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Volumn 5, Issue 7, 2003, Pages 647-654

Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 3; CASPASE 9; CELL EXTRACT; CYTOCHROME C; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OKADAIC ACID; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; PROTEINASE; RAF PROTEIN; RAS PROTEIN; STAUROSPORINE; THREONINE;

EID: 0038726089     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1005     Document Type: Article
Times cited : (408)

References (30)
  • 2
    • 0028880006 scopus 로고
    • Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
    • Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J. & Greenberg, M. E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331 (1995).
    • (1995) Science , vol.270 , pp. 1326-1331
    • Xia, Z.1    Dickens, M.2    Raingeaud, J.3    Davis, R.J.4    Greenberg, M.E.5
  • 3
    • 0032793067 scopus 로고    scopus 로고
    • B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
    • Erhardt, P., Schremser, E. J. & Cooper, G. M. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 19, 5308-5315 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5308-5315
    • Erhardt, P.1    Schremser, E.J.2    Cooper, G.M.3
  • 4
    • 0034103549 scopus 로고    scopus 로고
    • The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal
    • Le Gall, M. et al. The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal. Mol. Biol. Cell 11, 1103-1112 (2000).
    • (2000) Mol. Biol. Cell , vol.11 , pp. 1103-1112
    • Le Gall, M.1
  • 5
    • 0035102807 scopus 로고    scopus 로고
    • Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals
    • von Gise, A. et al. Apoptosis suppression by Raf-1 and MEK1 requires MEK- and phosphatidylinositol 3-kinase-dependent signals. Mol. Cell. Biol. 21, 2324-2336 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2324-2336
    • von Gise, A.1
  • 6
    • 0030947095 scopus 로고    scopus 로고
    • Programmed cell death in animal development
    • Jacobson, M. D., Weil, M. & Raff, M. C. Programmed cell death in animal development. Cell 88, 347-354 (1997).
    • (1997) Cell , vol.88 , pp. 347-354
    • Jacobson, M.D.1    Weil, M.2    Raff, M.C.3
  • 7
    • 0030745646 scopus 로고    scopus 로고
    • Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
    • Zou, H., Henzel, W. J., Liu, X., Lutschg, A. & Wang, X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405-413 (1997).
    • (1997) Cell , vol.90 , pp. 405-413
    • Zou, H.1    Henzel, W.J.2    Liu, X.3    Lutschg, A.4    Wang, X.5
  • 8
    • 0036187036 scopus 로고    scopus 로고
    • Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation
    • Acehan, D. et al. Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol. Cell 9, 423-432 (2002).
    • (2002) Mol. Cell , vol.9 , pp. 423-432
    • Acehan, D.1
  • 9
    • 0032544449 scopus 로고    scopus 로고
    • Apaf 1 (CED-4 homolog) regulates programmed cell death in mammalian development
    • Cecconi, F., Alvarez-Bolado, G., Meyer, B. I., Roth, K. A. & Gruss, P. Apaf 1 (CED-4 homolog) regulates programmed cell death in mammalian development. Cell 94, 727-737 (1998).
    • (1998) Cell , vol.94 , pp. 727-737
    • Cecconi, F.1    Alvarez-Bolado, G.2    Meyer, B.I.3    Roth, K.A.4    Gruss, P.5
  • 10
    • 0032544564 scopus 로고    scopus 로고
    • Apaf 1 is required for mitochondrial pathways of apoptosis and brain development
    • Yoshida, H. et al. Apaf 1 is required for mitochondrial pathways of apoptosis and brain development. Cell 94, 739-750 (1998).
    • (1998) Cell , vol.94 , pp. 739-750
    • Yoshida, H.1
  • 11
    • 0032493870 scopus 로고    scopus 로고
    • Differential requirement for caspase 9 in apoptotic pathways in vivo
    • Hakem, R. et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 94, 339-352 (1998).
    • (1998) Cell , vol.94 , pp. 339-352
    • Hakem, R.1
  • 12
    • 0032493910 scopus 로고    scopus 로고
    • Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
    • Kuida, K. et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94, 325-337 (1998).
    • (1998) Cell , vol.94 , pp. 325-337
    • Kuida, K.1
  • 13
    • 0033515883 scopus 로고    scopus 로고
    • Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition
    • Soengas, M. S. et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 284, 156-159 (1999).
    • (1999) Science , vol.284 , pp. 156-159
    • Soengas, M.S.1
  • 14
    • 0035843169 scopus 로고    scopus 로고
    • Inactivation of the apoptosis effector Apaf-1 in malignant melanoma
    • Soengas, M. S. et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409, 207-211 (2001).
    • (2001) Nature , vol.409 , pp. 207-211
    • Soengas, M.S.1
  • 15
    • 0032527705 scopus 로고    scopus 로고
    • The cellular response to oxidative stress: Influences of mitogen-activated protein kinase signalling pathways on cell survival
    • Wang, X., Martindale, J. L., Liu, Y. & Holbrook, N. J. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem. J. 333, 291-300 (1998).
    • (1998) Biochem. J. , vol.333 , pp. 291-300
    • Wang, X.1    Martindale, J.L.2    Liu, Y.3    Holbrook, N.J.4
  • 16
    • 0034648698 scopus 로고    scopus 로고
    • Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: Inhibition by PKB/Akt but not Raf signalling
    • Rytömaa, M., Lehmann, K. & Downward, J. Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling. Oncogene 19, 4461-4468 (2000).
    • (2000) Oncogene , vol.19 , pp. 4461-4468
    • Rytömaa, M.1    Lehmann, K.2    Downward, J.3
  • 17
    • 0034671527 scopus 로고    scopus 로고
    • MEK inhibition enhances paclitaxel-induced tumor apoptosis
    • MacKeigan, J. P., Collins, T. S. & Ting, J. P. MEK inhibition enhances paclitaxel-induced tumor apoptosis. J. Biol. Chem. 275, 38953-38956 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 38953-38956
    • MacKeigan, J.P.1    Collins, T.S.2    Ting, J.P.3
  • 18
    • 0036176054 scopus 로고    scopus 로고
    • Post-cytochrome c protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts
    • Tashker, J. S., Olson, M. & Kornbluth, S. Post-cytochrome c protection from apoptosis conferred by a MAPK pathway in Xenopus egg extracts. Mol. Biol. Cell 13, 393-401 (2002).
    • (2002) Mol. Biol. Cell , vol.13 , pp. 393-401
    • Tashker, J.S.1    Olson, M.2    Kornbluth, S.3
  • 19
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1-caspase-9 complex initiates an apoptotic protease cascade
    • Li, P. et al. Cytochrome c and dATP-dependent formation of Apaf-1-caspase-9 complex initiates an apoptotic protease cascade. Cell 91, 479-489 (1997).
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1
  • 21
    • 0034306450 scopus 로고    scopus 로고
    • Specificity and mechanism of action of some commonly used protein kinase inhibitors
    • Davies, S. P., Reddy, H., Caivano, M. & Cohen, P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105 (2000).
    • (2000) Biochem. J. , vol.351 , pp. 95-105
    • Davies, S.P.1    Reddy, H.2    Caivano, M.3    Cohen, P.4
  • 22
    • 0034613302 scopus 로고    scopus 로고
    • Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1
    • Jiang, X. & Wang, X. Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J. Biol. Chem. 275, 31199-31203 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 31199-31203
    • Jiang, X.1    Wang, X.2
  • 23
    • 0032509354 scopus 로고    scopus 로고
    • WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
    • Hu, Y., Ding, L., Spencer, D. M. & Nunez, G. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation. J. Biol. Chem. 273, 33489-33494 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 33489-33494
    • Hu, Y.1    Ding, L.2    Spencer, D.M.3    Nunez, G.4
  • 24
  • 25
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone, M. H. et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321 (1998).
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1
  • 26
    • 0035958732 scopus 로고    scopus 로고
    • Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway
    • Mody, N., Leitch, J., Armstrong, C., Dixon, J. & Cohen, P. Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. FEBS Lett. 502, 21-24 (2001).
    • (2001) FEBS Lett. , vol.502 , pp. 21-24
    • Mody, N.1    Leitch, J.2    Armstrong, C.3    Dixon, J.4    Cohen, P.5
  • 27
    • 0036479531 scopus 로고    scopus 로고
    • Regulation of cell number by MAPK-dependent control of apoptosis: A mechanism for trophic survival signaling
    • Bergmann, A., Tugentman, M., Shilo, B. Z. & Steller, H. Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling. Dev. Cell 2, 159-170 (2002).
    • (2002) Dev. Cell , vol.2 , pp. 159-170
    • Bergmann, A.1    Tugentman, M.2    Shilo, B.Z.3    Steller, H.4
  • 28
    • 0032582662 scopus 로고    scopus 로고
    • The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    • Bergmann, A., Agapite, J., McCall, K. & Steller, H. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95, 331-341 (1998).
    • (1998) Cell , vol.95 , pp. 331-341
    • Bergmann, A.1    Agapite, J.2    McCall, K.3    Steller, H.4
  • 29
    • 0032582793 scopus 로고    scopus 로고
    • Ras promotes cell survival in Drosophila by downregulating hid expression
    • Kurada, P. & White, K. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95, 319-329 (1998).
    • (1998) Cell , vol.95 , pp. 319-329
    • Kurada, P.1    White, K.2
  • 30
    • 0035375261 scopus 로고    scopus 로고
    • Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
    • Sapkota, G. P. et al. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J. Biol. Chem. 276, 19469-19482 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 19469-19482
    • Sapkota, G.P.1


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