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Volumn 60, Issue 8, 2000, Pages 1101-1107

Inhibition of the type I insulin-like growth factor receptor expression and signaling: Novel strategies for antimetastatic therapy

Author keywords

Cancer metastasis; IGF I receptor; Signal transduction

Indexed keywords

ANTIMETASTATIC AGENT; COMPLEMENTARY RNA; EPIDERMAL GROWTH FACTOR; FOCAL ADHESION KINASE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN C RECEPTOR;

EID: 0034668185     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00422-6     Document Type: Article
Times cited : (94)

References (68)
  • 2
    • 0023301838 scopus 로고
    • The biology of cancer metastasis and implications for therapy
    • Fidler I.J., Balch C.M. The biology of cancer metastasis and implications for therapy. Curr Probl Surg. 24:1987;129-209.
    • (1987) Curr Probl Surg , vol.24 , pp. 129-209
    • Fidler, I.J.1    Balch, C.M.2
  • 3
    • 0002690018 scopus 로고    scopus 로고
    • Adhesion receptors and proteolytic mechanisms in cancer invasion and metastasis
    • (Ed. Brodt P), R.G. Landes and Springer, Heidelberg and Austin TX
    • Brodt P, Adhesion receptors and proteolytic mechanisms in cancer invasion and metastasis. In: Cell Adhesion and Invasion in Cancer Metastasis (Ed. Brodt P), pp. 167-242. R.G. Landes and Springer, Heidelberg and Austin TX, 1996.
    • (1996) In: Cell Adhesion and Invasion in Cancer Metastasis , pp. 167-242
    • Brodt, P.1
  • 4
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta L.A., Steeg P.S., Stetler-Stevenson W.G. Cancer metastasis and angiogenesis An imbalance of positive and negative regulation . Cell. 64:1991;327-336.
    • (1991) Cell , vol.64 , pp. 327-336
    • Liotta, L.A.1    Steeg, P.S.2    Stetler-Stevenson, W.G.3
  • 5
    • 0024473604 scopus 로고
    • G1 events and regulation of cell proliferation
    • Pardee A.B. G1 events and regulation of cell proliferation. Science. 246:1989;603-608.
    • (1989) Science , vol.246 , pp. 603-608
    • Pardee, A.B.1
  • 6
    • 0023942517 scopus 로고
    • Growth factor receptor tyrosine kinases
    • Yarden Y., Ullrich A. Growth factor receptor tyrosine kinases. Annu Rev Biochem. 57:1988;443-478.
    • (1988) Annu Rev Biochem , vol.57 , pp. 443-478
    • Yarden, Y.1    Ullrich, A.2
  • 7
    • 0028859279 scopus 로고
    • Protein modules and signalling networks
    • Pawson T. Protein modules and signalling networks. Nature. 373:1995;573-580.
    • (1995) Nature , vol.373 , pp. 573-580
    • Pawson, T.1
  • 8
    • 0022800838 scopus 로고
    • Insulin-like growth factor I receptor primary structure: Comparison with insulin receptor suggests structural determinants that define functional specificity
    • Ullrich A., Gray A., Tam A.W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., Le Bon T., Kathuria S., Chen E., et al. Insulin-like growth factor I receptor primary structure Comparison with insulin receptor suggests structural determinants that define functional specificity . EMBO J. 5:1986;2503-2512.
    • (1986) EMBO J , vol.5 , pp. 2503-2512
    • Ullrich, A.1    Gray, A.2    Tam, A.W.3    Yang-Feng, T.4    Tsubokawa, M.5    Collins, C.6    Henzel, W.7    Le Bon, T.8    Kathuria, S.9    Chen, E.10
  • 9
    • 0020315756 scopus 로고
    • The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor
    • Massague J., Czech M.P. The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. J Biol Chem. 257:1982;5038-5045.
    • (1982) J Biol Chem , vol.257 , pp. 5038-5045
    • Massague, J.1    Czech, M.P.2
  • 11
    • 0025325049 scopus 로고
    • Insulin-like growth factors and their binding proteins
    • Sara V.R., Hall K. Insulin-like growth factors and their binding proteins. Physiol Rev. 70:1990;591-614.
    • (1990) Physiol Rev , vol.70 , pp. 591-614
    • Sara, V.R.1    Hall, K.2
  • 12
    • 0032565746 scopus 로고    scopus 로고
    • Role of insulin-like growth factor binding proteins in controlling IGF actions
    • Clemmons D.R. Role of insulin-like growth factor binding proteins in controlling IGF actions. Mol Cell Endocrinol. 140:1998;19-24.
    • (1998) Mol Cell Endocrinol , vol.140 , pp. 19-24
    • Clemmons, D.R.1
  • 14
    • 0029119731 scopus 로고
    • Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity
    • Rubin R., Baserga R. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Lab Invest. 73:1995;311-331.
    • (1995) Lab Invest , vol.73 , pp. 311-331
    • Rubin, R.1    Baserga, R.2
  • 15
    • 0028362024 scopus 로고
    • A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
    • Coppola D., Ferber A., Miura M., Sell C., D'Ambrosio C., Rubin R., Baserga R. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol. 14:1994;4588-4595.
    • (1994) Mol Cell Biol , vol.14 , pp. 4588-4595
    • Coppola, D.1    Ferber, A.2    Miura, M.3    Sell, C.4    D'Ambrosio, C.5    Rubin, R.6    Baserga, R.7
  • 16
    • 0029079589 scopus 로고
    • Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor
    • DeAngelis T., Ferber A., Baserga R. Insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the platelet-derived growth factor receptor. J Cell Physiol. 164:1995;214-221.
    • (1995) J Cell Physiol , vol.164 , pp. 214-221
    • Deangelis, T.1    Ferber, A.2    Baserga, R.3
  • 17
    • 0028263811 scopus 로고
    • C-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington E.A., Bennett M.R., Fanidi A., Evan G.I. c-Myc-induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 13:1994;3286-3295.
    • (1994) EMBO J , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fanidi, A.3    Evan, G.I.4
  • 18
    • 0026683954 scopus 로고
    • Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells
    • Rodriguez-Tarduchy G., Collins M.K., Garcia I., Lopez-Rivas A. Insulin-like growth factor-I inhibits apoptosis in IL-3-dependent hemopoietic cells. J Immunol. 149:1992;535-540.
    • (1992) J Immunol , vol.149 , pp. 535-540
    • Rodriguez-Tarduchy, G.1    Collins, M.K.2    Garcia, I.3    Lopez-Rivas, A.4
  • 21
    • 0032898811 scopus 로고    scopus 로고
    • Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses
    • Petley T., Graff K., Jiang W., Yang H., Florini J. Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses. Horm Metab Res. 31:1999;70-76.
    • (1999) Horm Metab Res , vol.31 , pp. 70-76
    • Petley, T.1    Graff, K.2    Jiang, W.3    Yang, H.4    Florini, J.5
  • 22
    • 0030748457 scopus 로고    scopus 로고
    • The insulin signaling system and the IRS proteins
    • White M.F. The insulin signaling system and the IRS proteins. Diabetologia. 2:1997;S2-S17.
    • (1997) Diabetologia , vol.2
    • White, M.F.1
  • 23
    • 0029074148 scopus 로고
    • Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor
    • Craparo A., O'Neill T.J., Gustafson T.A. Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine-dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J Biol Chem. 270:1995;15639-15643.
    • (1995) J Biol Chem , vol.270 , pp. 15639-15643
    • Craparo, A.1    O'Neill, T.J.2    Gustafson, T.A.3
  • 24
    • 0027512244 scopus 로고
    • The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro
    • Giorgetti S., Ballotti R., Kowalski-Chauvel A., Tartare S., Van Obberghen E. The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitro. J Biol Chem. 268:1993;7358-7364.
    • (1993) J Biol Chem , vol.268 , pp. 7358-7364
    • Giorgetti, S.1    Ballotti, R.2    Kowalski-Chauvel, A.3    Tartare, S.4    Van Obberghen, E.5
  • 25
    • 0028282967 scopus 로고
    • Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1
    • Sugimoto S., Wandless T.J., Shoelson S.E., Neel B.G., Walsh C.T. Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1. J Biol Chem. 269:1994;13614-13622.
    • (1994) J Biol Chem , vol.269 , pp. 13614-13622
    • Sugimoto, S.1    Wandless, T.J.2    Shoelson, S.E.3    Neel, B.G.4    Walsh, C.T.5
  • 26
    • 0027437376 scopus 로고
    • Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1
    • Sun X.J., Crimmins D.L., Myers M.G. Jr, Miralpeix M., White M.F. Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol. 13:1993;7418-7428.
    • (1993) Mol Cell Biol , vol.13 , pp. 7418-7428
    • Sun, X.J.1    Crimmins, D.L.2    Myers M.G., Jr.3    Miralpeix, M.4    White, M.F.5
  • 28
    • 0033617446 scopus 로고    scopus 로고
    • Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways
    • Valentinis B., Romano G., Peruzzi F., Morrione A., Prisco M., Soddu S., Cristofanelli B., Sacchi A., Baserga R. Growth and differentiation signals by the insulin-like growth factor 1 receptor in hemopoietic cells are mediated through different pathways. J Biol Chem. 274:1999;12423-12430.
    • (1999) J Biol Chem , vol.274 , pp. 12423-12430
    • Valentinis, B.1    Romano, G.2    Peruzzi, F.3    Morrione, A.4    Prisco, M.5    Soddu, S.6    Cristofanelli, B.7    Sacchi, A.8    Baserga, R.9
  • 29
    • 0031769049 scopus 로고    scopus 로고
    • Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor
    • Gual P., Baron V., Lequoy V., Van Obberghen E. Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor. Endocrinology. 139:1998;884-893.
    • (1998) Endocrinology , vol.139 , pp. 884-893
    • Gual, P.1    Baron, V.2    Lequoy, V.3    Van Obberghen, E.4
  • 30
    • 0034685906 scopus 로고    scopus 로고
    • Mechanism of STAT3 activation by insulin-like growth factor I receptor
    • Zong C.S., Chan J., Levy D.E., Horvath C., Sadowski H.B., Wang L.H. Mechanism of STAT3 activation by insulin-like growth factor I receptor. J Biol Chem. 275:2000;15099-15105.
    • (2000) J Biol Chem , vol.275 , pp. 15099-15105
    • Zong, C.S.1    Chan, J.2    Levy, D.E.3    Horvath, C.4    Sadowski, H.B.5    Wang, L.H.6
  • 31
    • 0032561353 scopus 로고    scopus 로고
    • STAT3 plays an important role in oncogenic Ros- And insulin-like growth factor I receptor-induced anchorage-independent growth
    • Zong C.S., Zeng L., Jiang Y., Sadowski H.B., Wang L.H. STAT3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth. J Biol Chem. 273:1998;28065-28072.
    • (1998) J Biol Chem , vol.273 , pp. 28065-28072
    • Zong, C.S.1    Zeng, L.2    Jiang, Y.3    Sadowski, H.B.4    Wang, L.H.5
  • 32
    • 0028953268 scopus 로고
    • Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk
    • Beitner-Johnson D., LeRoith D. Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk. J Biol Chem. 270:1995;5187-5190.
    • (1995) J Biol Chem , vol.270 , pp. 5187-5190
    • Beitner-Johnson, D.1    Leroith, D.2
  • 33
    • 0032511102 scopus 로고    scopus 로고
    • Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction
    • Koval A.P., Karas M., Zick Y., LeRoith D. Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. J Biol Chem. 273:1998;14780-14787.
    • (1998) J Biol Chem , vol.273 , pp. 14780-14787
    • Koval, A.P.1    Karas, M.2    Zick, Y.3    Leroith, D.4
  • 34
    • 0032549179 scopus 로고    scopus 로고
    • P125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors
    • Baron V., Calleja V., Ferrari P., Alengrin F., Van Obberghen E. p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors. J Biol Chem. 273:1998;7162-7168.
    • (1998) J Biol Chem , vol.273 , pp. 7162-7168
    • Baron, V.1    Calleja, V.2    Ferrari, P.3    Alengrin, F.4    Van Obberghen, E.5
  • 35
    • 0032475851 scopus 로고    scopus 로고
    • Insulin-like growth factor I stimulates tyrosine phosphorylation of p130 (Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3′-kinase and formation of a p130 (Cas). Crk complex
    • Casamassima A., Rozengurt E. Insulin-like growth factor I stimulates tyrosine phosphorylation of p130 (Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3′-kinase and formation of a p130 (Cas). Crk complex. J Biol Chem. 273:1998;26149-26156.
    • (1998) J Biol Chem , vol.273 , pp. 26149-26156
    • Casamassima, A.1    Rozengurt, E.2
  • 36
    • 0028263801 scopus 로고
    • Human insulin-like growth factor I receptor internalization. Role of the juxtamembrane domain
    • Prager D., Li H.L., Yamasaki H., Melmed S. Human insulin-like growth factor I receptor internalization. Role of the juxtamembrane domain. J Biol Chem. 269:1994;11934-11937.
    • (1994) J Biol Chem , vol.269 , pp. 11934-11937
    • Prager, D.1    Li, H.L.2    Yamasaki, H.3    Melmed, S.4
  • 37
    • 0031300006 scopus 로고    scopus 로고
    • IGF-I receptor protection from apoptosis in cells lacking the IRS proteins
    • Dews M., Nishimoto I., Baserga R. IGF-I receptor protection from apoptosis in cells lacking the IRS proteins. Recept Signal Transduct. 7:1997;231-240.
    • (1997) Recept Signal Transduct , vol.7 , pp. 231-240
    • Dews, M.1    Nishimoto, I.2    Baserga, R.3
  • 38
    • 0028558971 scopus 로고
    • Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain
    • Li S., Ferber A., Miura M., Baserga R. Mitogenicity and transforming activity of the insulin-like growth factor-I receptor with mutations in the tyrosine kinase domain. J Biol Chem. 269:1994;32558-32654.
    • (1994) J Biol Chem , vol.269 , pp. 32558-32654
    • Li, S.1    Ferber, A.2    Miura, M.3    Baserga, R.4
  • 39
    • 0028863148 scopus 로고
    • The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation and tumorigenesis
    • Hernandez-Sanchez C., Blakesley V., Kalebic T., Helman L., LeRoith D. The role of the tyrosine kinase domain of the insulin-like growth factor-I receptor in intracellular signaling, cellular proliferation and tumorigenesis. J Biol Chem. 270:1995;29176-29181.
    • (1995) J Biol Chem , vol.270 , pp. 29176-29181
    • Hernandez-Sanchez, C.1    Blakesley, V.2    Kalebic, T.3    Helman, L.4    Leroith, D.5
  • 40
    • 0031603311 scopus 로고    scopus 로고
    • Survival factors and apoptosis
    • O'Connor R. Survival factors and apoptosis. Adv Biochem Eng Biotechnol. 62:1998;137-166.
    • (1998) Adv Biochem Eng Biotechnol , vol.62 , pp. 137-166
    • O'Connor, R.1
  • 41
    • 0029145296 scopus 로고
    • Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor
    • Miura M., Surmacz E., Burgaud J.L., Baserga R. Different effects on mitogenesis and transformation of a mutation at tyrosine 1251 of the insulin-like growth factor I receptor. J Biol Chem. 270:1995;22639-22644.
    • (1995) J Biol Chem , vol.270 , pp. 22639-22644
    • Miura, M.1    Surmacz, E.2    Burgaud, J.L.3    Baserga, R.4
  • 42
    • 0032541182 scopus 로고    scopus 로고
    • Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth
    • Blakesley V.A., Koval A.P., Stannard B.S., Scrimgeour A., LeRoith D. Replacement of tyrosine 1251 in the carboxyl terminus of the insulin-like growth factor-I receptor disrupts the actin cytoskeleton and inhibits proliferation and anchorage-independent growth. J Biol Chem. 273:1998;18411-18422.
    • (1998) J Biol Chem , vol.273 , pp. 18411-18422
    • Blakesley, V.A.1    Koval, A.P.2    Stannard, B.S.3    Scrimgeour, A.4    Leroith, D.5
  • 43
    • 15844368106 scopus 로고    scopus 로고
    • Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor
    • Li S., Resnicoff M., Baserga R. Effect of mutations at serines 1280-1283 on the mitogenic and transforming activities of the insulin-like growth factor I receptor. J Biol Chem. 271:1996;12254-12260.
    • (1996) J Biol Chem , vol.271 , pp. 12254-12260
    • Li, S.1    Resnicoff, M.2    Baserga, R.3
  • 44
    • 0026576726 scopus 로고
    • Insulin-like growth factors and cancer
    • Macaulay V.M. Insulin-like growth factors and cancer. Br J Cancer. 65:1992;311-320.
    • (1992) Br J Cancer , vol.65 , pp. 311-320
    • Macaulay, V.M.1
  • 47
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • Ma J., Pollak M.N., Giovannucci E., Chan J.M., Tao Y., Hennekens C.H., Stampfer M.J. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst. 91:1999;620-625.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannucci, E.3    Chan, J.M.4    Tao, Y.5    Hennekens, C.H.6    Stampfer, M.J.7
  • 48
    • 0028050256 scopus 로고
    • Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor
    • Resnicoff M., Coppola D., Sell C., Rubin R., Ferrone S., Baserga R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res. 54:1994;4848-4850.
    • (1994) Cancer Res , vol.54 , pp. 4848-4850
    • Resnicoff, M.1    Coppola, D.2    Sell, C.3    Rubin, R.4    Ferrone, S.5    Baserga, R.6
  • 49
    • 0029937307 scopus 로고    scopus 로고
    • Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo
    • Burfeind P., Chernicky C.L., Rininsland F., Ilan J., Ilan J. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo. Proc Natl Acad Sci USA. 93:1996;7263-7268.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7263-7268
    • Burfeind, P.1    Chernicky, C.L.2    Rininsland, F.3    Ilan, J.4    Ilan, J.5
  • 50
    • 0033952237 scopus 로고    scopus 로고
    • Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines
    • Nakamura K., Hongo A., Kodama J., Miyagi Y., Yoshinouchi M., Kudo T. Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines. Cancer Res. 60:2000;760-765.
    • (2000) Cancer Res , vol.60 , pp. 760-765
    • Nakamura, K.1    Hongo, A.2    Kodama, J.3    Miyagi, Y.4    Yoshinouchi, M.5    Kudo, T.6
  • 51
    • 0027407639 scopus 로고
    • Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1
    • Pietrzkoski Z., Mulholland G., Gomella L., Jameson B.A., Wernicke D., Baserga R. Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1. Cancer Res. 53:1993;1102-1106.
    • (1993) Cancer Res , vol.53 , pp. 1102-1106
    • Pietrzkoski, Z.1    Mulholland, G.2    Gomella, L.3    Jameson, B.A.4    Wernicke, D.5    Baserga, R.6
  • 52
    • 0030987783 scopus 로고    scopus 로고
    • Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells
    • Rininsland F., Johnson T.R., Chernicky C.L., Schulze E., Burfeind P., Ilan J. Suppression of insulin-like growth factor type I receptor by a triple-helix strategy inhibits IGF-I transcription and tumorigenic potential of rat C6 glioblastoma cells. Proc Natl Acad Sci USA. 94:1997;5854-5859.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 5854-5859
    • Rininsland, F.1    Johnson, T.R.2    Chernicky, C.L.3    Schulze, E.4    Burfeind, P.5    Ilan, J.6
  • 53
    • 0029995770 scopus 로고    scopus 로고
    • Controlling IGF-receptor function: A possible strategy for tumor therapy
    • Baserga R. Controlling IGF-receptor function A possible strategy for tumor therapy . Trends Biotech. 14:1996;150-152.
    • (1996) Trends Biotech , vol.14 , pp. 150-152
    • Baserga, R.1
  • 54
    • 0033604523 scopus 로고    scopus 로고
    • The IGF-I receptor in cancer research
    • Baserga R. The IGF-I receptor in cancer research. Exp Cell Res. 253:1999;1-6.
    • (1999) Exp Cell Res , vol.253 , pp. 1-6
    • Baserga, R.1
  • 55
    • 0027977941 scopus 로고
    • Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-1: A regulatory mechanism for carcinoma cells metastatic to the liver
    • Long L., Nip J., Brodt P. Paracrine growth stimulation by hepatocyte-derived insulin-like growth factor-1 A regulatory mechanism for carcinoma cells metastatic to the liver . Cancer Res. 54:1994;3732-3737.
    • (1994) Cancer Res , vol.54 , pp. 3732-3737
    • Long, L.1    Nip, J.2    Brodt, P.3
  • 56
    • 0031844617 scopus 로고    scopus 로고
    • Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor
    • Long L., Rubin R., Brodt P. Enhanced invasion and liver colonization by lung carcinoma cells overexpressing the type 1 insulin-like growth factor receptor. Exp Cell Res. 238:1998;116-121.
    • (1998) Exp Cell Res , vol.238 , pp. 116-121
    • Long, L.1    Rubin, R.2    Brodt, P.3
  • 57
    • 0028920352 scopus 로고
    • Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor
    • Long L., Rubin R., Baserga R., Brodt P. Loss of the metastatic phenotype in murine carcinoma cells expressing an antisense RNA to the insulin-like growth factor receptor. Cancer Res. 55:1995;1006-1009.
    • (1995) Cancer Res , vol.55 , pp. 1006-1009
    • Long, L.1    Rubin, R.2    Baserga, R.3    Brodt, P.4
  • 58
    • 0032129270 scopus 로고    scopus 로고
    • r 72,000 type IV collagenase by the type I insulin-like growth factor receptor
    • r 72,000 type IV collagenase by the type I insulin-like growth factor receptor. Cancer Res. 58:1998;3243-3247.
    • (1998) Cancer Res , vol.58 , pp. 3243-3247
    • Long, L.1    Navab, R.2    Brodt, P.3
  • 59
    • 0029147719 scopus 로고
    • Mutant IGF-I receptors as dominant negatives for growth and transformation
    • Burgaud J.L., Resnicoff M., Baserga R. Mutant IGF-I receptors as dominant negatives for growth and transformation. Biochem Biophys Res Commun. 214:1995;475-481.
    • (1995) Biochem Biophys Res Commun , vol.214 , pp. 475-481
    • Burgaud, J.L.1    Resnicoff, M.2    Baserga, R.3
  • 60
    • 0031785253 scopus 로고    scopus 로고
    • Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect
    • Reiss K., D'Ambrosio C., Tu X., Tu C., Baserga R. Inhibition of tumor growth by a dominant negative mutant of the insulin-like growth factor I receptor with a bystander effect. Clin Cancer Res. 4:1998;2647-2655.
    • (1998) Clin Cancer Res , vol.4 , pp. 2647-2655
    • Reiss, K.1    D'Ambrosio, C.2    Tu, X.3    Tu, C.4    Baserga, R.5
  • 61
    • 0033613356 scopus 로고    scopus 로고
    • Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-1 receptor
    • Jiang Y., Rom W.N., Yie T.A., Chi C.X., Tchou-Wong K.M. Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-1 receptor. Oncogene. 44:1999;6071-6077.
    • (1999) Oncogene , vol.44 , pp. 6071-6077
    • Jiang, Y.1    Rom, W.N.2    Yie, T.A.3    Chi, C.X.4    Tchou-Wong, K.M.5
  • 62
    • 0021894454 scopus 로고
    • Uptake of insulin and other ligands into receptor-rich endocytic components of target cells: The endosomal apparatus
    • Bergeron J.J., Cruz J., Khan M.N., Posner B.I. Uptake of insulin and other ligands into receptor-rich endocytic components of target cells The endosomal apparatus . Annu Rev Physiol. 47:1985;383-403.
    • (1985) Annu Rev Physiol , vol.47 , pp. 383-403
    • Bergeron, J.J.1    Cruz, J.2    Khan, M.N.3    Posner, B.I.4
  • 63
    • 0032548865 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway
    • Chow J.C., Condorelli G., Smith R.J. Insulin-like growth factor-I receptor internalization regulates signaling via the Shc/mitogen-activated protein kinase pathway, but not the insulin receptor substrate-1 pathway. J Biol Chem. 273:1998;4672-4680.
    • (1998) J Biol Chem , vol.273 , pp. 4672-4680
    • Chow, J.C.1    Condorelli, G.2    Smith, R.J.3
  • 64
    • 0028355734 scopus 로고
    • Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts
    • Zapf A., Hsu D., Olefsky J.M. Comparison of the intracellular itineraries of insulin-like growth factor-I and insulin and their receptors in Rat-1 fibroblasts. Endocrinology. 134:1994;2445-2451.
    • (1994) Endocrinology , vol.134 , pp. 2445-2451
    • Zapf, A.1    Hsu, D.2    Olefsky, J.M.3
  • 65
    • 0023886620 scopus 로고
    • Receptor-mediated endocytosis and lysosomal processing of insulin-like growth factor I by mitogenically responsive cells
    • Furlanetto R.W. Receptor-mediated endocytosis and lysosomal processing of insulin-like growth factor I by mitogenically responsive cells. Endocrinology. 122:1988;2044-2053.
    • (1988) Endocrinology , vol.122 , pp. 2044-2053
    • Furlanetto, R.W.1
  • 66
    • 0039552134 scopus 로고    scopus 로고
    • Negative regulation of epidermal growth factor signaling by selective proteolytic mechanisms in the endosome mediated by cathepsin B
    • Authier R., Metioui M., Bell A.W., Mort J.S. Negative regulation of epidermal growth factor signaling by selective proteolytic mechanisms in the endosome mediated by cathepsin B. J Biol Chem. 274:1999;33723-33731.
    • (1999) J Biol Chem , vol.274 , pp. 33723-33731
    • Authier, R.1    Metioui, M.2    Bell, A.W.3    Mort, J.S.4
  • 67
    • 0032032628 scopus 로고    scopus 로고
    • Control of breast tumor cell growth using a targeted cysteine protease inhibitor
    • Xing R., Wu F., Mason R.W. Control of breast tumor cell growth using a targeted cysteine protease inhibitor. Cancer Res. 58:1998;904-909.
    • (1998) Cancer Res , vol.58 , pp. 904-909
    • Xing, R.1    Wu, F.2    Mason, R.W.3
  • 68
    • 0342494343 scopus 로고    scopus 로고
    • Cysteine proteinases can regulate the malignant phenotype through their involvement in IGF-1 receptor turnover
    • Navab R., DiGulielmo G.M., Bergeron J.J., Brodt P. Cysteine proteinases can regulate the malignant phenotype through their involvement in IGF-1 receptor turnover. Proc Am Assoc Cancer Res. 40:1999;4043.
    • (1999) Proc Am Assoc Cancer Res , vol.40 , pp. 4043
    • Navab, R.1    Digulielmo, G.M.2    Bergeron, J.J.3    Brodt, P.4


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