Lead identification to generate isoquinolinedione inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 12, 2008, Pages 3641-3645

  Mayer, Scott C ^a   Banker, Annette L ^a   Boschelli, Frank ^b   Di, Li ^a   Johnson, Mark ^a   Kenny, Cynthia Hess ^b   Krishnamurthy, Girija ^b   Kutterer, Kristina ^b   Moy, Franklin ^a   Petusky, Susan ^a   Ravi, Malini ^b   Tkach, Diane ^b   Tsou, Hwei Ru ^b   Xu, Weixin ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

'Hit to Lead' investigations; IGFR inhibitor; Isoquinolinedione

Indexed keywords

ANTINEOPLASTIC AGENT; RECEPTOR BLOCKING AGENT; SOMATOMEDIN C RECEPTOR;

ARTICLE; CANCER THERAPY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ISOQUINOLINES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTOR, IGF TYPE 1; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 44949188302     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.044     Document Type: Article

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