Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38

Science

Volumn 318, Issue 5852, 2007, Pages 977-980

  Bai, Xiaochun ^a,b   Ma, Dongzhu ^a   Liu, Anling ^a   Shen, Xiaoyun ^a   Wang, Qiming J ^a   Liu, Yongjian ^a   Jiang, Yu ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; FK 12 BINDING PROTEIN; FK 38 BINDING PROTEIN; FK 506 BINDING PROTEIN; GROWTH FACTOR; GUANOSINE TRIPHOSPHATE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RHEB PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTICS; GROWTH RESPONSE; MAMMAL; MOLECULAR ANALYSIS; NUTRIENT AVAILABILITY; PROTEIN;

ARTICLE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUTRIENT AVAILABILITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM;

AMINO ACIDS; CELL LINE; CULTURE MEDIA; GUANOSINE TRIPHOSPHATE; HUMANS; INSULIN; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MONOMERIC GTP-BINDING PROTEINS; MUTANT PROTEINS; NEUROPEPTIDES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERUM; SIGNAL TRANSDUCTION; SIROLIMUS; TACROLIMUS BINDING PROTEINS; TRANSCRIPTION FACTORS;

MAMMALIA;

EID: 36049043184     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1147379     Document Type: Article

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