Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 3, 2008, Pages 1359-1375

  Mulvihill, Mark J ^a   Ji, Qun Sheng ^a   Coate, Heather R ^a   Cooke, Andrew ^a   Dong, Hanqing ^a   Feng, Lixin ^a   Foreman, Kenneth ^a   Rosenfeld Franklin, Maryland ^a   Honda, Ayako ^a   Mak, Gilda ^a   Mulvihill, Kristen M ^a   Nigro, Anthony I ^a   O'Connor, Matthew ^a   Pirrit, Caroline ^a   Steinig, Arno G ^a   Siu, Kam ^a   Stolz, Kathryn M ^a   Sun, Yingchuan ^a   Tavares, Paula A R ^a   Yao, Yan ^a   Gibson, Neil W ^a   more..

^a OSI PHARMACEUTICALS INC   (United States)

Author keywords

Cancer; IGF 1R; IGF IR; Imidazopyrazines; Insulin like growth factor I receptor; Tumor growth inhibition; Tyrosine kinase inhibitor

Indexed keywords

2 PHENYLQUINOLINE DERIVATIVE; 3 (3 AZETIDIN 1 YLMETHYLCYCLOBUTYL) 1 (2 PHENYLQUINOLIN 7 YL)IMIDAZO[1,5 A]PYRAZIN 8 YLAMINE; GLUCOSE; INSULIN; PYRAZINE DERIVATIVE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD GLUCOSE; CELL LINE; DOGS; FEMALE; HUMANS; IMIDAZOLES; INSULIN; LIGANDS; MICE; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRAZINES; QUINOLINES; RATS; RECEPTOR, IGF TYPE 1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 38849133610     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.061     Document Type: Article

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