Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase γ

Journal of Medicinal Chemistry

Volumn 49, Issue 13, 2006, Pages 3857-3871

  Pomel, Vincent ^a   Klicic, Jasna ^a   Covini, David ^a   Church, Dennis D ^a   Shaw, Jeffrey P ^a   Roulin, Karen ^a   Burgat Charvillon, Fabienne ^a   Valognes, Delphine ^a   Camps, Montserrat ^a   Chabert, Christian ^a   Gillieron, Corinne ^a   Françon, Bernard ^a   Perrin, Dominique ^a   Leroy, Didier ^a   Gretener, Denise ^a   Nichols, Anthony ^a   Vitte, Pierre Alain ^a   Carboni, Susanna ^a   Rommel, Christian ^a   Schwarz, Matthias K ^a   Rückle, Thomas ^a   more..

^a SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [5 (4 FLUORO 2 HYDROXYPHENYL)FURAN 2 YLMETHYLENE]THIAZOLIDINE 2,4 DIONE; AS 252424; MYRICETIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; QUERCETIN; STAUROSPORINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; AUTOIMMUNE DISEASE; DRUG CLEARANCE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; INFLAMMATORY DISEASE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PERITONITIS; PHARMACOPHORE; X RAY CRYSTALLOGRAPHY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACUTE DISEASE; ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CHEMOTAXIS; CRYSTALLOGRAPHY, X-RAY; FURANS; HUMANS; ISOENZYMES; MAST CELLS; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MONOCYTES; NEUTROPHILS; PERITONITIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; THIOGLYCOLATES;

EID: 33745662579     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0601598     Document Type: Article

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