Rosiglitazone enhances glucose tolerance by mechanisms other than reduction of fatty acid accumulation within skeletal muscle

Endocrinology

Volumn 145, Issue 12, 2004, Pages 5665-5670

  Lessard, Sarah J ^a   Lo Giudice, Sonia L ^a   Lau, Winnie ^a   Reid, Julianne J ^a   Turner, Nigel ^b   Febbraio, Mark A ^a   Hawley, John A ^a   Watt, Matthew J ^a  

^a RMIT UNIVERSITY   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; DIACYLGLYCEROL; FATTY ACID; PALMITOLEIC ACID; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C DELTA; PROTEIN KINASE C THETA; ROSIGLITAZONE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG EFFECT; FEMALE; GLUCOSE TOLERANCE; LIPID COMPOSITION; MEMBRANE COMPONENT; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE;

ANIMALS; DIGLYCERIDES; FATTY ACIDS; FEMALE; GLUCOSE INTOLERANCE; HYPOGLYCEMIC AGENTS; MUSCLE, SKELETAL; OBESITY; RATS; RATS, ZUCKER; THIAZOLIDINEDIONES; TRIGLYCERIDES;

EID: 9444230624     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0659     Document Type: Article

References (45)

1. DeFronzo RA 1992 Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35:389-397
2. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH 1997 Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988
3. Krssak M, Roden M 2004 The role of lipid accumulation in liver and muscle for insulin resistance and type 2 diabetes mellitus in humans. Rev Endocr Metab Disord 5:127-134
4. Kelley DE, Goodpaster BH, Storlien L 2002 Muscle triglyceride and insulin resistance. Annu Rev Nutr 22:325-346
5. Shulman GI 2000 Cellular mechanisms of insulin resistance. J Clin Invest 106:171-176
6. Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI 2002 Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
7. Itani SI, Ruderman NB, Schmieder F, Boden G 2002 Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C and IKB-α. Diabetes 51:2005-2011
8. Kim JK, Fillmore JJ, Chen Y, Yu C, Moore IK, Pypaert M, Lutz EP, Kako Y, Velez-Carrasco W, Goldberg IJ, Breslow JL, Shulman GI Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci USA 98:7522-7527
9. Montell E, Turini M, Marotta M, Roberts M, Noe V, Ciudad CJ, Mace K, Gomez-Foix AM 2001 DAG accumulation from saturated fatty acids desensitises insulin stimulation of glucose uptake in muscle cells. Am J Physiol 280:E229-E237
10. Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ 1997 Alterations in the expression and cellular localization of protein kinase C isozymes ε and θ are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46:169-178
11. Qu X, Seale JP, Donnelly R 1999 Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats: effects of feeding. J Endocrinol 162:207-214
12. Cortright RN, Azevedo Jr JL, Zhou Q, Sinha M, Pories WJ, Itani SI, Dohm GL 2000 Protein kinase C modulates insulin action in human skeletal muscle. Am J Physiol 278:E553-E562
13. Lin Y, Itani SI, Kurowski TG, Dean DJ, Luo Z, Yaney GC, Ruderman NB 2001 Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Am J Physiol 281:E8-E15
14. Adams II JM, Pratipanawatr T, Berria R, Wang E, DeFronzo R, Sullards MC, Mandarino LJ 2004 Ceramide content is increased in skeletal muscle from obese insulin-resistant humans. Diabetes 53:25-31
15. Straczkowski M, Kowalska I, Nikolajuk A, Dzienis-Straczkowska S, Kinalska I, Baranowski M, Zendzian-Piotrowska M, Brzezinska Z, Gorski J 2004 Relationship between insulin sensitivity and sphingomyelin signaling path-way in human skeletal muscle. Diabetes 53:1215-1221
16. Turinsky J, O'Sullivan DM, Bayly BP 1990 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo. J Biol Chem 265:16880-16885
17. Schmitz-Peiffer C, Craig DL, Biden TJ 1999 Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem 274:24202-24210
18. Chavez JA, Knotts TA, Wang LP, Li G, Dobrowsky RT, Florant GL, Summers SA 2003 A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem 278:10297-10303
19. Muurling M, Mensink RP, Pijl H, Romijn JA, Havekes LM, Voshol PJ 2003 Rosiglitazone improves muscle insulin sensitivity, irrespective of increased triglyceride content, in ob/ob mice. Metabolism 52:1078-1083
20. Jucket BM, Schaeffer TR, Haimbach RE, Mayer ME, Ohlstein DH, Smith SA, Cobitz AR, Sarkar SK 2003 Reduction of intramyocellular lipid following short-term rosiglitazone treatment in Zucker fatty rats: an in vivo nuclear magnetic resonance study. Metabolism 52:218-225
21. Miyazaki Y, He H, Mandarino LJ, DeFronzo RA 2003 Rosiglitazone improves downstream insulin receptor signalling in type 2 diabetic patients. Diabetes 52:1943-1950
22. Buse JB, Tan MH, Prince MJ, Erickson PP 2004 The effects of oral antihyperglycaemic medication on serum lipid profiles in patients with type 2 diabetes. Diabetes Obes Metab 6:133-156
23. Wilmsen HM, Ciaraldi TP, Carter L, Reehman N, Mudaliar SR, Henry RR Thiazolidinediones upregulate impaired fatty acid uptake in skeletal muscle of type 2 diabetic subjects. Am J Physiol 285:E354-E362
24. Koh EH, Kim MS, Park JY, Kim HS, Youn JY, Park HS, Youn JH, Lee KU 2003 Peroxisome proliferator-activated receptor (PPAR)-α activation prevents diabetes in OLETF rats: comparison with PPAR-γ activation. Diabetes 52:2331-2337
25. Cha BS, Ciaraldi TP, Carter L, Nikoulina SE, Mudaliar S, Mukherjee R, Paterniti Jr JR, Henry RR 2001 Peroxisome proliferator-activated receptor (PPAR) γ and retinoid X receptor (RXR) agonists have complementary effects on glucose and lipid metabolism in human skeletal muscle. Diabetologia 44:444-452
26. Jiang G, Dallas-Yang Q, Li Z, Szalkowski D, Liu F, Shen X, Wu M, Zhou G, Doebber T, Berger J, Moller DE, Zhang BB 2002 Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPAR-γ agonists. Diabetes 51:2412-2419
27. Guo, Z 2001 Triglyceride content in skeletal muscle: variability and the source. Anal Biochem 296:1-8
28. Kuhlmann J, Neumann-Haefelin C, Belz U, Kalisch J, Juretschke H-P, Stein M, Kleinschmidt E, Kramer W, Herling AW 2003 A longitudinal in vivo 1H-spectroscopic study in Zucker diabetic fatty rats. Diabetes 52:138-144
29. Kim JK, Fillmore JJ, Gavrilova O, Chao L, Higashimori T, Choi J, Kim H-J, Yu C, Chen Y, Qu X, Haluzik M, Reitman ML, Shulman GI 2003 Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/ F-1 fatless mice. Diabetes 52:1311-1318
30. Hockings PD, Changani KK, Saeed N, Reid DG, Birmingham J, O'Brien P, Osborne J, Toseland CN, Buckingham RE 2003 Rapid reversal of hepatic steatosis, and reduction of muscle triglyceride, by rosiglitazone: MRI/S studies in Zucker fatty rats. Diabetes Obes Metab 5:234-243
31. Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF 2002 The effects of rosiglitazone on insulin sensitivity, lipolysis and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes 51:797-802
32. Frayn KN, Maycock PF 1980 Skeletal muscle triacylglycerol in the rat: methods for sampling and measurement, and studies of biological variability. J Lipid Res 1980 21:139-144
33. Folch J, Lees M, Sloane Stanley GH 1957 A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226:497-509
34. Pan DA, Storlien LH 1993 Dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats. J Nutr 123:512-519
35. Preiss J, Loomis CR, Bishop WR, Stein R, Niedel JE, Bell RM 1986 Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells J Biol Chem 261: 8597-600
36. Watt MJ, Heigenhauser GJ, Spriet LL 2003 Effects of dynamic exercise intensity on the activation of hormone-sensitive lipase in human skeletal muscle. J Physiol 547:301-308
37. Muoio DM, Seefeld K, Witters LA, Coleman RA 1999 AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. Biochem J 338:783-791
38. He J, Watkins S, Kelley D 2001 Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes 50:817-823
39. Dyck DJ, Peters SJ, Glatz J, Gorski J, Keizer H, Kiens B, Liu S, Richter EA, Spriet LL, van der Vusse GJ, Bonen A 1997 Functional differences in lipid metabolism in resting skeletal muscle of various fiber types. Am J Physiol 272:E340-E351
40. Henriksen EJ, Bourey RE, Rodnick KJ, Koranyi L, Pennutt MA, Holloszy JO Glucose transporter protein content and glucose transport capacity in rat skeletal muscles. Am J Physiol 259:E593-E598
41. Holm C 2000 Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans 31:1120-1124
42. Haemmerle G, Zimmermann R, Hayn M, Theussl C, Waeg G, Wagner E, Sattler W, Magin TM, Wagner EF, Zechner R 2002 Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis. J Biol Chem 277:4806-4815
43. Ide T, Nakazawa T, Mochizuki T, Murakami K 2000 Tissue-specific action of antidiabetic thiazolidinediones on the reduced fatty acid oxidation in skeletal muscle and liver of Zucker diabetic fatty rats. Metabolism 49:521-525
44. Sreenan S, Keck S, Fuller T, Cockbum B, Butant CF 1999 Effects of troglitazone on substrate storage and utilization in insulin-resistant rats. Am J Physiol 276:E1119-E1129
45. Manco M, Mingrone G, Greco AV, Capristo E, Gniuli D, De Gaetano A, Gasbarrini G 2000 Insulin resistance directly correlates with increased saturated fatty acids in skeletal muscle triglycerides. Metabolism 49:220-224