Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4] triazine inhibitors of IGF-1R kinase and IR kinase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5027-5030

  Sampognaro, Anthony J ^a   Wittman, Mark D ^a   Carboni, Joan M ^a   Chang, Chiehying ^a   Greer, Ann F ^a   Hurlburt, Warren W ^a   Sack, John S ^a   Vyas, Dolatrai M ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

IGF 1R; IR; Isosteres; Proline; Pyrrolotriazine

Indexed keywords

2,4 PYRROLO[1,2 F][1,2,4]TRIAZINE; AMIDE; FLUOROPYRIDINE AMIDE; PHOSPHOTRANSFERASE INHIBITOR; PROLINE; SOMATOMEDIN C RECEPTOR; TRIAZINE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

MODELS, MOLECULAR; PROLINE; PROTEIN KINASE INHIBITORS; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; TRIAZINES;

EID: 77955659488     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.045     Document Type: Article

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