Exploiting the PI3K/AKT pathway for cancer drug discovery

Nature Reviews Drug Discovery

Volumn 4, Issue 12, 2005, Pages 988-1004

  Hennessy, Bryan T ^a   Smith, Debra L ^a   Ram, Prahlad T ^a   Lu, Yiling ^a   Mills, Gordon B ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTINEOPLASTIC AGENT; AP 23573; AP 23841; CALMODULIN INHIBITOR; ERLOTINIB; EVEROLIMUS; GEFITINIB; GEMCITABINE; IMATINIB; KN 309; LETROZOLE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MILTEFOSINE; PERIFOSINE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PX 316; PX 866; RAPAMYCIN; RAPAMYCIN DERIVATIVE; SF 1124; TEMSIROLIMUS; TRASTUZUMAB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; WORTMANNIN;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; BREAST CANCER; BREAST METASTASIS; CANCER THERAPY; CELL ENERGY; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME ABERRATION; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; DRUG EFFICACY; DRUG TARGETING; ENZYME INHIBITION; ENZYME STRUCTURE; FUNCTIONAL GENOMICS; GASTROINTESTINAL STROMAL TUMOR; GENE AMPLIFICATION; GENE DELETION; GENE FREQUENCY; GENE FUSION; GENE MUTATION; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENE SEQUENCE; GENE TRANSLOCATION; GLIOBLASTOMA; GLUCOSE METABOLISM; GROWTH INHIBITION; HEAD AND NECK CANCER; HETEROZYGOSITY LOSS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTESTINE CANCER; KIDNEY CARCINOMA; LUNG CANCER; MAXIMUM TOLERATED DOSE; MEDULLOBLASTOMA; MISSENSE MUTATION; NONHUMAN; OLIGODENDROGLIOMA; OVARY CANCER; PANCREAS CANCER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; RNA SPLICING; SENESCENCE; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; SOMATIC MUTATION; STOMACH CANCER; UPREGULATION; UTERINE CERVIX CANCER; ANIMAL; DRUG DESIGN; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; METHODOLOGY; MUTATION; SYNTHESIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; DRUG DESIGN; DRUG EVALUATION; GENE AMPLIFICATION; HUMANS; MUTATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSLOCATION, GENETIC;

EID: 32044466838     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd1902     Document Type: Review

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