메뉴 건너뛰기




Volumn 13, Issue 5, 2013, Pages 653-681

Recent advancements in small molecule inhibitors of insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase as anticancer agents

Author keywords

Cancer; IGF 1R; IGF 1R inhibitors; IR; SAR; Tyrosine kinases

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTINEOPLASTIC AGENT; ARYL HETEROARYL UREA; BENZIMIDAZOLE; BMS 577098; CYANOQUINOLINE; DIARYL UREA; DIPYRONE; HEAT SHOCK PROTEIN 90 INHIBITOR; HYDANTOIN DERIVATIVE; IMIDAZO[1, 2 A]PYRIDINE; IMIDAZOPYRAZINE DERIVATIVE; IMIDAZOTRIAZINE; INDOLE BASED ALLOSTERIC INHIBITOR; INDOLE HYDRAZIDE; INDOLEALKYLAMINE; ISOQUINOLINEDIONE; NAPHTHALENE; OXAFLUORENE; PYRAZOLO[3,4 D]PYRIMIDINE; PYRIMIDINE; PYRROLO[1,2, F][1,2,4]TRIAZINE; PYRROLO[2,3 B]PYRIDINE; PYRROLOPYRIMIDINE DERIVATIVE; QUINOLINE DERIVATIVE; SMALL MOLECULE INHIBITOR; SOMATOMEDIN B RECEPTOR; SOMATOMEDIN C RECEPTOR; TRIAZINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84877797124     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557511313050004     Document Type: Review
Times cited : (28)

References (260)
  • 1
    • 3042634240 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in cancer therapy
    • Madhusudan, S.; Ganesan, T.S. Tyrosine kinase inhibitors in cancer therapy. Clin. Biochem., 2004, 37 (7), 618-635.
    • (2004) Clin. Biochem , vol.37 , Issue.7 , pp. 618-635
    • Madhusudan, S.1    Ganesan, T.S.2
  • 3
    • 84869237379 scopus 로고    scopus 로고
    • Mechanisms of acquired resistance to tyrosine kinase inhibitors
    • Chen, Y.; Fu, L. Mechanisms of acquired resistance to tyrosine kinase inhibitors. Acta Pharm. sin. B, 2011, 1 (4), 197-207.
    • (2011) Acta Pharm. Sin. B , vol.1 , Issue.4 , pp. 197-207
    • Chen, Y.1    Fu, L.2
  • 4
    • 0037130294 scopus 로고    scopus 로고
    • Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1
    • Hegedus, T.; Orfi, L.; Sepro di, A.; Váradi, A.; Sarkadi, B.; Kéri, G. Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. Biochem. Biophys. Acta Mol. Basis Dis., 2002, 1587 (2-3), 318-325.
    • (2002) Biochem. Biophys. Acta Mol. Basis Dis , vol.1587 , Issue.2-3 , pp. 318-325
    • Hegedus, T.1    Orfi, L.2    di Sepro, A.3    Váradi, A.4    Sarkadi, B.5    Kéri, G.6
  • 5
    • 78649719727 scopus 로고    scopus 로고
    • Targeting non-malignant disorders with tyrosine kinase inhibitors
    • Grimminger, F.; Schermuly, R.T.; Ghofrani, H.A. Targeting non-malignant disorders with tyrosine kinase inhibitors. Nat. Rev. Drug Discov., 2010, 9 (12), 956-970.
    • (2010) Nat. Rev. Drug Discov , vol.9 , Issue.12 , pp. 956-970
    • Grimminger, F.1    Schermuly, R.T.2    Ghofrani, H.A.3
  • 6
    • 15944404601 scopus 로고    scopus 로고
    • The development of imatinib as a therapeutic agent for chronic myeloid leukemia
    • Deininger, M.; Buchdunger, E.; Druker, B.J. The development of imatinib as a therapeutic agent for chronic myeloid leukemia. Blood, 2005, 105 (7), 2640-2653.
    • (2005) Blood , vol.105 , Issue.7 , pp. 2640-2653
    • Deininger, M.1    Buchdunger, E.2    Druker, B.J.3
  • 7
    • 4644318882 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors in renal cell carcinoma
    • Potti, A.; George, D.J. Tyrosine kinase inhibitors in renal cell carcinoma. Clin. Cancer Res., 2004, 10 (18), 6371S-6376S.
    • (2004) Clin. Cancer Res , vol.10 , Issue.18
    • Potti, A.1    George, D.J.2
  • 8
    • 0142055937 scopus 로고    scopus 로고
    • Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer
    • Kris, M.G.; Natale, R.B.; Herbst, R.S.; Lynch, T.J.; Prager, D.; Belani, C.P.; Schiller, J.H.; Kelly, K.; Spiridonidis, H.; Sandler, A. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer. J. Am. Med. Assoc., 2003, 290 (16), 2149.
    • (2149) J. Am. Med. Assoc , vol.290 , Issue.16 , pp. 2003
    • Kris, M.G.1    Natale, R.B.2    Herbst, R.S.3    Lynch, T.J.4    Prager, D.5    Belani, C.P.6    Schiller, J.H.7    Kelly, K.8    Spiridonidis, H.9    Sandler, A.10
  • 9
    • 85047696958 scopus 로고    scopus 로고
    • ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinaseinhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model
    • Williams, K.; Telfer, B.; Stratford, I.; Wedge, S. ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinaseinhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model. Br. J. Cancer, 2002, 86 (7), 1157-1161.
    • (2002) Br. J. Cancer , vol.86 , Issue.7 , pp. 1157-1161
    • Williams, K.1    Telfer, B.2    Stratford, I.3    Wedge, S.4
  • 10
    • 0036527429 scopus 로고    scopus 로고
    • Protein kinases-the major drug targets of the twenty-first century?
    • Cohen, P. Protein kinases-the major drug targets of the twenty-first century? Nat. Rev. Drug Discov., 2002, 1 (4), 309-315.
    • (2002) Nat. Rev. Drug Discov , vol.1 , Issue.4 , pp. 309-315
    • Cohen, P.1
  • 12
    • 84862103506 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitors: Multi-targeted or single-targeted?
    • Broekman, F.; Giovannetti, E.; Peters, G.J. Tyrosine kinase inhibitors: Multi-targeted or single-targeted? World J. Clin. Oncol., 2011, 2 (2), 80.
    • (2011) World J. Clin. Oncol , vol.2 , Issue.2 , pp. 80
    • Broekman, F.1    Giovannetti, E.2    Peters, G.J.3
  • 13
    • 0033786922 scopus 로고    scopus 로고
    • Protein tyrosine kinase structure and function
    • Hubbard, S.R.; Till, J.H. Protein tyrosine kinase structure and function. Annu. Rev. Biochem., 2000, 69 (1), 373-398.
    • (2000) Annu. Rev. Biochem , vol.69 , Issue.1 , pp. 373-398
    • Hubbard, S.R.1    Till, J.H.2
  • 15
    • 0036970842 scopus 로고    scopus 로고
    • The role of the IGF system in cancer: From basic to clinical studies and clinical applications
    • Moschos, S.J.; Mantzoros, C.S. The role of the IGF system in cancer: from basic to clinical studies and clinical applications. Oncology, 2002, 63 (4), 317-332.
    • (2002) Oncology , vol.63 , Issue.4 , pp. 317-332
    • Moschos, S.J.1    Mantzoros, C.S.2
  • 16
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: Overview and recent insights
    • Samani, A.A.; Yakar, S.; LeRoith, D.; Brodt, P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr. Rev., 2007, 28 (1), 20-47.
    • (2007) Endocr. Rev , vol.28 , Issue.1 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    Leroith, D.3    Brodt, P.4
  • 17
    • 0242594016 scopus 로고    scopus 로고
    • The IGF-1 receptor in cancer biology
    • Baserga, R.; Peruzzi, F.; Reiss, K. The IGF-1 receptor in cancer biology. Int. J. Cancer, 2003, 107 (6), 873-877.
    • (2003) Int. J. Cancer , vol.107 , Issue.6 , pp. 873-877
    • Baserga, R.1    Peruzzi, F.2    Reiss, K.3
  • 18
    • 23044493251 scopus 로고    scopus 로고
    • Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer
    • Hofmann, F.; García-Echeverría, C. Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer. Drug Discov. Today, 2005, 10 (15), 1041-1047.
    • (2005) Drug Discov. Today , vol.10 , Issue.15 , pp. 1041-1047
    • Hofmann, F.1    García-Echeverría, C.2
  • 19
    • 85028516874 scopus 로고    scopus 로고
    • Malaguarnera, R
    • LeRoith, D., Ed.; Springer Science, New York
    • Belfiore, A.; Malaguarnera, R. In: Insulin-like Growth Factors and Cancer; LeRoith, D., Ed.; Springer Science, New York, 2012, pp. 263-278.
    • (2012) Insulin-like Growth Factors and Cancer , pp. 263-278
    • Belfiore, A.1
  • 20
    • 84857640868 scopus 로고    scopus 로고
    • The insulin and insulin-like growth factor receptor family in neoplasia: An update
    • Pollak, M. The insulin and insulin-like growth factor receptor family in neoplasia: an update. Nat. Rev. Cancer, 2012, 12, 159-169.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 159-169
    • Pollak, M.1
  • 23
    • 79953647468 scopus 로고    scopus 로고
    • Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer
    • Buck, E.; Mulvihill, M. Small molecule inhibitors of the IGF-1R/IR axis for the treatment of cancer. Expert Opin. Invest. Drugs, 2011, 20, 605-621.
    • (2011) Expert Opin. Invest. Drugs , vol.20 , pp. 605-621
    • Buck, E.1    Mulvihill, M.2
  • 24
    • 79959466358 scopus 로고    scopus 로고
    • Minireview: IGF, insulin, and cancer
    • Gallagher, E.J.; LeRoith, D. Minireview: IGF, insulin, and cancer. Endocrinology, 2011, 152 (7), 2546-2551.
    • (2011) Endocrinology , vol.152 , Issue.7 , pp. 2546-2551
    • Gallagher, E.J.1    Leroith, D.2
  • 25
    • 0025009815 scopus 로고
    • The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras
    • Gustafson, T.; Rutter, W. The cysteine-rich domains of the insulin and insulin-like growth factor I receptors are primary determinants of hormone binding specificity. Evidence from receptor chimeras. J. Biol. Chem., 1990, 265 (30), 18663-18667.
    • (1990) J. Biol. Chem , vol.265 , Issue.30 , pp. 18663-18667
    • Gustafson, T.1    Rutter, W.2
  • 26
    • 84877831303 scopus 로고    scopus 로고
    • 1st ed.; Academic Press: London
    • Litwack, G. Insulin and IGFs, 1st ed.; Academic Press: London, 2009.
    • (2009) Insulin and IGFs
    • Litwack, G.1
  • 27
    • 0024539198 scopus 로고
    • Alternative splicing of human insulin receptor messenger RNA
    • Seino, S.; Bell, G.I. Alternative splicing of human insulin receptor messenger RNA. Biochem. Biophys. Res. Commun., 1989, 159 (1), 312-316.
    • (1989) Biochem. Biophys. Res. Commun , vol.159 , Issue.1 , pp. 312-316
    • Seino, S.1    Bell, G.I.2
  • 28
    • 0032726331 scopus 로고    scopus 로고
    • Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain
    • Nelms, K.; O'Neill, T.J.; Li, S.; Hubbard, S.R.; Gustafson, T.A.; Paul, W.E. Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. Mamm. Genome, 1999, 10 (12), 1160-1167.
    • (1999) Mamm. Genome , vol.10 , Issue.12 , pp. 1160-1167
    • Nelms, K.1    O'Neill, T.J.2    Li, S.3    Hubbard, S.R.4    Gustafson, T.A.5    Paul, W.E.6
  • 29
    • 20444411501 scopus 로고    scopus 로고
    • Characterization of the functional insulin binding epitopes of the full-length insulin receptor
    • Whittaker, J.; Whittaker, L. Characterization of the functional insulin binding epitopes of the full-length insulin receptor. J. Biol. Chem., 2005, 280 (22), 20932.
    • (2005) J. Biol. Chem , vol.280 , Issue.22 , pp. 20932
    • Whittaker, J.1    Whittaker, L.2
  • 30
    • 0024403208 scopus 로고
    • Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man
    • Moller, D.E.; Yokota, A.; Caro, J.F.; Flier, J.S. Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man. Mol. Endocrinol., 1989, 3 (8), 1263-1269.
    • (1989) Mol. Endocrinol , vol.3 , Issue.8 , pp. 1263-1269
    • Moller, D.E.1    Yokota, A.2    Caro, J.F.3    Flier, J.S.4
  • 31
    • 34247872895 scopus 로고    scopus 로고
    • Characterization of insulin/IGF hybrid receptors: Contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation
    • Benyoucef, S.; Surinya, K.H.; Hadaschik, D.; Siddle, K. Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation. Biochem. J., 2007, 403 (Pt 3), 603.
    • (2007) Biochem. J , vol.403 , Issue.Pt 3 , pp. 603
    • Benyoucef, S.1    Surinya, K.H.2    Hadaschik, D.3    Siddle, K.4
  • 33
    • 0029553646 scopus 로고
    • Localization of specific amino acids contributing to insulin specificity of the insulin receptor
    • Andersen, A.S.; Wiberg, F.C.; Kjeldsen, T. Localization of specific amino acids contributing to insulin specificity of the insulin receptor. Ann. N. Y. Acad. Sci., 1995, 766 (1), 466-468.
    • (1995) Ann. N. Y. Acad. Sci , vol.766 , Issue.1 , pp. 466-468
    • Andersen, A.S.1    Wiberg, F.C.2    Kjeldsen, T.3
  • 34
    • 0030756092 scopus 로고    scopus 로고
    • Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors
    • Mynarcik, D.C.; Williams, P.F.; Schaffer, L.; Yu, G.Q.; Whittaker, J. Identification of common ligand binding determinants of the insulin and insulin-like growth factor 1 receptors. J. Biol. Chem., 1997, 272 (30), 18650.
    • (1997) J. Biol. Chem , vol.272 , Issue.30 , pp. 18650
    • Mynarcik, D.C.1    Williams, P.F.2    Schaffer, L.3    Yu, G.Q.4    Whittaker, J.5
  • 35
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich, A.; Gray, A.; Tam, A.W.; Yang-Feng, T.; Tsubokawa, M.; Collins, C.; Henzel, W.; Le Bon, T.; Kathuria, S.; Chen, E. Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. EMBO J., 1986, 5 (10), 2503.
    • (1986) EMBO J , vol.5 , Issue.10 , pp. 2503
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3    Yang-Feng, T.4    Tsubokawa, M.5    Collins, C.6    Henzel, W.7    Le Bon, T.8    Kathuria, S.9    Chen, E.10
  • 36
    • 0018650525 scopus 로고
    • Insulin-binding sites in the rat brain: In vivo localization to the circumventricular organs by quantitative radioautography
    • Houten, M.V.A.N.; Posner, B.I.; Kopriwa, B.M.; Brawer, J.R. Insulin-binding sites in the rat brain: in vivo localization to the circumventricular organs by quantitative radioautography. Endocrinology, 1979, 105 (3), 666.
    • (1979) Endocrinology , vol.105 , Issue.3 , pp. 666
    • Houten, M.V.A.N.1    Posner, B.I.2    Kopriwa, B.M.3    Brawer, J.R.4
  • 37
    • 0035941231 scopus 로고    scopus 로고
    • Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site
    • Whittaker, J.; Groth, A.V.; Mynarcik, D.C.; Pluzek, L.; Gadsbøll, V.L.; Whittaker, L.J. Alanine scanning mutagenesis of a type 1 insulin-like growth factor receptor ligand binding site. J. Biol. Chem., 2001, 276 (47), 43980-43986.
    • (2001) J. Biol. Chem , vol.276 , Issue.47 , pp. 43980-43986
    • Whittaker, J.1    Groth, A.V.2    Mynarcik, D.C.3    Pluzek, L.4    Gadsbøll, V.L.5    Whittaker, L.J.6
  • 38
    • 0035185571 scopus 로고    scopus 로고
    • Structure and autoregulation of the insulin-like growth factor 1 receptor kinase
    • Favelyukis, S.; Till, J.H.; Hubbard, S.R.; Miller, W.T. Structure and autoregulation of the insulin-like growth factor 1 receptor kinase. Nat. Struct. Mol. Biol., 2001, 8 (12), 1058-1063.
    • (2001) Nat. Struct. Mol. Biol , vol.8 , Issue.12 , pp. 1058-1063
    • Favelyukis, S.1    Till, J.H.2    Hubbard, S.R.3    Miller, W.T.4
  • 39
    • 0028214152 scopus 로고
    • Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function
    • Faria, T.N.; Blakesley, V.A.; Kato, H.; Stannard, B.; LeRoith, D.; Roberts, C. Role of the carboxyl-terminal domains of the insulin and insulin-like growth factor I receptors in receptor function. J. Biol. Chem., 1994, 269 (19), 13922.
    • (1994) J. Biol. Chem , vol.269 , Issue.19 , pp. 13922
    • Faria, T.N.1    Blakesley, V.A.2    Kato, H.3    Stannard, B.4    Leroith, D.5    Roberts, C.6
  • 41
    • 2942587068 scopus 로고    scopus 로고
    • Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds
    • Li, W.; Favelyukis, S.; Yang, J.; Zeng, Y.; Yu, J.; Gangjee, A.; Miller, W.T. Inhibition of insulin-like growth factor I receptor autophosphorylation by novel 6-5 ring-fused compounds. Biochem. Pharmacol., 2004, 68 (1), 145-154.
    • (2004) Biochem. Pharmacol , vol.68 , Issue.1 , pp. 145-154
    • Li, W.1    Favelyukis, S.2    Yang, J.3    Zeng, Y.4    Yu, J.5    Gangjee, A.6    Miller, W.T.7
  • 42
    • 0032470252 scopus 로고    scopus 로고
    • The insulin receptor--a critical link in glucose homeostasis and insulin action
    • Patti, M.E.; Kahn, C.R. The insulin receptor--a critical link in glucose homeostasis and insulin action. J. Basic Clin. Physiol. Pharmacol., 1998, 9 (2-4), 89.
    • (1998) J. Basic Clin. Physiol. Pharmacol , vol.9 , Issue.2-4 , pp. 89
    • Patti, M.E.1    Kahn, C.R.2
  • 43
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews, D.; Hosker, J.; Rudenski, A.; Naylor, B.; Treacher, D.; Turner, R. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia, 1985, 28 (7), 412-419.
    • (1985) Diabetologia , vol.28 , Issue.7 , pp. 412-419
    • Matthews, D.1    Hosker, J.2    Rudenski, A.3    Naylor, B.4    Treacher, D.5    Turner, R.6
  • 44
    • 22044434446 scopus 로고    scopus 로고
    • Role of insulin-like growth factor 1 receptor signalling in cancer
    • Larsson, O.; Girnita, A.; Girnita, L. Role of insulin-like growth factor 1 receptor signalling in cancer. Br. J. Cancer, 2005, 92 (12), 2097-2101.
    • (2005) Br. J. Cancer , vol.92 , Issue.12 , pp. 2097-2101
    • Larsson, O.1    Girnita, A.2    Girnita, L.3
  • 45
    • 84867420359 scopus 로고    scopus 로고
    • Insulin resistance and cancer: Epidemiological evidence
    • Inoue, M.; Tsugane, S. Insulin resistance and cancer: epidemiological evidence. Endocr. Relat. Cancer, 2012, 19 (5), F1-F8.
    • (2012) Endocr. Relat. Cancer , vol.19 , Issue.5
    • Inoue, M.1    Tsugane, S.2
  • 46
    • 34047174592 scopus 로고    scopus 로고
    • The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    • Belfiore, A. The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr. Pharm. Des., 2007, 13 (7), 671-686.
    • (2007) Curr. Pharm. Des , vol.13 , Issue.7 , pp. 671-686
    • Belfiore, A.1
  • 47
  • 48
    • 0029913170 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells
    • Steller, M.A.; Delgado, C.H.; Bartels, C.J.; Woodworth, C.D.; Zou, Z. Overexpression of the insulin-like growth factor-1 receptor and autocrine stimulation in human cervical cancer cells. Cancer Res., 1996, 56 (8), 1761.
    • (1996) Cancer Res , vol.56 , Issue.8 , pp. 1761
    • Steller, M.A.1    Delgado, C.H.2    Bartels, C.J.3    Woodworth, C.D.4    Zou, Z.5
  • 49
    • 77957241580 scopus 로고    scopus 로고
    • The proliferating role of insulin and insulin-like growth factors in cancer
    • Gallagher, E.J.; LeRoith, D. The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol. Metab., 2010, 21 (10), 610-618.
    • (2010) Trends Endocrinol. Metab , vol.21 , Issue.10 , pp. 610-618
    • Gallagher, E.J.1    Leroith, D.2
  • 51
    • 38849088141 scopus 로고    scopus 로고
    • The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer
    • Ryan, P.D.; Goss, P.E. The emerging role of the insulin-like growth factor pathway as a therapeutic target in cancer. Oncologist, 2008, 13 (1), 16-24.
    • (2008) Oncologist , vol.13 , Issue.1 , pp. 16-24
    • Ryan, P.D.1    Goss, P.E.2
  • 52
    • 84864006046 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor receptor pathway in lung cancer: Problems and pitfalls
    • Fidler, M.J.; Shersher, D.D.; Borgia, J.A.; Bonomi, P. Targeting the insulin-like growth factor receptor pathway in lung cancer: problems and pitfalls. Ther. Adv. Med. Oncol., 2012, 4 (2), 51-60.
    • (2012) Ther. Adv. Med. Oncol , vol.4 , Issue.2 , pp. 51-60
    • Fidler, M.J.1    Shersher, D.D.2    Borgia, J.A.3    Bonomi, P.4
  • 53
    • 79955991871 scopus 로고    scopus 로고
    • 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer
    • McKinley, E.T.; Bugaj, J.E.; Zhao, P.; Guleryuz, S.; Mantis, C.; Gokhale, P.C.; Wild, R.; Manning, H.C. 18FDG-PET predicts pharmacodynamic response to OSI-906, a dual IGF-1R/IR inhibitor, in preclinical mouse models of lung cancer. Clin. Cancer Res., 2011, 17 (10), 3332-3340.
    • (2011) Clin. Cancer Res , vol.17 , Issue.10 , pp. 3332-3340
    • McKinley, E.T.1    Bugaj, J.E.2    Zhao, P.3    Guleryuz, S.4    Mantis, C.5    Gokhale, P.C.6    Wild, R.7    Manning, H.C.8
  • 54
    • 0024550730 scopus 로고
    • Analysis of insulin-like growth factor I gene expression in malignancy: Evidence for a paracrine role in human breast cancer
    • Yee, D.; Paik, S.; Lebovic, G.S.; Marcus, R.R.; Favoni, R.E.; Cullen, K.J.; Lippman, M.E.; Rosen, N. Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer. Mol. Endocrinol., 1989, 3 (3), 509-517.
    • (1989) Mol. Endocrinol , vol.3 , Issue.3 , pp. 509-517
    • Yee, D.1    Paik, S.2    Lebovic, G.S.3    Marcus, R.R.4    Favoni, R.E.5    Cullen, K.J.6    Lippman, M.E.7    Rosen, N.8
  • 56
    • 0034788985 scopus 로고    scopus 로고
    • The IGF system and breast cancer
    • Sachdev, D.; Yee, D. The IGF system and breast cancer. Endocr. Relat. Cancer, 2001, 8 (3), 197-209.
    • (2001) Endocr. Relat. Cancer , vol.8 , Issue.3 , pp. 197-209
    • Sachdev, D.1    Yee, D.2
  • 57
    • 0033838566 scopus 로고    scopus 로고
    • Function of the IGF-I receptor in breast cancer
    • Surmacz, E. Function of the IGF-I receptor in breast cancer. J. Mammary Gland Biol. Neoplasia, 2000, 5 (1), 95-105.
    • (2000) J. Mammary Gland Biol. Neoplasia , vol.5 , Issue.1 , pp. 95-105
    • Surmacz, E.1
  • 63
    • 0029885705 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) system components in human prostatic cancer cell-lines: LNCaP, DU145, and PC-3 cells
    • Kimura, G.; Kasuya, J.; Giannini, S.; Honda, Y.; Mohan, S.; Kawachi, M.; Akimoto, M.; Fujita-Yamaguchi, Y. Insulin-like growth factor (IGF) system components in human prostatic cancer cell-lines: LNCaP, DU145, and PC-3 cells. Int. J. Urol., 1996, 3 (1), 39.
    • (1996) Int. J. Urol , vol.3 , Issue.1 , pp. 39
    • Kimura, G.1    Kasuya, J.2    Giannini, S.3    Honda, Y.4    Mohan, S.5    Kawachi, M.6    Akimoto, M.7    Fujita-Yamaguchi, Y.8
  • 65
    • 0030799934 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia
    • Mantzoros, C.; Tzonou, A.; Signorello, L.; Stampfer, M.; Trichopoulos, D.; Adami, H. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. Br. J. Cancer, 1997, 76 (9), 1115.
    • (1997) Br. J. Cancer , vol.76 , Issue.9 , pp. 1115
    • Mantzoros, C.1    Tzonou, A.2    Signorello, L.3    Stampfer, M.4    Trichopoulos, D.5    Adami, H.6
  • 67
    • 84862908410 scopus 로고    scopus 로고
    • Circulating Insulin-Like Growth Factors and IGF-Binding Proteins in PSA-Detected Prostate Cancer: The Large Case-Control Study Protect
    • Rowlands, M.A.; Holly, J.M.P.; Gunnell, D.; Donovan, J.; Lane, J.A.; Hamdy, F.; Neal, D.E.; Oliver, S.; Smith, G.D.; Martin, R.M. Circulating Insulin-Like Growth Factors and IGF-Binding Proteins in PSA-Detected Prostate Cancer: The Large Case-Control Study Protect. Cancer Res., 2012, 72 (2), 503-515.
    • (2012) Cancer Res , vol.72 , Issue.2 , pp. 503-515
    • Rowlands, M.A.1    Holly, J.M.P.2    Gunnell, D.3    Donovan, J.4    Lane, J.A.5    Hamdy, F.6    Neal, D.E.7    Oliver, S.8    Smith, G.D.9    Martin, R.M.10
  • 68
    • 84860391606 scopus 로고    scopus 로고
    • Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: A review
    • Ozkan, E.E. Plasma and tissue insulin-like growth factor-I receptor (IGF-IR) as a prognostic marker for prostate cancer and anti-IGF-IR agents as novel therapeutic strategy for refractory cases: a review. Mol. Cell. Endocrinol., 2011, 344 (1), 1-24.
    • (2011) Mol. Cell. Endocrinol , vol.344 , Issue.1 , pp. 1-24
    • Ozkan, E.E.1
  • 69
    • 84864353160 scopus 로고    scopus 로고
    • Treatment of liver metastases in patients with neuroendocrine tumors of gastroesophageal and pancreatic origin
    • Gu, P.; Wu, J.; Newman, E.; Muggia, F. Treatment of liver metastases in patients with neuroendocrine tumors of gastroesophageal and pancreatic origin. Int. J. Heptol., 2012, 2012.
    • (2012) Int. J. Heptol , pp. 2012
    • Gu, P.1    Wu, J.2    Newman, E.3    Muggia, F.4
  • 70
    • 81055124254 scopus 로고    scopus 로고
    • Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells
    • Jameson, M.J.; Beckler, A.D.; Taniguchi, L.E.; Allak, A.; VanWagner, L.B.; Lee, N.G.; Thomsen, W.C.; Hubbard, M.A.; Thomas, C.Y. Activation of the insulin-like growth factor-1 receptor induces resistance to epidermal growth factor receptor antagonism in head and neck squamous carcinoma cells. Mol. Cancer Ther., 2011, 10 (11), 2124-2134.
    • (2011) Mol. Cancer Ther , vol.10 , Issue.11 , pp. 2124-2134
    • Jameson, M.J.1    Beckler, A.D.2    Taniguchi, L.E.3    Allak, A.4    Vanwagner, L.B.5    Lee, N.G.6    Thomsen, W.C.7    Hubbard, M.A.8    Thomas, C.Y.9
  • 71
    • 78650625659 scopus 로고    scopus 로고
    • A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers
    • Adachi, Y.; Yamamoto, H.; Ohashi, H.; Endo, T.; Carbone, D.P.; Imai, K.; Shinomura, Y. A candidate targeting molecule of insulin-like growth factor-I receptor for gastrointestinal cancers. World J. Gastroentero., 2010, 16 (46), 5779.
    • (2010) World J. Gastroentero , vol.16 , Issue.46 , pp. 5779
    • Adachi, Y.1    Yamamoto, H.2    Ohashi, H.3    Endo, T.4    Carbone, D.P.5    Imai, K.6    Shinomura, Y.7
  • 72
    • 79956337832 scopus 로고    scopus 로고
    • Targeting the insulin growth factor pathway in gastrointestinal cancers
    • Golan, T.; Javle, M. Targeting the insulin growth factor pathway in gastrointestinal cancers. Oncology, 2011, 25 (6).
    • (2011) Oncology , vol.25 , Issue.6
    • Golan, T.1    Javle, M.2
  • 73
    • 0026504138 scopus 로고
    • Characterization of insulinlike growth factor I receptors in human colon cancer
    • Guo, Y.; Narayan, S.; Yallampalli, C.; Singh, P. Characterization of insulinlike growth factor I receptors in human colon cancer. Gastroenterology, 1992, 102 (4 Pt 1), 1101.
    • (1992) Gastroenterology , vol.102 , Issue.4 Pt 1 , pp. 1101
    • Guo, Y.1    Narayan, S.2    Yallampalli, C.3    Singh, P.4
  • 74
    • 0027327503 scopus 로고
    • Insulinlike growth factors and binding proteins in colon cancer
    • Singh, P.; Rubin, N. Insulinlike growth factors and binding proteins in colon cancer. Gastroenterology, 1993, 105 (4), 1218.
    • (1993) Gastroenterology , vol.105 , Issue.4 , pp. 1218
    • Singh, P.1    Rubin, N.2
  • 75
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu, Y.; Yakar, S.; Zhao, L.; Hennighausen, L.; LeRoith, D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res., 2002, 62 (4), 1030.
    • (2002) Cancer Res , vol.62 , Issue.4 , pp. 1030
    • Wu, Y.1    Yakar, S.2    Zhao, L.3    Hennighausen, L.4    Leroith, D.5
  • 76
    • 78349254271 scopus 로고    scopus 로고
    • The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models
    • Flanigan, S.A.; Pitts, T.M.; Eckhardt, S.G.; Tentler, J.J.; Tan, A.C.; Thorburn, A.; Leong, S. The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models. Clin. Cancer Res., 2010, 16 (22), 5436-5446.
    • (2010) Clin. Cancer Res , vol.16 , Issue.22 , pp. 5436-5446
    • Flanigan, S.A.1    Pitts, T.M.2    Eckhardt, S.G.3    Tentler, J.J.4    Tan, A.C.5    Thorburn, A.6    Leong, S.7
  • 78
    • 0035160628 scopus 로고    scopus 로고
    • Insulin, insulin-like growth factors and colon cancer: A review of the evidence
    • Giovannucci, E. Insulin, insulin-like growth factors and colon cancer: a review of the evidence. J. Nutr., 2001, 131 (11), 3109S-3120S.
    • (2001) J. Nutr , vol.131 , Issue.11
    • Giovannucci, E.1
  • 79
    • 0346725866 scopus 로고    scopus 로고
    • The role of the IGF axis in hepatocarcinogenesis
    • Scharf, J.; Braulke, T. The role of the IGF axis in hepatocarcinogenesis. Horm. Metab. Res., 2003, 35 (11-12), 685-693.
    • (2003) Horm. Metab. Res , vol.35 , Issue.11-12 , pp. 685-693
    • Scharf, J.1    Braulke, T.2
  • 81
    • 79959848106 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor axis in hepatocellular carcinoma
    • Wu, J.; Zhu, A.X. Targeting insulin-like growth factor axis in hepatocellular carcinoma. J. Hematol. Oncol., 2011, 4 (1), 1-11.
    • (2011) J. Hematol. Oncol , vol.4 , Issue.1 , pp. 1-11
    • Wu, J.1    Zhu, A.X.2
  • 82
    • 84877812001 scopus 로고    scopus 로고
    • Predictive Biomarkers to Therapy, do they Exist in Hepatocellular Carcinoma
    • Wu, J. Predictive Biomarkers to Therapy, do they Exist in Hepatocellular Carcinoma. Chemotherapy, 2012, 1, e104.
    • (2012) Chemotherapy , vol.1
    • Wu, J.1
  • 83
    • 80053974116 scopus 로고    scopus 로고
    • Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma
    • Kaseb, A.O.; Morris, J.S.; Hassan, M.M.; Siddiqui, A.M.; Lin, E.; Xiao, L.; Abdalla, E.K.; Vauthey, J.N.; Aloia, T.A.; Krishnan, S. Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. J. Clin. Oncol., 2011, 29 (29), 3892-3899.
    • (2011) J. Clin. Oncol , vol.29 , Issue.29 , pp. 3892-3899
    • Kaseb, A.O.1    Morris, J.S.2    Hassan, M.M.3    Siddiqui, A.M.4    Lin, E.5    Xiao, L.6    Abdalla, E.K.7    Vauthey, J.N.8    Aloia, T.A.9    Krishnan, S.10
  • 84
    • 79960084386 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and the liver
    • Bonefeld, K.; Møller, S. Insulin-like growth factor-I and the liver. Liver Int., 2011, 31 (7), 911-919.
    • (2011) Liver Int , vol.31 , Issue.7 , pp. 911-919
    • Bonefeld, K.1    Møller, S.2
  • 85
    • 0031934765 scopus 로고    scopus 로고
    • Role of growth factors in pancreatic cancer
    • Korc, M. Role of growth factors in pancreatic cancer. Surg. Oncol. Clin. N. Am., 1998, 7 (1), 25.
    • (1998) Surg. Oncol. Clin. N. Am , vol.7 , Issue.1 , pp. 25
    • Korc, M.1
  • 86
    • 0028997487 scopus 로고    scopus 로고
    • Insulin-like growth factor I overexpression in human pancreatic cancer: Evidence for autocrine and paracrine roles
    • Bergmann, U.; Funatomi, H.; Yokoyama, M.; Beger, H.G.; Korc, M. Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles. Cancer Res., 1995, 55 (10), 2007.
    • (2007) Cancer Res , vol.55 , Issue.10 , pp. 1995
    • Bergmann, U.1    Funatomi, H.2    Yokoyama, M.3    Beger, H.G.4    Korc, M.5
  • 87
    • 84858793843 scopus 로고    scopus 로고
    • Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer
    • Dong, X.; Li, Y.; Tang, H.; Chang, P.; Hess, K.R.; Abbruzzese, J.L.; Li, D. Insulin-like growth factor axis gene polymorphisms modify risk of pancreatic cancer. Cancer Epidemiol., 2012, 36 (2), 206-211.
    • (2012) Cancer Epidemiol , vol.36 , Issue.2 , pp. 206-211
    • Dong, X.1    Li, Y.2    Tang, H.3    Chang, P.4    Hess, K.R.5    Abbruzzese, J.L.6    Li, D.7
  • 88
    • 79954614279 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor network in cancer therapy
    • Heidegger, I.; Pircher, A.; Klocker, H.; Massoner, P. Targeting the insulin-like growth factor network in cancer therapy. Cancer Biol. Ther., 2011, 11 (8), 701-707.
    • (2011) Cancer Biol. Ther , vol.11 , Issue.8 , pp. 701-707
    • Heidegger, I.1    Pircher, A.2    Klocker, H.3    Massoner, P.4
  • 89
    • 79951860072 scopus 로고    scopus 로고
    • Small is beautiful: Insulin-like growth factors and their role in growth, development, and cancer
    • Maki, R.G. Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J. Clin. Oncol., 2010, 28 (33), 4985-4995.
    • (2010) J. Clin. Oncol , vol.28 , Issue.33 , pp. 4985-4995
    • Maki, R.G.1
  • 90
    • 79960284689 scopus 로고    scopus 로고
    • Levels of insulin-like growth factor during pregnancy and maternal cancer risk: A nested case-control study
    • Jeffreys, M.; Northstone, K.; Holly, J.; Emmett, P.; Gunnell, D. Levels of insulin-like growth factor during pregnancy and maternal cancer risk: a nested case-control study. Cancer Causes Control, 2011, 22 (7), 945-953.
    • (2011) Cancer Causes Control , vol.22 , Issue.7 , pp. 945-953
    • Jeffreys, M.1    Northstone, K.2    Holly, J.3    Emmett, P.4    Gunnell, D.5
  • 91
    • 84855885822 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy
    • Tognon, C.E.; Sorensen, P.H.B. Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opin. Ther. Targets, 2012, 16 (1), 33-48.
    • (2012) Expert Opin. Ther. Targets , vol.16 , Issue.1 , pp. 33-48
    • Tognon, C.E.1    Sorensen, P.H.B.2
  • 92
    • 55849095485 scopus 로고    scopus 로고
    • Role of ubiquitination in IGF-1 receptor signaling and degradation
    • Sehat, B.; Andersson, S.; Vasilcanu, R.; Girnita, L.; Larsson, O. Role of ubiquitination in IGF-1 receptor signaling and degradation. PLoS ONE, 2007, 2 (4), e340.
    • (2007) PLoS ONE , vol.2 , Issue.4
    • Sehat, B.1    Andersson, S.2    Vasilcanu, R.3    Girnita, L.4    Larsson, O.5
  • 95
    • 0031918624 scopus 로고    scopus 로고
    • The IRS-signalling system: A network of docking proteins that mediate insulin action
    • White, M.F. The IRS-signalling system: a network of docking proteins that mediate insulin action. Mol. Cell. Biochem., 1998, 182 (1), 3-11.
    • (1998) Mol. Cell. Biochem , vol.182 , Issue.1 , pp. 3-11
    • White, M.F.1
  • 96
    • 0027312272 scopus 로고
    • Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling
    • Li, N.; Batzer, A.; Daly, R.; Yajnik, V.; Skolnik, E.; Chardin, P.; Bar-Sagi, D.; Margolis, B.; Schlessinger, J. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature, 1993, 363 (6424), 85-88.
    • (1993) Nature , vol.363 , Issue.6424 , pp. 85-88
    • Li, N.1    Batzer, A.2    Daly, R.3    Yajnik, V.4    Skolnik, E.5    Chardin, P.6    Bar-Sagi, D.7    Margolis, B.8    Schlessinger, J.9
  • 97
    • 0028123457 scopus 로고
    • A new function for a phosphotyrosine phosphatase: Linking GRB2-Sos to a receptor tyrosine kinase
    • Li, W.; Nishimura, R.; Kashishian, A.; Batzer, A.G.; Kim, W.; Cooper, J.A.; Schlessinger, J. A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase. Mol. Cell. Biol., 1994, 14 (1), 509-517.
    • (1994) Mol. Cell. Biol , vol.14 , Issue.1 , pp. 509-517
    • Li, W.1    Nishimura, R.2    Kashishian, A.3    Batzer, A.G.4    Kim, W.5    Cooper, J.A.6    Schlessinger, J.7
  • 98
    • 0029763774 scopus 로고    scopus 로고
    • Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases
    • Rao, G.N. Hydrogen peroxide induces complex formation of SHC-Grb2-SOS with receptor tyrosine kinase and activates Ras and extracellular signal-regulated protein kinases group of mitogen-activated protein kinases. Oncogene, 1996, 13 (4), 713.
    • (1996) Oncogene , vol.13 , Issue.4 , pp. 713
    • Rao, G.N.1
  • 99
    • 0027250250 scopus 로고
    • Mammalian Ras interacts directly with the serine/threonine kinase Raf
    • Vojtek, A.B.; Hollenberg, S.M.; Cooper, J.A. Mammalian Ras interacts directly with the serine/threonine kinase Raf. Cell, 1993, 74 (1), 205-214.
    • (1993) Cell , vol.74 , Issue.1 , pp. 205-214
    • Vojtek, A.B.1    Hollenberg, S.M.2    Cooper, J.A.3
  • 100
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch, W. Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem. J., 2000, 351 (Pt 2), 289.
    • (2000) Biochem. J , vol.351 , Issue.Pt 2 , pp. 289
    • Kolch, W.1
  • 101
    • 0027337519 scopus 로고
    • Complexes of Ras. GTP with Raf-1 and mitogen-activated protein kinase kinase
    • Moodie, S.A.; Willumsen, B.M.; Weber, M.J.; Wolfman, A. Complexes of Ras. GTP with Raf-1 and mitogen-activated protein kinase kinase. Science, 1993, 260 (5114), 1658-1661.
    • (1993) Science , vol.260 , Issue.5114 , pp. 1658-1661
    • Moodie, S.A.1    Willumsen, B.M.2    Weber, M.J.3    Wolfman, A.4
  • 102
    • 33746565515 scopus 로고    scopus 로고
    • Role of Raf kinase in cancer: Therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway
    • Gollob, J.A.; Wilhelm, S.; Carter, C.; Kelley, S.L. Role of Raf kinase in cancer: therapeutic potential of targeting the Raf/MEK/ERK signal transduction pathway. Semin. Oncol., 2006, 33 (4), 392-406.
    • (2006) Semin. Oncol , vol.33 , Issue.4 , pp. 392-406
    • Gollob, J.A.1    Wilhelm, S.2    Carter, C.3    Kelley, S.L.4
  • 103
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • Lange-Carter, C.A.; Pleiman, C.M.; Gardner, A.M.; Blumer, K.J.; Johnson, G.L. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 1993, 260 (5106), 315-319.
    • (1993) Science , vol.260 , Issue.5106 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blumer, K.J.4    Johnson, G.L.5
  • 104
    • 10944260245 scopus 로고    scopus 로고
    • Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1
    • Mawson, A.; Lai, A.; Carroll, J.S.; Sergio, C.M.; Mitchell, C.J.; Sarcevic, B. Estrogen and insulin/IGF-1 cooperatively stimulate cell cycle progression in MCF-7 breast cancer cells through differential regulation of c-Myc and cyclin D1. Mol. Cell. Endocrinol., 2005, 229 (1-2), 161-173.
    • (2005) Mol. Cell. Endocrinol , vol.229 , Issue.1-2 , pp. 161-173
    • Mawson, A.1    Lai, A.2    Carroll, J.S.3    Sergio, C.M.4    Mitchell, C.J.5    Sarcevic, B.6
  • 106
    • 33745886839 scopus 로고    scopus 로고
    • Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21 WAF1/CIP1
    • Chen, C.; Chang, Y.C.; Liu, C.L.; Chang, K.J.; Guo, I.C. Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21 WAF1/CIP1. Breast Cancer Res. Treat., 2006, 98 (2), 121-132.
    • (2006) Breast Cancer Res. Treat , vol.98 , Issue.2 , pp. 121-132
    • Chen, C.1    Chang, Y.C.2    Liu, C.L.3    Chang, K.J.4    Guo, I.C.5
  • 107
    • 21244471120 scopus 로고    scopus 로고
    • Sustained Akt/PKB activation and transient attenuation of c-jun N-terminal kinase in the inhibition of apoptosis by IGF-1 in vascular smooth muscle cells
    • Allen, R.; Krueger, K.; Dhume, A.; Agrawal, D. Sustained Akt/PKB activation and transient attenuation of c-jun N-terminal kinase in the inhibition of apoptosis by IGF-1 in vascular smooth muscle cells. Apoptosis, 2005, 10 (3), 525-535.
    • (2005) Apoptosis , vol.10 , Issue.3 , pp. 525-535
    • Allen, R.1    Krueger, K.2    Dhume, A.3    Agrawal, D.4
  • 109
    • 0037098951 scopus 로고    scopus 로고
    • PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway
    • Weng, L.P.; Brown, J.L.; Baker, K.M.; Ostrowski, M.C.; Eng, C. PTEN blocks insulin-mediated ETS-2 phosphorylation through MAP kinase, independently of the phosphoinositide 3-kinase pathway. Hum. Mol. Genet., 2002, 11 (15), 1687-1696.
    • (2002) Hum. Mol. Genet , vol.11 , Issue.15 , pp. 1687-1696
    • Weng, L.P.1    Brown, J.L.2    Baker, K.M.3    Ostrowski, M.C.4    Eng, C.5
  • 110
    • 0033035897 scopus 로고    scopus 로고
    • ERK Pathway Mediates the Activation of Cdk2 in IGF-1-Induced Proliferation of Human Osteosarcoma MG-63 Cells
    • Zhang, W.; Lee, J.C.; Kumar, S.; Gowen, M. ERK Pathway Mediates the Activation of Cdk2 in IGF-1-Induced Proliferation of Human Osteosarcoma MG-63 Cells. J. Bone Miner. Res., 1999, 14 (4), 528-535.
    • (1999) J. Bone Miner. Res , vol.14 , Issue.4 , pp. 528-535
    • Zhang, W.1    Lee, J.C.2    Kumar, S.3    Gowen, M.4
  • 111
    • 0033614021 scopus 로고    scopus 로고
    • Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells
    • Pugazhenthi, S.; Boras, T.; O'Connor, D.; Meintzer, M.K.; Heidenreich, K.A.; Reusch, J.E.B. Insulin-like growth factor I-mediated activation of the transcription factor cAMP response element-binding protein in PC12 cells. J. Biol. Chem., 1999, 274 (5), 2829-2837.
    • (1999) J. Biol. Chem , vol.274 , Issue.5 , pp. 2829-2837
    • Pugazhenthi, S.1    Boras, T.2    O'Connor, D.3    Meintzer, M.K.4    Heidenreich, K.A.5    Reusch, J.E.B.6
  • 112
    • 0036669037 scopus 로고    scopus 로고
    • Control of cell survival by IGF signaling pathways
    • Vincent, A.M.; Feldman, E.L. Control of cell survival by IGF signaling pathways. Growth Horm. IGF Res., 2002, 12 (4), 193-197.
    • (2002) Growth Horm. IGF Res , vol.12 , Issue.4 , pp. 193-197
    • Vincent, A.M.1    Feldman, E.L.2
  • 113
    • 0035940387 scopus 로고    scopus 로고
    • In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein
    • Mehrhof, F.B.; Müller, F.U.; Bergmann, M.W.; Li, P.; Wang, Y.; Schmitz, W.; Dietz, R.; von Harsdorf, R. In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein. Circulation, 2001, 104 (17), 2088-2094.
    • (2001) Circulation , vol.104 , Issue.17 , pp. 2088-2094
    • Mehrhof, F.B.1    Müller, F.U.2    Bergmann, M.W.3    Li, P.4    Wang, Y.5    Schmitz, W.6    Dietz, R.7    von Harsdorf, R.8
  • 114
    • 57049094383 scopus 로고    scopus 로고
    • Activation of adenosine A1 receptor-induced neural stem cell proliferation via MEK/ERK and Akt signaling pathways
    • Migita, H.; Kominami, K.; Higashida, M.; Maruyama, R.; Tuchida, N.; McDonald, F.; Shimada, F.; Sakurada, K. Activation of adenosine A1 receptor-induced neural stem cell proliferation via MEK/ERK and Akt signaling pathways. J. Neurosci. Res., 2008, 86 (13), 2820-2828.
    • (2008) J. Neurosci. Res , vol.86 , Issue.13 , pp. 2820-2828
    • Migita, H.1    Kominami, K.2    Higashida, M.3    Maruyama, R.4    Tuchida, N.5    McDonald, F.6    Shimada, F.7    Sakurada, K.8
  • 115
    • 34547817154 scopus 로고    scopus 로고
    • A new paradigm for protein kinase inhibition: Blocking phosphorylation without directly targeting ATP binding
    • Bogoyevitch, M.A.; Fairlie, D.P. A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding. Drug Discov. Today, 2007, 12 (15-16), 622-633.
    • (2007) Drug Discov. Today , vol.12 , Issue.15-16 , pp. 622-633
    • Bogoyevitch, M.A.1    Fairlie, D.P.2
  • 116
    • 33749319933 scopus 로고    scopus 로고
    • Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells
    • Lee, H.C.; Tian, B.; Sedivy, J.M.; Wands, J.R.; Kim, M. Loss of Raf kinase inhibitor protein promotes cell proliferation and migration of human hepatoma cells. Gastroenterology, 2006, 131 (4), 1208-1217.
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1208-1217
    • Lee, H.C.1    Tian, B.2    Sedivy, J.M.3    Wands, J.R.4    Kim, M.5
  • 118
    • 0034954277 scopus 로고    scopus 로고
    • X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis
    • Diao, J.; Garces, R.; Richardson, C.D. X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction pathways during the course of viral infections and hepatocarcinogenesis. Cytokine Growth Factor Rev., 2001, 12 (2), 189-205.
    • (2001) Cytokine Growth Factor Rev , vol.12 , Issue.2 , pp. 189-205
    • Diao, J.1    Garces, R.2    Richardson, C.D.3
  • 119
    • 3843138659 scopus 로고    scopus 로고
    • B-Raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells
    • Shelton, J.G.; Chang, F.; Lee, J.T.; Franklin, R.A.; Steelman, L.S.; McCubrey, J.A. B-Raf and insulin synergistically prevent apoptosis and induce cell cycle progression in hematopoietic cells. Cell cycle, 2004, 3 (2), 189-196.
    • (2004) Cell Cycle , vol.3 , Issue.2 , pp. 189-196
    • Shelton, J.G.1    Chang, F.2    Lee, J.T.3    Franklin, R.A.4    Steelman, L.S.5    McCubrey, J.A.6
  • 120
    • 0037810249 scopus 로고    scopus 로고
    • Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention
    • Chang, F.; Steelman, L.; Lee, J.; Shelton, J.; Navolanic, P.; Blalock, W.; Franklin, R.; McCubrey, J. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention. Leukemia, 2003, 17 (7), 1263-1293.
    • (2003) Leukemia , vol.17 , Issue.7 , pp. 1263-1293
    • Chang, F.1    Steelman, L.2    Lee, J.3    Shelton, J.4    Navolanic, P.5    Blalock, W.6    Franklin, R.7    McCubrey, J.8
  • 121
    • 0029808748 scopus 로고    scopus 로고
    • Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
    • Whitmarsh, A.; Davis, R. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J. Mol. Med., 1996, 74 (10), 589-607.
    • (1996) J. Mol. Med , vol.74 , Issue.10 , pp. 589-607
    • Whitmarsh, A.1    Davis, R.2
  • 122
    • 0347997608 scopus 로고    scopus 로고
    • MAPK signal pathways in the regulation of cell proliferation in mammalian cells
    • Zhang, W.; Liu, H.T. MAPK signal pathways in the regulation of cell proliferation in mammalian cells. Cell Res., 2002, 12 (1), 9-18.
    • (2002) Cell Res , vol.12 , Issue.1 , pp. 9-18
    • Zhang, W.1    Liu, H.T.2
  • 123
    • 34248572839 scopus 로고    scopus 로고
    • MAP kinases and the control of nuclear events
    • Turjanski, A.; Vaque, J.; Gutkind, J. MAP kinases and the control of nuclear events. Oncogene, 2007, 26 (22), 3240-3253.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3240-3253
    • Turjanski, A.1    Vaque, J.2    Gutkind, J.3
  • 124
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • Acehan, D.; Jiang, X.; Morgan, D.G.; Heuser, J.E.; Wang, X.; Akey, C.W. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell, 2002, 9 (2), 423-432.
    • (2002) Mol. Cell , vol.9 , Issue.2 , pp. 423-432
    • Acehan, D.1    Jiang, X.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.5    Akey, C.W.6
  • 125
    • 0035798361 scopus 로고    scopus 로고
    • Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding
    • Chai, J.; Wu, Q.; Shiozaki, E.; Srinivasula, S.M.; Alnemri, E.S.; Shi, Y. Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell, 2001, 107 (3), 399-407.
    • (2001) Cell , vol.107 , Issue.3 , pp. 399-407
    • Chai, J.1    Wu, Q.2    Shiozaki, E.3    Srinivasula, S.M.4    Alnemri, E.S.5    Shi, Y.6
  • 128
    • 0037058964 scopus 로고    scopus 로고
    • Structure and zymogen activation of caspases
    • Donepudi, M.; Grütter, M.G. Structure and zymogen activation of caspases. Biophys. Chem., 2002, 101, 145-153.
    • (2002) Biophys. Chem , vol.101 , pp. 145-153
    • Donepudi, M.1    Grütter, M.G.2
  • 129
    • 0038726089 scopus 로고    scopus 로고
    • Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
    • Allan, L.A.; Morrice, N.; Brady, S.; Magee, G.; Pathak, S.; Clarke, P.R. Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat. Cell Biol., 2003, 5 (7), 647-654.
    • (2003) Nat. Cell Biol , vol.5 , Issue.7 , pp. 647-654
    • Allan, L.A.1    Morrice, N.2    Brady, S.3    Magee, G.4    Pathak, S.5    Clarke, P.R.6
  • 131
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • Schubbert, S.; Shannon, K.; Bollag, G. Hyperactive Ras in developmental disorders and cancer. Nat. Rev. Cancer, 2007, 7 (4), 295-308.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.4 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 133
    • 13844273087 scopus 로고    scopus 로고
    • PI3K-Akt pathway: Its functions and alterations in human cancer
    • Osaki, M.; Oshimura, M.; Ito, H. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis, 2004, 9 (6), 667-676.
    • (2004) Apoptosis , vol.9 , Issue.6 , pp. 667-676
    • Osaki, M.1    Oshimura, M.2    Ito, H.3
  • 134
    • 0031887249 scopus 로고    scopus 로고
    • Regulation of the p85/p110 phosphatidylinositol 3'-kinase: Stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit
    • Yu, J.; Zhang, Y.; McIlroy, J.; Rordorf-Nikolic, T.; Orr, G.A.; Backer, J.M. Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110α catalytic subunit by the p85 regulatory subunit. Mol. Cell. Biol., 1998, 18 (3), 1379-1387.
    • (1998) Mol. Cell. Biol , vol.18 , Issue.3 , pp. 1379-1387
    • Yu, J.1    Zhang, Y.2    McIlroy, J.3    Rordorf-Nikolic, T.4    Orr, G.A.5    Backer, J.M.6
  • 135
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco, I.; Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nat. Rev. Cancer, 2002, 2 (7), 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 136
    • 0027191192 scopus 로고
    • Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase
    • Booker, G.W.; Gout, I.; Downing, A.; Driscoll, P.C.; Boyd, J.; Waterfield, M.D.; Campbell, I.D. Solution structure and ligand-binding site of the SH3 domain of the p85 alpha subunit of phosphatidylinositol 3-kinase. Cell, 1993, 73 (4), 813.
    • (1993) Cell , vol.73 , Issue.4 , pp. 813
    • Booker, G.W.1    Gout, I.2    Downing, A.3    Driscoll, P.C.4    Boyd, J.5    Waterfield, M.D.6    Campbell, I.D.7
  • 137
    • 0028120902 scopus 로고
    • Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits
    • Holt, K.H.; Olson, L.; Moye-Rowley, W.S.; Pessin, J.E. Phosphatidylinositol 3-kinase activation is mediated by high-affinity interactions between distinct domains within the p110 and p85 subunits. Mol. Cell. Biol., 1994, 14 (1), 42-49.
    • (1994) Mol. Cell. Biol , vol.14 , Issue.1 , pp. 42-49
    • Holt, K.H.1    Olson, L.2    Moye-Rowley, W.S.3    Pessin, J.E.4
  • 138
    • 0033952239 scopus 로고    scopus 로고
    • The PI 3-kinase isoforms p110 (alpha) and p110 (beta) have differential roles in PDGF-and insulin-mediated signaling
    • Hooshmand-Rad, R.; Hájková, L.; Klint, P.; Karlsson, R.; Vanhaesebroeck, B.; Claesson-Welsh, L.; Heldin, C.H. The PI 3-kinase isoforms p110 (alpha) and p110 (beta) have differential roles in PDGF-and insulin-mediated signaling. J. Cell Sci., 2000, 113 (2), 207-214.
    • (2000) J. Cell Sci , vol.113 , Issue.2 , pp. 207-214
    • Hooshmand-Rad, R.1    Hájková, L.2    Klint, P.3    Karlsson, R.4    Vanhaesebroeck, B.5    Claesson-Welsh, L.6    Heldin, C.H.7
  • 139
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: More than just a road to PKB
    • Vanhaesebroeck, B.; Alessi, D.R. The PI3K-PDK1 connection: more than just a road to PKB. Biochem. J., 2000, 346 (Pt 3), 561.
    • (2000) Biochem. J , vol.346 , Issue.Pt 3 , pp. 561
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 140
    • 0035020950 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signalling pathways
    • Cantrell, D.A. Phosphoinositide 3-kinase signalling pathways. J. Cell Sci., 2001, 114 (8), 1439-1445.
    • (2001) J. Cell Sci , vol.114 , Issue.8 , pp. 1439-1445
    • Cantrell, D.A.1
  • 141
    • 0032443803 scopus 로고    scopus 로고
    • The akt kinase: Molecular determinants of oncogenicity
    • Aoki, M.; Batista, O.; Bellacosa, A.; Tsichlis, P.; Vogt, P.K. The akt kinase: molecular determinants of oncogenicity. PNAS, 1998, 95 (25), 14950.
    • (1998) PNAS , vol.95 , Issue.25 , pp. 14950
    • Aoki, M.1    Batista, O.2    Bellacosa, A.3    Tsichlis, P.4    Vogt, P.K.5
  • 142
    • 0032053709 scopus 로고    scopus 로고
    • Mechanisms and consequences of activation of protein kinase B/Akt
    • Downward, J. Mechanisms and consequences of activation of protein kinase B/Akt. Curr. Opin. Cell Biol., 1998, 10 (2), 262-267.
    • (1998) Curr. Opin. Cell Biol , vol.10 , Issue.2 , pp. 262-267
    • Downward, J.1
  • 143
    • 0033604585 scopus 로고    scopus 로고
    • The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB
    • Kandel, E.S.; Hay, N. The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res., 1999, 253 (1), 210-229.
    • (1999) Exp. Cell Res , vol.253 , Issue.1 , pp. 210-229
    • Kandel, E.S.1    Hay, N.2
  • 144
    • 10744228945 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-xL pathway
    • Sekharam, M.; Zhao, H.; Sun, M.; Fang, Q.; Zhang, Q.; Yuan, Z.; Dan, H.C.; Boulware, D.; Cheng, J.Q.; Coppola, D. Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-xL pathway. Cancer Res., 2003, 63 (22), 7708.
    • (2003) Cancer Res , vol.63 , Issue.22 , pp. 7708
    • Sekharam, M.1    Zhao, H.2    Sun, M.3    Fang, Q.4    Zhang, Q.5    Yuan, Z.6    Dan, H.C.7    Boulware, D.8    Cheng, J.Q.9    Coppola, D.10
  • 145
    • 0035853833 scopus 로고    scopus 로고
    • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology
    • Plas, D.R.; Talapatra, S.; Edinger, A.L.; Rathmell, J.C.; Thompson, C.B. Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem., 2001, 276 (15), 12041-12048.
    • (2001) J. Biol. Chem , vol.276 , Issue.15 , pp. 12041-12048
    • Plas, D.R.1    Talapatra, S.2    Edinger, A.L.3    Rathmell, J.C.4    Thompson, C.B.5
  • 146
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta, S.R.; Dudek, H.; Tao, X.; Masters, S.; Fu, H.; Gotoh, Y.; Greenberg, M.E. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell, 1997, 91 (2), 231-242.
    • (1997) Cell , vol.91 , Issue.2 , pp. 231-242
    • Datta, S.R.1    Dudek, H.2    Tao, X.3    Masters, S.4    Fu, H.5    Gotoh, Y.6    Greenberg, M.E.7
  • 147
    • 0033635235 scopus 로고    scopus 로고
    • 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
    • Datta, S.R.; Katsov, A.; Hu, L.; Petros, A.; Fesik, S.W.; Yaffe, M.B.; Greenberg, M.E. 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol. Cell, 2000, 6 (1), 41-51.
    • (2000) Mol. Cell , vol.6 , Issue.1 , pp. 41-51
    • Datta, S.R.1    Katsov, A.2    Hu, L.3    Petros, A.4    Fesik, S.W.5    Yaffe, M.B.6    Greenberg, M.E.7
  • 148
    • 0034682812 scopus 로고    scopus 로고
    • BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival
    • Tan, Y.; Demeter, M.R.; Ruan, H.; Comb, M.J. BAD Ser-155 phosphorylation regulates BAD/Bcl-XL interaction and cell survival. J. Biol. Chem., 2000, 275 (33), 25865-25869.
    • (2000) J. Biol. Chem , vol.275 , Issue.33 , pp. 25865-25869
    • Tan, Y.1    Demeter, M.R.2    Ruan, H.3    Comb, M.J.4
  • 149
    • 0035843148 scopus 로고    scopus 로고
    • Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation
    • Desbois-Mouthon, C.; Cadoret, A.; Blivet-Van Eggelpoël, M.J.; Bertrand, F.; Cherqui, G.; Perret, C.; Capeau, J. Insulin and IGF-1 stimulate the beta-catenin pathway through two signalling cascades involving GSK-3beta inhibition and Ras activation. Oncogene, 2001, 20 (2), 252.
    • (2001) Oncogene , vol.20 , Issue.2 , pp. 252
    • Desbois-Mouthon, C.1    Cadoret, A.2    Blivet-Van Eggelpoël, M.J.3    Bertrand, F.4    Cherqui, G.5    Perret, C.6    Capeau, J.7
  • 150
    • 0037383322 scopus 로고    scopus 로고
    • GSK-3: Tricks of the trade for a multi-tasking kinase
    • Doble, B.W.; Woodgett, J.R. GSK-3: tricks of the trade for a multi-tasking kinase. J. Cell Sci., 2003, 116 (7), 1175-1186.
    • (2003) J. Cell Sci , vol.116 , Issue.7 , pp. 1175-1186
    • Doble, B.W.1    Woodgett, J.R.2
  • 151
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay, N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell, 2005, 8 (3), 179-183.
    • (2005) Cancer Cell , vol.8 , Issue.3 , pp. 179-183
    • Hay, N.1
  • 153
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K.; Li, Y.; Zhu, T.; Wu, J.; Guan, K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol., 2002, 4 (9), 648-657.
    • (2002) Nat. Cell Biol , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 154
    • 36049043184 scopus 로고    scopus 로고
    • Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
    • Bai, X.; Ma, D.; Liu, A.; Shen, X.; Wang, Q.J.; Liu, Y.; Jiang, Y. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Sci. STKE, 2007, 318 (5852), 977.
    • (2007) Sci. STKE , vol.318 , Issue.5852 , pp. 977
    • Bai, X.1    Ma, D.2    Liu, A.3    Shen, X.4    Wang, Q.J.5    Liu, Y.6    Jiang, Y.7
  • 155
    • 84875226458 scopus 로고    scopus 로고
    • MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor
    • Zhao, X.; Dou, W.; He, L.; Liang, S.; Tie, J.; Liu, C.; Li, T.; Lu, Y.; Mo, P.; Shi, Y. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulin-like growth factor-1 receptor. Oncogene, 2012.
    • (2012) Oncogene
    • Zhao, X.1    Dou, W.2    He, L.3    Liang, S.4    Tie, J.5    Liu, C.6    Li, T.7    Lu, Y.8    Mo, P.9    Shi, Y.10
  • 156
    • 84861991534 scopus 로고    scopus 로고
    • MiR-139 Inhibits Invasion and Metastasis of Colorectal Cancer by Targeting the Type I Insulin-like Growth Factor Receptor
    • Shen, K.; Liang, Q.; Xu, K.; Cui, D.; Jiang, L.; Yin, P.; Lu, Y.; Li, Q.; Liu, J. MiR-139 Inhibits Invasion and Metastasis of Colorectal Cancer by Targeting the Type I Insulin-like Growth Factor Receptor. Biochem. Pharmacol., 2012, 84 (3), 320-330.
    • (2012) Biochem. Pharmacol , vol.84 , Issue.3 , pp. 320-330
    • Shen, K.1    Liang, Q.2    Xu, K.3    Cui, D.4    Jiang, L.5    Yin, P.6    Lu, Y.7    Li, Q.8    Liu, J.9
  • 157
    • 84876134466 scopus 로고    scopus 로고
    • MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer
    • Guo, S.; Jiang, C.; Wang, G.; Li, Y.; Wang, C.; Guo, X.; Yang, R.; Feng, Y.; Wang, F.; Tseng, H. MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer. Oncogene, 2012.
    • (2012) Oncogene
    • Guo, S.1    Jiang, C.2    Wang, G.3    Li, Y.4    Wang, C.5    Guo, X.6    Yang, R.7    Feng, Y.8    Wang, F.9    Tseng, H.10
  • 158
    • 3042775027 scopus 로고    scopus 로고
    • The insulin like growth factor-1 receptor (IGF-1R) as a drug target: Novel approaches to cancer therapy
    • Bähr, C.; Groner, B. The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm. IGF Res., 2004, 14 (4), 287-295.
    • (2004) Growth Horm. IGF Res , vol.14 , Issue.4 , pp. 287-295
    • Bähr, C.1    Groner, B.2
  • 159
    • 0242624594 scopus 로고    scopus 로고
    • Growth factor receptors as therapeutic targets: Strategies to inhibit the insulin-like growth factor I receptor
    • Surmacz, E. Growth factor receptors as therapeutic targets: strategies to inhibit the insulin-like growth factor I receptor. Oncogene, 2003, 22 (42), 6589-6597.
    • (2003) Oncogene , vol.22 , Issue.42 , pp. 6589-6597
    • Surmacz, E.1
  • 160
    • 0034719133 scopus 로고    scopus 로고
    • Substrate competitive inhibitors of IGF-1 receptor kinase
    • Blum, G.; Gazit, A.; Levitzki, A. Substrate competitive inhibitors of IGF-1 receptor kinase. Biochemistry (Mosc). 2000, 39 (51), 15705-15712.
    • (2000) Biochemistry (Mosc) , vol.39 , Issue.51 , pp. 15705-15712
    • Blum, G.1    Gazit, A.2    Levitzki, A.3
  • 161
    • 75249097799 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: A phase 1 expansion cohort study
    • Olmos, D.; Postel-Vinay, S.; Molife, L.; Okuno, S.H.; Schuetze, S.M.; Paccagnella, M.L.; Batzel, G.N.; Yin, D.; Pritchard-Jones, K.; Judson, I. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol., 2010, 11 (2), 129-135.
    • (2010) Lancet Oncol , vol.11 , Issue.2 , pp. 129-135
    • Olmos, D.1    Postel-Vinay, S.2    Molife, L.3    Okuno, S.H.4    Schuetze, S.M.5    Paccagnella, M.L.6    Batzel, G.N.7    Yin, D.8    Pritchard-Jones, K.9    Judson, I.10
  • 163
    • 84855398829 scopus 로고    scopus 로고
    • Targeting the Insulin-like Growth Factor Axis for the Development of Novel Therapeutics in Oncology
    • Gao, J.; Chang, Y.S.; Jallal, B.; Viner, J. Targeting the Insulin-like Growth Factor Axis for the Development of Novel Therapeutics in Oncology. Cancer Res., 2012, 72 (1), 3-12.
    • (2012) Cancer Res , vol.72 , Issue.1 , pp. 3-12
    • Gao, J.1    Chang, Y.S.2    Jallal, B.3    Viner, J.4
  • 164
    • 36549015742 scopus 로고    scopus 로고
    • Insulin receptor structure and its implications for the IGF-1 receptor
    • Lawrence, M.C.; McKern, N.M.; Ward, C.W. Insulin receptor structure and its implications for the IGF-1 receptor. Curr. Opin. Struct. Biol., 2007, 17 (6), 699-705.
    • (2007) Curr. Opin. Struct. Biol , vol.17 , Issue.6 , pp. 699-705
    • Lawrence, M.C.1    McKern, N.M.2    Ward, C.W.3
  • 166
    • 0028271497 scopus 로고    scopus 로고
    • Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors
    • Resnicoff, M.; Sell, C.; Rubini, M.; Coppola, D.; Ambrose, D.; Baserga, R.; Rubin, R. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res., 1994, 54 (8), 2218.
    • (2218) Cancer Res , vol.54 , Issue.8 , pp. 1994
    • Resnicoff, M.1    Sell, C.2    Rubini, M.3    Coppola, D.4    Ambrose, D.5    Baserga, R.6    Rubin, R.7
  • 167
    • 0028050256 scopus 로고
    • Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor
    • Resnicoff, M.; Coppola, D.; Sell, C.; Rubin, R.; Ferrone, S.; Baserga, R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res., 1994, 54 (18), 4848.
    • (1994) Cancer Res , vol.54 , Issue.18 , pp. 4848
    • Resnicoff, M.1    Coppola, D.2    Sell, C.3    Rubin, R.4    Ferrone, S.5    Baserga, R.6
  • 168
    • 0028920352 scopus 로고
    • Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor
    • Long, L.; Rubin, R.; Baserga, R.; Brodt, P. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. Cancer Res., 1995, 55 (5), 1006.
    • (1995) Cancer Res , vol.55 , Issue.5 , pp. 1006
    • Long, L.1    Rubin, R.2    Baserga, R.3    Brodt, P.4
  • 169
    • 73449103570 scopus 로고    scopus 로고
    • Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer
    • Furukawa, J.; Wraight, C.J.; Freier, S.M.; Peralta, E.; Atley, L.M.; Monia, B.P.; Gleave, M.E.; Cox, M.E. Antisense oligonucleotide targeting of insulin-like growth factor-1 receptor (IGF-1R) in prostate cancer. The Prostate, 2010, 70 (2), 206-218.
    • (2010) The Prostate , vol.70 , Issue.2 , pp. 206-218
    • Furukawa, J.1    Wraight, C.J.2    Freier, S.M.3    Peralta, E.4    Atley, L.M.5    Monia, B.P.6    Gleave, M.E.7    Cox, M.E.8
  • 170
    • 41249093600 scopus 로고    scopus 로고
    • Role of insulin-like growth factor-1R system in colorectal carcinogenesis
    • Donovan, E.A.; Kummar, S. Role of insulin-like growth factor-1R system in colorectal carcinogenesis. Crit. Rev. Oncol./Hematol., 2008, 66 (2), 91-98.
    • (2008) Crit. Rev. Oncol./Hematol , vol.66 , Issue.2 , pp. 91-98
    • Donovan, E.A.1    Kummar, S.2
  • 171
    • 33947265626 scopus 로고    scopus 로고
    • In the absence of IGF-1 signaling, IFN-γ suppresses human malignant T-cell growth
    • Conti, L.; Regis, G.; Longo, A.; Bernabei, P.; Chiarle, R.; Giovarelli, M.; Novelli, F. In the absence of IGF-1 signaling, IFN-γ suppresses human malignant T-cell growth. Blood, 2007, 109 (6), 2496-2504.
    • (2007) Blood , vol.109 , Issue.6 , pp. 2496-2504
    • Conti, L.1    Regis, G.2    Longo, A.3    Bernabei, P.4    Chiarle, R.5    Giovarelli, M.6    Novelli, F.7
  • 172
    • 0034668185 scopus 로고    scopus 로고
    • Inhibition of the type I insulin-like growth factor receptor expression and signaling: Novel strategies for antimetastatic therapy
    • Brodt, P.; Samani, A.; Navab, R. Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy. Biochem. Pharmacol., 2000, 60 (8), 1101-1107.
    • (2000) Biochem. Pharmacol , vol.60 , Issue.8 , pp. 1101-1107
    • Brodt, P.1    Samani, A.2    Navab, R.3
  • 173
    • 0033179378 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor-1 receptor in synovial sarcoma
    • Xie, Y.; Skytting, B.; Nilsson, G.; Brodin, B.; Larsson, O. Expression of insulin-like growth factor-1 receptor in synovial sarcoma. Cancer Res., 1999, 59 (15), 3588.
    • (1999) Cancer Res , vol.59 , Issue.15 , pp. 3588
    • Xie, Y.1    Skytting, B.2    Nilsson, G.3    Brodin, B.4    Larsson, O.5
  • 174
    • 57149127369 scopus 로고    scopus 로고
    • IGF-1 receptor inhibitors in clinical trials-early lessons
    • Weroha, S.J.; Haluska, P. IGF-1 receptor inhibitors in clinical trials-early lessons. J. Mammary Gland Biol. Neoplasia, 2008, 13 (4), 471-483.
    • (2008) J. Mammary Gland Biol. Neoplasia , vol.13 , Issue.4 , pp. 471-483
    • Weroha, S.J.1    Haluska, P.2
  • 175
    • 1642421788 scopus 로고    scopus 로고
    • The new kid on the blockade of the IGF-1 receptor
    • LeRoith, D.; Helman, L. The new kid on the blockade of the IGF-1 receptor. Cancer Cell, 2004, 5 (3), 201-202.
    • (2004) Cancer Cell , vol.5 , Issue.3 , pp. 201-202
    • Leroith, D.1    Helman, L.2
  • 176
    • 84855467975 scopus 로고    scopus 로고
    • The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology
    • Pollak, M. The insulin receptor/insulin-like growth factor receptor family as a therapeutic target in oncology. Clin. Cancer Res., 2012, 18 (1), 40-50.
    • (2012) Clin. Cancer Res , vol.18 , Issue.1 , pp. 40-50
    • Pollak, M.1
  • 177
    • 69449097339 scopus 로고    scopus 로고
    • Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
    • Gualberto, A.; Pollak, M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene, 2009, 28 (34), 3009-3021.
    • (2009) Oncogene , vol.28 , Issue.34 , pp. 3009-3021
    • Gualberto, A.1    Pollak, M.2
  • 178
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R.A. Hallmarks of cancer: the next generation. Cell, 2011, 144 (5), 646-674.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 180
    • 77952109477 scopus 로고    scopus 로고
    • Recent Progress in the Development of Small Molecule Inhibitors of Insulin-Like Growth Factor-1 Receptor Kinase
    • Wittman, M.D.; Velaparthi, U.; Vyas, D.M. Recent Progress in the Development of Small Molecule Inhibitors of Insulin-Like Growth Factor-1 Receptor Kinase. Annu. Rep. Med. Chem., 2009, 44, 281-299.
    • (2009) Annu. Rep. Med. Chem , vol.44 , pp. 281-299
    • Wittman, M.D.1    Velaparthi, U.2    Vyas, D.M.3
  • 181
    • 69049108757 scopus 로고    scopus 로고
    • Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach
    • Li, R.; Pourpak, A.; Morris, S.W. Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J. Med. Chem., 2009, 52 (16), 4981.
    • (2009) J. Med. Chem , vol.52 , Issue.16 , pp. 4981
    • Li, R.1    Pourpak, A.2    Morris, S.W.3
  • 182
    • 83455236504 scopus 로고    scopus 로고
    • Insulin-like Growth Factor: Current Concepts and New Developments in Cancer Therapy
    • King, E.R.; Wong, K.K. Insulin-like Growth Factor: Current Concepts and New Developments in Cancer Therapy. Recent Pat. Anticancer Drug Discov., 2012, 7 (1), 14-30.
    • (2012) Recent Pat. Anticancer Drug Discov , vol.7 , Issue.1 , pp. 14-30
    • King, E.R.1    Wong, K.K.2
  • 183
    • 84875543855 scopus 로고    scopus 로고
    • Clinical development of insulin-like growth factor receptor-1 (IGF-1R) inhibitors: At the crossroad?
    • Gombos, A.; Metzger-Filho, O.; Dal Lago, L.; Awada-Hussein, A. Clinical development of insulin-like growth factor receptor-1 (IGF-1R) inhibitors: At the crossroad? Invest. New Drugs, 2012, 1-10.
    • (2012) Invest. New Drugs , pp. 1-10
    • Gombos, A.1    Metzger-Filho, O.2    Dal Lago, L.3    Awada-Hussein, A.4
  • 184
    • 84863900275 scopus 로고    scopus 로고
    • Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater?
    • Yee, D. Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater? J. Natl. Cancer Inst., 2012, 104 (13), 975-981.
    • (2012) J. Natl. Cancer Inst , vol.104 , Issue.13 , pp. 975-981
    • Yee, D.1
  • 185
    • 84861720634 scopus 로고    scopus 로고
    • Insulin-like Growth Factor-1 Receptor (IGF-1R) Kinase Inhibitorsin Cancer Therapy: Advances and Perspectives
    • Xue, M.; Cao, X.; Zhong, Y.; Kuang, D.; Liu, X.; Zhao, Z.; Li, H. Insulin-like Growth Factor-1 Receptor (IGF-1R) Kinase Inhibitorsin Cancer Therapy: Advances and Perspectives. Curr. Pharm. Des., 2012, 18 (20), 2901-2913.
    • (2012) Curr. Pharm. Des , vol.18 , Issue.20 , pp. 2901-2913
    • Xue, M.1    Cao, X.2    Zhong, Y.3    Kuang, D.4    Liu, X.5    Zhao, Z.6    Li, H.7
  • 186
    • 0034793734 scopus 로고    scopus 로고
    • Crystal Structure of Bisphosphorylated IGF-1 Receptor Kinase: Insight into Domain Movements upon Kinase Activation
    • Pautsch, A.; Zoephel, A.; Ahorn, H.; Spevak, W.; Hauptmann, R.; Nar, H. Crystal Structure of Bisphosphorylated IGF-1 Receptor Kinase: Insight into Domain Movements upon Kinase Activation. Structure, 2001, 9 (10), 955-965.
    • (2001) Structure , vol.9 , Issue.10 , pp. 955-965
    • Pautsch, A.1    Zoephel, A.2    Ahorn, H.3    Spevak, W.4    Hauptmann, R.5    Nar, H.6
  • 189
    • 57749093097 scopus 로고    scopus 로고
    • Optimization of a series of 4, 6-bis-anilino-1h-pyrrolo [2, 3-d] pyrimidine inhibitors of igf-1r: Elimination of an acid-mediated decomposition pathway
    • Chamberlain, S.D.; Redman, A.M.; Patnaik, S.; Brickhouse, K.; Chew, Y.C.; Deanda, F.; Gerding, R.; Lei, H.; Moorthy, G.; Patrick, M. Optimization of a series of 4, 6-bis-anilino-1h-pyrrolo [2, 3-d] pyrimidine inhibitors of igf-1r: elimination of an acid-mediated decomposition pathway. Bioorg. Med. Chem. Lett., 2009, 19 (2), 373-377.
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , Issue.2 , pp. 373-377
    • Chamberlain, S.D.1    Redman, A.M.2    Patnaik, S.3    Brickhouse, K.4    Chew, Y.C.5    Deanda, F.6    Gerding, R.7    Lei, H.8    Moorthy, G.9    Patrick, M.10
  • 190
    • 57949114351 scopus 로고    scopus 로고
    • Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
    • Miller, L.M.; Mayer, S.C.; Berger, D.M.; Boschelli, D.H.; Boschelli, F.; Di, L.; Du, X.; Dutia, M.; Floyd, M.B.; Johnson, M. Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg. Med. Chem. Lett., 2009, 19 (1), 62-66.
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , Issue.1 , pp. 62-66
    • Miller, L.M.1    Mayer, S.C.2    Berger, D.M.3    Boschelli, D.H.4    Boschelli, F.5    Di, L.6    Du, X.7    Dutia, M.8    Floyd, M.B.9    Johnson, M.10
  • 191
    • 44949188302 scopus 로고    scopus 로고
    • Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment
    • Mayer, S.C.; Banker, A.L.; Boschelli, F.; Di, L.; Johnson, M.; Kenny, C.H.; Krishnamurthy, G.; Kutterer, K.; Moy, F.; Petusky, S. Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment. Bioorg. Med. Chem. Lett., 2008, 18 (12), 3641-3645.
    • (2008) Bioorg. Med. Chem. Lett , vol.18 , Issue.12 , pp. 3641-3645
    • Mayer, S.C.1    Banker, A.L.2    Boschelli, F.3    Di, L.4    Johnson, M.5    Kenny, C.H.6    Krishnamurthy, G.7    Kutterer, K.8    Moy, F.9    Petusky, S.10
  • 192
    • 33947581423 scopus 로고    scopus 로고
    • Discovery and initial SAR of 3-(1H-benzo [d] imidazol-2-yl) pyridin-2 (1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)
    • Velaparthi, U.; Wittman, M.; Liu, P.; Stoffan, K.; Zimmermann, K.; Sang, X.; Carboni, J.; Li, A.; Attar, R.; Gottardis, M. Discovery and initial SAR of 3-(1H-benzo [d] imidazol-2-yl) pyridin-2 (1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R). Bioorg. Med. Chem. Lett., 2007, 17 (8), 2317-2321.
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , Issue.8 , pp. 2317-2321
    • Velaparthi, U.1    Wittman, M.2    Liu, P.3    Stoffan, K.4    Zimmermann, K.5    Sang, X.6    Carboni, J.7    Li, A.8    Attar, R.9    Gottardis, M.10
  • 193
    • 77955659488 scopus 로고    scopus 로고
    • Proline isosteres in a series of 2, 4-disubstituted pyrrolo [1, 2-f][1, 2, 4] triazine inhibitors of IGF-1R kinase and IR kinase
    • Sampognaro, A.J.; Wittman, M.D.; Carboni, J.M.; Chang, C.; Greer, A.F.; Hurlburt, W.W.; Sack, J.S.; Vyas, D.M. Proline isosteres in a series of 2, 4-disubstituted pyrrolo [1, 2-f][1, 2, 4] triazine inhibitors of IGF-1R kinase and IR kinase. Bioorg. Med. Chem. Lett., 2010, 20 (17), 5027-5030.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , Issue.17 , pp. 5027-5030
    • Sampognaro, A.J.1    Wittman, M.D.2    Carboni, J.M.3    Chang, C.4    Greer, A.F.5    Hurlburt, W.W.6    Sack, J.S.7    Vyas, D.M.8
  • 199
    • 72249089981 scopus 로고    scopus 로고
    • Discovery of a 2, 4-disubstituted pyrrolo [1, 2-f][1, 2, 4] triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development
    • Wittman, M.D.; Carboni, J.M.; Yang, Z.; Lee, F.Y.; Antman, M.; Attar, R.; Balimane, P.; Chang, C.; Chen, C.; Discenza, L. Discovery of a 2, 4-disubstituted pyrrolo [1, 2-f][1, 2, 4] triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J. Med. Chem., 2009, 52 (23), 7360-7363.
    • (2009) J. Med. Chem , vol.52 , Issue.23 , pp. 7360-7363
    • Wittman, M.D.1    Carboni, J.M.2    Yang, Z.3    Lee, F.Y.4    Antman, M.5    Attar, R.6    Balimane, P.7    Chang, C.8    Chen, C.9    Discenza, L.10
  • 200
    • 47949113688 scopus 로고    scopus 로고
    • Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor
    • Wu, J.; Li, W.; Craddock, B.P.; Foreman, K.W.; Mulvihill, M.J.; Ji, Q.; Miller, W.T.; Hubbard, S.R. Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor. EMBO J., 2008, 27 (14), 1985-1994.
    • (2008) EMBO J , vol.27 , Issue.14 , pp. 1985-1994
    • Wu, J.1    Li, W.2    Craddock, B.P.3    Foreman, K.W.4    Mulvihill, M.J.5    Ji, Q.6    Miller, W.T.7    Hubbard, S.R.8
  • 204
    • 14644433735 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy
    • Warshamana-Greene, G.S.; Litz, J.; Buchdunger, E.; García-Echeverría, C.; Hofmann, F.; Krystal, G.W. The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy. Clin. Cancer Res., 2005, 11 (4), 1563-1571.
    • (2005) Clin. Cancer Res , vol.11 , Issue.4 , pp. 1563-1571
    • Warshamana-Greene, G.S.1    Litz, J.2    Buchdunger, E.3    García-Echeverría, C.4    Hofmann, F.5    Krystal, G.W.6
  • 208
    • 61349088756 scopus 로고    scopus 로고
    • Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases
    • Hubbard, R.D.; Bamaung, N.Y.; Fidanze, S.D.; Erickson, S.A.; Palazzo, F.; Wilsbacher, J.L.; Zhang, Q.; Tucker, L.A.; Hu, X.; Kovar, P. Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg. Med. Chem. Lett., 2009, 19 (6), 1718-1721.
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , Issue.6 , pp. 1718-1721
    • Hubbard, R.D.1    Bamaung, N.Y.2    Fidanze, S.D.3    Erickson, S.A.4    Palazzo, F.5    Wilsbacher, J.L.6    Zhang, Q.7    Tucker, L.A.8    Hu, X.9    Kovar, P.10
  • 209
    • 77956898555 scopus 로고    scopus 로고
    • Substituted 4-amino-1H-pyrazolo [3, 4-d] pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases
    • Wang, G.T.; Mantei, R.A.; Hubbard, R.D.; Wilsbacher, J.L.; Zhang, Q.; Tucker, L.; Hu, X.; Kovar, P.; Johnson, E.F.; Osterling, D.J. Substituted 4-amino-1H-pyrazolo [3, 4-d] pyrimidines as multi-targeted inhibitors of insulin-like growth factor-1 receptor (IGF1R) and members of ErbB-family receptor kinases. Bioorg. Med. Chem. Lett., 2010, 20 (20), 6067-6071.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , Issue.20 , pp. 6067-6071
    • Wang, G.T.1    Mantei, R.A.2    Hubbard, R.D.3    Wilsbacher, J.L.4    Zhang, Q.5    Tucker, L.6    Hu, X.7    Kovar, P.8    Johnson, E.F.9    Osterling, D.J.10
  • 211
    • 38849133610 scopus 로고    scopus 로고
    • Novel 2-phenylquinolin-7-yl-derived imidazo [1, 5-a] pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors
    • Mulvihill, M.J.; Ji, Q.S.; Coate, H.R.; Cooke, A.; Dong, H.; Feng, L.; Foreman, K.; Honda, A.; Mak, G.; Mulvihill, K.M. Novel 2-phenylquinolin-7-yl-derived imidazo [1, 5-a] pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors. Biorg. Med. Chem., 2008, 16 (3), 1359-1375.
    • (2008) Biorg. Med. Chem , vol.16 , Issue.3 , pp. 1359-1375
    • Mulvihill, M.J.1    Ji, Q.S.2    Coate, H.R.3    Cooke, A.4    Dong, H.5    Feng, L.6    Foreman, K.7    Honda, A.8    Mak, G.9    Mulvihill, K.M.10
  • 212
    • 34548058890 scopus 로고    scopus 로고
    • A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor-dependent tumor growth in vivo
    • Ji, Q.; Mulvihill, M.J.; Cooke, A.; Feng, L.; Mak, G.; O'Connor, M.; Yao, Y.; Pirritt, C.; Buck, E.; Eyzaguirre, A. A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor-dependent tumor growth in vivo. Mol. Cancer Ther., 2007, 6 (8), 2158.
    • (2158) Mol. Cancer Ther , vol.6 , Issue.8 , pp. 2007
    • Ji, Q.1    Mulvihill, M.J.2    Cooke, A.3    Feng, L.4    Mak, G.5    O'Connor, M.6    Yao, Y.7    Pirritt, C.8    Buck, E.9    Eyzaguirre, A.10
  • 218
    • 1842639592 scopus 로고    scopus 로고
    • Imidazo [1, 2-a] pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors
    • Byth, K.F.; Culshaw, J.D.; Green, S.; Oakes, S.E.; Thomas, A.P. Imidazo [1, 2-a] pyridines. Part 2: SAR and optimisation of a potent and selective class of cyclin-dependent kinase inhibitors. Bioorg. Med. Chem. Lett., 2004, 14 (9), 2245-2248.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , Issue.9 , pp. 2245-2248
    • Byth, K.F.1    Culshaw, J.D.2    Green, S.3    Oakes, S.E.4    Thomas, A.P.5
  • 220
    • 79960927448 scopus 로고    scopus 로고
    • Novel imidazo [1, 2-a] pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline
    • Ducray, R.; Jones, C.D.; Jung, F.H.; Simpson, I.; Curwen, J.; Pass, M. Novel imidazo [1, 2-a] pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline. Bioorg. Med. Chem. Lett., 2011, 21 (16), 4702-4704.
    • (2011) Bioorg. Med. Chem. Lett , vol.21 , Issue.16 , pp. 4702-4704
    • Ducray, R.1    Jones, C.D.2    Jung, F.H.3    Simpson, I.4    Curwen, J.5    Pass, M.6
  • 221
    • 24744437999 scopus 로고    scopus 로고
    • Discovery of a 1 H-Benzoimidazol-2-yl)-1 H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity
    • Wittman, M.; Carboni, J.; Attar, R.; Balasubramanian, B.; Balimane, P.; Brassil, P.; Beaulieu, F.; Chang, C.; Clarke, W.; Dell, J. Discovery of a 1 H-Benzoimidazol-2-yl)-1 H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity. J. Med. Chem., 2005, 48 (18), 5639-5643.
    • (2005) J. Med. Chem , vol.48 , Issue.18 , pp. 5639-5643
    • Wittman, M.1    Carboni, J.2    Attar, R.3    Balasubramanian, B.4    Balimane, P.5    Brassil, P.6    Beaulieu, F.7    Chang, C.8    Clarke, W.9    Dell, J.10
  • 223
    • 34247844537 scopus 로고    scopus 로고
    • Imidazole moiety replacements in the 3-(1H-benzo [d] imidazol-2-yl) pyridin-2 (1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile
    • Velaparthi, U.; Liu, P.; Balasubramanian, B.; Carboni, J.; Attar, R.; Gottardis, M.; Li, A.; Greer, A.; Zoeckler, M.; Wittman, M.D. Imidazole moiety replacements in the 3-(1H-benzo [d] imidazol-2-yl) pyridin-2 (1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile. Bioorg. Med. Chem. Lett., 2007, 17 (11), 3072-3076.
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , Issue.11 , pp. 3072-3076
    • Velaparthi, U.1    Liu, P.2    Balasubramanian, B.3    Carboni, J.4    Attar, R.5    Gottardis, M.6    Li, A.7    Greer, A.8    Zoeckler, M.9    Wittman, M.D.10
  • 224
    • 84862907716 scopus 로고    scopus 로고
    • IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer
    • Dool, C.J.; Mashhedi, H.; Zakikhani, M.; David, S.; Zhao, Y.; Birman, E.; Carboni, J.M.; Gottardis, M.; Blouin, M.J.; Pollak, M. IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer. Endocr. Relat. Cancer, 2011, 18 (6), 699-709.
    • (2011) Endocr. Relat. Cancer , vol.18 , Issue.6 , pp. 699-709
    • Dool, C.J.1    Mashhedi, H.2    Zakikhani, M.3    David, S.4    Zhao, Y.5    Birman, E.6    Carboni, J.M.7    Gottardis, M.8    Blouin, M.J.9    Pollak, M.10
  • 226
    • 53549109444 scopus 로고    scopus 로고
    • Discovery and Evaluation of 4-(2-(4-chloro-1 H-pyrazol-1-yl) ethylamino)-3-(6-(1-(3-fluoropropyl) piperidin-4-yl)-4-methyl-1 H-benzo [d] imidazol-2-yl) pyridin-2 (1 H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity
    • Velaparthi, U.; Wittman, M.; Liu, P.; Carboni, J.M.; Lee, F.Y.; Attar, R.; Balimane, P.; Clarke, W.; Sinz, M.W.; Hurlburt, W. Discovery and Evaluation of 4-(2-(4-chloro-1 H-pyrazol-1-yl) ethylamino)-3-(6-(1-(3-fluoropropyl) piperidin-4-yl)-4-methyl-1 H-benzo [d] imidazol-2-yl) pyridin-2 (1 H)-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity. J. Med. Chem., 2008, 51 (19), 5897-5900.
    • (2008) J. Med. Chem , vol.51 , Issue.19 , pp. 5897-5900
    • Velaparthi, U.1    Wittman, M.2    Liu, P.3    Carboni, J.M.4    Lee, F.Y.5    Attar, R.6    Balimane, P.7    Clarke, W.8    Sinz, M.W.9    Hurlburt, W.10
  • 227
    • 77952110655 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one
    • Velaparthi, U.; Saulnier, M.G.; Wittman, M.D.; Liu, P.; Frennesson, D.B.; Zimmermann, K.; Carboni, J.M.; Gottardis, M.; Li, A.; Greer, A. Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one. Bioorg. Med. Chem. Lett., 2010, 20 (10), 3182-3185.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , Issue.10 , pp. 3182-3185
    • Velaparthi, U.1    Saulnier, M.G.2    Wittman, M.D.3    Liu, P.4    Frennesson, D.B.5    Zimmermann, K.6    Carboni, J.M.7    Gottardis, M.8    Li, A.9    Greer, A.10
  • 228
    • 33750081128 scopus 로고    scopus 로고
    • Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor
    • Anderson, M.O.; Yu, H.; Penaranda, C.; Maddux, B.A.; Goldfine, I.D.; Youngren, J.F.; Guy, R.K. Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor. J. Comb. Chem., 2006, 8 (5), 784-790.
    • (2006) J. Comb. Chem , vol.8 , Issue.5 , pp. 784-790
    • Anderson, M.O.1    Yu, H.2    Penaranda, C.3    Maddux, B.A.4    Goldfine, I.D.5    Youngren, J.F.6    Guy, R.K.7
  • 230
    • 77955468949 scopus 로고    scopus 로고
    • Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R)
    • Engen, W.; O'Brien, T.E.; Kelly, B.; Do, J.; Rillera, L.; Stapleton, L.K.; Youngren, J.F.; Anderson, M.O. Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R). Biorg. Med. Chem., 2010, 18 (16), 5995-6005.
    • (2010) Biorg. Med. Chem , vol.18 , Issue.16 , pp. 5995-6005
    • Engen, W.1    O'Brien, T.E.2    Kelly, B.3    Do, J.4    Rillera, L.5    Stapleton, L.K.6    Youngren, J.F.7    Anderson, M.O.8
  • 231
    • 79957474318 scopus 로고    scopus 로고
    • Dual Igf-1r/Src Inhibitors Based On A N'-Aroyl-2-(1H-Indol-3-Yl)-2-Oxoacetohydrazide Structure
    • Schmidt, S.; Preu, L.; Lemcke, T.; Totzke, F.; Schächtele, C.; Kubbutat, M.H.G.; Kunick, C. Dual Igf-1r/Src Inhibitors Based On A N'-Aroyl-2-(1H-Indol-3-Yl)-2-Oxoacetohydrazide Structure. Eur. J. Med. Chem., 2011, 46 (7), 2759-2769.
    • (2011) Eur. J. Med. Chem , vol.46 , Issue.7 , pp. 2759-2769
    • Schmidt, S.1    Preu, L.2    Lemcke, T.3    Totzke, F.4    Schächtele, C.5    Kubbutat, M.H.G.6    Kunick, C.7
  • 232
    • 77953126861 scopus 로고    scopus 로고
    • Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors
    • Büttner, A.; Cottin, T.; Xu, J.; Tzagkaroulaki, L.; Giannis, A. Serotonin derivatives as a new class of non-ATP-competitive receptor tyrosine kinase inhibitors. Biorg. Med. Chem., 2010, 18 (10), 3387-3402.
    • (2010) Biorg. Med. Chem , vol.18 , Issue.10 , pp. 3387-3402
    • Büttner, A.1    Cottin, T.2    Xu, J.3    Tzagkaroulaki, L.4    Giannis, A.5
  • 233
    • 0025668424 scopus 로고
    • Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors
    • Geissler, J.; Traxler, P.; Regenass, U.; Murray, B.; Roesel, J.; Meyer, T.; McGlynn, E.; Storni, A.; Lydon, N. Thiazolidine-diones. Biochemical and biological activity of a novel class of tyrosine protein kinase inhibitors. J. Biol. Chem., 1990, 265 (36), 22255.
    • (1990) J. Biol. Chem , vol.265 , Issue.36 , pp. 22255
    • Geissler, J.1    Traxler, P.2    Regenass, U.3    Murray, B.4    Roesel, J.5    Meyer, T.6    McGlynn, E.7    Storni, A.8    Lydon, N.9
  • 234
    • 0035998737 scopus 로고    scopus 로고
    • Physiological and therapeutic roles of peroxisome proliferator-activated receptors
    • Berger, J.; Wagner, J.A. Physiological and therapeutic roles of peroxisome proliferator-activated receptors. Diabetes Technol. Ther., 2002, 4 (2), 163-174.
    • (2002) Diabetes Technol. Ther , vol.4 , Issue.2 , pp. 163-174
    • Berger, J.1    Wagner, J.A.2
  • 237
    • 72249122328 scopus 로고    scopus 로고
    • Design, Synthesis, and Structure? Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl) furans as HIV-1 Entry Inhibitors?
    • Katritzky, A.R.; Tala, S.R.; Lu, H.; Vakulenko, A.V.; Chen, Q.Y.; Sivapackiam, J.; Pandya, K.; Jiang, S.; Debnath, A.K. Design, Synthesis, and Structure? Activity Relationship of a Novel Series of 2-Aryl 5-(4-Oxo-3-phenethyl-2-thioxothiazolidinylidenemethyl) furans as HIV-1 Entry Inhibitors?. J. Med. Chem., 2009, 52 (23), 7631-7639.
    • (2009) J. Med. Chem , vol.52 , Issue.23 , pp. 7631-7639
    • Katritzky, A.R.1    Tala, S.R.2    Lu, H.3    Vakulenko, A.V.4    Chen, Q.Y.5    Sivapackiam, J.6    Pandya, K.7    Jiang, S.8    Debnath, A.K.9
  • 238
    • 67649307131 scopus 로고    scopus 로고
    • Novel benzylidene-thiazolidine-2, 4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells
    • Beharry, Z.; Zemskova, M.; Mahajan, S.; Zhang, F.; Ma, J.; Xia, Z.; Lilly, M.; Smith, C.D.; Kraft, A.S. Novel benzylidene-thiazolidine-2, 4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. Mol. Cancer Ther., 2009, 8 (6), 1473-1483.
    • (2009) Mol. Cancer Ther , vol.8 , Issue.6 , pp. 1473-1483
    • Beharry, Z.1    Zemskova, M.2    Mahajan, S.3    Zhang, F.4    Ma, J.5    Xia, Z.6    Lilly, M.7    Smith, C.D.8    Kraft, A.S.9
  • 239
    • 77949859256 scopus 로고    scopus 로고
    • Discovery and SAR of thiazolidine-2, 4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening
    • Liu, X.; Xie, H.; Luo, C.; Tong, L.; Wang, Y.; Peng, T.; Ding, J.; Jiang, H.; Li, H. Discovery and SAR of thiazolidine-2, 4-dione analogues as insulin-like growth factor-1 receptor (IGF-1R) inhibitors via hierarchical virtual screening. J. Med. Chem., 2010, 53 (6), 2661-2665.
    • (2010) J. Med. Chem , vol.53 , Issue.6 , pp. 2661-2665
    • Liu, X.1    Xie, H.2    Luo, C.3    Tong, L.4    Wang, Y.5    Peng, T.6    Ding, J.7    Jiang, H.8    Li, H.9
  • 240
    • 78149280763 scopus 로고    scopus 로고
    • Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors
    • Krug, M.; Erlenkamp, G.; Sippl, W.; Schächtele, C.; Totzke, F.; Hilgeroth, A. Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg. Med. Chem. Lett., 2010, 20 (23), 6915-6919.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , Issue.23 , pp. 6915-6919
    • Krug, M.1    Erlenkamp, G.2    Sippl, W.3    Schächtele, C.4    Totzke, F.5    Hilgeroth, A.6
  • 241
    • 80052023098 scopus 로고    scopus 로고
    • Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: A novel approach for overcoming resistance in anticancer treatment
    • Tandon, R.; Kapoor, S.; Vali, S.; Senthil, V.; Nithya, D.; Venkataramanan, R.; Sharma, A.; Talwadkar, A.; Ray, A.; Bhatnagar, P.K. Dual epidermal growth factor receptor (EGFR)/insulin-like growth factor-1 receptor (IGF-1R) inhibitor: A novel approach for overcoming resistance in anticancer treatment. Eur. J. Pharmacol., 2011, 667 (1-3), 56-65.
    • (2011) Eur. J. Pharmacol , vol.667 , Issue.1-3 , pp. 56-65
    • Tandon, R.1    Kapoor, S.2    Vali, S.3    Senthil, V.4    Nithya, D.5    Venkataramanan, R.6    Sharma, A.7    Talwadkar, A.8    Ray, A.9    Bhatnagar, P.K.10
  • 242
    • 79955536242 scopus 로고    scopus 로고
    • Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative
    • Chakravarti, B.; Siddiqui, J.A.; Dwivedi, S.K.D.; Deshpande, S.; Samanta, K.; Bhatta, R.S.; Panda, G.; Prabhakar, Y.S.; Konwar, R.; Sanyal, S. Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. Mol. Cell. Endocrinol., 2011, 338 (1-2), 68-78.
    • (2011) Mol. Cell. Endocrinol , vol.338 , Issue.1-2 , pp. 68-78
    • Chakravarti, B.1    Siddiqui, J.A.2    Dwivedi, S.K.D.3    Deshpande, S.4    Samanta, K.5    Bhatta, R.S.6    Panda, G.7    Prabhakar, Y.S.8    Konwar, R.9    Sanyal, S.10
  • 244
    • 1642494838 scopus 로고    scopus 로고
    • Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth
    • Girnita, A.; Girnita, L.; del Prete, F.; Bartolazzi, A.; Larsson, O.; Axelson, M. Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res., 2004, 64 (1), 236-242.
    • (2004) Cancer Res , vol.64 , Issue.1 , pp. 236-242
    • Girnita, A.1    Girnita, L.2    del Prete, F.3    Bartolazzi, A.4    Larsson, O.5    Axelson, M.6
  • 245
    • 33644751770 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells
    • Girnita, A.; All-Ericsson, C.; Economou, M.A.; Astr, K.; Axelson, M.; Seregard, S.; Larsson, O.; Girnita, L. The insulin-like growth factor-I receptor inhibitor picropodophyllin causes tumor regression and attenuates mechanisms involved in invasion of uveal melanoma cells. Clin. Cancer Res., 2006, 12 (4), 1383-1391.
    • (2006) Clin. Cancer Res , vol.12 , Issue.4 , pp. 1383-1391
    • Girnita, A.1    All-Ericsson, C.2    Economou, M.A.3    Astr, K.4    Axelson, M.5    Seregard, S.6    Larsson, O.7    Girnita, L.8
  • 246
    • 33745100153 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection
    • Vasilcanu, D.; Weng, W.; Girnita, A.; Lui, W.; Vasilcanu, R.; Axelson, M.; Larsson, O.; Larsson, C.; Girnita, L. The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection. Oncogene, 2006, 25 (22), 3186-3195.
    • (2006) Oncogene , vol.25 , Issue.22 , pp. 3186-3195
    • Vasilcanu, D.1    Weng, W.2    Girnita, A.3    Lui, W.4    Vasilcanu, R.5    Axelson, M.6    Larsson, O.7    Larsson, C.8    Girnita, L.9
  • 247
    • 33947508482 scopus 로고    scopus 로고
    • ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents
    • Steiner, L.; Blum, G.; Friedmann, Y.; Levitzki, A. ATP non-competitive IGF-1 receptor kinase inhibitors as lead anti-neoplastic and anti-papilloma agents. Eur. J. Pharmacol., 2007, 562 (1-2), 1-11.
    • (2007) Eur. J. Pharmacol , vol.562 , Issue.1-2 , pp. 1-11
    • Steiner, L.1    Blum, G.2    Friedmann, Y.3    Levitzki, A.4
  • 249
    • 38649115388 scopus 로고    scopus 로고
    • Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells
    • Zavodovskaya, M.; Campbell, M.J.; Maddux, B.A.; Shiry, L.; Allan, G.; Hodges, L.; Kushner, P.; Kerner, J.A.; Youngren, J.F.; Goldfine, I.D. Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells. J. Cell. Biochem., 2008, 103 (2), 624-635.
    • (2008) J. Cell. Biochem , vol.103 , Issue.2 , pp. 624-635
    • Zavodovskaya, M.1    Campbell, M.J.2    Maddux, B.A.3    Shiry, L.4    Allan, G.5    Hodges, L.6    Kushner, P.7    Kerner, J.A.8    Youngren, J.F.9    Goldfine, I.D.10
  • 252
    • 0344625376 scopus 로고    scopus 로고
    • Mevalonate deprivation impairs IGF-I/insulin signaling in human vascular smooth muscle cells
    • Martínez-González, J.; Viņals, M.; Vidal, F.; Llorente-Cortés, V.; Badimon, L. Mevalonate deprivation impairs IGF-I/insulin signaling in human vascular smooth muscle cells. Atherosclerosis, 1997, 135 (2), 213-223.
    • (1997) Atherosclerosis , vol.135 , Issue.2 , pp. 213-223
    • Martínez-González, J.1    Viņals, M.2    Vidal, F.3    Llorente-Cortés, V.4    Badimon, L.5
  • 253
    • 0030808048 scopus 로고    scopus 로고
    • Mevalonate-regulated mechanisms in cell growth control: Role of dolichyl phosphate in expression of the insulin-like growth factor-1 receptor (IGF-1R) in comparison to Ras prenylation and expression of c-myc
    • Dricu, A.; Wang, M.; Hjertman, M.; Malec, M.; Blegen, H.; Wejde, J.; Carlberg, M.; Larsson, O. Mevalonate-regulated mechanisms in cell growth control: role of dolichyl phosphate in expression of the insulin-like growth factor-1 receptor (IGF-1R) in comparison to Ras prenylation and expression of c-myc. Glycobiology, 1997, 7 (5), 625.
    • (1997) Glycobiology , vol.7 , Issue.5 , pp. 625
    • Dricu, A.1    Wang, M.2    Hjertman, M.3    Malec, M.4    Blegen, H.5    Wejde, J.6    Carlberg, M.7    Larsson, O.8
  • 254
    • 0034120198 scopus 로고    scopus 로고
    • Inhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewings sarcoma cells: Therapeutic implications
    • Girnita, L.; Wang, M.; Xie, Y.; Nilsson, G.; Dricu, A.; Wejde, J.; Larsson, O. Inhibition of N-linked glycosylation down-regulates insulin-like growth factor-1 receptor at the cell surface and kills Ewings sarcoma cells: therapeutic implications. Anti-Cancer Drug Des., 2000, 15 (1), 67-72.
    • (2000) Anti-Cancer Drug Des , vol.15 , Issue.1 , pp. 67-72
    • Girnita, L.1    Wang, M.2    Xie, Y.3    Nilsson, G.4    Dricu, A.5    Wejde, J.6    Larsson, O.7
  • 255
    • 14344264703 scopus 로고    scopus 로고
    • Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics-an update
    • Neckers, L.; Neckers, K. Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics-an update. Expert Opin. Emerg. Drugs, 2005, 10 (1), 137-149.
    • (2005) Expert Opin. Emerg. Drugs , vol.10 , Issue.1 , pp. 137-149
    • Neckers, L.1    Neckers, K.2
  • 257
    • 0024151897 scopus 로고
    • The heat-shock proteins
    • Lindquist, S.; Craig, E. The heat-shock proteins. Annu. Rev. Genet., 1988, 22 (1), 631-677.
    • (1988) Annu. Rev. Genet , vol.22 , Issue.1 , pp. 631-677
    • Lindquist, S.1    Craig, E.2
  • 258
    • 35948977339 scopus 로고    scopus 로고
    • Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1? autocrine loop, and reduces orthotopic tumor growth
    • Lang, S.A.; Moser, C.; Gaumann, A.; Klein, D.; Glockzin, G.; Popp, F.C.; Dahlke, M.H.; Piso, P.; Schlitt, H.J.; Geissler, E.K. Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1? autocrine loop, and reduces orthotopic tumor growth. Clin. Cancer Res., 2007, 13 (21), 6459-6468.
    • (2007) Clin. Cancer Res , vol.13 , Issue.21 , pp. 6459-6468
    • Lang, S.A.1    Moser, C.2    Gaumann, A.3    Klein, D.4    Glockzin, G.5    Popp, F.C.6    Dahlke, M.H.7    Piso, P.8    Schlitt, H.J.9    Geissler, E.K.10
  • 259
    • 67650930911 scopus 로고    scopus 로고
    • Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer
    • MOSER, C.; Lang, S.A.; Stoeltzing, O. Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer. Anticancer Res., 2009, 29 (6), 2031.
    • (2031) Anticancer Res , vol.29 , Issue.6 , pp. 2009
    • Moser, C.1    Lang, S.A.2    Stoeltzing, O.3
  • 260
    • 84863239500 scopus 로고    scopus 로고
    • Small-molecule ATP-competitive dual IGF-1R and insulin receptor inhibitors: Structural insights, chemical diversity and molecular evolution
    • Jin, M.; Wang, J.; Buck, E.; Mulvihill, M.J. Small-molecule ATP-competitive dual IGF-1R and insulin receptor inhibitors: structural insights, chemical diversity and molecular evolution. Future Med. Chem., 2012, 4 (3), 315-328.
    • (2012) Future Med. Chem , vol.4 , Issue.3 , pp. 315-328
    • Jin, M.1    Wang, J.2    Buck, E.3    Mulvihill, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.