Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors

Proteins: Structure, Function and Genetics

Volumn 73, Issue 4, 2008, Pages 795-801

  Katayama, Naoko ^a   Orita, Masaya ^a   Yamaguchi, Tomohiko ^a   Hisamichi, Hiroyuki ^a   Kuromitsu, Sadao ^a   Kurihara, Hiroyuki ^a   Sakashita, Hitoshi ^a   Matsumoto, Yuzo ^a   Fujita, Shigeo ^a   Niimi, Tatsuya ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Binding mode; Drug design; ERK2; Hydrogen bond; IRK; PDB; Ramachandran plot; Sequence alignment

Indexed keywords

INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; ADENOSINE TRIPHOSPHATE; INSULIN RECEPTOR TYROSINE KINASE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME INHIBITOR COMPLEX; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN DATA BANK; SEQUENCE ALIGNMENT; CHEMISTRY; DRUG ANTAGONISM; PROTEIN DATABASE; SEQUENCE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ADENOSINE TRIPHOSPHATE; CRYSTALLOGRAPHY, X-RAY; DATABASES, PROTEIN; HUMANS; HYDROGEN BONDING; MITOGEN-ACTIVATED PROTEIN KINASE 1; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SEQUENCE ANALYSIS, PROTEIN;

EID: 58149311431     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.22207     Document Type: Article

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