NO Induced Apoptosis of Vascular Smooth Muscle Cells Accompanied by Ceramide Increase

Journal of Cellular Physiology

Volumn 199, Issue 2, 2004, Pages 310-315

  Pilane, Cyril M ^a   Labelle, Edward F ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CALCIUM; CASPASE ACTIVATED DEOXYRIBONUCLEASE; CATHEPSIN D; CERAMIDE; DESIPRAMINE; DNA FRAGMENT; FUMONISIN B1; NITRIC OXIDE; PHOSPHOLIPASE A2; SPHINGOSINE ACYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; CELL LINE, TRANSFORMED; CERAMIDES; ENZYME INHIBITORS; IMMUNOBLOTTING; IN SITU NICK-END LABELING; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NITRIC OXIDE; RATS;

EID: 0346577312     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.10464     Document Type: Article

References (24)

1. Arora AS, Jones BJ, Patel TC, Bronk SF, Gores GJ. 1997. Ceramide induces hepatocyte cell death through disruption of mitochondrial function in the rat. Hepatology 25:958-963.
2. Bennett MR, Evan GI, Schwartz SM. 1995. Apoptosis of human vascular smooth muscle cells derived from normal vessel and coronary atherosclerotic plaques. J Clin Invest 95:2266-2274.
3. Bjorkerud S, Bjorkerud B. 1996. Apoptosis is abundant in human atherosclerotic lesions, especially in inflammatory cells (macrophages and T cells), and may contribute to the accumulation of gruel and plaque instability. Am J Pathol 149:367-380.
4. Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917.
5. Bose R, Verheij M, Haimovitz-Friedman A, Scotto K, Fuks Z, Kolesnick R. 1995. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals. Cell 82:405-414.
6. Enari M, Sakahari H, Yokoyama H, Okawa K, Imamatsu A, Nagata S. 1998. A caspase-activated DNase that degrade DNA during apoptosis, and its inhibitor ICAD. Nature 391:43-50.
7. Halenbeck R, MacDonald H, Rouston A, Chen TT, Conroy L, Williams LT. 1998. CPAN, a human nuclease regulated by the caspase sensitive inhibitor DFF-45. Curr Biol 8:537-540.
8. Han DKM, Haudenschild CC, Hong MK, Tinkle BT, Leon MB, Liau G. 1995. Evidence for apoptosis in human atherogenesis and in rat vascular injury model. Am J Pathol 147:267-277.
9. Heinrich M, Wickel M, Schneider-Brachert W, Sandberg C, Gahr J, Schwandner R, Weber T, Brunner J, Kronke M, Schutze S. 1999. Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J 18:5252-5263.
10. Hurwitz R, Ferlinz K, Sandhoff K. 1994. The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol Chem Hoppe-Seyler 375:447-450.
11. Huwiler A, Johansen B, Skarstad A, Pfeilschifter J. 2001. Ceramide binds to CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release. FASEB J 15:7-9.
12. Isner JM, Kearney M, Bortman S, Passeri J. 1995. Apoptosis in human atherosclerosis and restenosis. Circulation 91:2703-2711.
13. Jayadev S, Linardic CM, Hannun YA. 1994. Identification of arachidonic acid as a mediator of sphingomyelin hydrolysis in response to tumor necrosis factor-α. J Biol Chem 269:5757-5763.
14. LaBelle EF, Polyak E. 1996. Phospholipase Cβ2 in vascular smooth muscle. J Cell Physiol 169:358-363.
15. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem 193:265-275.
16. Obeid LM, Linardic CM, Karolak LA, Hannun YA. 1993. Programmed cell death induced by ceramide. Science 259:1769-1771.
17. 2 may be causally related to NO-induced apoptosis of vascular smooth muscle cells. J Cell Physiol 191:191-197.
18. Pronk GJ, Ramer K, Amiri P, Williams LT. 1996. Requirement of an ICE-like protease for induction of apoptosis and ceramide generation by REAPER. Science 271:808-810.
19. Pushkareva M, Obeid LM, Hannun YA. 1995. Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol Today 16:294-297.
20. Reilly CF. 1990. Rat vascular smooth muscle cells immortalized with SV-40 large T-antigen possess defined smooth muscle cell characteristics including growth inhibition by heparin. J Cell Physiol 142:342-351.
21. Sakahira H, Enari M, Nagata S. 1998. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391:96-99.
22. Schmuth M, Man M-Q, Weber F, Gao W, Feingold KR, Fritsch P, Elias PM, Holleran WM. 2000. Permeability barrier disorder in Niemann-Pick Disease: Sphingomyelin-ceramide processing required for normal barrier homeostasis. J Invest Dermatol 115:459-466.
23. Smyth MJ, Perry DK, Zhang J, Poirier GG, Hannun YA, Obeid L. 1996. +Pr-ICE: A downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2. Biochem J 316:25-28.
24. Witty JP, Bridgham JT, Johnson AL. 1996. Induction of apoptotic cell death in hen granulose cells by ceramide. Endo 137:5269-5277.