Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R)

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5995-6005

  Engen, William ^a   O'Brien, Terrence E ^a   Kelly, Brendan ^a   Do, Jacinda ^a   Rillera, Liezel ^a   Stapleton, Lance K ^b   Youngren, Jack F ^b   Anderson, Marc O ^a  

^a SAN FRANCISCO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

2 Chloroquinoline; 2 Quinolone; Aryl heteroaryl urea; Diaryl urea; IGF 1R; Insulin like growth factor receptor; Kinase inhibition; Naphthyridine; Pharmacophore based virtual screening; Quinoline

Indexed keywords

2 CHLORO QUINOLIN 4 YLAMINE 3; 2 METHYL 5,6,7,8 TETRAHYDRO [1,8]NAPHTHYRIDIN 4 YLAMINE 3; 2,4 DICHLOROQUINOLINE; 4 AMINO 1H QUINOLIN 2 ONE 3; 4 AMINO 2 METHYL 1,7 NAPHTHYRIDINE 3; 4 AMINO 2 METHYL 1,8 NAPHTHYRIDINE 3; 4 AMINO 2 TRIFLUOROMETHYL QUINOLINE 3; 4 AMINOQUINOLINE; 4 AZIDO 1H QUINOLIN 2 ONE; 4 AZIDO 2 METHYL 1,7 NAPHTHYRIDINE; 4 AZIDO 2 METHYL 1,8 NAPHTHYRIDINE; 4 AZIDO 2 TRIFLUOROMETHYLQUINOLINE; 4 CHLORO 1H QUINOLIN 2 ONE; 4 CHLORO 2 METHYL 1,7 NAPHTHYRIDINE; 4 CHLORO 2 METHYL 1,8 NAPHTHYRIDINE; ARYL HETEROARYL UREA; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; DRUG BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

AMINOQUINOLINES; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, SOMATOMEDIN; UREA;

EID: 77955468949     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.071     Document Type: Article

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