Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

Journal of Biological Chemistry

Volumn 280, Issue 20, 2005, Pages 20148-20153

  Chavez, Jose Antonio ^a   Holland, William L ^a   Bär, Julia ^b   Sandhoff, Konrad ^b   Summers, Scott A ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BRAIN; CELLS; FATTY ACIDS; INSULIN; LIPIDS; MUSCLE; YEAST;

ACID CERAMIDASE; FREE FATTY ACID (FFA); INSULIN SIGNALING; LIVER;

ENZYMES;

ACID CERAMIDASE; ACYLSPHINGOSINE DEACYLASE; CERAMIDE; FATTY ACID; INSULIN; PROTEIN KINASE B; SATURATED FATTY ACID; SPHINGOLIPID; SPHINGOSINE; UNCLASSIFIED DRUG; AKT1 PROTEIN, HUMAN; COMPLEMENTARY DNA; GALACTOSYLGALACTOSYLGLUCOSYLCERAMIDASE; ONCOPROTEIN; PALMITIC ACID; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE TRANSPORT; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; LIVER; LYSOSOME; MOUSE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; ANIMAL; CELL LINE; DRUG EFFECT; GENE EXPRESSION; GENETICS; METABOLISM; MUSCLE CELL; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ANIMALS; BASE SEQUENCE; CELL LINE; CERAMIDE TRIHEXOSIDASE; DNA, COMPLEMENTARY; FATTY ACIDS, NONESTERIFIED; GENE EXPRESSION; HUMANS; INSULIN; MICE; MUSCLE FIBERS; PALMITIC ACID; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 21244442275     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M412769200     Document Type: Article

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