Bioactive sphingolipids: Metabolism and function

Journal of Lipid Research

Volumn 50, Issue SUPPL., 2009, Pages

  Bartke, Nana ^a   Hannun, Yusuf A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Bioactive lipids; Ceramide; Compartmentalization

Indexed keywords

ESTERASE; PHOSPHOLIPASE; SPHINGOLIPID;

ANIMAL; HUMAN; LIPID METABOLISM; METABOLISM; REVIEW; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; ESTERASES; HUMANS; LIPID METABOLISM; PHOSPHOLIPASES; SPHINGOLIPIDS;

EID: 66349086742     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R800080-JLR200     Document Type: Review

References (50)

1. Simons, K., and E. Ikonen. 1997. Functional rafts in cell membranes. Nature. 387: 569-572. (Pubitemid 27248754)
2. Kolesnick, R. N., A. Haimovitz-Friedman, and Z. Fuks. 1994. The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation. Biochem. Cell Biol. 72: 471-474.
3. Becker, K. P., K. Kitatani, J. Idkowiak-Baldys, J. Bielawski, and Y. A. Hannun. 2005. Selective inhibition of juxtanuclear translocation of protein kinase C betaII by a negative feedback mechanism involving ceramide formed from the salvage pathway. J. Biol. Chem. 280: 2606-2612. (Pubitemid 40189363)
4. Jenkins, G. M., L. A. Cowart, P. Signorelli, B. J. Pettus, C. E. Chalfant, and Y. A. Hannun. 2002. Acute activation of de novo sphingolipid biosynthesis upon heat shock causes an accumulation of ceramide and subsequent dephosphorylation of SR proteins. J. Biol. Chem. 277: 42572-42578. (Pubitemid 35285625)
5. Goldkorn, T., N. Balaban, M. Shannon, V. Chea, K. Matsukuma, D. Gilchrist, H. Wang, and C. Chan. 1998. H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells. J. Cell Sci. 111: 3209-3220. (Pubitemid 28532431)
6. Bose, R., M. Verheij, A. Haimovitz-Friedman, K. Scotto, Z. Fuks, and R. Kolesnick. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell. 82: 405-414.
7. Hannun, Y. A., and L. M. Obeid. 2008. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 9: 139-150. (Pubitemid 351158911)
8. Ogretmen, B., and Y. A. Hannun. 2004. Biologically active sphingolipids in cancer pathogenesis and treatment. Nat. Rev. 4: 604-616. (Pubitemid 39025055)
9. Zheng, W., J. Kollmeyer, H. Symolon, A. Momin, E. Munter, E. Wang, S. Kelly, J. C. Allegood, Y. Liu, Q. Peng, et al. 2006. Ceramides and other bioactive sphingolipid backbones in health and disease: lipidomic analysis, metabolism and roles in membrane structure, dynamics, signaling and autophagy. Biochim. Biophys. Acta. 1758: 1864-1884. (Pubitemid 44879367)
10. Mandon, E. C., I. Ehses, J. Rother, G. van Echten, and K. Sandhoff. 1992. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem. 267: 11144-11148.
11. Pewzner-Jung, Y., S. Ben-Dor, and A. H. Futerman. 2006. When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: insights into the regulation of ceramide synthesis. J. Biol. Chem. 281: 25001-25005. (Pubitemid 44401887)
12. Michel, C., and G. van Echten-Deckert. 1997. Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett. 416: 153-155. (Pubitemid 27462776)
13. Tafesse, F. G., P. Ternes, and J. C. Holthuis. 2006. The multigenic sphingomyelin synthase family. J. Biol. Chem. 281: 29421-29425. (Pubitemid 44536948)
14. Shinghal, R., R. H. Scheller, and S. M. Bajjalieh. 1993. Ceramide 1-phosphate phosphatase activity in brain. J. Neurochem. 61: 2279-2285. (Pubitemid 23354089)
15. Ichikawa, S., and Y. Hirabayashi. 1998. Glucosylceramide synthase and glycosphingolipid synthesis. Trends Cell Biol. 8: 198-202. (Pubitemid 28188114)
16. Marchesini, N., and Y. A. Hannun. 2004. Acid and neutral sphingomyelinases: roles and mechanisms of regulation. Biochem. Cell Biol. 82: 27-44. (Pubitemid 38580872)
17. Tettamanti, G. 2004. Ganglioside/glycosphingolipid turnover: new concepts. Glycoconj. J. 20: 301-317. (Pubitemid 39024039)
18. Mao, C., and L. M. Obeid. 2008. Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate. Biochim. Biophys. Acta. 1781: 424-434.
19. Hait, N. C., C. A. Oskeritzian, S. W. Paugh, S. Milstien, and S. Spiegel. 2006. Sphingosine kinases, sphingosine 1-phosphate, apoptosis and diseases. Biochim. Biophys. Acta. 1758: 2016-2026. (Pubitemid 44879368)
20. Johnson, K. R., K. Y. Johnson, K. P. Becker, J. Bielawski, C. Mao, and L. M. Obeid. 2003. Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability. J. Biol. Chem. 278: 34541-34547. (Pubitemid 37553303)
21. Bandhuvula, P., and J. D. Saba. 2007. Sphingosine-1-phosphate lyase in immunity and cancer: silencing the siren. Trends Mol. Med. 13: 210-217. (Pubitemid 46687129)
22. Yamaji, T., K. Kumagai, N. Tomishige, and K. Hanada. 2008. Two sphingolipid transfer proteins, CERT and FAPP2: their roles in sphingolipid metabolism. IUBMB Life. 60: 511-518.
23. Lannert, H., K. Gorgas, I. Meissner, F. T. Wieland, and D. Jeckel. 1998. Functional organization of the Golgi apparatus in glycosphingolipid biosynthesis. Lactosylceramide and subsequent glycosphingolipids are formed in the lumen of the late Golgi. J. Biol. Chem. 273: 2939-2946. (Pubitemid 28133945)
24. Riboni, L., R. Bassi, A. Caminiti, A. Prinetti, P. Viani, andG. Tettamanti. 1998. Metabolic fate of exogenous sphingosine in neuroblastoma neuro2A cells. Dose-dependence and biological effects. Ann. N. Y. Acad. Sci. 845: 46-56.
25. Okazaki, T., R. M. Bell, and Y. A. Hannun. 1989. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem. 264: 19076-19080. (Pubitemid 19285812)
26. Venable, M. E., J. Y. Lee, M. J. Smyth, A. Bielawska, and L. M. Obeid. 1995. Role of ceramide in cellular senescence. J. Biol. Chem. 270: 30701-30708. (Pubitemid 26005136)
27. Hetz, C. A., M. Hunn, P. Rojas, V. Torres, L. Leyton, and A. F. Quest. 2002. Caspase-dependent initiation of apoptosis and necrosis by the Fas receptor in lymphoid cells: onset of necrosis is associated with delayed ceramide increase. J. Cell Sci. 115: 4671-4683.
28. Adam, D., M. Heinrich, D. Kabelitz, and S. Schutze. 2002. Ceramide: does it matter for T cells? Trends Immunol. 23: 1-4. (Pubitemid 34098949)
29. Obeid, L. M., C. M. Linardic, L. A. Karolak, and Y. A. Hannun. 1993. Programmed cell death induced by ceramide. Science. 259: 1769-1771. (Pubitemid 23114667)
30. Chalfant, C. E., K. Kishikawa, M. C. Mumby, C. Kamibayashi, A. Bielawska, and Y. A. Hannun. 1999. Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. J. Biol. Chem. 274: 20313-20317.
31. Wang, G., J. Silva, K. Krishnamurthy, E. Tran, B. G. Condie, and E. Bieberich. 2005. Direct binding to ceramide activates protein kinase Czeta before the formation of a pro-apoptotic complex with PAR-4 in differentiating stem cells. J. Biol. Chem. 280: 26415-26424. (Pubitemid 41022238)
32. Blazquez, C., I. Galve-Roperh, and M. Guzman. 2000. De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J. 14: 2315-2322.
33. Ruvolo, P. P. 2003. Intracellular signal transduction pathways activated by ceramide and its metabolites. Pharmacol. Res. 47: 383-392. (Pubitemid 36379200)
34. Heinrich, M., M. Wickel, W. Schneider-Brachert, C. Sandberg, J. Gahr, R. Schwandner, T. Weber, P. Saftig, C. Peters, J. Brunner, et al. 1999. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 18: 5252-5263. (Pubitemid 29465576)
35. Smith, E. R., A. H. Merrill, L. M. Obeid, and Y. A. Hannun. 2000. Effects of sphingosine and other sphingolipids on protein kinase C. Methods Enzymol. 312: 361-373.
36. Cowart, L. A., and Y. A. Hannun. 2007. Selective substrate supply in the regulation of yeast de novo sphingolipid synthesis. J. Biol. Chem. 282: 12330-12340. (Pubitemid 47100697)
37. Spiegel, S., and S. Milstien. 2003. Sphingosine-1-phosphate: an enigmatic signalling lipid. Nat. Rev. Mol. Cell Biol. 4: 397-407. (Pubitemid 36565571)
38. Taha, T. A., K. M. Argraves, and L. M. Obeid. 2004. Sphingosine-1- phosphate receptors: receptor specificity versus functional redundancy. Biochim. Biophys. Acta. 1682: 48-55. (Pubitemid 38670534)
39. Kihara, A., S. Mitsutake, Y. Mizutani, and Y. Igarashi. 2007. Metabolism and biological functions of two phosphorylated sphingolipids, sphingosine 1-phosphate and ceramide 1-phosphate. Prog. Lipid Res. 46: 126-144. (Pubitemid 46661866)
40. Chalfant, C. E., and S. Spiegel. 2005. Sphingosine 1-phosphate and ceramide 1-phosphate: expanding roles in cell signaling. J. Cell Sci. 118: 4605-4612. (Pubitemid 41646371)
41. Pettus, B. J., A. Bielawska, P. Subramanian, D. S. Wijesinghe, M. Maceyka, C. C. Leslie, J. H. Evans, J. Freiberg, P. Roddy, Y. A. Hannun, et al. 2004. Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2. J. Biol. Chem. 279: 11320-11326. s (Pubitemid 38401629)
42. Radin, N. S., J. A. Shayman, and J. Inokuchi. 1993. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Adv. Lipid Res. 26: 183-213.
43. Hernandez, O. M., D. J. Discher, N. H. Bishopric, and K. A. Webster. 2000. Rapid activation of neutral sphingomyelinase by hypoxiareoxygenation of cardiac myocytes. Circ. Res. 86: 198-204. (Pubitemid 30086181)
44. Haimovitz-Friedman, A., C. Cordon-Cardo, S. Bayoumy, M. Garzotto, M. McLoughlin, R. Gallily, C. K. Edwards III, E. H. Schuchman, Z. Fuks, and R. Kolesnick. 1997. Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med. 186: 1831-1841. (Pubitemid 27524593)
45. Lee, J. T., J. Xu, J. M. Lee, G. Ku, X. Han, D. I. Yang, S. Chen, and C. Y. Hsu. 2004. Amyloid-beta peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J. Cell Biol. 164: 123-131. (Pubitemid 38082463)
46. Castillo, S. S., M. Levy, J. V. Thaikoottathil, and T. Goldkorn. 2007. Reactive nitrogen and oxygen species activate different sphingomyelinases to induce apoptosis in airway epithelial cells. Exp. Cell Res. 313: 2680-2686. (Pubitemid 46977336)
47. Johnson, K. R., K. P. Becker, M. M. Facchinetti, Y. A. Hannun, and L. M. Obeid. 2002. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J. Biol. Chem. 277: 35257-35262.
48. Melendez, A., R. A. Floto, D. J. Gillooly, M. M. Harnett, and J. M. Allen. 1998. FcgammaRI coupling to phospholipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. J. Biol. Chem. 273: 9393-9402. (Pubitemid 28183019)
49. El Alwani, M., B. X. Wu, L. M. Obeid, and Y. A. Hannun. 2006. Bioactive sphingolipids in the modulation of the inflammatory response. Pharmacol. Ther. 112: 171-183. (Pubitemid 44301491)
50. Levade, T., N. Auge, R. J. Veldman, O. Cuvillier, A. Negre-Salvayre, and R. Salvayre. 2001. Sphingolipid mediators in cardiovascular cell biology and pathology. Circ. Res. 89: 957-968. (Pubitemid 34640861)