shimeno, H.3    Nagamatsu, A.4
  • 49
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers SA. Ceramides in insulin resistance and lipotoxicity. Prog Lipid Res 45: 42-72, 2006.
    • (2006) Prog Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 50
    • 3142723189 scopus 로고    scopus 로고
    • Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
    • Ueki K, Kondo T, Tseng YH, Kahn CR. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci USA 101: 10422-10427, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10422-10427
    • Ueki, K.1    Kondo, T.2    Tseng, Y.H.3    Kahn, C.R.4
  • 51
    • 0345374579 scopus 로고    scopus 로고
    • Minireview. Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger RH. Minireview. Weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144: 5159-5165, 2003.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 52
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-α function
    • Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 389: 610-614, 1997.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 53
    • 29144510014 scopus 로고    scopus 로고
    • Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity
    • Wang MY, Orci L, Ravazzola M, Unger RH. Fat storage in adipocytes requires inactivation of leptin's paracrine activity: implications for treatment of human obesity. Proc Natl Acad Sci USA 102: 18011-18016, 2005.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18011-18016
    • Wang, M.Y.1    Orci, L.2    Ravazzola, M.3    Unger, R.H.4
  • 54
    • 0035162054 scopus 로고    scopus 로고
    • The role of leptin resistance in the lipid abnormalities of aging
    • Wang ZW, Pan WT, Lee Y, Kakuma T, Zhou YT, Unger RH. The role of leptin resistance in the lipid abnormalities of aging. FASEB J 15: 108-114, 2001.
    • (2001) FASEB J , vol.15 , pp. 108-114
    • Wang, Z.W.1    Pan, W.T.2    Lee, Y.3    Kakuma, T.4    Zhou, Y.T.5    Unger, R.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.