Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells

Biochemical Journal

Volumn 438, Issue 1, 2011, Pages 177-189

  Véret, Julien ^a   Coant, Nicolas ^a   Berdyshev, Evgeny V ^b   Skobeleva, Anastasia ^b   Therville, Nicole ^c   Bailbé, Danielle ^a   Gorshkova, Irina ^b   Natarajan, Viswanathan ^b   Portha, Bernard ^a   Le Stunff, Hervé ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c CANCER RESEARCH CENTER OF TOULOUSE   (France)

Author keywords

Apoptosis; Ceramide; Ceramide synthase; Glucolipotoxicity; Pancreatic cell; Type 2 diabetes

Indexed keywords

CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; CERAMIDE SYNTHASE 4; DEXTRO LEVO THREO 1 PHENYL 2 PALMITOYLAMINO 3 MORPHOLINOPROPAN 1 OL; FUMONISIN B1; GLUCOSE; PALMITIC ACID; SMALL INTERFERING RNA; SPHINGANINE; STEARIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; LIPID ANALYSIS; LIPID STORAGE; LIPOTOXICITY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PANCREAS ISLET BETA CELL; PHOSPHOLIPID SYNTHESIS; PRIORITY JOURNAL; RAT; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL PROLIFERATION; CERAMIDES; ENZYME INHIBITORS; FUMONISINS; GLUCOSE; HUMANS; INSULIN-SECRETING CELLS; OXIDOREDUCTASES; PALMITATES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SWEETENING AGENTS;

EID: 79960814460     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101386     Document Type: Article

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