Overlaps between the insulin and IGF-I receptor and cancer

Insulin-like Growth Factors and Cancer: From Basic Biology to Therapeutics

Volumn , Issue , 2012, Pages 263-278

  Belfiore, Antonino ^a   Malaguarnera, Roberta ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85028516874     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-0598-6_14     Document Type: Chapter

References (81)

1. Accili D, Drago J, Lee EJ, et al (1996) Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet 12:106-109
2. Alexandrides TK, Smith RJ (1989) A novel fetal insulin-like growth factor (IGF) I receptor. Mechanism for increased IGF I- and insulin-stimulated tyrosine kinase activity in fetal muscle. J Biol Chem 264:12922-12930
3. Bailyes EM, Nave BT, Soos MA, et al (1997) Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting. Biochem J 327(Pt 1):209-215
4. Beck EP, Russo P, Gliozzo B, et al (1994) Identification of insulin and insulin-like growth factor I (IGF I) receptors in ovarian cancer tissue. Gynecol Oncol 53:196-201
5. Beitner-Johnson D, LeRoith D (1995) Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk. J Biol Chem 270:5187-5190
6. Belfiore A (2007) The role of insulin receptor isoforms and hybrid insulin/IGF-I receptors in human cancer. Curr Pharm Des 13:671-686
7. Benecke H, Flier JS, Moller DE (1992) Alternatively spliced variants of the insulin receptor protein. Expression in normal and diabetic human tissues. J Clin Invest 89:2066-2070
8. Benyoucef S, Surinya KH, Hadaschik D, et al (2007) Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation. Biochem J 403:603-613
9. Bondy CA, Werner H, Roberts CT, Jr., et al (1990) Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Mol Endocrinol 4:1386-1398
10. Cusi K, Maezono K, Osman A, et al (2000) Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 105:311-320
11. Denley A, Carroll JM, Brierley GV, et al (2007) Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors. Mol Cell Biol 27:3569-3577
12. DiGiovanni J, Kiguchi K, Frijhoff A, et al (2000) Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice. Proc Natl Acad Sci U S A 97:3455-3460
13. Dupont J, Fernandez AM, Glackin CA, et al (2001a) Insulin-like growth factor 1 (IGF-1)-induced twist expression is involved in the anti-apoptotic effects of the IGF-1 receptor. J Biol Chem 276:26699-26707
14. Dupont J, Khan J, Qu BH, et al (2001b) Insulin and IGF-1 induce different patterns of gene expression in mouse fibroblast NIH-3T3 cells: identification by cDNA microarray analysis. Endocrinology 142:4969-4975
15. Entingh AJ, Taniguchi CM, Kahn CR (2003) Bi-directional regulation of brown fat adipogenesis by the insulin receptor. J Biol Chem 278:33377-33383
16. Fair AM, Dai Q, Shu XO, et al (2007) Energy balance, insulin resistance biomarkers, and breast cancer risk. Cancer Detect Prev 31:214-219
17. Frasca F, Pandini G, Scalia P, et al (1999) Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol 19:3278-3288
18. Frystyk J (2004) Free insulin-like growth factors - measurements and relationships to growth hormone secretion and glucose homeostasis. Growth Horm IGF Res 14:337-375
19. Furlanetto RW, Dey BR, Lopaczynski W, et al (1997) 14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor. Biochem J 327(Pt 3):765-771
20. Gicquel C, Bertagna X, Gaston V, et al (2001) Molecular markers and long-term recurrences in a large cohort of patients with sporadic adrenocortical tumors. Cancer Res 61:6762-6767
21. Giorgino F, Belfiore A, Milazzo G, et al (1991) Overexpression of insulin receptors in fibroblast and ovary cells induces a ligand-mediated transformed phenotype. Mol Endocrinol 5:452-459
22. Gual P, Le Marchand-Brustel Y, Tanti JF (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87:99-109
23. Hakam A, Yeatman TJ, Lu L, et al (1999) Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol 30:1128-1133
24. Hernandez-Sanchez C, Mansilla A, de Pablo F, et al (2008) Evolution of the insulin receptor family and receptor isoform expression in vertebrates. Mol Biol Evol 25:1043-1053
25. Jiang ZY, Lin YW, Clemont A, et al (1999) Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 104:447-457
26. Jonas HA, Cox AJ (1991) Insulin receptor sub-types in a human lymphoid-derived cell line (IM-9): differential regulation by insulin, dexamethasone and monensin. J Recept Res 11:813-829
27. Kaplan SA (1984) The insulin receptor. J Pediatr 104:327-336
28. Koda M, Sulkowski S, Garofalo C, et al (2003) Expression of the insulin-like growth factor-I receptor in primary breast cancer and lymph node metastases: correlations with estrogen receptors alpha and beta. Horm Metab Res 35:794-801
29. Kornfeld S (1992) Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors. Annu Rev Biochem 61:307-330
30. Kosaki A, Webster NJ (1993) Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J Biol Chem 268:21990-21996
31. Kotzke G, Schutt M, Missler U, et al (1995) Binding of human, porcine and bovine insulin to insulin receptors from human brain, muscle and adipocytes and to expressed recombinant alternatively spliced insulin receptor isoforms. Diabetologia 38:757-763
32. Laviola L GF, Chow JC, Baquero JA, Hansen H, Ooi J, Zhu J, Riedel, HSR (1997) The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-1 receptor in mouse fibroblasts. J Clin Invest 99:830-837
33. Leibiger B, Leibiger IB, Moede T, et al (2001) Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells. Mol Cell 7:559-570
34. LeRoith D, Roberts CT, Jr. (2003) The insulin-like growth factor system and cancer. Cancer Lett 195:127-137
35. Liu JP, Baker J, Perkins AS, et al (1993) Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72
36. Louvi A, Accili D, Efstratiadis A (1997) Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development. Dev Biol 189:33-48
37. Mastick CC, Kato H, Roberts CT, Jr., et al (1994) Insulin and insulin-like growth factor-I receptors similarly stimulate deoxyribonucleic acid synthesis despite differences in cellular protein tyrosine phosphorylation. Endocrinology 135:214-222
38. Michell NP, Langman MJ, Eggo MC (1997) Insulin-like growth factors and their binding proteins in human colonocytes: preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. Br J Cancer 76:60-66
39. Milazzo G, Giorgino F, Damante G, et al (1992a) Insulin receptor expression and function in human breast cancer cell lines. Cancer Res 52:3924-3930
40. Milazzo G, Yip CC, Maddux BA, et al (1992b) High-affinity insulin binding to an atypical insulinlike growth factor-I receptor in human breast cancer cells. J Clin Invest 89:899-908
41. Morrione A, Valentinis B, Xu SQ, et al (1997) Insulin-like growth factor II stimulates cell proliferation through the insulin receptor. Proc Natl Acad Sci U S A 94:3777-3782
42. Moxham CP, Jacobs S (1992) Insulin/IGF-I receptor hybrids: a mechanism for increasing receptor diversity. J Cell Biochem 48:136-140
43. Mulligan C, Rochford J, Denyer G, et al (2002) Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1. J Biol Chem 277:42480-42487
44. Murphy LJ (2006) Insulin-like growth factor-I: a treatment for type 2 diabetes revisited. Endocrinology 147:2616-2618
45. Nakae J, Kido Y, Accili D (2001) Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev 22:818-835
46. Navarro M, Joulia D, Fedon Y, et al (2008) The atypical alpha2beta2 IGF receptor expressed in inducible c2.7 myoblasts is derived from post-translational modifications of the mouse IGF-I receptor. Growth Horm IGF Res 18:412-423
47. O'Connor R, Kauffmann-Zeh A, Liu Y, et al (1997) Identification of domains of the insulin-like growth factor I receptor that are required for protection from apoptosis. Mol Cell Biol 17:427-435
48. Palmade F S-CO, Coquelet C, Bonne C (1994) Insulin-like growth factor-1 (IGF-1) specifically binds to bovine lens epithelial cells and increases the number of fibronectin receptor sites. Curr Eye Res 13:531-537
49. Pandini G, Vigneri R, Costantino A, et al (1999) Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 5:1935-1944
50. Pandini G, Frasca F, Mineo R, et al (2002) Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved. J Biol Chem 277:39684-39695
51. Pandini G, Medico E, Conte E, et al (2003) Differential gene expression induced by insulin and insulin-like growth factor-II through the insulin receptor isoform A. J Biol Chem 278:42178-42189
52. Pandini G, Wurch T, Akla B, et al (2007) Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer 43:1318-1327
53. Papa V, Pezzino V, Costantino A, et al (1990) Elevated insulin receptor content in human breast cancer. J Clin Invest 86:1503-1510
54. Papa V, Gliozzo B, Clark GM, et al (1993) Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Res 53:3736-3740
55. Pezzino V, Papa V, Trischitta V, et al (1989) Human insulin receptor radioimmunoassay: applicability to insulin-resistant states. Am J Physiol 257:E451-457
56. Pillay TS, Sasaoka T, Olefsky JM (1995) Insulin stimulates the tyrosine dephosphorylation of pp125 focal adhesion kinase. J Biol Chem 270:991-994
57. Pollak MN, Schernhammer ES, Hankinson SE (2004) Insulin-like growth factors and neoplasia. Nat Rev Cancer 4:505-518
58. Rajaram S, Baylink DJ, Mohan S (1997) Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev 18:801-831
59. Rasmussen AA, Cullen KJ (1998) Paracrine/autocrine regulation of breast cancer by the insulinlike growth factors. Breast Cancer Res Treat 47:219-233
60. Redig AJ, Munshi HG (2010) Care of the cancer survivor: metabolic syndrome after hormonemodifying therapy. Am J Med 123:87 e81-86
61. Sacco A, Morcavallo A, Pandini G, et al (2009) Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A. Endocrinology 150:3594-3602
62. Samani AA, Yakar S, LeRoith D, et al (2007) The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 28:20-47
63. Sandhu MS, Dunger DB, Giovannucci EL (2002) Insulin, insulin-like growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst 94:972-980
64. Sasaoka T, Ishiki M, Sawa T, et al (1996) Comparison of the insulin and insulin-like growth factor 1 mitogenic intracellular signaling pathways. Endocrinology 137:4427-4434
65. Sciacca L, Mineo R, Pandini G, et al (2002) In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A. Oncogene 21:8240-8250
66. Sciacca L, Prisco M, Wu A, et al (2003) Signaling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1. Endocrinology 144:2650-2658
67. Seino S, Bell GI (1989) Alternative splicing of human insulin receptor messenger RNA. Biochem Biophys Res Commun 159:312-316
68. Sell C, Dumenil G, Deveaud C, et al (1994) Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts. Mol Cell Biol 14:3604-3612
69. Shen S, Alt A, Wertheimer E, et al (2001) PKCdelta activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes. Diabetes 50:255-264
70. Slaaby R, Schaffer L, Lautrup-Larsen I, et al (2006) Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant. J Biol Chem 281:25869-25874
71. Soni P, Lakkis M, Poy MN, et al (2000) The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor. Mol Cell Biol 20:3896-3905
72. Soos MA, Field CE, Siddle K (1993) Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity. Biochem J 290(Pt 2):419-426
73. Spampinato D, Pandini G, Iuppa A, et al (2000) Insulin/insulin-like growth factor I hybrid receptors overexpression is not an early defect in insulin-resistant subjects. J Clin Endocrinol Metab 85:4219-4223
74. Strammiello R, Benini S, Manara MC, et al (2003) Impact of IGF-I/IGF-IR circuit on the angiogenetic properties of Ewing's sarcoma cells. Horm Metab Res 35:675-684
75. Tennant MK, Thrasher JB, Twomey PA, et al (1996) Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium. J Clin Endocrinol Metab 81:3774-3782
76. Ullrich A, Gray A, Tam AW, et al (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity. Embo J 5:2503-2512
77. Urso B, Cope DL, Kalloo-Hosein HE, et al (1999) Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes. J Biol Chem 274:30864-30873
78. Valentinis B, Porcu PL, Quinn K, et al (1994) The role of the insulin-like growth factor I receptor in the transformation by simian virus 40 T antigen. Oncogene 9:825-831
79. Vella V, Pandini G, Sciacca L, et al (2002) A novel autocrine loop involving IGF-II and the insulin receptor isoform-A stimulates growth of thyroid cancer. J Clin Endocrinol Metab 87:245-254
80. Yamada T, De Souza AT, Finkelstein S, et al (1997) Loss of the gene encoding mannose 6-phosphate/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc Natl Acad Sci U S A 94:10351-10355
81. Yamaguchi Y, Flier JS, Benecke H, et al (1993) Ligand-binding properties of the two isoforms of the human insulin receptor. Endocrinology 132:1132-1138