Novel imidazo[1,2-a]pyridine based inhibitors of the IGF-1 receptor tyrosine kinase: Optimization of the aniline

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 16, 2011, Pages 4702-4704

  Ducray, Richard ^a   Jones, Clifford D ^a   Jung, Frederic H ^a   Simpson, Iain ^a   Curwen, Jon ^a   Pass, Martin ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

IGF1 R; Insulin like growth factor 1 receptor; Kinase inhibitor

Indexed keywords

ANILINE; IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; SOMATOMEDIN C RECEPTOR;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; DRUG DISCOVERY; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRIDINES; RECEPTOR, IGF TYPE 1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960927448     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.06.090     Document Type: Article

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