Type 1 diabetic cardiomyopathy in the Akita (Ins2WT/C96Y) mouse model is characterized by lipotoxicity and diastolic dysfunction with preserved systolic function

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 6, 2009, Pages

  Basu, Ratnadeep ^a   Oudit, Gavin Y ^a   Wang, Xiuhua ^a   Zhang, Liyan ^a   Ussher, John R ^a   Lopaschuk, Gary D ^a   Kassiri, Zamaneh ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Fibrosis; Hypertrophy; Insulin; Sarco(endo)plasmic reticulum calcium ATPase 2a

Indexed keywords

BRAIN NATRIURETIC PEPTIDE; CERAMIDE; DIACYLGLYCEROL; ENZYME; FIBRONECTIN; GLUCOSE; INSULIN; LIPID; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; LONG CHAIN FATTY ACID; MYOSIN HEAVY CHAIN BETA; PROCOLLAGEN; PROCOLLAGEN ALPHA TYPE 1; PROCOLLAGEN ALPHA TYPE 3; PYRUVATE DEHYDROGENASE KINASE 4; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE 2A; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC LIPOTOXICITY; CARDIOMYOPATHY; CARDIOTOXICITY; COMPARATIVE STUDY; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; ECHOCARDIOGRAPHY; EX VIVO STUDY; FATTY ACID OXIDATION; FEMALE; FIBROSING ALVEOLITIS; GENETICS; GLUCOSE OXIDATION; HEART; HEART EJECTION FRACTION; HEART FUNCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE; HEART MUSCLE FIBROSIS; HEART WORK; HEMODYNAMICS; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; LIPID STORAGE; MALE; MITOCHONDRION; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RELAXATION TIME; SYSTOLE; SYSTOLIC BLOOD PRESSURE; TISSUE DOPPLER IMAGING; VELOCITY;

ACYL-COA DEHYDROGENASE, LONG-CHAIN; AGE FACTORS; ANIMALS; BLOOD GLUCOSE; CARDIOMYOPATHIES; CERAMIDES; DIABETES MELLITUS, TYPE 1; DIASTOLE; DIGLYCERIDES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ECHOCARDIOGRAPHY, DOPPLER, PULSED; FATTY ACIDS; HYPOGLYCEMIC AGENTS; INSULIN; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MITOCHONDRIA, HEART; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOSIN HEAVY CHAINS; NATRIURETIC PEPTIDE, BRAIN; PROTEIN-SERINE-THREONINE KINASES; SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES; STROKE VOLUME; SYSTOLE; TRIGLYCERIDES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR PRESSURE;

EID: 72249100585     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00452.2009     Document Type: Article

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