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Volumn 84, Issue 1, 2012, Pages 8-17

Targeting insulin-like growth factor in breast cancer therapeutics

Author keywords

Breast cancer; IGF receptor; Insulin like growth factor (IGF); Monoclonal antibody; Signal transduction; Tyrosine kinase

Indexed keywords

ANTHRACYCLINE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; AROMATASE INHIBITOR; BMS 754807; CAPECITABINE; CIXUTUMUMAB; CP 751 871; DALOTUZUMAB; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERLOTINIB; EXEMESTANE; FIGITUMUMAB; FULVESTRANT; GANITUMAB; LAPATINIB; LETROZOLE; LINSITINIB; MEDI 573; MONOCLONAL ANTIBODY; OCTREOTIDE; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C RECEPTOR; SOMATOSTATIN DERIVATIVE; TAMOXIFEN; TAXANE DERIVATIVE; TEMSIROLIMUS; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 84866486496     PISSN: 10408428     EISSN: 18790461     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2012.02.010     Document Type: Review
Times cited : (29)

References (95)
  • 1
    • 33847638137 scopus 로고    scopus 로고
    • Estimates of the cancer incidence and mortality in Europe in 2006
    • Ferlay J., Autier P., Boniol M., et al. Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol 2007, 18:581-592.
    • (2007) Ann Oncol , vol.18 , pp. 581-592
    • Ferlay, J.1    Autier, P.2    Boniol, M.3
  • 3
    • 34548277030 scopus 로고    scopus 로고
    • Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study
    • Berrino F., De A.R., Sant M., et al. Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol 2007, 8:773-783.
    • (2007) Lancet Oncol , vol.8 , pp. 773-783
    • Berrino, F.1    De, A.R.2    Sant, M.3
  • 4
    • 73949105921 scopus 로고    scopus 로고
    • Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study
    • Kaufman B., Mackey J.R., Clemens M.R., et al. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009, 27:5529-5537.
    • (2009) J Clin Oncol , vol.27 , pp. 5529-5537
    • Kaufman, B.1    Mackey, J.R.2    Clemens, M.R.3
  • 5
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab - mechanism of action and use in clinical practice
    • Hudis C.A. Trastuzumab - mechanism of action and use in clinical practice. N Engl J Med 2007, 357:39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 6
    • 33845886440 scopus 로고    scopus 로고
    • Lapatinib plus capecitabine for HER2-positive advanced breast cancer
    • Geyer C.E., Forster J., Lindquist D., et al. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006, 355:2733-2743.
    • (2006) N Engl J Med , vol.355 , pp. 2733-2743
    • Geyer, C.E.1    Forster, J.2    Lindquist, D.3
  • 7
    • 77954700380 scopus 로고    scopus 로고
    • Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer
    • Miles D.W., Chan A., Dirix L.Y., et al. Phase III study of bevacizumab plus docetaxel compared with placebo plus docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010, 28:3239-3247.
    • (2010) J Clin Oncol , vol.28 , pp. 3239-3247
    • Miles, D.W.1    Chan, A.2    Dirix, L.Y.3
  • 8
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K., Wang M., Gralow J., et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007, 357:2666-2676.
    • (2007) N Engl J Med , vol.357 , pp. 2666-2676
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 9
    • 84871672449 scopus 로고    scopus 로고
    • on behalf of AROME. Therapeutic strategies and mechanisms of tumorigenesis of HER-2 overexpressing breast cancer
    • in press. doi:10.1016/j.critrevonc.2010.09.002
    • Emde A, Kostler WJ, Yarden Y, on behalf of AROME. Therapeutic strategies and mechanisms of tumorigenesis of HER-2 overexpressing breast cancer. Crit Rev Oncol Hematol;, in press. doi:10.1016/j.critrevonc.2010.09.002.
    • Crit Rev Oncol Hematol
    • Emde, A.1    Kostler, W.J.2    Yarden, Y.3
  • 10
    • 80655124771 scopus 로고    scopus 로고
    • Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. Biological bases to develop oxidative-based therapies
    • Vera-Ramirez L., Sanchez-Rovira P., Ramirez-Trtosa M.C., et al. Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. Biological bases to develop oxidative-based therapies. Crit Rev Oncol Heamtol 2011, 80:347-368.
    • (2011) Crit Rev Oncol Heamtol , vol.80 , pp. 347-368
    • Vera-Ramirez, L.1    Sanchez-Rovira, P.2    Ramirez-Trtosa, M.C.3
  • 11
    • 77953806733 scopus 로고    scopus 로고
    • Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies
    • Sogno I., Vene R., Ferrari N., et al. Angioprevention with fenretinide: targeting angiogenesis in prevention and therapeutic strategies. Crit Rev Oncol Hematol 2010, 75:2-14.
    • (2010) Crit Rev Oncol Hematol , vol.75 , pp. 2-14
    • Sogno, I.1    Vene, R.2    Ferrari, N.3
  • 12
    • 84862914692 scopus 로고    scopus 로고
    • Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
    • Baselga J., Cortes J., Kim S.B., et al. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012, 366:109-119.
    • (2012) N Engl J Med , vol.366 , pp. 109-119
    • Baselga, J.1    Cortes, J.2    Kim, S.B.3
  • 13
    • 84863078767 scopus 로고    scopus 로고
    • Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
    • Baselga J., Campone M., Piccart M., et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012, 366:520-529.
    • (2012) N Engl J Med , vol.366 , pp. 520-529
    • Baselga, J.1    Campone, M.2    Piccart, M.3
  • 14
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008, 8:915-928.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 16
    • 0036905115 scopus 로고    scopus 로고
    • Cellular actions of the insulin-like growth factor binding proteins
    • Firth S.M., Baxter R.C. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev 2002, 23:824-854.
    • (2002) Endocr Rev , vol.23 , pp. 824-854
    • Firth, S.M.1    Baxter, R.C.2
  • 17
    • 0023846016 scopus 로고
    • A single receptor binds both insulin-like growth factor II and mannose-6-phosphate
    • MacDonald R.G., Pfeffer S.R., Coussens L., et al. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science 1988, 239:1134-1137.
    • (1988) Science , vol.239 , pp. 1134-1137
    • MacDonald, R.G.1    Pfeffer, S.R.2    Coussens, L.3
  • 18
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • Belfiore A., Frasca F., Pandini G., Sciacca L., Vigneri R. Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 2009, 30:586-623.
    • (2009) Endocr Rev , vol.30 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 19
    • 0842303519 scopus 로고    scopus 로고
    • Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells
    • Frasca F., Pandini G., Vigneri R., Goldfine I.D. Insulin and hybrid insulin/IGF receptors are major regulators of breast cancer cells. Breast Dis 2003, 17:73-89.
    • (2003) Breast Dis , vol.17 , pp. 73-89
    • Frasca, F.1    Pandini, G.2    Vigneri, R.3    Goldfine, I.D.4
  • 20
    • 84874017572 scopus 로고    scopus 로고
    • Trnsgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands
    • in press.
    • Tian J, Lambertz I, Berton TR, et al. Trnsgenic insulin-like growth factor-1 stimulates activation of COX-2 signaling in mammary glands. Mol Carcinog; in press.
    • Mol Carcinog
    • Tian, J.1    Lambertz, I.2    Berton, T.R.3
  • 21
    • 84055177114 scopus 로고    scopus 로고
    • Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity
    • Potter A.S., Casa A.J., Lee A.V. Forkhead box A1 (FOXA1) is a key mediator of insulin-like growth factor I (IGF-I) activity. J Cell Biochem 2012, 113:110-121.
    • (2012) J Cell Biochem , vol.113 , pp. 110-121
    • Potter, A.S.1    Casa, A.J.2    Lee, A.V.3
  • 22
    • 0022414038 scopus 로고
    • Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues
    • Scott J., Cowell J., Robertson M.E., et al. Insulin-like growth factor-II gene expression in Wilms' tumour and embryonic tissues. Nature 1985, 317:260-262.
    • (1985) Nature , vol.317 , pp. 260-262
    • Scott, J.1    Cowell, J.2    Robertson, M.E.3
  • 23
    • 84856067760 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor (IGF-IR) translocates to the nucleus and autoregulates IGF-1R gene expression in breast cancer cells
    • Sarfstein R., Pasmanik-Chor M., Yeheskel A., et al. The insulin-like growth factor-I receptor (IGF-IR) translocates to the nucleus and autoregulates IGF-1R gene expression in breast cancer cells. J Biol Chem 2012, 287:2766-2776.
    • (2012) J Biol Chem , vol.287 , pp. 2766-2776
    • Sarfstein, R.1    Pasmanik-Chor, M.2    Yeheskel, A.3
  • 24
    • 33846807433 scopus 로고    scopus 로고
    • Disrupting insulin-like growth factor signaling as a potential cancer therapy
    • Sachdev D., Yee D. Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol Cancer Ther 2007, 6:1-12.
    • (2007) Mol Cancer Ther , vol.6 , pp. 1-12
    • Sachdev, D.1    Yee, D.2
  • 25
    • 9144223655 scopus 로고    scopus 로고
    • Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin
    • Nielsen T.O., Andrews H.N., Cheang M., et al. Expression of the insulin-like growth factor I receptor and urokinase plasminogen activator in breast cancer is associated with poor survival: potential for intervention with 17-allylamino geldanamycin. Cancer Res 2004, 64:286-291.
    • (2004) Cancer Res , vol.64 , pp. 286-291
    • Nielsen, T.O.1    Andrews, H.N.2    Cheang, M.3
  • 26
    • 0033561728 scopus 로고    scopus 로고
    • Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism
    • Sciacca L., Costantino A., Pandini G., et al. Insulin receptor activation by IGF-II in breast cancers: evidence for a new autocrine/paracrine mechanism. Oncogene 1999, 18:2471-2479.
    • (1999) Oncogene , vol.18 , pp. 2471-2479
    • Sciacca, L.1    Costantino, A.2    Pandini, G.3
  • 27
    • 33748199077 scopus 로고    scopus 로고
    • Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer
    • Sachdev D., Yee D. Inhibitors of insulin-like growth factor signaling: a therapeutic approach for breast cancer. J Mammary Gland Biol Neoplasia 2006, 11:27-39.
    • (2006) J Mammary Gland Biol Neoplasia , vol.11 , pp. 27-39
    • Sachdev, D.1    Yee, D.2
  • 28
    • 0027366338 scopus 로고
    • Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor
    • Sell C., Rubini M., Rubin R., Efstratiadis A., Baserga R. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. Proc Natl Acad Sci USA 1993, 90:11217-11221.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 11217-11221
    • Sell, C.1    Rubini, M.2    Rubin, R.3    Efstratiadis, A.4    Baserga, R.5
  • 29
    • 0032146711 scopus 로고    scopus 로고
    • A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer
    • Dunn S.E., Ehrlich M., Sharp N.J., et al. A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer. Cancer Res 1998, 58:3353-3361.
    • (1998) Cancer Res , vol.58 , pp. 3353-3361
    • Dunn, S.E.1    Ehrlich, M.2    Sharp, N.J.3
  • 30
    • 1042301373 scopus 로고    scopus 로고
    • A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells
    • Sachdev D., Hartell J.S., Lee A.V., Zhang X., Yee D. A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells. J Biol Chem 2004, 279:5017-5024.
    • (2004) J Biol Chem , vol.279 , pp. 5017-5024
    • Sachdev, D.1    Hartell, J.S.2    Lee, A.V.3    Zhang, X.4    Yee, D.5
  • 31
    • 80054716488 scopus 로고    scopus 로고
    • P.I3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer
    • Zhu C., Qi X., Chen Y., Sun B., Dai Y., Gu Y. P.I3K/Akt and MAPK/ERK1/2 signaling pathways are involved in IGF-1-induced VEGF-C upregulation in breast cancer. J Cancer Res Clin Oncol 2011, 137:1587-1594.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1587-1594
    • Zhu, C.1    Qi, X.2    Chen, Y.3    Sun, B.4    Dai, Y.5    Gu, Y.6
  • 32
    • 77955712930 scopus 로고    scopus 로고
    • Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy
    • Taunk N.K., Goyal S., Moran M.S., Yang Q., Parikh R., Haffty B.G. Prognostic significance of IGF-1R expression in patients treated with breast-conserving surgery and radiation therapy. Radiother Oncol 2010, 96:204-208.
    • (2010) Radiother Oncol , vol.96 , pp. 204-208
    • Taunk, N.K.1    Goyal, S.2    Moran, M.S.3    Yang, Q.4    Parikh, R.5    Haffty, B.G.6
  • 33
    • 0032499440 scopus 로고    scopus 로고
    • Circulating concentrations of insulin-like growth factor-I and risk of breast cancer
    • Hankinson S.E., Willett W.C., Colditz G.A., et al. Circulating concentrations of insulin-like growth factor-I and risk of breast cancer. Lancet 1998, 351:1393-1396.
    • (1998) Lancet , vol.351 , pp. 1393-1396
    • Hankinson, S.E.1    Willett, W.C.2    Colditz, G.A.3
  • 34
    • 77953536809 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies
    • Key T.J., Appleby P.N., Reeves G.K., Roddam A.W. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol 2010, 11:530-542.
    • (2010) Lancet Oncol , vol.11 , pp. 530-542
    • Key, T.J.1    Appleby, P.N.2    Reeves, G.K.3    Roddam, A.W.4
  • 35
    • 57749089652 scopus 로고    scopus 로고
    • Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival
    • Law J.H., Habibi G., Hu K., et al. Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res 2008, 68:10238-10246.
    • (2008) Cancer Res , vol.68 , pp. 10238-10246
    • Law, J.H.1    Habibi, G.2    Hu, K.3
  • 36
    • 10944249457 scopus 로고    scopus 로고
    • Expression of insulin-like growth factor 1 in primary breast cancer: immunohistochemical analysis
    • Shimizu C., Hasegawa T., Tani Y., et al. Expression of insulin-like growth factor 1 in primary breast cancer: immunohistochemical analysis. Hum Pathol 2004, 35:1537-1542.
    • (2004) Hum Pathol , vol.35 , pp. 1537-1542
    • Shimizu, C.1    Hasegawa, T.2    Tani, Y.3
  • 37
    • 84655169981 scopus 로고    scopus 로고
    • Practical implications of gene-expression-based assays for breast oncologists
    • Prat A., Ellis M.J., Perou C.M. Practical implications of gene-expression-based assays for breast oncologists. Nat Rev Clin Oncol 2012, 9:48-57.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 48-57
    • Prat, A.1    Ellis, M.J.2    Perou, C.M.3
  • 38
    • 84857920393 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF-1R) in breast cancer subtypes
    • Yerushalmi R., Gelmon K.A., Leung S., et al. Insulin-like growth factor (IGF-1R) in breast cancer subtypes. Breast Cancer Res Treat 2012, 132:131-142.
    • (2012) Breast Cancer Res Treat , vol.132 , pp. 131-142
    • Yerushalmi, R.1    Gelmon, K.A.2    Leung, S.3
  • 39
    • 82455167825 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression
    • Fu P., Ibusuki M., Yamamoto Y., et al. Insulin-like growth factor-1 receptor gene expression is associated with survival in breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression. Breast Cancer Treat Rev 2011, 130:307-312.
    • (2011) Breast Cancer Treat Rev , vol.130 , pp. 307-312
    • Fu, P.1    Ibusuki, M.2    Yamamoto, Y.3
  • 40
    • 79958120631 scopus 로고    scopus 로고
    • Insulin-like growth factor-dependent proliferation and survival of triple-negative breast cancer cells: implications for therapy
    • Davison Z., de Blacquiere G.E., Westley B.R., May F.E.B. Insulin-like growth factor-dependent proliferation and survival of triple-negative breast cancer cells: implications for therapy. Neoplasia 2011, 13:504-515.
    • (2011) Neoplasia , vol.13 , pp. 504-515
    • Davison, Z.1    de Blacquiere, G.E.2    Westley, B.R.3    May, F.E.B.4
  • 41
    • 84874020037 scopus 로고    scopus 로고
    • Use of insulin-like growth factor (IGF) pathway polymorphism IGFIR_rs2016347 to predict tumor recurrence in estrogen receptor-positive breast cancer patients
    • Winder T., Giamas G., Zhang W., et al. Use of insulin-like growth factor (IGF) pathway polymorphism IGFIR_rs2016347 to predict tumor recurrence in estrogen receptor-positive breast cancer patients. J Clin Oncol 2011, 29:538.
    • (2011) J Clin Oncol , vol.29 , pp. 538
    • Winder, T.1    Giamas, G.2    Zhang, W.3
  • 42
    • 0034772891 scopus 로고    scopus 로고
    • Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone
    • Chatzistamou I., Schally A.V., Varga J.L., et al. Inhibition of growth and metastases of MDA-MB-435 human estrogen-independent breast cancers by an antagonist of growth hormone-releasing hormone. Anticancer Drugs 2001, 12:761-768.
    • (2001) Anticancer Drugs , vol.12 , pp. 761-768
    • Chatzistamou, I.1    Schally, A.V.2    Varga, J.L.3
  • 43
    • 0028670841 scopus 로고
    • Somatostatin analogue octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(alpha)anthracene-induced rat mammary carcinomas
    • Weckbecker G., Tolcsvai L., Stolz B., Pollak M., Bruns C. Somatostatin analogue octreotide enhances the antineoplastic effects of tamoxifen and ovariectomy on 7,12-dimethylbenz(alpha)anthracene-induced rat mammary carcinomas. Cancer Res 1994, 54:6334-6337.
    • (1994) Cancer Res , vol.54 , pp. 6334-6337
    • Weckbecker, G.1    Tolcsvai, L.2    Stolz, B.3    Pollak, M.4    Bruns, C.5
  • 44
    • 80053932300 scopus 로고    scopus 로고
    • Randomized trial of tamoxifen versus combined tamoxifen and octeotide LAR therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14
    • Pritchard K.I., Shepherd L.E., Chapman J.A.W., et al. Randomized trial of tamoxifen versus combined tamoxifen and octeotide LAR therapy in the adjuvant treatment of early-stage breast cancer in postmenopausal women: NCIC CTG MA.14. J Clin Oncol 2011, 29:3869-3876.
    • (2011) J Clin Oncol , vol.29 , pp. 3869-3876
    • Pritchard, K.I.1    Shepherd, L.E.2    Chapman, J.A.W.3
  • 45
    • 0036682286 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility
    • Zhang X., Yee D. Insulin-like growth factor binding protein-1 (IGFBP-1) inhibits breast cancer cell motility. Cancer Res 2002, 62:4369-4375.
    • (2002) Cancer Res , vol.62 , pp. 4369-4375
    • Zhang, X.1    Yee, D.2
  • 46
    • 33644857143 scopus 로고    scopus 로고
    • Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function
    • Feng Y., Zhu Z., Xiao X., Choudhry V., Barrett J.C., Dimitrov D.S. Novel human monoclonal antibodies to insulin-like growth factor (IGF)-II that potently inhibit the IGF receptor type I signal transduction function. Mol Cancer Ther 2006, 5:114-120.
    • (2006) Mol Cancer Ther , vol.5 , pp. 114-120
    • Feng, Y.1    Zhu, Z.2    Xiao, X.3    Choudhry, V.4    Barrett, J.C.5    Dimitrov, D.S.6
  • 47
    • 2442673123 scopus 로고    scopus 로고
    • Loss of tumorigenicity and metastatic potential in carcinoma cells expressing the extracellular domain of the type 1 insulin-like growth factor receptor
    • Samani A.A., Chevet E., Fallavollita L., Galipeau J., Brodt P. Loss of tumorigenicity and metastatic potential in carcinoma cells expressing the extracellular domain of the type 1 insulin-like growth factor receptor. Cancer Res 2004, 64:3380-3385.
    • (2004) Cancer Res , vol.64 , pp. 3380-3385
    • Samani, A.A.1    Chevet, E.2    Fallavollita, L.3    Galipeau, J.4    Brodt, P.5
  • 48
    • 0028050256 scopus 로고
    • Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor
    • Resnicoff M., Coppola D., Sell C., Rubin R., Ferrone S., Baserga R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the type 1 insulin-like growth factor receptor. Cancer Res 1994, 54:4848-4850.
    • (1994) Cancer Res , vol.54 , pp. 4848-4850
    • Resnicoff, M.1    Coppola, D.2    Sell, C.3    Rubin, R.4    Ferrone, S.5    Baserga, R.6
  • 49
    • 0028271497 scopus 로고
    • Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors
    • Resnicoff M., Sell C., Rubini M., et al. Rat glioblastoma cells expressing an antisense RNA to the insulin-like growth factor-1 (IGF-1) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 1994, 54:2218-2222.
    • (1994) Cancer Res , vol.54 , pp. 2218-2222
    • Resnicoff, M.1    Sell, C.2    Rubini, M.3
  • 50
    • 9144234724 scopus 로고    scopus 로고
    • A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo
    • Burtrum D., Zhu Z., Lu D., et al. A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo. Cancer Res 2003, 63:8912-8921.
    • (2003) Cancer Res , vol.63 , pp. 8912-8921
    • Burtrum, D.1    Zhu, Z.2    Lu, D.3
  • 51
    • 35148889523 scopus 로고    scopus 로고
    • A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
    • Higano C.S., Yu E.Y., Whiting S.H., et al. A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J Clin Oncol 2007, 25:3505.
    • (2007) J Clin Oncol , vol.25 , pp. 3505
    • Higano, C.S.1    Yu, E.Y.2    Whiting, S.H.3
  • 52
    • 84861995584 scopus 로고    scopus 로고
    • Phase II trial of capecitabine and lapatinib plus or minus cixutumumab in HER2-positive breast cancer
    • Haluska P., Reinholz M.M., Dueck A.C., et al. Phase II trial of capecitabine and lapatinib plus or minus cixutumumab in HER2-positive breast cancer. J Clin Oncol 2010, 28:TPS129.
    • (2010) J Clin Oncol , vol.28
    • Haluska, P.1    Reinholz, M.M.2    Dueck, A.C.3
  • 53
    • 73349099049 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic and pharmacodynamic study of AMG479, a fully human monoclonal antibody to insulin-like growth factor receptor 1
    • Tolcher A.W., Sarantopoulos J., Patnaik A., et al. Phase I, pharmacokinetic and pharmacodynamic study of AMG479, a fully human monoclonal antibody to insulin-like growth factor receptor 1. J Clin Oncol 2009, 27:5800-5807.
    • (2009) J Clin Oncol , vol.27 , pp. 5800-5807
    • Tolcher, A.W.1    Sarantopoulos, J.2    Patnaik, A.3
  • 54
    • 80052157331 scopus 로고    scopus 로고
    • A randomized double-blind, placebo-controlled, phase 2 study of AMG479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC)
    • Kaufman P.A., Ferrero J.M., Bourgeois H., et al. A randomized double-blind, placebo-controlled, phase 2 study of AMG479 with exemestane (E) or fulvestrant (F) in postmenopausal women with hormone-receptor positive (HR+) metastatic (M) or locally advanced (LA) breast cancer (BC). San Antonio breast cancer symposium, CTRC-AACR 2010.
    • (2010) San Antonio breast cancer symposium, CTRC-AACR
    • Kaufman, P.A.1    Ferrero, J.M.2    Bourgeois, H.3
  • 55
    • 35348815620 scopus 로고    scopus 로고
    • Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors
    • Haluska P., Shaw H.M., Batzel G.N., et al. Phase I dose escalation study of the anti insulin-like growth factor-I receptor monoclonal antibody CP-751,871 in patients with refractory solid tumors. Clin Cancer Res 2007, 13:5834-5840.
    • (2007) Clin Cancer Res , vol.13 , pp. 5834-5840
    • Haluska, P.1    Shaw, H.M.2    Batzel, G.N.3
  • 56
    • 77956227862 scopus 로고    scopus 로고
    • Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC)
    • Jassem J., Langer C., Karp D.D., et al. Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC). J Clin Oncol 2010, 28:7500.
    • (2010) J Clin Oncol , vol.28 , pp. 7500
    • Jassem, J.1    Langer, C.2    Karp, D.D.3
  • 57
    • 84874019511 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I (IGF1R) inhibitors may be synergistic with chemotherapy in basal breast cancer
    • Offor O., Sullivan C., Rodov S., et al. Insulin-like growth factor receptor I (IGF1R) inhibitors may be synergistic with chemotherapy in basal breast cancer. San Antonio breast cancer symposium, CTRC-AACR 2010.
    • (2010) San Antonio breast cancer symposium, CTRC-AACR
    • Offor, O.1    Sullivan, C.2    Rodov, S.3
  • 59
    • 56149086171 scopus 로고    scopus 로고
    • A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors
    • Atzori F., Tabernero J., Cervantes A., et al. A phase I, pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (qW) MK-0646, an insulin-like growth factor-1 receptor (IGF1R) monoclonal antibody (MAb) in patients (pts) with advanced solid tumors. J Clin Oncol 2008, 26:3519.
    • (2008) J Clin Oncol , vol.26 , pp. 3519
    • Atzori, F.1    Tabernero, J.2    Cervantes, A.3
  • 60
    • 79551547098 scopus 로고    scopus 로고
    • Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth
    • Gao J., Chesebrough J.W., Cartlidge S.A., et al. Dual IGF-I/II-neutralizing antibody MEDI-573 potently inhibits IGF signaling and tumor growth. Cancer Res 2011, 71:1029-1040.
    • (2011) Cancer Res , vol.71 , pp. 1029-1040
    • Gao, J.1    Chesebrough, J.W.2    Cartlidge, S.A.3
  • 61
    • 79955536242 scopus 로고    scopus 로고
    • Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative
    • Chakravarti B., Siddiqui J.A., Dwivedi S.K.D., et al. Specific targeting of insulin-like growth factor 1 receptor signaling in human estrogen dependent breast cancer cell by a novel tyrosine-based benzoxazepine derivative. Mol Cell Endocrinol 2011, 338:68-78.
    • (2011) Mol Cell Endocrinol , vol.338 , pp. 68-78
    • Chakravarti, B.1    Siddiqui, J.A.2    Dwivedi, S.K.D.3
  • 62
    • 84255192030 scopus 로고    scopus 로고
    • Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer
    • Hou X., Huang F., Macedo L.F., et al. Dual IGF-1R/InsR inhibitor BMS-754807 synergizes with hormonal agents in treatment of estrogen-dependent breast cancer. Cancer Res 2011, 71:7597-7607.
    • (2011) Cancer Res , vol.71 , pp. 7597-7607
    • Hou, X.1    Huang, F.2    Macedo, L.F.3
  • 63
    • 72249089981 scopus 로고    scopus 로고
    • Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,2] triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development
    • Wittman M.D., Carboni J.M., Yang Z., et al. Discovery of a 2,4-disubstituted pyrrolo[1,2-f][1,2,2] triazine inhibitor (BMS-754807) of insulin-like growth factor receptor (IGF-1R) kinase in clinical development. J Med Chem 2009, 52:7360-7363.
    • (2009) J Med Chem , vol.52 , pp. 7360-7363
    • Wittman, M.D.1    Carboni, J.M.2    Yang, Z.3
  • 64
    • 84855440110 scopus 로고    scopus 로고
    • Phase II trial of the dual IGF-1R/IR inhibitor BMS-754807 with or without letrozole in aromatase inhibitor-resistant breast cancer
    • Haluska P., Dhar A., Hou X., et al. Phase II trial of the dual IGF-1R/IR inhibitor BMS-754807 with or without letrozole in aromatase inhibitor-resistant breast cancer. J Clin Oncol 2011, 29:TPS111.
    • (2011) J Clin Oncol , vol.29
    • Haluska, P.1    Dhar, A.2    Hou, X.3
  • 65
    • 79954575067 scopus 로고    scopus 로고
    • High IGF-1R activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-1R therapy
    • Litzenburger B.C., Creighton C.J., Tsimelzon A., et al. High IGF-1R activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-1R therapy. Clin Cancer Res 2011, 17:2314-2327.
    • (2011) Clin Cancer Res , vol.17 , pp. 2314-2327
    • Litzenburger, B.C.1    Creighton, C.J.2    Tsimelzon, A.3
  • 66
    • 80155131176 scopus 로고    scopus 로고
    • A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer
    • Fox E.M., Miller T.W., Balko J.M., et al. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res 2011, 71:6773-6784.
    • (2011) Cancer Res , vol.71 , pp. 6773-6784
    • Fox, E.M.1    Miller, T.W.2    Balko, J.M.3
  • 67
    • 0033374830 scopus 로고    scopus 로고
    • Insulin-like-growth-factor-I (IGF-I) antagonizes apoptosis induced by serum deficiency and doxorubicin in neuronal cell culture
    • Gil-Ad I., Shtaif B., Luria D., Karp L., Fridman Y., Weizman A. Insulin-like-growth-factor-I (IGF-I) antagonizes apoptosis induced by serum deficiency and doxorubicin in neuronal cell culture. Growth Horm IGF Res 1999, 9:458-464.
    • (1999) Growth Horm IGF Res , vol.9 , pp. 458-464
    • Gil-Ad, I.1    Shtaif, B.2    Luria, D.3    Karp, L.4    Fridman, Y.5    Weizman, A.6
  • 68
    • 0032850369 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death - proliferative and anti-apoptotic effects
    • Gooch J.L., Van Den Berg C.L., Yee D. Insulin-like growth factor (IGF)-I rescues breast cancer cells from chemotherapy-induced cell death - proliferative and anti-apoptotic effects. Breast Cancer Res Treat 1999, 56:1-10.
    • (1999) Breast Cancer Res Treat , vol.56 , pp. 1-10
    • Gooch, J.L.1    Van Den Berg, C.L.2    Yee, D.3
  • 69
    • 0037379216 scopus 로고    scopus 로고
    • Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses
    • Guo G., Yan-Sanders Y., Lyn-Cook B.D., et al. Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Mol Cell Biol 2003, 23:2362-2378.
    • (2003) Mol Cell Biol , vol.23 , pp. 2362-2378
    • Guo, G.1    Yan-Sanders, Y.2    Lyn-Cook, B.D.3
  • 70
    • 0030738695 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs
    • Dunn S.E., Hardman R.A., Kari F.W., Barrett J.C. Insulin-like growth factor 1 (IGF-1) alters drug sensitivity of HBL100 human breast cancer cells by inhibition of apoptosis induced by diverse anticancer drugs. Cancer Res 1997, 57:2687-2693.
    • (1997) Cancer Res , vol.57 , pp. 2687-2693
    • Dunn, S.E.1    Hardman, R.A.2    Kari, F.W.3    Barrett, J.C.4
  • 71
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer
    • Tao Y., Pinzi V., Bourhis J., Deutsch E. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat Clin Pract Oncol 2007, 4:591-602.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 591-602
    • Tao, Y.1    Pinzi, V.2    Bourhis, J.3    Deutsch, E.4
  • 72
    • 84860390217 scopus 로고    scopus 로고
    • Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes
    • Zhang Y., Moerkens M., Ramaiahgari S., et al. Elevated insulin-like growth factor 1 receptor signaling induces antiestrogen resistance through the MAPK/ERK and PI3K/Akt signaling routes. Breast Cancer Res 2011, 13:R52.
    • (2011) Breast Cancer Res , vol.13
    • Zhang, Y.1    Moerkens, M.2    Ramaiahgari, S.3
  • 73
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance
    • Campbell R.A., Bhat-Nakshatri P., Patel N.M., Constantinidou D., Ali S., Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 2001, 276:9817-9824.
    • (2001) J Biol Chem , vol.276 , pp. 9817-9824
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 74
    • 80053174807 scopus 로고    scopus 로고
    • ErbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines
    • Knowlden J.M., Gee J.M.W., Barrow D., et al. erbB3 recruitment of insulin receptor substrate 1 modulates insulin-like growth factor receptor signalling in oestrogen receptor-positive breast cancer cell lines. Breast Cancer Res 2011, 13:R93.
    • (2011) Breast Cancer Res , vol.13
    • Knowlden, J.M.1    Gee, J.M.W.2    Barrow, D.3
  • 75
    • 77950691907 scopus 로고    scopus 로고
    • Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines
    • Chakraborty A.K., Welsh A., Digiovanna M.P. Co-targeting the insulin-like growth factor I receptor enhances growth-inhibitory and pro-apoptotic effects of anti-estrogens in human breast cancer cell lines. Breast Cancer Res Treat 2010, 120:327-335.
    • (2010) Breast Cancer Res Treat , vol.120 , pp. 327-335
    • Chakraborty, A.K.1    Welsh, A.2    Digiovanna, M.P.3
  • 76
    • 33748080758 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator
    • Juncker-Jensen A., Lykkesfeldt A.E., Worm J., Ralfkiaer U., Espelund U., Jepsen J.S. Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator. Growth Horm IGF Res 2006, 16:224-239.
    • (2006) Growth Horm IGF Res , vol.16 , pp. 224-239
    • Juncker-Jensen, A.1    Lykkesfeldt, A.E.2    Worm, J.3    Ralfkiaer, U.4    Espelund, U.5    Jepsen, J.S.6
  • 77
    • 0035852706 scopus 로고    scopus 로고
    • ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
    • Peretz S., Jensen R., Baserga R., Glazer P.M. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc Natl Acad Sci USA 2001, 98:1676-1681.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1676-1681
    • Peretz, S.1    Jensen, R.2    Baserga, R.3    Glazer, P.M.4
  • 78
    • 16944364325 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation
    • Turner B.C., Haffty B.G., Narayanan L., et al. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Res 1997, 57:3079-3083.
    • (1997) Cancer Res , vol.57 , pp. 3079-3083
    • Turner, B.C.1    Haffty, B.G.2    Narayanan, L.3
  • 79
    • 0035556142 scopus 로고    scopus 로고
    • Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells
    • Wen B., Deutsch E., Marangoni E., et al. Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells. Br J Cancer 2001, 85:2017-2021.
    • (2001) Br J Cancer , vol.85 , pp. 2017-2021
    • Wen, B.1    Deutsch, E.2    Marangoni, E.3
  • 80
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • Nahta R., Yuan L.X., Zhang B., Kobayashi R., Esteva F.J. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005, 65:11118-11128.
    • (2005) Cancer Res , vol.65 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.2    Zhang, B.3    Kobayashi, R.4    Esteva, F.J.5
  • 81
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin)
    • Lu Y., Zi X., Zhao Y., Mascarenhas D., Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001, 93:1852-1857.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3    Mascarenhas, D.4    Pollak, M.5
  • 82
    • 40449120461 scopus 로고    scopus 로고
    • Co-targeting insulin-like growth factor I receptor and HER2: dramatic effects of HER2 inhibitors on non-overexpressing breast cancer
    • Chakraborty A.K., Liang K., DiGiovanna M.P. Co-targeting insulin-like growth factor I receptor and HER2: dramatic effects of HER2 inhibitors on non-overexpressing breast cancer. Cancer Res 2008, 68:1538-1545.
    • (2008) Cancer Res , vol.68 , pp. 1538-1545
    • Chakraborty, A.K.1    Liang, K.2    DiGiovanna, M.P.3
  • 84
    • 84874021838 scopus 로고    scopus 로고
    • Effect of IGF1R protein expression on benefit to adjuvant trastuzumab in early-stage HER2+ breast cancer in NCCTG N9831 trial
    • Reinholz M.M., Dueck A.C., Chen B., et al. Effect of IGF1R protein expression on benefit to adjuvant trastuzumab in early-stage HER2+ breast cancer in NCCTG N9831 trial. J Clin Oncol 2011, 29:10503.
    • (2011) J Clin Oncol , vol.29 , pp. 10503
    • Reinholz, M.M.1    Dueck, A.C.2    Chen, B.3
  • 85
    • 79958754613 scopus 로고    scopus 로고
    • Trastuzumab regulates IGFBP-2 and IGFBP-3 to mediate growth inhibition: implications for the development of predictive biomarkers for trastuzumab resistance
    • Dokmanovic M., Shen Y., Bonacci T.M., Hirsch D.S., Wu W.J. Trastuzumab regulates IGFBP-2 and IGFBP-3 to mediate growth inhibition: implications for the development of predictive biomarkers for trastuzumab resistance. Mol Cancer Ther 2011, 10:917-928.
    • (2011) Mol Cancer Ther , vol.10 , pp. 917-928
    • Dokmanovic, M.1    Shen, Y.2    Bonacci, T.M.3    Hirsch, D.S.4    Wu, W.J.5
  • 86
    • 79952135852 scopus 로고    scopus 로고
    • The IGF pathway regulates ERa through a S6K1-dependent mechanism in breast cancer cells
    • Becker M.A., Igrahim Y.H., Cui X., Lee A.V., Yee D. The IGF pathway regulates ERa through a S6K1-dependent mechanism in breast cancer cells. Mol Endocrinol 2011, 25:516-528.
    • (2011) Mol Endocrinol , vol.25 , pp. 516-528
    • Becker, M.A.1    Igrahim, Y.H.2    Cui, X.3    Lee, A.V.4    Yee, D.5
  • 87
    • 84855819195 scopus 로고    scopus 로고
    • Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001
    • Loehberg C.R., Strissel P.L., Dittrich R., et al. Akt and p53 are potential mediators of reduced mammary tumor growth by Chloroquine and the mTOR inhibitor RAD001. Biochem Pharmacol 2012, 83:480-488.
    • (2012) Biochem Pharmacol , vol.83 , pp. 480-488
    • Loehberg, C.R.1    Strissel, P.L.2    Dittrich, R.3
  • 88
    • 35648962915 scopus 로고    scopus 로고
    • Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation
    • Wang X., Yue P., Chan C.B., et al. Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol 2007, 27:7405-7413.
    • (2007) Mol Cell Biol , vol.27 , pp. 7405-7413
    • Wang, X.1    Yue, P.2    Chan, C.B.3
  • 89
    • 54049108939 scopus 로고    scopus 로고
    • Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials
    • Rodon J., DeSantos V., Ferry R.J., Kurzrock R. Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: lessons from the first clinical trials. Mol Cancer Ther 2008, 7:2575-2588.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2575-2588
    • Rodon, J.1    DeSantos, V.2    Ferry, R.J.3    Kurzrock, R.4
  • 90
    • 72449159103 scopus 로고    scopus 로고
    • Targeting insulin-like growth factor type 1 receptor in cancer therapy
    • Atzori F., Traina T.A., Ionta M.T., Massidda B. Targeting insulin-like growth factor type 1 receptor in cancer therapy. Target Oncol 2009, 4:255-266.
    • (2009) Target Oncol , vol.4 , pp. 255-266
    • Atzori, F.1    Traina, T.A.2    Ionta, M.T.3    Massidda, B.4
  • 91
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang F., Greer A., Hurlburt W., et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res 2009, 69:161-170.
    • (2009) Cancer Res , vol.69 , pp. 161-170
    • Huang, F.1    Greer, A.2    Hurlburt, W.3
  • 92
    • 77953973648 scopus 로고    scopus 로고
    • Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy
    • Ulanet D.B., Ludwig D.L., Kahn C.R., Hanahan D. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy. Proc Natl Acad Sci USA 2010, 107:10791-10798.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10791-10798
    • Ulanet, D.B.1    Ludwig, D.L.2    Kahn, C.R.3    Hanahan, D.4
  • 94
    • 80055026624 scopus 로고    scopus 로고
    • Altered expression of insulin receptor isoforms in breast cancer
    • Huang J., Morehouse C., Streicher K., et al. Altered expression of insulin receptor isoforms in breast cancer. PLoS One 2011, 6:e26177.
    • (2011) PLoS One , vol.6
    • Huang, J.1    Morehouse, C.2    Streicher, K.3
  • 95
    • 84874018592 scopus 로고    scopus 로고
    • IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors
    • Becker M.A., Hou X., Harrington S.C., et al. IGFBP ratio confers resistance to IGF targeting and correlates with increased invasion and poor outcome in breast tumors. San Antonio breast cancer symposium, CTRC-AACR 2011.
    • (2011) San Antonio breast cancer symposium, CTRC-AACR
    • Becker, M.A.1    Hou, X.2    Harrington, S.C.3


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