Ceramide synthase is essential for endonuclease-mediated death of renal tubular epithelial cells induced by hypoxia-reoxygenation

American Journal of Physiology - Renal Physiology

Volumn 288, Issue 2 57-2, 2005, Pages

  Basnakian, Alexei G ^a   Ueda, Norishi ^a   Hong, Xiaoman ^a   Galitovsky, Valentin E ^a   Yin, Xiaoyan ^a   Shah, Sudhir V ^a,b  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

Author keywords

DNA fragmentation; Endonuclease G; Fumonisin B1; Kidney; NRK 52E cells

Indexed keywords

CERAMIDE; DNA FRAGMENT; ENDONUCLEASE; FUMONISIN B1; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE ACYLTRANSFERASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CYTOPLASM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HYPOXIA; KIDNEY EPITHELIUM; KIDNEY INJURY; KIDNEY TUBULE CELL; LIPOGENESIS; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; REOXYGENATION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 12144252951     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00204.2004     Document Type: Article

References (40)

1. Baliga R, Ueda N, Walker PD, and Shah SV. Oxidant mechanisms in toxic acute renal failure. Am J Kidney Dis 29: 465-477, 1997.
2. Basnakian AG and James SJ. Quantification of 3′OH DNA breaks by random oligonucleotide-primed synthesis (ROPS) assay. DNA Cell Biol 15: 255-262, 1996.
3. Basnakian AG, Kaushal GP, and Shah SV. Apoptotic pathways of oxidative damage to renal tubular epithelial cells. Antioxid Redox Signal 4: 915-924, 2002.
4. Basnakian AG, Kaushal GP, Ueda N, and Shah SV. Oxidant mechanisms in toxic acute renal failure. In: Toxicology of the Kidney (3rd ed.), edited by Tarloff JB and Lash LH. Boca Raton, FL: CRC, p. 499-524, 2004.
5. Boniece IR and Wagner JA. Growth factors protect PC12 cells against ischemia by a mechanism that is independent of PKA, PKC, and protein synthesis. J Neurosci 13: 4220-4228, 1993.
6. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, and Kolesnick R. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82: 405-414, 1995.
7. Buttke TM and Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 15: 7-10, 1994.
8. Charles AG, Han TY, Liu YY, Hansen N, Giuliano AE, and Cabot MC. Taxol-induced ceramide generation and apoptosis in human breast cancer cells. Cancer Chemother Pharmacol 47: 444-450, 2001.
9. Cuvillier O, Edsall L, and Spiegel S. Involvement of sphingosine in mitochondria-dependent Fas-induced apoptosis of type II Jurkat T cells. J Biol Chem 275: 15691-15700, 2000.
10. De Maria R, Rippo MR, Schuchman EH, and Testi R. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells. J Exp Med 187: 897-902, 1998.
11. De Souza Durao M Jr, Razvickas CV, Goncalves EA, Okano IR, Camargo SM, Monte JC, and dos Santos OF. The role of growth factors on renal tubular cells submitted to hypoxia and deprived of glucose. Ren Fail 25: 341-353, 2003.
12. Garzotto M, White-Jones M, Jiang Y, Ehleiter D, Liao WC, Haimovitz-Friedman A, Fuks Z, and Kolesnick R. 12-O-tetradecanoylphorbol-13- acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer Res 58: 2260-2264, 1998.
13. Ghafourifar P, Klein SD, Schucht O, Schenk U, Pruschy M, Rocha S, and Richter C. Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state. J Biol Chem 274: 6080-6084, 1999.
14. Goldberg M, Zhang HL, and Steinberg SF. Hypoxia alters the subcellular distribution of protein kinase C isoforms in neonatal rat ventricular myocytes. J Clin Invest 99: 55-61, 1997.
15. Gstraunthaler G, Seppi T, and Pfaller W. Impact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures. Are renal cells in tissue culture hypoxic? Cell Physiol Biochem 9: 150-172, 1999.
16. Hannun YA. Functions of ceramide in coordinating cellular responses to stress. Science 274: 1855-1859, 1996.
17. Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269: 3125-3128, 1994.
18. Kaushal GP, Ueda N, and Shah SV. Role of caspases (ICE/CED 3 proteases) in DNA damage and cell death in response to a mitochondrial inhibitor, antimycin A. Kidney Int 52: 438-445, 1997.
19. Kubota M, Narita K, Nakagomi T, Tamura A, Shimasaki H, Ueta N, and Yoshida S. Sphingomyelin changes in rat cerebral cortex during focal ischemia. Neurol Res 18: 337-341, 1996.
20. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685, 1970.
21. Li LY, Luo X, and Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412: 95-99, 2001.
22. Pena LA, Fuks Z, and Kolesnick R. Stress-induced apoptosis and the sphingomyelin pathway. Biochem Pharmacol 53: 615-621, 1997.
23. Rabkin SW. Fumonisin blunts nitric oxide-induced and nitroprusside- induced cardiomyocyte death. Nitric Oxide 7: 229-235, 2002.
24. Siskind LJ and Colombini M. The lipids C2- and C16-ceramide form large stable channels. Implications for apoptosis. J Biol Chem 275: 38640-38644, 2000.
25. Siskind LJ, Kolesnick RN, and Colombini M. Ceramide channels increase the permeability of the mitochondrial outer membrane to small proteins. J Biol Chem 277: 26796-26803, 2002.
26. Tepper AD, de Vries E, van Blitterswijk WJ, and Borst J. Ordering of ceramide formation, caspase activation, and mitochondrial changes during CD95- and DNA damage-induced apoptosis. J Clin Invest 103: 971-978, 1999.
27. Towbin H, Staehelin T, and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76: 4350-4354, 1979.
28. Uchida Y, Nardo AD, Collins V, Elias PM, and Holleran WM. De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. J Invest Dermatol 120: 662-669, 2003.
29. Ueda N, Camargo SM, Hong X, Basnakian AG, Walker PD, and Shah SV. Role of ceramide synthase in oxidant injury to renal tubular epithelial cells. J Am Soc Nephrol 12: 2384-2391, 2001.
30. 1 cells. Kidney Int 54: 399-406, 1998.
31. Ueda N and Shah SV. Endonuclease-induced DNA damage and cell death in oxidant injury to renal tubular epithelial cells. J Clin Invest 90: 2593-2597, 1992.
32. Ueda N, Walker PD, Hsu SM, and Shah SV. Activation of a 15-kDa endonuclease in hypoxia/reoxygenation injury without morphologic features of apoptosis. Proc Natl Acad Sci USA 92: 7202-7206, 1995.
33. Wang E, Norred WP, Bacon CW, Riley RT, and Merrill AH Jr. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266: 14486-14490, 1991.
34. Wieder T, Orfanos CE, and Geilen CC. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog, hexadecylphosphocholine. J Biol Chem 273: 11025-11031, 1998.
35. Wiegmann K, Schutze S, Machleidt T, Witte D, and Kronke M. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78: 1005-1015, 1994.
36. Wu WI, McDonough VM, Nickels JT Jr, Ko J, Fischl AS, Vales TR, Merrill AH Jr, and Carman GM. Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1. J Biol Chem 270: 13171-13178, 1995.
37. Yoshimura S, Banno Y, Nakashima S, Takenaka K, Sakai H, Nishimura Y, Sakai N, Shimizu S, Eguchi Y, Tsujimoto Y, and Nozawa Y. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation. J Biol Chem 273: 6921-6927, 1998.
38. Zager RA, Conrad DS, and Burkhart K. Ceramide accumulation during oxidant renal tubular injury: mechanisms and potential consequences. J Am Soc Nephrol 9: 1670-1680, 1998.
39. Zager RA, Conrad S, Lochhead K, Sweeney EA, Igarashi Y, and Burkhart KM. Altered sphingomyelinase and ceramide expression in the setting of ischemic and nephrotoxic acute renal failure. Kidney Int 53: 573-582, 1998.
40. Zager RA, Iwata M, Conrad DS, Burkhart KM, and Igarashi Y. Altered ceramide and sphingosine expression during the induction phase of ischemic acute renal failure. Kidney Int 52: 60-70, 1997.