Akt and Bcl-xL Promote Growth Factor-independent Survival through Distinct Effects on Mitochondrial Physiology

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 12041-12048

  Plas, David R ^b   Talapatra, Sunit ^b   Edinger, Aimee L ^b   Rathmell, Jeffrey C ^b   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; GENES; GLUCOSE; GROWTH KINETICS;

CELL DEATH; GLYCOLYSIS;

BIOCHEMISTRY;

GLUCOSE TRANSPORTER; GROWTH FACTOR; INTERLEUKIN 3; PROTEIN BCL XL; PROTEIN KINASE B; GLUCOSE TRANSPORTER 1; GROWTH PROMOTOR; MESSENGER RNA; ONCOPROTEIN; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL PROTECTION; CELL SIZE; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; EXTRACELLULAR SPACE; GENE FUNCTION; GLYCOLYSIS; MEMBRANE POTENTIAL; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; NUTRIENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; CELL LINE; COMPARATIVE STUDY; FLOW CYTOMETRY; GENETICS; PHYSIOLOGY;

ANIMALIA;

ANIMALS; BCL-X PROTEIN; CELL LINE; CELL SURVIVAL; FLOW CYTOMETRY; GLUCOSE TRANSPORTER TYPE 1; GROWTH SUBSTANCES; MITOCHONDRIA; MONOSACCHARIDE TRANSPORT PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, MESSENGER;

EID: 0035853833     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M010551200     Document Type: Article

References (40)

1. Raff, M. C. (1992) Nature 356, 397-400
2. Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., and Greenberg, M. E. (1997) Science 275, 661-665
3. Yao, R., and Cooper, G. M. (1995) Science 267, 2003-2006
4. Kandel, E. S., and Hay, N. (1999) Exp. Cell Res. 253, 210-229
5. Bellacosa, A., Testa, J. R., Staal, S. P., and Tsichlis, P. N. (1991) Science 254, 274-277
6. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H., and Tavtigian, S. V. (1997) Nat. Genet. 15, 356-362
7. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H., and Parsons, R. (1997) Science 275, 1943-1947
8. Kennedy, S. G., Kandel, E. S., Cross, T. K., and Hay, N. (1999) Mol. Cell. Biol. 19, 5800-5810
9. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., and Greenberg, M. E. (1997) Cell 91, 231-241
10. Kops, G. J., and Burgering, B. M. (1999) J. Mol. Med. 77, 656-665
11. Jones, R. G., Parsons, M., Bonnard, M., Chan, V. S., Yeh, W. C., Woodgett, J. R., and Ohashi, P. S. (2000) J. Exp. Med. 191, 1721-1734
12. Zong, W. X., Edelstein, L. C., Chen, C., Bash, J., and Gelinas, C. (1999) Genes Dev. 13, 382-387
13. Chao, D. T., Linette, G. P., Boise, L. H., White, L. S., Thompson, C. B., and Korsmeyer, S. J. (1995) J. Exp. Med. 182, 821-828
14. Grillot, D. A., Merino, R., Pena, J. C., Fanslow, W. C., Finkelman, F. D., Thompson, C. B., and Nunez, G. (1996) J. Exp. Med. 183, 381-391
15. Vander Heiden, M. G., Chandel, N. S., Schumacker, P. T., and Thompson, C. B. (1999) Mol. Cell 3, 159-167
16. Vander Heiden, M. G., Chandel, N. S., Li, X. X., Schumacker, P. T., Colombini, M., and Thompson, C. B. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4666-4671
17. Vander Heiden, M. G., Chandel, N. S., Williamson, E. K., Schumacker, P. T., and Thompson, C. B. (1997) Cell 91, 627-637
18. Pear, W. S., Nolan, G. P., Scott, M. L., and Baltimore, D. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 8392-8396
19. Chang, B. S., Kelekar, A., Harris, M. H., Harlan, J. E., Fesik, S. W., and Thompson, C. B. (1999) Mol. Cell. Biol. 19, 6673-6681
20. Ashcroft, S. J., Weerasinghe, L. C., Bassett, J. M., and Randle, P. J. (1972) Biochem. J. 126, 525-532
21. Conlon, I., and Raff, M. (1999) Cell 96, 235-244
22. Rathmell, J. C., Vander Heiden, M. G., Harris, M. H., Frauwirth, K. A., and Thompson, C. B. (2000) Mol. Cell 6, 683-692
23. Verdu, J., Buratovich, M. A., Wilder, E. L., and Birnbaum, M. J. (1999) Nat. Cell Biol. 1, 500-506
24. Weinkove, D., Neufeld, T. P., Twardzik, T., Waterfield, M. D., and Leevers, S. J. (1999) Curr. Biol. 9, 1019-1029
25. Kulik, G., Klippel, A., and Weber, M. J. (1997) Mol. Cell. Biol. 17, 1595-1606
26. Kennedy, S. G., Wagner, A. J., Conzen, S. D., Jordan, J., Bellacosa, A., Tsichlis, P. N., and Hay, N. (1997) Genes Dev. 11, 701-713
27. Kohn, A. D., Takeuchi, F., and Roth, R. A. (1996) J. Biol. Chem. 271, 21920-21926
28. Boise, L. H., Gonzalez-Garcia, M., Postema, C. E., Ding, L., Lindsten, T., Turka, L. A., Mao, X., Nunez, G., and Thompson, C. B. (1993) Cell 74, 597-608
29. Muise-Helmericks, R. C., Grimes, H. L., Bellacosa, A., Malstrom, S. E., Tsichlis, P. N., and Rosen, N. (1998) J. Biol. Chem. 273, 29864-29872
30. Franklin, J. L., and Johnson, E. M. (1998) J. Cell Biol. 142, 1313-1324
31. Deshmukh, M., Vasilakos, J., Deckwerth, T. L., Lampe, P. A., Shivers, B. D., and Johnson, E. M., Jr. (1996) J. Cell Biol. 135, 1341-1354
32. Deckwerth, T. L., and Johnson, E. M., Jr. (1993) J. Cell Biol. 123, 1207-1222
33. Deprez, J., Vertommen, D., Alessi, D. R., Hue, L., and Rider, M. H. (1997) J. Biol. Chem. 272, 17269-17275
34. Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Nature 378, 785-789
35. Barthel, A., Okino, S. T., Liao, J., Nakatani, K., Li, J., Whitlock, J. P., Jr., and Roth, R. A. (1999) J. Biol. Chem. 274, 20281-20286
36. Brand, K., Leibold, W., Luppa, P., Schoerner, C., and Schulz, A. (1986) Immunobiology 173, 23-34
37. Brand, K., Fekl, W., von Hintzenstern, J., Langer, K., Luppa, P., and Schoerner, C. (1989) Metabolism 38, 29-33
38. Staveley, B. E., Ruel, L., Jin, J., Stambolic, V., Mastronardi, F. G., Heitzler, P., Woodgett, J. R., and Manoukian, A. S. (1998) Curr. Biol. 8, 599-602
39. Pap, M., and Cooper, G. M. (1998) J. Biol. Chem. 273, 19929-19932
40. Zhang, G. J., Kimijima, I., Abe, R., Watanabe, T., Kanno, M., Hara, K., and Tsuchiya, A. (1998) Anticancer Res. 18, 1989-1998