메뉴 건너뛰기




Volumn 72, Issue 1, 2012, Pages 3-12

Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncology

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AVE 1642; BIIB 022; CARBOPLATIN; CETUXIMAB; CIXUTUMUMAB; CONATUMUMAB; DALOTUZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; ESTROGEN RECEPTOR; EVEROLIMUS; FIGITUMUMAB; GANITUMAB; GEMCITABINE; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; IRINOTECAN; MEDI 573; MONOCLONAL ANTIBODY; PACLITAXEL; PANITUMUMAB; PLACEBO; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN C RECEPTOR; SORAFENIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; UVOMORULIN;

EID: 84855398829     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-0550     Document Type: Review
Times cited : (74)

References (41)
  • 1
    • 79951860072 scopus 로고    scopus 로고
    • Small is beautiful: Insulin-like growth factors and their role in growth, development, and cancer
    • Maki RG. Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol 2010;28: 4985-95.
    • (2010) J Clin Oncol , vol.28 , pp. 4985-4995
    • Maki, R.G.1
  • 2
    • 34047174592 scopus 로고    scopus 로고
    • The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer
    • DOI 10.2174/138161207780249173
    • Belfiore A. The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 2007;13:671-86. (Pubitemid 46510744)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.7 , pp. 671-686
    • Belfiore, A.1
  • 3
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-28.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 4
    • 43349088787 scopus 로고    scopus 로고
    • Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer
    • DOI 10.1517/14728222.12.5.589
    • Yuen JS, Macaulay VM. Targeting the type 1 insulin-like growth factor receptor as a treatment for cancer. Expert Opin Ther Targets 2008;12:589-603. (Pubitemid 351699478)
    • (2008) Expert Opinion on Therapeutic Targets , vol.12 , Issue.5 , pp. 589-603
    • Yuen, J.S.P.1    Macaulay, V.M.2
  • 5
    • 70349754556 scopus 로고    scopus 로고
    • Resistance pathways relevant to insulinlike growth factor-1 receptor-targeted therapy
    • Hendrickson AW, Haluska P. Resistance pathways relevant to insulinlike growth factor-1 receptor-targeted therapy. Curr Opin Investig Drugs 2009;10:1032-40.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1032-1040
    • Hendrickson, A.W.1    Haluska, P.2
  • 6
    • 57149127369 scopus 로고    scopus 로고
    • IGF-1 receptor inhibitors in clinical trials-early lessons
    • Weroha SJ, Haluska P. IGF-1 receptor inhibitors in clinical trials-early lessons. J Mammary Gland Biol Neoplasia 2008;13:471-83.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 471-483
    • Weroha, S.J.1    Haluska, P.2
  • 7
    • 33745100153 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection
    • DOI 10.1038/sj.onc.1209339, PII 1209339
    • Vasilcanu D, Weng WH, Girnita A, Lui WO, Vasilcanu R, Axelson M, et al. The insulin-like growth factor-1 receptor inhibitor PPP produces only very limited resistance in tumor cells exposed to long-term selection. Oncogene 2006;25:3186-95. (Pubitemid 43881559)
    • (2006) Oncogene , vol.25 , Issue.22 , pp. 3186-3195
    • Vasilcanu, D.1    Weng, W.-H.2    Girnita, A.3    Lui, W.-O.4    Vasilcanu, R.5    Axelson, M.6    Larsson, O.7    Larsson, C.8    Girnita, L.9
  • 9
    • 72749095742 scopus 로고    scopus 로고
    • Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: Inhibition of proliferation, adhesion, and motility
    • Massoner P, Colleselli D, Matscheski A, Pircher H, Geley S, Jansen Dürr P, et al. Novel mechanism of IGF-binding protein-3 action on prostate cancer cells: inhibition of proliferation, adhesion, and motility. Endocr Relat Cancer 2009;16:795-808.
    • (2009) Endocr Relat Cancer , vol.16 , pp. 795-808
    • Massoner, P.1    Colleselli, D.2    Matscheski, A.3    Pircher, H.4    Geley, S.5    Jansen Dürr, P.6
  • 10
    • 75249097799 scopus 로고    scopus 로고
    • Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: A phase 1 expansion cohort study
    • Olmos D, Postel-Vinay S, Molife LR, Okuno SH, Schuetze SM, Paccagnella ML, et al. Safety, pharmacokinetics, and preliminary activity of the anti-IGF-1R antibody figitumumab (CP-751,871) in patients with sarcoma and Ewing's sarcoma: a phase 1 expansion cohort study. Lancet Oncol 2010;11:129-35.
    • (2010) Lancet Oncol , vol.11 , pp. 129-135
    • Olmos, D.1    Postel-Vinay, S.2    Molife, L.R.3    Okuno, S.H.4    Schuetze, S.M.5    Paccagnella, M.L.6
  • 11
    • 75749102231 scopus 로고    scopus 로고
    • Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma
    • Haluska P, Worden F, Olmos D, Yin D, Schteingart D, Batzel GN, et al. Safety, tolerability, and pharmacokinetics of the anti-IGF-1R monoclonal antibody figitumumab in patients with refractory adrenocortical carcinoma. Cancer Chemother Pharmacol 2010;65:765-73.
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 765-773
    • Haluska, P.1    Worden, F.2    Olmos, D.3    Yin, D.4    Schteingart, D.5    Batzel, G.N.6
  • 12
    • 49249125421 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic and pharmacodynamic study of the antiinsulin like growth factor type 1 Receptor monoclonal antibody CP- 751,871 in patients with multiple myeloma
    • Lacy MQ,Alsina M, Fonseca R, Paccagnella ML, Melvin CL, Yin D, et al. Phase I, pharmacokinetic and pharmacodynamic study of the antiinsulin like growth factor type 1 Receptor monoclonal antibody CP- 751,871 in patients with multiple myeloma. J Clin Oncol 2008;26:3196-203.
    • (2008) J Clin Oncol , vol.26 , pp. 3196-3203
    • Lacy, M.Q.1    Alsina, M.2    Fonseca, R.3    Paccagnella, M.L.4    Melvin, C.L.5    Yin, D.6
  • 13
    • 77955049754 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor inhibitor figitumumab (CP- 751,871) in combination with docetaxel in patients with advanced solid tumours: Results of a phase Ib dose-escalation, open-label study
    • Molife LR, Fong PC, Paccagnella L, Reid AH, Shaw HM, Vidal L, et al. The insulin-like growth factor-I receptor inhibitor figitumumab (CP- 751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study. Br J Cancer 2010;103:332-9.
    • (2010) Br J Cancer , vol.103 , pp. 332-339
    • Molife, L.R.1    Fong, P.C.2    Paccagnella, L.3    Reid, A.H.4    Shaw, H.M.5    Vidal, L.6
  • 14
    • 66349091290 scopus 로고    scopus 로고
    • Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer
    • Karp DD, Paz-Ares LG, Novello S, Haluska P, Garland L, Cardenal F, et al. Phase II study of the anti-insulin-like growth factor type 1 receptor antibody CP-751,871 in combination with paclitaxel and carboplatin in previously untreated, locally advanced, or metastatic non-small-cell lung cancer. J Clin Oncol 2009;27:2516-22.
    • (2009) J Clin Oncol , vol.27 , pp. 2516-2522
    • Karp, D.D.1    Paz-Ares, L.G.2    Novello, S.3    Haluska, P.4    Garland, L.5    Cardenal, F.6
  • 15
    • 74749085657 scopus 로고    scopus 로고
    • Continued high activity of figitumumab (CP-751,871) combination therapy in squamous lung cancer
    • abstr 8072
    • Karp DD, Novello S, Cardenal F, Haluska P, Blakely LJ, Garland L, et al. Continued high activity of figitumumab (CP-751,871) combination therapy in squamous lung cancer. J Clin Oncol 2009;27:15s (abstr 8072).
    • (2009) J Clin Oncol , vol.27
    • Karp, D.D.1    Novello, S.2    Cardenal, F.3    Haluska, P.4    Blakely, L.J.5    Garland, L.6
  • 16
    • 77949460318 scopus 로고    scopus 로고
    • Correlation of plasma levels of free insulin-like growth factor 1 and clinical benefit of the IGF-IR inhibitor figitumumab (CP- 751, 871)
    • abstr 3539
    • Hixon ML, Gualberto A, Demers L, Paz-Ares LG, Novello S, Blakely LJ, et al. Correlation of plasma levels of free insulin-like growth factor 1 and clinical benefit of the IGF-IR inhibitor figitumumab (CP- 751, 871). J Clin Oncol 2009;27:15s (abstr 3539).
    • (2009) J Clin Oncol , vol.27
    • Hixon, M.L.1    Gualberto, A.2    Demers, L.3    Paz-Ares, L.G.4    Novello, S.5    Blakely, L.J.6
  • 17
    • 77956227862 scopus 로고    scopus 로고
    • Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
    • abstr 7500
    • Jassem J, Langer CJ, Karp DD, Mok T, Benner RJ, Green SJ, et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 2010;28:15s (abstr 7500).
    • (2010) J Clin Oncol , vol.28
    • Jassem, J.1    Langer, C.J.2    Karp, D.D.3    Mok, T.4    Benner, R.J.5    Green, S.J.6
  • 18
    • 79951816312 scopus 로고    scopus 로고
    • Combination mTOR and IGF-1R inhibition: Phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors
    • Quek R, Wang Q, Morgan JA, Shapiro GI, Butrynski JE, Ramaiya N, et al. Combination mTOR and IGF-1R inhibition: phase I trial of everolimus and figitumumab in patients with advanced sarcomas and other solid tumors. Clin Cancer Res 2011;17:871-9.
    • (2011) Clin Cancer Res , vol.17 , pp. 871-879
    • Quek, R.1    Wang, Q.2    Morgan, J.A.3    Shapiro, G.I.4    Butrynski, J.E.5    Ramaiya, N.6
  • 19
    • 84855378754 scopus 로고    scopus 로고
    • A phase II study of cixutumumab (IMC-A12), a monoclonal antibody (mAb) against the insulin-like growth factor 1 receptor (IGF-IR), monotherapy in metastatic castration-resistant prostate cancer (mCRPC): Feasibility of every 3-week dosing and updated results
    • Abstr 189
    • Higano CS, Alumkal JJ, Ryan CJ, Yu EY, Beer TM, Fox FE, et al. A phase II study of cixutumumab (IMC-A12), a monoclonal antibody (mAb) against the insulin-like growth factor 1 receptor (IGF-IR), monotherapy in metastatic castration-resistant prostate cancer (mCRPC): Feasibility of every 3-week dosing and updated results. Genitourinary Cancers Symposium, 2010; San Francisco, CA, USA. Abstr 189.
    • Genitourinary Cancers Symposium, 2010; San Francisco, CA, USA
    • Higano, C.S.1    Alumkal, J.J.2    Ryan, C.J.3    Yu, E.Y.4    Beer, T.M.5    Fox, F.E.6
  • 20
    • 77957583631 scopus 로고    scopus 로고
    • Phase II study of the insulin-like growth factor-1 receptor (IGF-1R) antibody cixutumumab (C) in patients (pts) with thymoma (T) and thymic carcinoma (TC)
    • Rajan A, Berman AW, Kelly RJ, Lopez-Chavez A, Dechowdhury R, Chen H, et al. Phase II study of the insulin-like growth factor-1 receptor (IGF-1R) antibody cixutumumab (C) in patients (pts) with thymoma (T) and thymic carcinoma (TC). J Clin Oncol 2010;28:15s (e17525).
    • (2010) J Clin Oncol , vol.28
    • Rajan, A.1    Berman, A.W.2    Kelly, R.J.3    Lopez-Chavez, A.4    Dechowdhury, R.5    Chen, H.6
  • 21
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher AW, Sarantopoulos J, Patnaik A, Papadopoulos K, Lin CC, Rodon J, et al. Phase I, pharmacokinetic, and pharmacodynamic study of AMG 479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009;27:5800-7.
    • (2009) J Clin Oncol , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3    Papadopoulos, K.4    Lin, C.C.5    Rodon, J.6
  • 22
    • 84857914686 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 479 in combination with erlotinib (E) or sorafenib (S) in patients (pts) with advanced solid tumors
    • abstr 3018
    • Puzanov I, Sarantopoulos J, Gilbert J, Mahalingam D, Chap LI, Deng H, et al. Safety and pharmacokinetics (PK) of AMG 479 in combination with erlotinib (E) or sorafenib (S) in patients (pts) with advanced solid tumors. J Clin Oncol 2010;28:15s (abstr 3018).
    • (2010) J Clin Oncol , vol.28
    • Puzanov, I.1    Sarantopoulos, J.2    Gilbert, J.3    Mahalingam, D.4    Chap, L.I.5    Deng, H.6
  • 23
    • 79960974964 scopus 로고    scopus 로고
    • Phase I evaluation of the safety of conatumumab (AMG 655) in combination with AMG 479 in patients (pts) with advanced, refractory solid tumors
    • abstr 3102
    • Chawla SP, Tabernero J, Kindler HL, Chiorean EG, LoRusso P, Hsu M, et al. Phase I evaluation of the safety of conatumumab (AMG 655) in combination with AMG 479 in patients (pts) with advanced, refractory solid tumors. J Clin Oncol 2010;28:15s (abstr 3102).
    • (2010) J Clin Oncol , vol.28
    • Chawla, S.P.1    Tabernero, J.2    Kindler, H.L.3    Chiorean, E.G.4    LoRusso, P.5    Hsu, M.6
  • 24
    • 56149094007 scopus 로고    scopus 로고
    • A phase IB study ofAMG479, a type 1 insulin-like growth factor receptor (IGF1R) antibody, in combination with panitumumab (P) orgemcitabine (G)
    • abstr 3583
    • Sarantopoulos J, Mita AC, Mulay M, Romero O, Lu J, Capilla F, et al. A phase IB study ofAMG479, a type 1 insulin-like growth factor receptor (IGF1R) antibody, in combination with panitumumab (P) orgemcitabine (G). J Clin Oncol 2008;26:abstr 3583.
    • (2008) J Clin Oncol , vol.26
    • Sarantopoulos, J.1    Mita, A.C.2    Mulay, M.3    Romero, O.4    Lu, J.5    Capilla, F.6
  • 25
    • 78650750911 scopus 로고    scopus 로고
    • AMG 479 in relapsed or refractory Ewing's family tumors (EFT) or desmoplastic small round cell tumors (DSRCT): Phase II results
    • abstr 10001
    • Tap WD, Demetri GD, Barnette P, Desai J, Kavan P, Tozer R, et al.AMG 479 in relapsed or refractory Ewing's family tumors (EFT) or desmoplastic small round cell tumors (DSRCT): Phase II results. J Clin Oncol 2010;28:15s (abstr 10001).
    • (2010) J Clin Oncol , vol.28
    • Tap, W.D.1    Demetri, G.D.2    Barnette, P.3    Desai, J.4    Kavan, P.5    Tozer, R.6
  • 26
    • 84855401562 scopus 로고    scopus 로고
    • Exposureresponse (E-R)analysis tofacilitate phase III (P3) dose selection forAMG 479 (A479) in combination with gemcitabine (G) to treat metastatic pancreatic cancer (mPC)
    • abstr 263
    • Lu J, Deng H, Tang R, Hsu C, Kindler HL, Fuchs C, et al. Exposureresponse (E-R)analysis tofacilitate phase III (P3) dose selection forAMG 479 (A479) in combination with gemcitabine (G) to treat metastatic pancreatic cancer (mPC). J Clin Oncol 2011;29 (suppl 4; abstr 263).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4
    • Lu, J.1    Deng, H.2    Tang, R.3    Hsu, C.4    Kindler, H.L.5    Fuchs, C.6
  • 27
    • 56149086171 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (mAb) in patients (pts) with advanced solid tumors
    • abstr 3519
    • Atzori F, Tabernero J, Cervantes A, Botero M, Hsu K, Brown H, et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (mAb) in patients (pts) with advanced solid tumors. J Clin Oncol 2008;26: abstr 3519.
    • (2008) J Clin Oncol , vol.26
    • Atzori, F.1    Tabernero, J.2    Cervantes, A.3    Botero, M.4    Hsu, K.5    Brown, H.6
  • 29
    • 77953182864 scopus 로고    scopus 로고
    • A phase II study of the anti-IGFR antibody MK-0646 in combination with cetuximab and irinotecan in the treatment of chemorefractory metastatic colorectal cancer
    • abstr 4127
    • Watkins DJ, Tabernero J, Schmoll HJ, Trarbach T, Ramos FJ, Hsu K, et al. A phase II study of the anti-IGFR antibody MK-0646 in combination with cetuximab and irinotecan in the treatment of chemorefractory metastatic colorectal cancer. J Clin Oncol 2009;27:15s (abstr 4127).
    • (2009) J Clin Oncol , vol.27
    • Watkins, D.J.1    Tabernero, J.2    Schmoll, H.J.3    Trarbach, T.4    Ramos, F.J.5    Hsu, K.6
  • 30
    • 78349267741 scopus 로고    scopus 로고
    • Phase I/II study of MK-0646, the humanized monoclonal IGF-1R antibody in combination with gemcitabine or gemcitabine plus erlotinib (E) for advanced pancreatic cancer
    • abstr 4039
    • Javle MM, Varadhachary GR, Shroff RT, Bhosale P, Overman MJ, Weatherly J, et al. Phase I/II study of MK-0646, the humanized monoclonal IGF-1R antibody in combination with gemcitabine or gemcitabine plus erlotinib (E) for advanced pancreatic cancer. J Clin Oncol 2010;28:15s (abstr 4039).
    • (2010) J Clin Oncol , vol.28
    • Javle, M.M.1    Varadhachary, G.R.2    Shroff, R.T.3    Bhosale, P.4    Overman, M.J.5    Weatherly, J.6
  • 31
    • 84855385558 scopus 로고    scopus 로고
    • A phase I study of AVE1642, a human monoclonal antibodyblocking insulin-like growth factor-1 receptor (IGF-1R), given as a single agent and in combination with sorafenib as first-line therapy in patients with advanced hepatocellular carcinoma (HCC)
    • abstr 270
    • Faivre SJ, Fartoux L, Bouattour M, Bumsel F, Dreyer C, Raymond E, et al. A phase I study of AVE1642, a human monoclonal antibodyblocking insulin-like growth factor-1 receptor (IGF-1R), given as a single agent and in combination with sorafenib as first-line therapy in patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol 2011;29: (suppl 4; abstr 270).
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL. 4
    • Faivre, S.J.1    Fartoux, L.2    Bouattour, M.3    Bumsel, F.4    Dreyer, C.5    Raymond, E.6
  • 34
    • 79959265311 scopus 로고    scopus 로고
    • Targeting the insulin-like growth factor 1 receptor in Ewing's sarcoma: Reality and expectations
    • e pub 402508
    • Olmos D, Martins AS, Jones RL, Alam S, Scurr M, Judson IR. Targeting the insulin-like growth factor 1 receptor in Ewing's sarcoma: reality and expectations. Sarcoma 2011:e pub 402508.
    • (2011) Sarcoma
    • Olmos, D.1    Martins, A.S.2    Jones, R.L.3    Alam, S.4    Scurr, M.5    Judson, I.R.6
  • 35
    • 84855365964 scopus 로고    scopus 로고
    • A randomized phase II/III study of the anti-IGF-1R antibody MK- 0646 (dalotuzumab) in combination with cetuximab (Cx) and irinotecan (Ir) in the treatment of chemorefractory metastatic colorectal cancer (mCRC) with wild-type (wt) KRAS status
    • abstr 3501
    • Watkins DJ, Tabernero J, Schmoll H, Trarbach T, Ramos FJ, Howe J, et al. A randomized phase II/III study of the anti-IGF-1R antibody MK- 0646 (dalotuzumab) in combination with cetuximab (Cx) and irinotecan (Ir) in the treatment of chemorefractory metastatic colorectal cancer (mCRC) with wild-type (wt) KRAS status. J Clin Oncol 2011;29: abstr 3501.
    • (2011) J Clin Oncol , vol.29
    • Watkins, D.J.1    Tabernero, J.2    Schmoll, H.3    Trarbach, T.4    Ramos, F.J.5    Howe, J.6
  • 36
    • 78650858388 scopus 로고    scopus 로고
    • Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab
    • Gualberto A, Hixon ML, Karp DD, Li D, Green S, Dolled-Filhart M, et al. Pre-treatment levels of circulating free IGF-1 identify NSCLC patients who derive clinical benefit from figitumumab. Br J Cancer 2011; 104:68-74.
    • (2011) Br J Cancer , vol.104 , pp. 68-74
    • Gualberto, A.1    Hixon, M.L.2    Karp, D.D.3    Li, D.4    Green, S.5    Dolled-Filhart, M.6
  • 37
    • 79958863370 scopus 로고    scopus 로고
    • Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling
    • Garofalo C, Manara MC, Nicoletti G, Marino MT, Lollini PL, Astolfi A, et al. Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signaling. Oncogene 2011;30:2730-40.
    • (2011) Oncogene , vol.30 , pp. 2730-2740
    • Garofalo, C.1    Manara, M.C.2    Nicoletti, G.3    Marino, M.T.4    Lollini, P.L.5    Astolfi, A.6
  • 38
    • 59849091763 scopus 로고    scopus 로고
    • The insulin receptor substrate-1: A biomarker for cancer?
    • Baserga R. The insulin receptor substrate-1: a biomarker for cancer? Exp Cell Res 2009;315:727-32.
    • (2009) Exp Cell Res , vol.315 , pp. 727-732
    • Baserga, R.1
  • 39
    • 70350227313 scopus 로고    scopus 로고
    • The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma
    • Kurmasheva RT, Dudkin L, Billups C, Debelenko LV, Morton CL, Houghton PJ. The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma. Cancer Res 2009;69:7662-71.
    • (2009) Cancer Res , vol.69 , pp. 7662-7671
    • Kurmasheva, R.T.1    Dudkin, L.2    Billups, C.3    Debelenko, L.V.4    Morton, C.L.5    Houghton, P.J.6
  • 40
    • 51649091930 scopus 로고    scopus 로고
    • Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis
    • Creighton CJ, Casa A, Lazard Z, Huang S, Tsimelzon A, Hilsenbeck SG, et al. Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. J Clin Oncol 2008;26:4078-85.
    • (2008) J Clin Oncol , vol.26 , pp. 4078-4085
    • Creighton, C.J.1    Casa, A.2    Lazard, Z.3    Huang, S.4    Tsimelzon, A.5    Hilsenbeck, S.G.6
  • 41
    • 57149142057 scopus 로고    scopus 로고
    • IGFand insulin receptor signaling in breast cancer
    • Belfiore A, Frasca F. IGFand insulin receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia 2008;13:381-406.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 381-406
    • Belfiore, A.1    Frasca, F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.