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Volumn 1585, Issue 2-3, 2002, Pages 202-212

Lipoapoptosis: Its mechanism and its diseases

Author keywords

Cell; Lipoapoptosis; Obesity

Indexed keywords

CYTOCHROME C; LEPTIN; LIPID; NITRIC OXIDE;

EID: 0037203345     PISSN: 13881981     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-1981(02)00342-6     Document Type: Review
Times cited : (327)

References (73)
  • 2
    • 0035125917 scopus 로고    scopus 로고
    • Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover
    • Unger R.H., Zhou Y.-T. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes. 50:2001;S118-S121.
    • (2001) Diabetes , vol.50 , pp. 118-S121
    • Unger, R.H.1    Zhou, Y.-T.2
  • 3
    • 0033967128 scopus 로고    scopus 로고
    • Apoptosis in cardiac diseases: Stress- and mitogen-activated signaling pathways
    • Feuerstein G.Z., Young P.R. Apoptosis in cardiac diseases: stress- and mitogen-activated signaling pathways. Cardiovasc. Res. 45:2000;560-569.
    • (2000) Cardiovasc. Res. , vol.45 , pp. 560-569
    • Feuerstein, G.Z.1    Young, P.R.2
  • 4
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner M.O. The biochemistry of apoptosis. Nature. 407:2000;770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 5
    • 0034097798 scopus 로고    scopus 로고
    • MAP kinase pathways activated by stress: The p38 MAPk pathway
    • Obata T., Brown G.E., Yaffe M.B. MAP kinase pathways activated by stress: the p38 MAPk pathway. Crit. Care Med. 28:2000;N67-N77.
    • (2000) Crit. Care Med. , vol.28 , pp. 67-N77
    • Obata, T.1    Brown, G.E.2    Yaffe, M.B.3
  • 7
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta-cell apoptosis: A link between obesity and diabetes
    • Shimabukuro M., Zhou Y.-T., Levi M., Unger R.H. Fatty acid-induced beta-cell apoptosis: a link between obesity and diabetes. Proc. Natl. Acad. Sci. 95:1998;2498-2502.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.-T.2    Levi, M.3    Unger, R.H.4
  • 8
    • 0032482988 scopus 로고    scopus 로고
    • Protection against lipoapoptosis of beta-cell through leptin-dependent maintenance of Bcl-2 expression
    • Shimabukuro M., Wang M.-Y., Zhou Y.-T., Newgard C.B., Unger R.H. Protection against lipoapoptosis of beta-cell through leptin-dependent maintenance of Bcl-2 expression. Proc. Natl. Acad. Sci. 95:1998;9558-9561.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 9558-9561
    • Shimabukuro, M.1    Wang, M.-Y.2    Zhou, Y.-T.3    Newgard, C.B.4    Unger, R.H.5
  • 9
    • 0032488968 scopus 로고    scopus 로고
    • Troglitazone lowers islet fat and restores beta-cell function of Zucker Diabetic Fatty rats
    • Shimabukuro M., Zhou Y.-T., Lee Y., Unger R.H. Troglitazone lowers islet fat and restores beta-cell function of Zucker Diabetic Fatty rats. J. Biol. Chem. 273:1998;3547-3550.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3547-3550
    • Shimabukuro, M.1    Zhou, Y.-T.2    Lee, Y.3    Unger, R.H.4
  • 10
    • 0032484132 scopus 로고    scopus 로고
    • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats: Role of serine palmitoyl transferase overexpression
    • Shimabukuro M., Higa M., Zhou Y.-T., Wang M.-Y., Newgard C.B., Unger R.H. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats: role of serine palmitoyl transferase overexpression. J. Biol. Chem. 273:1998;32487-32490.
    • (1998) J. Biol. Chem. , vol.273 , pp. 32487-32490
    • Shimabukuro, M.1    Higa, M.2    Zhou, Y.-T.3    Wang, M.-Y.4    Newgard, C.B.5    Unger, R.H.6
  • 11
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr J.F., Wyllie A.H., Currie A.R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:1972;239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 13
    • 0033539017 scopus 로고    scopus 로고
    • Identification of caspases and apoptosis in the simple metazoan Hydra
    • Cikala M., Wilm B., Hobmayer E., Bottger A., David C.N. Identification of caspases and apoptosis in the simple metazoan Hydra. Curr. Biol. 9:1999;959-962.
    • (1999) Curr. Biol. , vol.9 , pp. 959-962
    • Cikala, M.1    Wilm, B.2    Hobmayer, E.3    Bottger, A.4    David, C.N.5
  • 15
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science. 261:1998;1312-1316.
    • (1998) Science , vol.261 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 16
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie A.H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature. 284:1980;555-556.
    • (1980) Nature , vol.284 , pp. 555-556
    • Wyllie, A.H.1
  • 17
    • 0030916417 scopus 로고    scopus 로고
    • DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
    • Liu X., Zou H., Slaughter C., Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell. 89:1997;175-184.
    • (1997) Cell , vol.89 , pp. 175-184
    • Liu, X.1    Zou, H.2    Slaughter, C.3    Wang, X.4
  • 18
    • 0031888955 scopus 로고    scopus 로고
    • A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
    • Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 391:1998;43-50.
    • (1998) Nature , vol.391 , pp. 43-50
    • Enari, M.1    Sakahira, H.2    Yokoyama, H.3    Okawa, K.4    Iwamatsu, A.5    Nagata, S.6
  • 19
    • 0031889132 scopus 로고    scopus 로고
    • Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
    • Sakahira H., Enari M., Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature. 391:1998;96-99.
    • (1998) Nature , vol.391 , pp. 96-99
    • Sakahira, H.1    Enari, M.2    Nagata, S.3
  • 20
    • 0030979773 scopus 로고    scopus 로고
    • Double identity for proteins of the Bcl-2 family
    • Reed J.C. Double identity for proteins of the Bcl-2 family. Nature. 387:1997;773-776.
    • (1997) Nature , vol.387 , pp. 773-776
    • Reed, J.C.1
  • 21
    • 0030581151 scopus 로고    scopus 로고
    • Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome C
    • Liu W., Kim C.N., Yang J., Jimmerson R., Wang K. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome C. Cell. 86:1996;147-157.
    • (1996) Cell , vol.86 , pp. 147-157
    • Liu, W.1    Kim, C.N.2    Yang, J.3    Jimmerson, R.4    Wang, K.5
  • 22
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, beta-cell destruction and diabetes in obese prediabetic rats
    • Higa M., Zhou Y.-T., Ravazzola M., Baetens D., Orci L., Unger R.H. Troglitazone prevents mitochondrial alterations, beta-cell destruction and diabetes in obese prediabetic rats. Proc. Natl. Acad. Sci. 96:1999;11513-11518.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 11513-11518
    • Higa, M.1    Zhou, Y.-T.2    Ravazzola, M.3    Baetens, D.4    Orci, L.5    Unger, R.H.6
  • 24
    • 0030755002 scopus 로고    scopus 로고
    • Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis
    • Weiss B., Stoffel W. Human and murine serine-palmitoyl-CoA transferase. Cloning, expression and characterization of the key enzyme in sphingolipid synthesis. Eur. J. Biochem. 249:1997;239-247.
    • (1997) Eur. J. Biochem. , vol.249 , pp. 239-247
    • Weiss, B.1    Stoffel, W.2
  • 26
    • 0034610449 scopus 로고    scopus 로고
    • Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of P13 kinase/Akt
    • Aikawa R., Nawano M., Gu Y., Katagiri H., Asano T., Zhu W., Nagai R., Komuro I. Insulin prevents cardiomyocytes from oxidative stress-induced apoptosis through activation of P13 kinase/Akt. Circulation. 102:2000;2873-2879.
    • (2000) Circulation , vol.102 , pp. 2873-2879
    • Aikawa, R.1    Nawano, M.2    Gu, Y.3    Katagiri, H.4    Asano, T.5    Zhu, W.6    Nagai, R.7    Komuro, I.8
  • 27
    • 0033758144 scopus 로고    scopus 로고
    • Akt mediates insulin rescue from apoptosis in brown adipocytes: Effect of ceramide
    • Navarro P., Valverde A.M., Rohn J.L., Benito M., Lorenzo M. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth Horm. IGF Res. 10:2000;256-266.
    • (2000) Growth Horm. IGF Res. , vol.10 , pp. 256-266
    • Navarro, P.1    Valverde, A.M.2    Rohn, J.L.3    Benito, M.4    Lorenzo, M.5
  • 28
    • 0032514918 scopus 로고    scopus 로고
    • BAD enables ceramide to signal apoptosis via Ras and Raf-1
    • Basu S., Bayoumy S., Zhang Y., Lozano J., Kolesnick R. BAD enables ceramide to signal apoptosis via Ras and Raf-1. J. Biol. Chem. 273:1998;30419-30426.
    • (1998) J. Biol. Chem. , vol.273 , pp. 30419-30426
    • Basu, S.1    Bayoumy, S.2    Zhang, Y.3    Lozano, J.4    Kolesnick, R.5
  • 29
    • 0034612304 scopus 로고    scopus 로고
    • Ceramide interaction with the respiratory chain of heart mitochondria
    • DiPaola M., Cocco T., Lorusso M. Ceramide interaction with the respiratory chain of heart mitochondria. Biochemistry. 39:2000;6660-6668.
    • (2000) Biochemistry , vol.39 , pp. 6660-6668
    • DiPaola, M.1    Cocco, T.2    Lorusso, M.3
  • 30
    • 0032053709 scopus 로고    scopus 로고
    • Mechanisms and consequences of activation of protein kinase B/Akt
    • Downward J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol. 10:1998;262-267.
    • (1998) Curr. Opin. Cell Biol. , vol.10 , pp. 262-267
    • Downward, J.1
  • 31
    • 0033000423 scopus 로고    scopus 로고
    • The "thrifty genotype" in 1998
    • Neel J.-V. The "thrifty genotype" in 1998. Nutr. Rev. 57:1999;S2-S9.
    • (1999) Nutr. Rev. , vol.57 , pp. 2-S9
    • Neel, J.-V.1
  • 32
    • 0029895842 scopus 로고    scopus 로고
    • Generalized lipodystrophy, congenital and acquired (lipoatrophy)
    • Seip M., Trygstad O. Generalized lipodystrophy, congenital and acquired (lipoatrophy). Acta Paediatr. 413:1996;2-28.
    • (1996) Acta Paediatr. , vol.413 , pp. 2-28
    • Seip, M.1    Trygstad, O.2
  • 33
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • Shimomura I., Hammer R.E., Richardson J.A., Ikemoto S., Bashmakov Y., Goldstein J.L., Brown M.S. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12:1998;3182-3194.
    • (1998) Genes Dev. , vol.12 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5    Goldstein, J.L.6    Brown, M.S.7
  • 36
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I., Hammer R.E., Ikemoto S., Brown M.S., Goldstein J.L. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature. 401:1999;73-76.
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 40
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • Scherer P.E., Williams S., Fogliano M., Baldini G., Lodish H.F. A novel serum protein similar to C1q, produced exclusively in adipocytes. J. Biol. Chem. 270:1995;26746-26749.
    • (1995) J. Biol. Chem. , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 41
    • 17544382289 scopus 로고    scopus 로고
    • AdipoQ is a novel adipose-specific gene dysregulated in obesity
    • Hu E., Liang P., Spiegelman B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 271:1996;10697-10703.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 43
  • 45
    • 0033514956 scopus 로고    scopus 로고
    • Regulation of fatty acid homeostasis in cells: Novel role of leptin
    • Unger R.H., Zhou Y.-T., Orci L. Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc. Natl. Acad. Sci. 96:1999;2391-2395.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 2391-2395
    • Unger, R.H.1    Zhou, Y.-T.2    Orci, L.3
  • 46
    • 0034714051 scopus 로고    scopus 로고
    • Leptin physiology: A second look
    • Unger R.H. Leptin physiology: a second look. Regul. Pept. 92:2000;87-95.
    • (2000) Regul. Pept. , vol.92 , pp. 87-95
    • Unger, R.H.1
  • 49
    • 0030590070 scopus 로고    scopus 로고
    • Substitution at codon 269 (glutamine→proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat
    • Iida M., Murakami T., Ishida K., Mizuno A., Kuwajima M., Shima K. Substitution at codon 269 (glutamine→proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem. Biophys. Res. Commun. 224:1996;597-604.
    • (1996) Biochem. Biophys. Res. Commun. , vol.224 , pp. 597-604
    • Iida, M.1    Murakami, T.2    Ishida, K.3    Mizuno, A.4    Kuwajima, M.5    Shima, K.6
  • 50
    • 0030642245 scopus 로고    scopus 로고
    • Role of insulin resistance in human disease
    • Reaven G.M. Role of insulin resistance in human disease. Nutr. Rev. 13:1997;65-66.
    • (1997) Nutr. Rev. , vol.13 , pp. 65-66
    • Reaven, G.M.1
  • 55
    • 0027648820 scopus 로고
    • ADD1: A novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation
    • Tontonoz P., Kim J.B., Graves R.A., Spiegelman B.M. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13:1993;4753-4759.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4753-4759
    • Tontonoz, P.1    Kim, J.B.2    Graves, R.A.3    Spiegelman, B.M.4
  • 56
    • 0028225462 scopus 로고
    • SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis
    • Wang X., Sato R., Brown M.S., Hua X., Goldstein J.L. SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell. 77:1994;53-62.
    • (1994) Cell , vol.77 , pp. 53-62
    • Wang, X.1    Sato, R.2    Brown, M.S.3    Hua, X.4    Goldstein, J.L.5
  • 58
    • 0034682474 scopus 로고    scopus 로고
    • Leptin, troglitazone and the expression of sterol regulatory element binding proteins in liver and pancreas
    • Kakuma T., Lee Y., Higa M., Wang Z.-W., Pan W., Shimomura I., Unger R.H. Leptin, troglitazone and the expression of sterol regulatory element binding proteins in liver and pancreas. Proc. Natl. Acad. Sci. 97:2000;8536-8541.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 8536-8541
    • Kakuma, T.1    Lee, Y.2    Higa, M.3    Wang, Z.-W.4    Pan, W.5    Shimomura, I.6    Unger, R.H.7
  • 59
    • 0031738017 scopus 로고    scopus 로고
    • Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: Role in the pathogenesis of lipotoxic diabetes
    • Zhou Y.-T., Shimabukuro M., Lee Y., Koyama K., Higa M., Ferguson T., Unger R.H. Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats: role in the pathogenesis of lipotoxic diabetes. Diabetes. 47:1998;1904-1908.
    • (1998) Diabetes , vol.47 , pp. 1904-1908
    • Zhou, Y.-T.1    Shimabukuro, M.2    Lee, Y.3    Koyama, K.4    Higa, M.5    Ferguson, T.6    Unger, R.H.7
  • 60
    • 0031048115 scopus 로고    scopus 로고
    • Increased lipogenic capacity of the islets of obese rats: A role in the pathogenesis of NIDDM
    • Lee Y., Hirose H., Zhou Y.-T., Esser V., McGarry J.D., Unger R.H. Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes. 46:1997;408-413.
    • (1997) Diabetes , vol.46 , pp. 408-413
    • Lee, Y.1    Hirose, H.2    Zhou, Y.-T.3    Esser, V.4    McGarry, J.D.5    Unger, R.H.6
  • 61
    • 0035130102 scopus 로고    scopus 로고
    • Diseases of liporegulation: New perspective on obesity and related disorders
    • Unger R.H., Orci L. Diseases of liporegulation: new perspective on obesity and related disorders. FASEB J. 15:2001;312-321.
    • (2001) FASEB J. , vol.15 , pp. 312-321
    • Unger, R.H.1    Orci, L.2
  • 62
    • 0030885230 scopus 로고    scopus 로고
    • Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1B cytotoxicity
    • Shimabukuro M., Koyama K., Lee Y., Unger R.H. Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1B cytotoxicity. J. Clin. Invest. 100:1997;1750-1754.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1750-1754
    • Shimabukuro, M.1    Koyama, K.2    Lee, Y.3    Unger, R.H.4
  • 63
    • 0030856714 scopus 로고    scopus 로고
    • Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
    • Gudz T.I., Tserng K.Y., Hoppel C.L. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J. Biol. Chem. 272:1997;24154-24158.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24154-24158
    • Gudz, T.I.1    Tserng, K.Y.2    Hoppel, C.L.3
  • 65
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signaling by the insulin-like growth factor I receptor phosphatidylinositol 3-kinase, and Akt
    • Kulik G., Klippel A., Weber M.J. Antiapoptotic signaling by the insulin-like growth factor I receptor phosphatidylinositol 3-kinase, and Akt. Mol. Cell. Biol. 17:1997;1595-1606.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 66
    • 0032569026 scopus 로고    scopus 로고
    • Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis
    • Zhou H., Summers S.A., Birnbaum M.J., Pittman R.N. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J. Biol. Chem. 273:1998;16568-16575.
    • (1998) J. Biol. Chem. , vol.273 , pp. 16568-16575
    • Zhou, H.1    Summers, S.A.2    Birnbaum, M.J.3    Pittman, R.N.4
  • 67
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • Listenberger L.L., Ory D.S., Schaffer J.E. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J. Biol. Chem. 276:2001;14890-14895.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 68
    • 0032710389 scopus 로고    scopus 로고
    • Essential fatty acids, lipid peroxidation and apoptosis
    • Das U.N. Essential fatty acids, lipid peroxidation and apoptosis. Prostaglandins, Leukot. Essent. Fat. Acids. 61:1999;157-163.
    • (1999) Prostaglandins, Leukot. Essent. Fat. Acids , vol.61 , pp. 157-163
    • Das, U.N.1
  • 70
    • 0032836828 scopus 로고    scopus 로고
    • Diabetes, insulin resistance and dyslipidaemia in lipodystrophic HIV-infected patients on highly active antiretroviral therapy (HAART)
    • Vigouroux C., Gharakhanian S., Salhi Y., Nguyen T.H., Chevenne D., Capeau J., Rosenbaum W. Diabetes, insulin resistance and dyslipidaemia in lipodystrophic HIV-infected patients on highly active antiretroviral therapy (HAART). Diabetes Metab. 25:1999;225-232.
    • (1999) Diabetes Metab. , vol.25 , pp. 225-232
    • Vigouroux, C.1    Gharakhanian, S.2    Salhi, Y.3    Nguyen, T.H.4    Chevenne, D.5    Capeau, J.6    Rosenbaum, W.7
  • 73
    • 0035162054 scopus 로고    scopus 로고
    • The role of leptin resistance in the lipid abnormalities of aging
    • Wang Z.-W., Pan W., Lee Y., Kakuma T., Zhou Y.-T., Unger R.H. The role of leptin resistance in the lipid abnormalities of aging. FASEB J. 15:2001;108-114.
    • (2001) FASEB J. , vol.15 , pp. 108-114
    • Wang, Z.-W.1    Pan, W.2    Lee, Y.3    Kakuma, T.4    Zhou, Y.-T.5    Unger, R.H.6


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