Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells

Diabetologia

Volumn 44, Issue 2, 2001, Pages 173-183

  Hajduch, E ^a   Balendran, A ^a   Batty, I H ^a   Litherland, G J ^a   Blair, A S ^a   Downes, C P ^a   Hundal, H S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Glucose transport; Glycogen synthesis; IRS1; Membrane; Muscle; PI3K; TNF

Indexed keywords

CERAMIDE; GLUCOSE; GLYCOGEN; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOGEN SYNTHESIS; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BIOLOGICAL TRANSPORT; CELL LINE; CELL MEMBRANE; ENZYME ACTIVATION; GLUCOSE; GLYCOGEN; INOSITOL PHOSPHATES; INSULIN; MUSCLE, SKELETAL; OKADAIC ACID; PHOSPHOPROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 0035133331     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051596     Document Type: Article

References (57)

1. Mechanism of activation of Protein Kinase B by insulin and IGF-1
2. Update: Signal transduction - PtdIns(3,4,5)P-3 gets its message across
3. Molecular-cloning and characterization of a novel putative protein-serine kinase related to the cAMP-dependent and Protein-Kinase-C families
4. AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation
5. Role of translocation in the activation and function of Protein Kinase B
6. Characterization of a 3-phosphoinositide-dependent PKwhich phosphorylates and activates PKBα
7. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of Protein Kinase B
8. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and PKB/AKT by the integrin-linked kinase
9. PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
10. The tenth datta lecture - PDK1, one of the missing links in insulin signal transduction?
11. Inhibition of glycogen synthase kinase-3 by insulin-mediated PKB
12. Expression of a constitutively active Akt ser/thr kinase in 3T3-L1 adipocytes stimulates glucose-uptake and glucose-transporter-4 translocation
13. Potential role of Protein Kinase B in glucose transporter 4 translocation in adipocytes
14. Constitutive activation of Protein Kinase Bα (PKBα) by membrane targeting promotes glucose and System A amino acid transport, protein synthesis and GSK3 inactivation in L6 muscle cells
15. Hyperglycemia inhibits insulin activation of Akt/PKB but not phosphatidylinositol 3-kinase in rat skeletal muscle
16. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
17. Tumour necrosis factor, a key role in obesity?
18. Effect of tumor necrosis factor-alpha on insulin action in cultured rat skeletal muscle cells
19. Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha
20. Signal transduction of stress via ceramide
21. The sphingomyelin cycle and the second messenger function of ceramide
22. Stress signals for apoptosis: Ceramide and c-Jun kinase
23. Effect of tumor necrosis factor-alpha on insulin-stimulated mitogen-activated PKcascade in cultured rat skeletal muscle cells
24. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress
25. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
26. Lipid mediators of insulin resistance: Ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes
27. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
28. Activation of rat adipocyte glycogen synthase by insulin
29. Serotonin (5-HT), a novel regulator of glucose transport in rat skeletal muscle
30. Leptin stimulates glucose transport and glycogen synthesis in C2C12 myotubes: Evidence for a PI3-kinase mediated effect
31. A novel, rapid, and highly sensitive mass assay for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P-3) and its application to measure insulin-stimulated PtdIns(3,4,5)P-3 production in rat skeletal muscle in vivo
32. Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain
33. Activation of Protein Kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: Comparison with Protein Kinase B alpha
34. Intracellular signalling: PDK1-a kinase at the hub of things
35. Functions of ceramide in coordinating cellular responses to stress
36. Ceramide-activated protein phosphatase-2A activity in insulin-secreting cells
37. Insulin-induced translocation of PKB to the plasma membrane in rat adipocytes
38. Developmental regulation of subcellular distribution and glycosylation of GLUT1 and GLUT4 glucose transporters during myogenesis of L6 muscle cells
39. 1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo
40. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
41. Effects of cellpermeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes
42. Cross-talk mechanisms in the development of insulin resistance of skeletal muscle cells palmitate rather than tumour necrosis factor inhibits insulin-dependent PKB (PKB)/Akt stimulation and glucose uptake
43. Sphingomyelinase and ceramide suppress insulin-induced tyrosine phosphorylation of the insulin receptor substrate-1
44. Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction
45. TNF-alpha impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells
46. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
47. Ceramide stimulates a cytosolic protein phosphatase
48. Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells
49. Akt/PKB localisation and 3′ phosphoinositide generation at sites of epithelial cellmatrix and cell-cell interaction
50. Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains
51. Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated PKpathways
52. Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153
53. Endothelial cell inflammatory responses to tumor necrosis factor alpha. Ceramide-dependent and -independent mitogen-activated PKcascades
54. Regulation of glucose transport and glycogen synthesis in L6 muscle cells during oxidative stress: Evidence for crosstalk between the insulin and SAPK2/p38 MAP kinase signalling pathways
55. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
56. PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
57. Regulation of ceramide production and apoptosis