Ceramide formation as a target in beta-cell survival and function

Expert Opinion on Therapeutic Targets

Volumn 15, Issue 9, 2011, Pages 1061-1071

  Lang, Florian ^a   Ullrich, Susanne ^b   Gulbins, Erich ^c  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Amyloid; Apoptosis; Channels; Diabetes; Insulin; Lipotoxicity

Indexed keywords

AMITRIPTYLINE; AMYLOID; CALCIUM ACTIVATED POTASSIUM CHANNEL; CERAMIDASE; CERAMIDE; CYTOCHROME C; FATTY ACID; GAMMA INTERFERON; HYPOXIA INDUCIBLE FACTOR 1BETA; INSULIN; INTERLEUKIN 1BETA; LIPID PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SINGLE MINDED KINASE; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; SPHINGOMYELIN SYNTHASE 1; SPHINGOSINE ACYLTRANSFERASE; SUPEROXIDE; SYNTHETASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

APOPTOSIS; CELL FUNCTION; CELL SURVIVAL; CYTOSOL; DIABETES MELLITUS; DIABETOGENESIS; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; FATTY ACID OXIDATION; HUMAN; INSULIN RELEASE; LIPID METABOLISM; LIPOTOXICITY; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PANCREAS ISLET BETA CELL; REVIEW; SIGNAL TRANSDUCTION;

AMYLOID; ANIMALS; APOPTOSIS; CELL SURVIVAL; CERAMIDES; DIABETES MELLITUS; DRUG DELIVERY SYSTEMS; HUMANS; INSULIN-SECRETING CELLS; ION CHANNELS; SIGNAL TRANSDUCTION; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOSINE N-ACYLTRANSFERASE;

EID: 80051757598     PISSN: 14728222     EISSN: 17447631     Source Type: Journal    
DOI: 10.1517/14728222.2011.588209     Document Type: Review

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