-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. The protein kinase complement of the human genome. Science. 298:2002;1912-1934
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
0038549051
-
The repertoire of protein kinases encoded in the draft version of the human genome: Atypical variations and uncommon domain combinations
-
[RESEARCH0066.1-.0066.14]
-
Krupa A., Srinivasan N. The repertoire of protein kinases encoded in the draft version of the human genome: atypical variations and uncommon domain combinations. Genome Biol. 3:2002;. [RESEARCH0066.1-.0066.14]
-
(2002)
Genome Biol.
, vol.3
-
-
Krupa, A.1
Srinivasan, N.2
-
3
-
-
0034693799
-
The protein tyrosine kinase family of the human genome
-
Robinson D.R., Wu Y.M., Lin S.F. The protein tyrosine kinase family of the human genome. Oncogene. 19:2000;5548-5557
-
(2000)
Oncogene
, vol.19
, pp. 5548-5557
-
-
Robinson, D.R.1
Wu, Y.M.2
Lin, S.F.3
-
4
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell. 103:2000;211-225
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
5
-
-
0032577051
-
The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: Its role in cell growth and disease
-
Hunter T. The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. Philos. Trans. R. Soc. Lond., B Biol. Sci. 353:1998;583-605
-
(1998)
Philos. Trans. R. Soc. Lond., B Biol. Sci.
, vol.353
, pp. 583-605
-
-
Hunter, T.1
-
6
-
-
0033915130
-
Growth factor receptor tyrosine kinases: Cell adhesion kinase family suggests a novel signaling mechanism in cancer
-
Weiner H.L., Zagzag D. Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancer. Cancer Invest. 18:2000;544-554
-
(2000)
Cancer Invest.
, vol.18
, pp. 544-554
-
-
Weiner, H.L.1
Zagzag, D.2
-
7
-
-
0035176191
-
Biological activity of tyrosine kinase inhibitors: Novel agents for psoriasis therapy
-
Ben-Bassat H. Biological activity of tyrosine kinase inhibitors: novel agents for psoriasis therapy. Curr. Opin. Invest. Drugs. 2:2001;1539-1545
-
(2001)
Curr. Opin. Invest. Drugs
, vol.2
, pp. 1539-1545
-
-
Ben-Bassat, H.1
-
8
-
-
0037103913
-
RET receptor tyrosine kinase isoforms in kidney function and disease
-
Lee D.C., Chan K.W., Chan S.Y. RET receptor tyrosine kinase isoforms in kidney function and disease. Oncogene. 21:2002;5582-5592
-
(2002)
Oncogene
, vol.21
, pp. 5582-5592
-
-
Lee, D.C.1
Chan, K.W.2
Chan, S.Y.3
-
9
-
-
0036250154
-
Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor
-
Indo Y. Genetics of congenital insensitivity to pain with anhidrosis (CIPA) or hereditary sensory and autonomic neuropathy type IV. Clinical, biological and molecular aspects of mutations in TRKA(NTRK1) gene encoding the receptor tyrosine kinase for nerve growth factor. Clinic. Auton. Res. 12(Suppl. 1):2002;I20-I32
-
(2002)
Clinic. Auton. Res.
, vol.12
, Issue.SUPPL. 1
, pp. 20-I32
-
-
Indo, Y.1
-
10
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature. 411:2001;355-365
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
11
-
-
0032053944
-
Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells
-
Grandis J.R., Chakraborty A., Zeng Q., Melhem M.F., Tweardy D.J. Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J. Cell. Biochem. 69:1998;55-62
-
(1998)
J. Cell. Biochem.
, vol.69
, pp. 55-62
-
-
Grandis, J.R.1
Chakraborty, A.2
Zeng, Q.3
Melhem, M.F.4
Tweardy, D.J.5
-
13
-
-
0024360141
-
HER-2/neu oncogene protein and prognosis in breast cancer
-
Tandon A.K., Clark G.M., Chamness G.C., Ullrich A., McGuire W.L. HER-2/neu oncogene protein and prognosis in breast cancer. J. Clin. Oncol. 7:1989;1120-1128
-
(1989)
J. Clin. Oncol.
, vol.7
, pp. 1120-1128
-
-
Tandon, A.K.1
Clark, G.M.2
Chamness, G.C.3
Ullrich, A.4
McGuire, W.L.5
-
14
-
-
0031080971
-
Overexpression of the oncogene c-erbB-2 (HER2/neu) in ovarian cancer: A new prognostic factor
-
Meden H., Kuhn W. Overexpression of the oncogene c-erbB-2 (HER2/neu) in ovarian cancer: a new prognostic factor. Eur. J. Obstet. Gynecol. Reprod. Biol. 71:1997;173-179
-
(1997)
Eur. J. Obstet. Gynecol. Reprod. Biol.
, vol.71
, pp. 173-179
-
-
Meden, H.1
Kuhn, W.2
-
15
-
-
0027238684
-
Overexpression of Her-2/neu may be an indicator of poor prognosis in prostate cancer
-
Sadasivan R., Morgan R., Jennings S., Austenfeld M., Van Veldhuizen P., Stephens R., et al. Overexpression of Her-2/neu may be an indicator of poor prognosis in prostate cancer. J. Urol. 150:1993;126-131
-
(1993)
J. Urol.
, vol.150
, pp. 126-131
-
-
Sadasivan, R.1
Morgan, R.2
Jennings, S.3
Austenfeld, M.4
Van Veldhuizen, P.5
Stephens, R.6
-
16
-
-
0037093969
-
HER-2/neu overexpression in patients with radically resected nonsmall cell lung carcinoma. Impact on long-term survival
-
Selvaggi G., Scagliotti G.V., Torri V., Novello S., Leonardo E., Cappia S., et al. HER-2/neu overexpression in patients with radically resected nonsmall cell lung carcinoma. Impact on long-term survival. Cancer. 94:2002;2669-2674
-
(2002)
Cancer
, vol.94
, pp. 2669-2674
-
-
Selvaggi, G.1
Scagliotti, G.V.2
Torri, V.3
Novello, S.4
Leonardo, E.5
Cappia, S.6
-
17
-
-
0037227104
-
Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification
-
Zhou H., Randall R.L., Brothman A.R., Maxwell T., Coffin C.M., Goldsby R.E. Her-2/neu expression in osteosarcoma increases risk of lung metastasis and can be associated with gene amplification. J. Pediatr. Hematol. Oncol. 25:2003;27-32
-
(2003)
J. Pediatr. Hematol. Oncol.
, vol.25
, pp. 27-32
-
-
Zhou, H.1
Randall, R.L.2
Brothman, A.R.3
Maxwell, T.4
Coffin, C.M.5
Goldsby, R.E.6
-
18
-
-
0033199890
-
Effect of c-KIT mutation on prognosis of gastrointestinal stromal tumors
-
Taniguchi M., Nishida T., Hirota S., Isozaki K., Ito T., Nomura T., et al. Effect of c-KIT mutation on prognosis of gastrointestinal stromal tumors. Cancer Res. 59:1999;4297-4300
-
(1999)
Cancer Res.
, vol.59
, pp. 4297-4300
-
-
Taniguchi, M.1
Nishida, T.2
Hirota, S.3
Isozaki, K.4
Ito, T.5
Nomura, T.6
-
19
-
-
0038170400
-
Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias
-
Care R.S., Valk P.J., Goodeve A.C., Abu-Duhier F.M., Geertsma-Kleinekoort W.M., Wilson G.A., et al. Incidence and prognosis of c-KIT and FLT3 mutations in core binding factor (CBF) acute myeloid leukaemias. Br. J. Haematol. 121:2003;775-777
-
(2003)
Br. J. Haematol.
, vol.121
, pp. 775-777
-
-
Care, R.S.1
Valk, P.J.2
Goodeve, A.C.3
Abu-Duhier, F.M.4
Geertsma-Kleinekoort, W.M.5
Wilson, G.A.6
-
20
-
-
0036912115
-
Analysis of c-KIT protein expression in small-cell lung carcinoma and its implication for prognosis
-
Naeem M., Dahiya M., Clark J.I., Creech S.D., Alkan S. Analysis of c-KIT protein expression in small-cell lung carcinoma and its implication for prognosis. Hum. Pathol. 33:2002;1182-1187
-
(2002)
Hum. Pathol.
, vol.33
, pp. 1182-1187
-
-
Naeem, M.1
Dahiya, M.2
Clark, J.I.3
Creech, S.D.4
Alkan, S.5
-
21
-
-
0042856233
-
IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer
-
Peters G., Gongoll S., Langner C., Mengel M., Piso P., Klempnauer J., et al. IGF-1R, IGF-1 and IGF-2 expression as potential prognostic and predictive markers in colorectal-cancer. Virchows Arch. 2003
-
(2003)
Virchows Arch.
-
-
Peters, G.1
Gongoll, S.2
Langner, C.3
Mengel, M.4
Piso, P.5
Klempnauer, J.6
-
22
-
-
0036659931
-
Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
-
Schnittger S., Schoch C., Dugas M., Kern W., Staib P., Wuchter C., et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 100:2002;59-66
-
(2002)
Blood
, vol.100
, pp. 59-66
-
-
Schnittger, S.1
Schoch, C.2
Dugas, M.3
Kern, W.4
Staib, P.5
Wuchter, C.6
-
23
-
-
0035352721
-
Angiogenesis: Pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs
-
Fox S.B., Gasparini G., Harris A.L. Angiogenesis: pathological, prognostic, and growth-factor pathways and their link to trial design and anticancer drugs. Lancet Oncol. 2:2001;278-289
-
(2001)
Lancet Oncol.
, vol.2
, pp. 278-289
-
-
Fox, S.B.1
Gasparini, G.2
Harris, A.L.3
-
24
-
-
0037439321
-
Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma
-
Arinaga M., Noguchi T., Takeno S., Chujo M., Miura T., Uchida Y. Clinical significance of vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 in patients with nonsmall cell lung carcinoma. Cancer. 97:2003;457-464
-
(2003)
Cancer
, vol.97
, pp. 457-464
-
-
Arinaga, M.1
Noguchi, T.2
Takeno, S.3
Chujo, M.4
Miura, T.5
Uchida, Y.6
-
25
-
-
1142270447
-
Quantitative analysis of lymphangiogenic markers in human colorectal cancer
-
Parr C., Jiang W.G. Quantitative analysis of lymphangiogenic markers in human colorectal cancer. Int. J. Oncol. 23:2003;533-539
-
(2003)
Int. J. Oncol.
, vol.23
, pp. 533-539
-
-
Parr, C.1
Jiang, W.G.2
-
26
-
-
0033849491
-
Prognostic and biological role of neurotrophin-receptor TrkA and TrkB in neuroblastoma
-
Eggert A., Ikegaki N., Liu X.G., Brodeur G.M. Prognostic and biological role of neurotrophin-receptor TrkA and TrkB in neuroblastoma. Klin. Padiatr. 212:2000;200-205
-
(2000)
Klin. Padiatr.
, vol.212
, pp. 200-205
-
-
Eggert, A.1
Ikegaki, N.2
Liu, X.G.3
Brodeur, G.M.4
-
27
-
-
0037331996
-
Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas
-
Baykal C., Ayhan A., Al A., Yuce K. Overexpression of the c-Met/HGF receptor and its prognostic significance in uterine cervix carcinomas. Gynecol. Oncol. 88:2003;123-129
-
(2003)
Gynecol. Oncol.
, vol.88
, pp. 123-129
-
-
Baykal, C.1
Ayhan, A.2
Al, A.3
Yuce, K.4
-
28
-
-
0033966745
-
Expression of hepatocyte growth factor (HGF)/scatter factor and its receptor c-Met correlates with poor prognosis in synovial sarcoma
-
Oda Y., Sakamoto A., Saito T., Kinukawa N., Iwamoto Y., Tsuneyoshi M. Expression of hepatocyte growth factor (HGF)/scatter factor and its receptor c-Met correlates with poor prognosis in synovial sarcoma. Hum. Pathol. 31:2000;185-192
-
(2000)
Hum. Pathol.
, vol.31
, pp. 185-192
-
-
Oda, Y.1
Sakamoto, A.2
Saito, T.3
Kinukawa, N.4
Iwamoto, Y.5
Tsuneyoshi, M.6
-
29
-
-
0031044486
-
Expression of hepatocyte growth factor and its receptor c-Met proto-oncogene in hepatocellular carcinoma
-
Ueki T., Fujimoto J., Suzuki T., Yamamoto H., Okamoto E. Expression of hepatocyte growth factor and its receptor c-Met proto-oncogene in hepatocellular carcinoma. Hepatology. 25:1997;862-866
-
(1997)
Hepatology
, vol.25
, pp. 862-866
-
-
Ueki, T.1
Fujimoto, J.2
Suzuki, T.3
Yamamoto, H.4
Okamoto, E.5
-
30
-
-
0032820867
-
Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): Results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK)
-
Rochlitz C., Lohri A., Bacchi M., Schmidt M., Nagel S., Fopp M., et al. Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK). Leukemia. 13:1999;1352-1358
-
(1999)
Leukemia
, vol.13
, pp. 1352-1358
-
-
Rochlitz, C.1
Lohri, A.2
Bacchi, M.3
Schmidt, M.4
Nagel, S.5
Fopp, M.6
-
31
-
-
0032767069
-
Tie-1 protein tyrosine kinase: A novel independent prognostic marker for gastric cancer
-
Lin W.C., Li A.F., Chi C.W., Chung W.W., Huang C.L., Lui W.Y., et al. Tie-1 protein tyrosine kinase: a novel independent prognostic marker for gastric cancer. Clin. Cancer Res. 5:1999;1745-1751
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1745-1751
-
-
Lin, W.C.1
Li, A.F.2
Chi, C.W.3
Chung, W.W.4
Huang, C.L.5
Lui, W.Y.6
-
32
-
-
0036499982
-
Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia
-
Verstovsek S., Kantarjian H., Manshouri T., O'Brien S., Faderl S., Talpaz M., et al. Prognostic significance of Tie-1 protein expression in patients with early chronic phase chronic myeloid leukemia. Cancer. 94:2002;1517-1521
-
(2002)
Cancer
, vol.94
, pp. 1517-1521
-
-
Verstovsek, S.1
Kantarjian, H.2
Manshouri, T.3
O'Brien, S.4
Faderl, S.5
Talpaz, M.6
-
33
-
-
0036023218
-
Soluble Tie-2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma
-
Homer J.J., Greenman J., Drevs J., Marme D., Stafford N.D. Soluble Tie-2 receptor levels independently predict locoregional recurrence in head and neck squamous cell carcinoma. Head Neck. 24:2002;773-778
-
(2002)
Head Neck
, vol.24
, pp. 773-778
-
-
Homer, J.J.1
Greenman, J.2
Drevs, J.3
Marme, D.4
Stafford, N.D.5
-
34
-
-
0033151520
-
Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma
-
Gascoyne R.D., Aoun P., Wu D., Chhanabhai M., Skinnider B.F., Greiner T.C., et al. Prognostic significance of anaplastic lymphoma kinase (ALK) protein expression in adults with anaplastic large cell lymphoma. Blood. 93:1999;3913-3921
-
(1999)
Blood
, vol.93
, pp. 3913-3921
-
-
Gascoyne, R.D.1
Aoun, P.2
Wu, D.3
Chhanabhai, M.4
Skinnider, B.F.5
Greiner, T.C.6
-
35
-
-
0037080135
-
Activation of Src kinase in primary colorectal carcinoma: An indicator of poor clinical prognosis
-
Aligayer H., Boyd D.D., Heiss M.M., Abdalla E.K., Curley S.A., Gallick G.E. Activation of Src kinase in primary colorectal carcinoma: an indicator of poor clinical prognosis. Cancer. 94:2002;344-351
-
(2002)
Cancer
, vol.94
, pp. 344-351
-
-
Aligayer, H.1
Boyd, D.D.2
Heiss, M.M.3
Abdalla, E.K.4
Curley, S.A.5
Gallick, G.E.6
-
36
-
-
0035869422
-
Early detection of BCR-ABL transcripts by quantitative reverse transcriptase-polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia
-
Olavarria E., Kanfer E., Szydlo R., Kaeda J., Rezvani K., Cwynarski K., et al. Early detection of BCR-ABL transcripts by quantitative reverse transcriptase-polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia. Blood. 97:2001;1560-1565
-
(2001)
Blood
, vol.97
, pp. 1560-1565
-
-
Olavarria, E.1
Kanfer, E.2
Szydlo, R.3
Kaeda, J.4
Rezvani, K.5
Cwynarski, K.6
-
37
-
-
0036217230
-
Multifaceted approach to the treatment of BCR-ABL-positive leukemias
-
O'Dwyer M. Multifaceted approach to the treatment of BCR-ABL-positive leukemias. Oncologist. 7(Suppl. 1):2002;30-38
-
(2002)
Oncologist
, vol.7
, Issue.SUPPL. 1
, pp. 30-38
-
-
O'Dwyer, M.1
-
38
-
-
0036493694
-
Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: A prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis
-
Gleissner B., Gokbuget N., Bartram C.R., Janssen B., Rieder H., Janssen J.W., et al. Leading prognostic relevance of the BCR-ABL translocation in adult acute B-lineage lymphoblastic leukemia: a prospective study of the German Multicenter Trial Group and confirmed polymerase chain reaction analysis. Blood. 99:2002;1536-1543
-
(2002)
Blood
, vol.99
, pp. 1536-1543
-
-
Gleissner, B.1
Gokbuget, N.2
Bartram, C.R.3
Janssen, B.4
Rieder, H.5
Janssen, J.W.6
-
39
-
-
0041369959
-
FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma
-
Miyazaki T., Kato H., Nakajima M., Sohda M., Fukai Y., Masuda N., et al. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br. J. Cancer. 89:2003;140-145
-
(2003)
Br. J. Cancer
, vol.89
, pp. 140-145
-
-
Miyazaki, T.1
Kato, H.2
Nakajima, M.3
Sohda, M.4
Fukai, Y.5
Masuda, N.6
-
40
-
-
0037427571
-
Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer
-
Toyama T., Iwase H., Yamashita H., Hara Y., Omoto Y., Sugiura H., et al. Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer. Cancer Lett. 189:2003;97-102
-
(2003)
Cancer Lett.
, vol.189
, pp. 97-102
-
-
Toyama, T.1
Iwase, H.2
Yamashita, H.3
Hara, Y.4
Omoto, Y.5
Sugiura, H.6
-
41
-
-
0034693811
-
Development of inhibitors for protein tyrosine kinases
-
Al-Obeidi F.A., Lam K.S. Development of inhibitors for protein tyrosine kinases. Oncogene. 19:2000;5690-5701
-
(2000)
Oncogene
, vol.19
, pp. 5690-5701
-
-
Al-Obeidi, F.A.1
Lam, K.S.2
-
42
-
-
0035990893
-
Protein kinases as targets for anticancer agents: From inhibitors to useful drugs
-
Fabbro D., Ruetz S., Buchdunger E., Cowan-Jacob S.W., Fendrich G., Liebetanz J., et al. Protein kinases as targets for anticancer agents: from inhibitors to useful drugs. Pharmacol. Ther. 93:2002;79-98
-
(2002)
Pharmacol. Ther.
, vol.93
, pp. 79-98
-
-
Fabbro, D.1
Ruetz, S.2
Buchdunger, E.3
Cowan-Jacob, S.W.4
Fendrich, G.5
Liebetanz, J.6
-
43
-
-
0036769770
-
Tyrosine kinases as targets for cancer therapy
-
Levitzki A. Tyrosine kinases as targets for cancer therapy. Eur. J. Cancer. 38(Suppl. 5):2002;S11-S18
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
, pp. 11-S18
-
-
Levitzki, A.1
-
44
-
-
0141599428
-
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor
-
Stamos J., Sliwkowski M.X., Eigenbrot C. Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor. J. Biol. Chem. 277:2002;46265-46272
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 46265-46272
-
-
Stamos, J.1
Sliwkowski, M.X.2
Eigenbrot, C.3
-
45
-
-
0037232108
-
Small molecule tyrosine kinase inhibitors: Clinical development of anticancer agents
-
Laird A.D., Cherrington J.M. Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents. Expert Opin. Invest. Drugs. 12:2003;51-64
-
(2003)
Expert Opin. Invest. Drugs
, vol.12
, pp. 51-64
-
-
Laird, A.D.1
Cherrington, J.M.2
-
46
-
-
0037429659
-
Mechanism of action of erbB tyrosine kinase inhibitors
-
Fry D.W. Mechanism of action of erbB tyrosine kinase inhibitors. Exp. Cell Res. 284:2003;131-139
-
(2003)
Exp. Cell Res.
, vol.284
, pp. 131-139
-
-
Fry, D.W.1
-
47
-
-
0035990923
-
Irreversible inhibitors of the erbB family of protein tyrosine kinases
-
Denny W.A. Irreversible inhibitors of the erbB family of protein tyrosine kinases. Pharmacol. Ther. 93:2002;253-261
-
(2002)
Pharmacol. Ther.
, vol.93
, pp. 253-261
-
-
Denny, W.A.1
-
48
-
-
0037105743
-
Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts
-
Mellinghoff I.K., Tran C., Sawyers C.L. Growth inhibitory effects of the dual ErbB1/ErbB2 tyrosine kinase inhibitor PKI-166 on human prostate cancer xenografts. Cancer Res. 62:2002;5254-5259
-
(2002)
Cancer Res.
, vol.62
, pp. 5254-5259
-
-
Mellinghoff, I.K.1
Tran, C.2
Sawyers, C.L.3
-
50
-
-
0035525054
-
SU6668, a multitargeted angiogenesis inhibitor
-
Hoekman K. SU6668, a multitargeted angiogenesis inhibitor. Cancer J. 7(Suppl. 3):2001;S134-S138
-
(2001)
Cancer J.
, vol.7
, Issue.SUPPL. 3
, pp. 134-S138
-
-
Hoekman, K.1
-
51
-
-
0036769158
-
Pharmacology of imatinib (STI571)
-
Buchdunger E., O'Reilly T., Wood J. Pharmacology of imatinib (STI571). Eur. J. Cancer. 38(Suppl. 5):2002;S28-S36
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
, pp. 28-S36
-
-
Buchdunger, E.1
O'Reilly, T.2
Wood, J.3
-
52
-
-
0037663473
-
Suppression of ARG kinase activity by STI571 induces cell cycle arrest through up-regulation of CDK inhibitor p18/INK4c
-
Nishimura N., Furukawa Y., Sutheesophon K., Nakamura M., Kishi K., Okuda K., et al. Suppression of ARG kinase activity by STI571 induces cell cycle arrest through up-regulation of CDK inhibitor p18/INK4c. Oncogene. 22:2003;4074-4082
-
(2003)
Oncogene
, vol.22
, pp. 4074-4082
-
-
Nishimura, N.1
Furukawa, Y.2
Sutheesophon, K.3
Nakamura, M.4
Kishi, K.5
Okuda, K.6
-
53
-
-
0019453755
-
Quercetin inhibits tyrosine phosphorylation by the cyclic nucleotide-independent, transforming protein kinase, pp60src
-
Glossmann H., Presek P., Eigenbrodt E. Quercetin inhibits tyrosine phosphorylation by the cyclic nucleotide-independent, transforming protein kinase, pp60src. Naunyn-Schmiedeberg's Arch. Pharmacol. 317:1981;100-102
-
(1981)
Naunyn-Schmiedeberg's Arch. Pharmacol.
, vol.317
, pp. 100-102
-
-
Glossmann, H.1
Presek, P.2
Eigenbrodt, E.3
-
54
-
-
0023664272
-
Genistein, a specific inhibitor of tyrosine-specific protein kinases
-
Akiyama T., Ishida J., Nakagawa S., Ogawara H., Watanabe S., Itoh N., et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262:1987;5592-5595
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 5592-5595
-
-
Akiyama, T.1
Ishida, J.2
Nakagawa, S.3
Ogawara, H.4
Watanabe, S.5
Itoh, N.6
-
55
-
-
0037106273
-
Targeting the epidermal growth factor receptor for cancer therapy
-
Mendelsohn J. Targeting the epidermal growth factor receptor for cancer therapy. J. Clin. Oncol. 20:2002;1S-13S
-
(2002)
J. Clin. Oncol.
, vol.20
-
-
Mendelsohn, J.1
-
57
-
-
0032822839
-
Recombinant antibody constructs in cancer therapy
-
Hudson P.J. Recombinant antibody constructs in cancer therapy. Curr. Opin. Immunol. 11:1999;548-557
-
(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 548-557
-
-
Hudson, P.J.1
-
58
-
-
0032698140
-
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
-
Prewett M., Huber J., Li Y., Santiago A., O'Connor W., King K., et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res. 59:1999;5209-5218
-
(1999)
Cancer Res.
, vol.59
, pp. 5209-5218
-
-
Prewett, M.1
Huber, J.2
Li, Y.3
Santiago, A.4
O'Connor, W.5
King, K.6
-
59
-
-
0037386937
-
A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
-
Posey J.A., Ng T.C., Yang B., Khazaeli M.B., Carpenter M.D., Fox F., et al. A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin. Cancer Res. 9:2003;1323-1332
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1323-1332
-
-
Posey, J.A.1
Ng, T.C.2
Yang, B.3
Khazaeli, M.B.4
Carpenter, M.D.5
Fox, F.6
-
60
-
-
0036139884
-
Receptor tyrosine kinases as targets for anticancer drugs
-
Zwick E., Bange J., Ullrich A. Receptor tyrosine kinases as targets for anticancer drugs. Trends Mol. Med. 8:2002;17-23
-
(2002)
Trends Mol. Med.
, vol.8
, pp. 17-23
-
-
Zwick, E.1
Bange, J.2
Ullrich, A.3
-
62
-
-
0035313488
-
FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition
-
Cross M.J., Claesson-Welsh L. FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition. Trends Pharmacol. Sci. 22:2001;201-207
-
(2001)
Trends Pharmacol. Sci.
, vol.22
, pp. 201-207
-
-
Cross, M.J.1
Claesson-Welsh, L.2
-
63
-
-
0033772236
-
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice
-
Blaskovich M.A., Lin Q., Delarue F.L., Sun J., Park H.S., Coppola D., et al. Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. Nat. Biotechnol. 18:2000;1065-1070
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 1065-1070
-
-
Blaskovich, M.A.1
Lin, Q.2
Delarue, F.L.3
Sun, J.4
Park, H.S.5
Coppola, D.6
-
64
-
-
0033338730
-
Clinical pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-genistein in patients with B-lineage lymphoid malignancies
-
Chen C.L., Levine A., Rao A., O'Neill K., Messinger Y., Myers D.E., et al. Clinical pharmacokinetics of the CD19 receptor-directed tyrosine kinase inhibitor B43-genistein in patients with B-lineage lymphoid malignancies. J. Clin. Pharmacol. 39:1999;1248-1255
-
(1999)
J. Clin. Pharmacol.
, vol.39
, pp. 1248-1255
-
-
Chen, C.L.1
Levine, A.2
Rao, A.3
O'Neill, K.4
Messinger, Y.5
Myers, D.E.6
-
65
-
-
0029383734
-
Targeting diphtheria toxin to growth factor receptors
-
Murphy J.R., vanderSpek J.C. Targeting diphtheria toxin to growth factor receptors. Semin. Cancer Biol. 6:1995;259-267
-
(1995)
Semin. Cancer Biol.
, vol.6
, pp. 259-267
-
-
Murphy, J.R.1
Vanderspek, J.C.2
-
66
-
-
0033778445
-
Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: Differential effect on proliferating endothelial cells
-
Wild R., Dhanabal M., Olson T.A., Ramakrishnan S. Inhibition of angiogenesis and tumour growth by VEGF121-toxin conjugate: differential effect on proliferating endothelial cells. Br. J. Cancer. 83:2000;1077-1083
-
(2000)
Br. J. Cancer
, vol.83
, pp. 1077-1083
-
-
Wild, R.1
Dhanabal, M.2
Olson, T.A.3
Ramakrishnan, S.4
-
67
-
-
0034791993
-
Clinical translation of peptide-based vaccine trials: The HER-2/neu model
-
Disis M.L., Knutson K.L., McNeel D.G., Davis D., Schiffman K. Clinical translation of peptide-based vaccine trials: the HER-2/neu model. Crit. Rev. Immunol. 21:2001;263-273
-
(2001)
Crit. Rev. Immunol.
, vol.21
, pp. 263-273
-
-
Disis, M.L.1
Knutson, K.L.2
McNeel, D.G.3
Davis, D.4
Schiffman, K.5
-
68
-
-
0033048807
-
Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine
-
Disis M.L., Grabstein K.H., Sleath P.R., Cheever M.A. Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine. Clin. Cancer Res. 5:1999;1289-1297
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1289-1297
-
-
Disis, M.L.1
Grabstein, K.H.2
Sleath, P.R.3
Cheever, M.A.4
-
69
-
-
0037089223
-
Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers
-
Disis M.L., Rinn K., Knutson K.L., Davis D., Caron D., dela Rosa C., et al. Flt3 ligand as a vaccine adjuvant in association with HER-2/neu peptide-based vaccines in patients with HER-2/neu-overexpressing cancers. Blood. 99:2002;2845-2850
-
(2002)
Blood
, vol.99
, pp. 2845-2850
-
-
Disis, M.L.1
Rinn, K.2
Knutson, K.L.3
Davis, D.4
Caron, D.5
Dela Rosa, C.6
-
70
-
-
0035998727
-
Lack of toxicity of EGFR antisense gene therapy
-
Zeng Q., Kanter P.M., Dhir R., Gooding W.E., Huang L., Grandis J.R. Lack of toxicity of EGFR antisense gene therapy. J. Exp. Ther. Oncol. 2:2002;174-186
-
(2002)
J. Exp. Ther. Oncol.
, vol.2
, pp. 174-186
-
-
Zeng, Q.1
Kanter, P.M.2
Dhir, R.3
Gooding, W.E.4
Huang, L.5
Grandis, J.R.6
-
71
-
-
0035871490
-
Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas
-
Andrews D.W., Resnicoff M., Flanders A.E., Kenyon L., Curtis M., Merli G., et al. Results of a pilot study involving the use of an antisense oligodeoxynucleotide directed against the insulin-like growth factor type I receptor in malignant astrocytomas. J. Clin. Oncol. 19:2001;2189-2200
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 2189-2200
-
-
Andrews, D.W.1
Resnicoff, M.2
Flanders, A.E.3
Kenyon, L.4
Curtis, M.5
Merli, G.6
-
72
-
-
0033671412
-
TGF-alpha antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo
-
Endo S., Zeng Q., Burke N.A., He Y., Melhem M.F., Watkins S.F., et al. TGF-alpha antisense gene therapy inhibits head and neck squamous cell carcinoma growth in vivo. Gene Ther. 7:2000;1906-1914
-
(2000)
Gene Ther.
, vol.7
, pp. 1906-1914
-
-
Endo, S.1
Zeng, Q.2
Burke, N.A.3
He, Y.4
Melhem, M.F.5
Watkins, S.F.6
-
74
-
-
0642364466
-
Harnessing the power of RNA interference to advance anticancer drug development
-
Mousses S. Harnessing the power of RNA interference to advance anticancer drug development. Mol. Cancer Ther. 2:2003;217-218
-
(2003)
Mol. Cancer Ther.
, vol.2
, pp. 217-218
-
-
Mousses, S.1
-
75
-
-
0344211452
-
Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer
-
Zhang L., Yang N., Mohamed-Hadley A., Rubin S.C., Coukos G. Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer. Biochem. Biophys. Res. Commun. 303:2003;1169-1178
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.303
, pp. 1169-1178
-
-
Zhang, L.1
Yang, N.2
Mohamed-Hadley, A.3
Rubin, S.C.4
Coukos, G.5
-
76
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
Dancey J., Sausville E.A. Issues and progress with protein kinase inhibitors for cancer treatment. Nat. Rev., Drug Discov. 2:2003;296-313
-
(2003)
Nat. Rev., Drug Discov.
, vol.2
, pp. 296-313
-
-
Dancey, J.1
Sausville, E.A.2
-
77
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells
-
Druker B.J., Tamura S., Buchdunger E., Ohno S., Segal G.M., Fanning S., et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells. Nat. Med. 2:1996;561-566
-
(1996)
Nat. Med.
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
-
78
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E., Zimmermann J., Mett H., Meyer T., Muller M., Druker B.J., et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56:1996;100-104
-
(1996)
Cancer Res.
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
Meyer, T.4
Muller, M.5
Druker, B.J.6
-
79
-
-
0036769168
-
Imatinib: A selective tyrosine kinase inhibitor
-
Manley P.W., Cowan-Jacob S.W., Buchdunger E., Fabbro D., Fendrich G., Furet P., et al. Imatinib: a selective tyrosine kinase inhibitor. Eur. J. Cancer. 38(Suppl. 5):2002;S19-S27
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
, pp. 19-S27
-
-
Manley, P.W.1
Cowan-Jacob, S.W.2
Buchdunger, E.3
Fabbro, D.4
Fendrich, G.5
Furet, P.6
-
80
-
-
0033614446
-
Chronic myeloid leukemia
-
Sawyers C.L. Chronic myeloid leukemia. N. Engl. J. Med. 340:1999;1330-1340
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 1330-1340
-
-
Sawyers, C.L.1
-
81
-
-
0030853063
-
The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells
-
Deininger M.W., Goldman J.M., Lydon N., Melo J.V. The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells. Blood. 90:1997;3691-3698
-
(1997)
Blood
, vol.90
, pp. 3691-3698
-
-
Deininger, M.W.1
Goldman, J.M.2
Lydon, N.3
Melo, J.V.4
-
82
-
-
0032859309
-
Favorable therapeutic index of a p210(BCR-ABL)-specific tyrosine kinase inhibitor; Activity on lineage-committed and primitive chronic myelogenous leukemia progenitors
-
Kasper B., Fruehauf S., Schiedlmeier B., Buchdunger E., Ho A.D., Zeller W.J. Favorable therapeutic index of a p210(BCR-ABL)-specific tyrosine kinase inhibitor; activity on lineage-committed and primitive chronic myelogenous leukemia progenitors. Cancer Chemother. Pharmacol. 44:1999;433-438
-
(1999)
Cancer Chemother. Pharmacol.
, vol.44
, pp. 433-438
-
-
Kasper, B.1
Fruehauf, S.2
Schiedlmeier, B.3
Buchdunger, E.4
Ho, A.D.5
Zeller, W.J.6
-
83
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
le Coutre P., Mologni L., Cleris L., Marchesi E., Buchdunger E., Giardini R., et al. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J. Natl. Cancer Inst. 91:1999;163-168
-
(1999)
J. Natl. Cancer Inst.
, vol.91
, pp. 163-168
-
-
Le Coutre, P.1
Mologni, L.2
Cleris, L.3
Marchesi, E.4
Buchdunger, E.5
Giardini, R.6
-
84
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker B.J., Talpaz M., Resta D.J., Peng B., Buchdunger E., Ford J.M., et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344:2001;1031-1037
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
-
85
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker B.J., Sawyers C.L., Kantarjian H., Resta D.J., Reese S.F., Ford J.M., et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N. Engl. J. Med. 344:2001;1038-1042
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
-
86
-
-
4243926785
-
Imatinib and chronic myeloid leukemia: Validating the promise of molecularly targeted therapy
-
Druker B.J. Imatinib and chronic myeloid leukemia: validating the promise of molecularly targeted therapy. Eur. J. Cancer. 38(Suppl. 5):2002;S70-S76
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
, pp. 70-S76
-
-
Druker, B.J.1
-
87
-
-
10744220743
-
Approval summary: Imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase
-
Johnson J.R., Bross P., Cohen M., Rothmann M., Chen G., Zajicek A., et al. Approval summary: imatinib mesylate capsules for treatment of adult patients with newly diagnosed Philadelphia chromosome-positive chronic myelogenous leukemia in chronic phase. Clin. Cancer Res. 9:2003;1972-1979
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1972-1979
-
-
Johnson, J.R.1
Bross, P.2
Cohen, M.3
Rothmann, M.4
Chen, G.5
Zajicek, A.6
-
88
-
-
0036682230
-
Characterization of potent inhibitors of the BCR-ABL and the c-KIT receptor tyrosine kinases
-
Wisniewski D., Lambek C.L., Liu C., Strife A., Veach D.R., Nagar B., et al. Characterization of potent inhibitors of the BCR-ABL and the c-KIT receptor tyrosine kinases. Cancer Res. 62:2002;4244-4255
-
(2002)
Cancer Res.
, vol.62
, pp. 4244-4255
-
-
Wisniewski, D.1
Lambek, C.L.2
Liu, C.3
Strife, A.4
Veach, D.R.5
Nagar, B.6
-
89
-
-
0036770178
-
Identification and treatment of chemoresistant inoperable or metastatic GIST: Experience with the selective tyrosine kinase inhibitor imatinib mesylate (STI571)
-
Demetri G.D. Identification and treatment of chemoresistant inoperable or metastatic GIST: experience with the selective tyrosine kinase inhibitor imatinib mesylate (STI571). Eur. J. Cancer. 38(Suppl. 5):2002;S52-S59
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
, pp. 52-S59
-
-
Demetri, G.D.1
-
90
-
-
0035890740
-
KIT activation is a ubiquitous feature of gastrointestinal stromal tumors
-
Rubin B.P., Singer S., Tsao C., Duensing A., Lux M.L., Ruiz R., et al. KIT activation is a ubiquitous feature of gastrointestinal stromal tumors. Cancer Res. 61:2001;8118-8121
-
(2001)
Cancer Res.
, vol.61
, pp. 8118-8121
-
-
Rubin, B.P.1
Singer, S.2
Tsao, C.3
Duensing, A.4
Lux, M.L.5
Ruiz, R.6
-
91
-
-
0035899418
-
STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
-
Tuveson D.A., Willis N.A., Jacks T., Griffin J.D., Singer S., Fletcher C.D., et al. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications. Oncogene. 20:2001;5054-5058
-
(2001)
Oncogene
, vol.20
, pp. 5054-5058
-
-
Tuveson, D.A.1
Willis, N.A.2
Jacks, T.3
Griffin, J.D.4
Singer, S.5
Fletcher, C.D.6
-
92
-
-
0036795899
-
Approval summary: Imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors
-
Dagher R., Cohen M., Williams G., Rothmann M., Gobburu J., Robbie G., et al. Approval summary: imatinib mesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors. Clin. Cancer Res. 8:2002;3034-3038
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3034-3038
-
-
Dagher, R.1
Cohen, M.2
Williams, G.3
Rothmann, M.4
Gobburu, J.5
Robbie, G.6
-
93
-
-
0036769721
-
Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: A report of the EORTC Soft Tissue and Bone Sarcoma Group
-
van Oosterom A.T., Judson I.R., Verweij J., Stroobants S., Dumez H., Donato di Paola E., et al. Update of phase I study of imatinib (STI571) in advanced soft tissue sarcomas and gastrointestinal stromal tumors: a report of the EORTC Soft Tissue and Bone Sarcoma Group. Eur. J. Cancer. 38(Suppl. 5):2002;S83-S87
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.SUPPL. 5
, pp. 83-S87
-
-
Van Oosterom, A.T.1
Judson, I.R.2
Verweij, J.3
Stroobants, S.4
Dumez, H.5
Donato Di Paola, E.6
-
94
-
-
0033883653
-
The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth
-
Krystal G.W., Honsawek S., Litz J., Buchdunger E. The selective tyrosine kinase inhibitor STI571 inhibits small cell lung cancer growth. Clin. Cancer Res. 6:2000;3319-3326
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 3319-3326
-
-
Krystal, G.W.1
Honsawek, S.2
Litz, J.3
Buchdunger, E.4
-
96
-
-
0038035638
-
Sensitivity to imatinib but low frequency of the TEL/PDGFRb fusion protein in chronic myelomonocytic leukemia
-
Gunby R.H., Cazzaniga G., Tassi E., Le Coutre P., Pogliani E., Specchia G., et al. Sensitivity to imatinib but low frequency of the TEL/PDGFRb fusion protein in chronic myelomonocytic leukemia. Haematologica. 88:2003;408-415
-
(2003)
Haematologica
, vol.88
, pp. 408-415
-
-
Gunby, R.H.1
Cazzaniga, G.2
Tassi, E.3
Le Coutre, P.4
Pogliani, E.5
Specchia, G.6
-
97
-
-
10744229862
-
Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders
-
Cortes J., Giles F., O'Brien S., Thomas D., Albitar M., Rios M.B., et al. Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders. Cancer. 97:2003;2760-2766
-
(2003)
Cancer
, vol.97
, pp. 2760-2766
-
-
Cortes, J.1
Giles, F.2
O'Brien, S.3
Thomas, D.4
Albitar, M.5
Rios, M.B.6
-
98
-
-
0036731703
-
Imatinib GIST keeps finding new indications: Successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet-derived growth factor receptor
-
Sawyers C.L. Imatinib GIST keeps finding new indications: successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet-derived growth factor receptor. J. Clin. Oncol. 20:2002;3568-3569
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3568-3569
-
-
Sawyers, C.L.1
-
99
-
-
0034665138
-
Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class
-
Kilic T., Alberta J.A., Zdunek P.R., Acar M., Iannarelli P., O'Reilly T., et al. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 60:2000;5143-5150
-
(2000)
Cancer Res.
, vol.60
, pp. 5143-5150
-
-
Kilic, T.1
Alberta, J.A.2
Zdunek, P.R.3
Acar, M.4
Iannarelli, P.5
O'Reilly, T.6
-
100
-
-
0035297541
-
Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
-
Pietras K., Ostman A., Sjoquist M., Buchdunger E., Reed R.K., Heldin C.H., et al. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 61:2001;2929-2934
-
(2001)
Cancer Res.
, vol.61
, pp. 2929-2934
-
-
Pietras, K.1
Ostman, A.2
Sjoquist, M.3
Buchdunger, E.4
Reed, R.K.5
Heldin, C.H.6
-
101
-
-
0037018763
-
Treatment of hypereosinophilic syndrome with imatinib mesilate
-
Gleich G.J., Leiferman K.M., Pardanani A., Tefferi A., Butterfield J.H. Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet. 359:2002;1577-1578
-
(2002)
Lancet
, vol.359
, pp. 1577-1578
-
-
Gleich, G.J.1
Leiferman, K.M.2
Pardanani, A.3
Tefferi, A.4
Butterfield, J.H.5
-
102
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J., DeAngelo D.J., Gotlib J., Stover E.H., Legare R.D., Cortes J., et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348:2003;1201-1214
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
Deangelo, D.J.2
Gotlib, J.3
Stover, E.H.4
Legare, R.D.5
Cortes, J.6
-
103
-
-
10744228486
-
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
-
Pardanani A., Ketterling R.P., Brockman S.R., Flynn H.C., Paternoster S.F., Shearer B.M., et al. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood. 102:2003;3093-3096
-
(2003)
Blood
, vol.102
, pp. 3093-3096
-
-
Pardanani, A.1
Ketterling, R.P.2
Brockman, S.R.3
Flynn, H.C.4
Paternoster, S.F.5
Shearer, B.M.6
-
104
-
-
0038718522
-
Developing inhibitors of the epidermal growth factor receptor for cancer treatment
-
Grunwald V., Hidalgo M. Developing inhibitors of the epidermal growth factor receptor for cancer treatment. J. Natl. Cancer Inst. 95:2003;851-867
-
(2003)
J. Natl. Cancer Inst.
, vol.95
, pp. 851-867
-
-
Grunwald, V.1
Hidalgo, M.2
-
105
-
-
0037295398
-
Studies with ZD1839 in preclinical models
-
Sirotnak F.M. Studies with ZD1839 in preclinical models. Semin. Oncol. 30:2003;12-20
-
(2003)
Semin. Oncol.
, vol.30
, pp. 12-20
-
-
Sirotnak, F.M.1
-
106
-
-
0036570203
-
ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
-
Hirata A., Ogawa S., Kometani T., Kuwano T., Naito S., Kuwano M., et al. ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase. Cancer Res. 62:2002;2554-2560
-
(2002)
Cancer Res.
, vol.62
, pp. 2554-2560
-
-
Hirata, A.1
Ogawa, S.2
Kometani, T.3
Kuwano, T.4
Naito, S.5
Kuwano, M.6
-
107
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardiello F., Caputo R., Bianco R., Damiano V., Pomatico G., De Placido S., et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin. Cancer Res. 6:2000;2053-2063
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2053-2063
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Pomatico, G.5
De Placido, S.6
-
108
-
-
0032731892
-
Tumor invasion: Role of growth factor-induced cell motility
-
Wells A. Tumor invasion: role of growth factor-induced cell motility. Adv. Cancer Res. 78:2000;31-101
-
(2000)
Adv. Cancer Res.
, vol.78
, pp. 31-101
-
-
Wells, A.1
-
109
-
-
0003008222
-
Effects of ZD1839 (Iressa), a novel EGF receptor tyrosine kinase inhibitor on breast cancer cell proliferation and invasiveness
-
[abstract]
-
Anderson N.G., Ahmad T., Chan K.C., et al. Effects of ZD1839 (Iressa), a novel EGF receptor tyrosine kinase inhibitor on breast cancer cell proliferation and invasiveness. Breast Cancer Res. Treat. 2000;64. [abstract]
-
(2000)
Breast Cancer Res. Treat.
, pp. 64
-
-
Anderson, N.G.1
Ahmad, T.2
Chan, K.C.3
-
110
-
-
0034489914
-
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
-
Sirotnak F.M., Zakowski M.F., Miller V.A., Scher H.I., Kris M.G. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin. Cancer Res. 6:2000;4885-4892
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 4885-4892
-
-
Sirotnak, F.M.1
Zakowski, M.F.2
Miller, V.A.3
Scher, H.I.4
Kris, M.G.5
-
111
-
-
0003200669
-
Evaluation of ZD1839 (Iressa) alone or in combination with Irinotecan (CPT-11) against pediatric solid tumour xenografts
-
[abstract]
-
Houghton P.J., Cheshire P.J., Harwood F.C. Evaluation of ZD1839 (Iressa) alone or in combination with Irinotecan (CPT-11) against pediatric solid tumour xenografts. Clin. Cancer Res. 6(Suppl.):2000;4542s. [abstract]
-
(2000)
Clin. Cancer Res.
, vol.6
, Issue.SUPPL.
-
-
Houghton, P.J.1
Cheshire, P.J.2
Harwood, F.C.3
-
112
-
-
0036569870
-
ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
-
Ranson M., Hammond L.A., Ferry D., Kris M., Tullo A., Murray P.I., et al. ZD1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J. Clin. Oncol. 20:2002;2240-2250
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2240-2250
-
-
Ranson, M.1
Hammond, L.A.2
Ferry, D.3
Kris, M.4
Tullo, A.5
Murray, P.I.6
-
113
-
-
3042548488
-
Final results of a phase I intermittent dose-escalation trial of ZD1839 ('Iressa') in Japanese patients with various solid tumours [abstract no. 1292]
-
Negoro S., Nakagawa K., Fukuoka M., Kudoh S., Tamura T., Yoshimura N., et al. Final results of a phase I intermittent dose-escalation trial of ZD1839 ('Iressa') in Japanese patients with various solid tumours [abstract no. 1292]. Proc. ASCO. 20:2001
-
(2001)
Proc. ASCO
, vol.20
-
-
Negoro, S.1
Nakagawa, K.2
Fukuoka, M.3
Kudoh, S.4
Tamura, T.5
Yoshimura, N.6
-
114
-
-
0000240853
-
Continuous administration of ZD1839 (Iressa), a novel oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in patients with five selected tumor types: Evidence of activity and good tolerability [abstract no. 686]
-
Baselga J., Herbst R., LoRusso P., Rischin D., Ranson M., Plummer M., et al. Continuous administration of ZD1839 (Iressa), a novel oral epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), in patients with five selected tumor types: evidence of activity and good tolerability [abstract no. 686]. Proc. ASCO. 19:2000
-
(2000)
Proc. ASCO
, vol.19
-
-
Baselga, J.1
Herbst, R.2
Lorusso, P.3
Rischin, D.4
Ranson, M.5
Plummer, M.6
-
115
-
-
0001752172
-
Final results of the dose escalation phase of a phase I pharmacokinetic (PK), pharmacodynamic (PD) and biological activity study of ZD1839: NCIC CTG Ind.122 [abstract no. 335]
-
Goss G.D., Hirte H., Lorimer I., Miller W., Stewart D.J., Batish G., et al. Final results of the dose escalation phase of a phase I pharmacokinetic (PK), pharmacodynamic (PD) and biological activity study of ZD1839: NCIC CTG Ind.122 [abstract no. 335]. Proc. ASCO. 20:2001
-
(2001)
Proc. ASCO
, vol.20
-
-
Goss, G.D.1
Hirte, H.2
Lorimer, I.3
Miller, W.4
Stewart, D.J.5
Batish, G.6
-
116
-
-
0036139727
-
Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: Histopathologic and molecular consequences of receptor inhibition
-
Albanell J., Rojo F., Averbuch S., Feyereislova A., Mascaro J.M., Herbst R., et al. Pharmacodynamic studies of the epidermal growth factor receptor inhibitor ZD1839 in skin from cancer patients: histopathologic and molecular consequences of receptor inhibition. J. Clin. Oncol. 20:2002;110-124
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 110-124
-
-
Albanell, J.1
Rojo, F.2
Averbuch, S.3
Feyereislova, A.4
Mascaro, J.M.5
Herbst, R.6
-
117
-
-
0003336304
-
Final results from a phase II trial of ZD1839 (Iressa) for patients with advanced non-small cell lung cancer (IDEAL 1) [abstract no. 1188]
-
Fukuoka M., Yano S., Giaccone G., Tanura T., Nakagawa K., Douillard J., et al. Final results from a phase II trial of ZD1839 (Iressa) for patients with advanced non-small cell lung cancer (IDEAL 1) [abstract no. 1188]. Proc. ASCO. 21:2002
-
(2002)
Proc. ASCO
, vol.21
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tanura, T.4
Nakagawa, K.5
Douillard, J.6
-
118
-
-
0001303063
-
A phase II trial of ZD1839 (Iressa) in advanced non-small cell lung cancer (NSCLC) patients who failed platinum- and docetaxel-based regimens (IDEAL 2) [abstract no. 1166]
-
Kris M.G., Natale R.B., Herbst R., Lynch T.J., Prager D., Belani C.P., et al. A phase II trial of ZD1839 (Iressa) in advanced non-small cell lung cancer (NSCLC) patients who failed platinum- and docetaxel-based regimens (IDEAL 2) [abstract no. 1166]. Proc. ASCO. 21:2002
-
(2002)
Proc. ASCO
, vol.21
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.3
Lynch, T.J.4
Prager, D.5
Belani, C.P.6
-
119
-
-
3042590706
-
Geftinib (Iressa): The first effective EGFR-targeted agent in non-small cell lung cancer
-
The Netherlands: Amsterdam. Vol.; abstract no. O.21
-
Ronald N.B. Geftinib (Iressa): the first effective EGFR-targeted agent in non-small cell lung cancer. 2nd international symposium on signal transduction modulators in cancer therapy:2003;Amsterdam, The Netherlands. Vol.; abstract no. O.21
-
(2003)
2nd International Symposium on Signal Transduction Modulators in Cancer Therapy
-
-
Ronald, N.B.1
-
120
-
-
3042692141
-
Skin toxicity is not a clinically meaningful prognostic marker for tumor response to geftinib ('Iressa', ZD1839) in pre-treated patients with advanced non-small-cell lung cancer
-
The Netherlands: Amsterdam. Vol.; abstract no. C.02
-
Ranson M., Herbst R., Fukuoka M., Lynch T. Skin toxicity is not a clinically meaningful prognostic marker for tumor response to geftinib ('Iressa', ZD1839) in pre-treated patients with advanced non-small-cell lung cancer. 2nd international symposium on signal transduction modulators in cancer therapy. 2003;Amsterdam, The Netherlands. Vol.; abstract no. C.02
-
(2003)
2nd International Symposium on Signal Transduction Modulators in Cancer Therapy
-
-
Ranson, M.1
Herbst, R.2
Fukuoka, M.3
Lynch, T.4
-
121
-
-
0002806626
-
A phase III clinical trial of ZD1839 (Iressa) in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (INTACT 1)
-
[abstract 4]
-
Giaccone G., Johnson D.H., Manegold C., et al. A phase III clinical trial of ZD1839 (Iressa) in combination with gemcitabine and cisplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (INTACT 1). Ann. Oncol. 13:2002;2. [abstract 4]
-
(2002)
Ann. Oncol.
, vol.13
, pp. 2
-
-
Giaccone, G.1
Johnson, D.H.2
Manegold, C.3
-
122
-
-
0000780450
-
ZD1839 (Iressa) in combination with paclitaxel and carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): Results from a phase III clinical trial (INTACT 2)
-
[abstract 468]
-
Johnson D.H., Herbst R., Giaccone G., et al. ZD1839 (Iressa) in combination with paclitaxel and carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC): results from a phase III clinical trial (INTACT 2). Ann. Oncol. 13:2002;127. [abstract 468]
-
(2002)
Ann. Oncol.
, vol.13
, pp. 127
-
-
Johnson, D.H.1
Herbst, R.2
Giaccone, G.3
-
123
-
-
0037561111
-
Inhibitors of epidermal-growth-factor receptors: A review of clinical research with a focus on non-small-cell lung cancer
-
Sridhar S.S., Seymour L., Shepherd F.A. Inhibitors of epidermal-growth-factor receptors: a review of clinical research with a focus on non-small-cell lung cancer. Lancet Oncol. 4:2003;397-406
-
(2003)
Lancet Oncol.
, vol.4
, pp. 397-406
-
-
Sridhar, S.S.1
Seymour, L.2
Shepherd, F.A.3
-
124
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer J.D., Barbacci E.G., Iwata K.K., Arnold L., Boman B., Cunningham A., et al. Induction of apoptosis and cell cycle arrest by CP-358, 774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 57:1997;4838-4848
-
(1997)
Cancer Res.
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
Arnold, L.4
Boman, B.5
Cunningham, A.6
-
125
-
-
0032695910
-
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
-
Pollack V.A., Savage D.M., Baker D.A., Tsaparikos K.E., Sloan D.E., Moyer J.D., et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358, 774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J. Pharmacol. Exp. Ther. 291:1999;739-748
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.291
, pp. 739-748
-
-
Pollack, V.A.1
Savage, D.M.2
Baker, D.A.3
Tsaparikos, K.E.4
Sloan, D.E.5
Moyer, J.D.6
-
126
-
-
0037667417
-
Preclinical studies with erlotinib (Tarceva)
-
Akita R.W., Sliwkowski M.X. Preclinical studies with erlotinib (Tarceva). Semin. Oncol. 30:2003;15-24
-
(2003)
Semin. Oncol.
, vol.30
, pp. 15-24
-
-
Akita, R.W.1
Sliwkowski, M.X.2
-
127
-
-
0036690404
-
Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma
-
Ng S.S., Tsao M.S., Nicklee T., Hedley D.W. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol. Cancer Ther. 1:2002;777-783
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 777-783
-
-
Ng, S.S.1
Tsao, M.S.2
Nicklee, T.3
Hedley, D.W.4
-
128
-
-
0038343121
-
Erlotinib (Tarceva): An update on the clinical trial program
-
Herbst R.S. Erlotinib (Tarceva): an update on the clinical trial program. Semin. Oncol. 30:2003;34-46
-
(2003)
Semin. Oncol.
, vol.30
, pp. 34-46
-
-
Herbst, R.S.1
-
129
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M., Siu L.L., Nemunaitis J., Rizzo J., Hammond L.A., Takimoto C., et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J. Clin. Oncol. 19:2001;3267-3279
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
Rizzo, J.4
Hammond, L.A.5
Takimoto, C.6
-
130
-
-
0037838557
-
Development of the epidermal growth factor receptor inhibitor OSI-774
-
Grunwald V., Hidalgo M. Development of the epidermal growth factor receptor inhibitor OSI-774. Semin. Oncol. 30:2003;23-31
-
(2003)
Semin. Oncol.
, vol.30
, pp. 23-31
-
-
Grunwald, V.1
Hidalgo, M.2
-
131
-
-
0036316380
-
Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer
-
Allen L.F., Lenehan P.F., Eiseman I.A., Elliott W.L., Fry D.W. Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer. Semin Oncol. 29:2002;11-21
-
(2002)
Semin Oncol.
, vol.29
, pp. 11-21
-
-
Allen, L.F.1
Lenehan, P.F.2
Eiseman, I.A.3
Elliott, W.L.4
Fry, D.W.5
-
132
-
-
13144266690
-
Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor
-
Fry D.W., Bridges A.J., Denny W.A., Doherty A., Greis K.D., Hicks J.L., et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc. Natl. Acad. Sci. U. S. A. 95:1998;12022-12027
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 12022-12027
-
-
Fry, D.W.1
Bridges, A.J.2
Denny, W.A.3
Doherty, A.4
Greis, K.D.5
Hicks, J.L.6
-
133
-
-
0034853561
-
Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033
-
Gieseg M.A., de Bock C., Ferguson L.R., Denny W.A. Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033. Anticancer Drugs. 12:2001;683-690
-
(2001)
Anticancer Drugs
, vol.12
, pp. 683-690
-
-
Gieseg, M.A.1
De Bock, C.2
Ferguson, L.R.3
Denny, W.A.4
-
134
-
-
0035553174
-
The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo
-
Rusnak D.W., Lackey K., Affleck K., Wood E.R., Alligood K.J., Rhodes N., et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol. Cancer Ther. 1:2001;85-94
-
(2001)
Mol. Cancer Ther.
, vol.1
, pp. 85-94
-
-
Rusnak, D.W.1
Lackey, K.2
Affleck, K.3
Wood, E.R.4
Alligood, K.J.5
Rhodes, N.6
-
135
-
-
0034212763
-
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
-
Bruns C.J., Solorzano C.C., Harbison M.T., Ozawa S., Tsan R., Fan D., et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60:2000;2926-2935
-
(2000)
Cancer Res.
, vol.60
, pp. 2926-2935
-
-
Bruns, C.J.1
Solorzano, C.C.2
Harbison, M.T.3
Ozawa, S.4
Tsan, R.5
Fan, D.6
-
136
-
-
0042591422
-
The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells
-
Barbacci E.G., Pustilnik L.R., Rossi A.M., Emerson E., Miller P.E., Boscoe B.P., et al. The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells. Cancer Res. 63:2003;4450-4459
-
(2003)
Cancer Res.
, vol.63
, pp. 4450-4459
-
-
Barbacci, E.G.1
Pustilnik, L.R.2
Rossi, A.M.3
Emerson, E.4
Miller, P.E.5
Boscoe, B.P.6
-
137
-
-
0032893263
-
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
-
Fong T.A., Shawver L.K., Sun L., Tang C., App H., Powell T.J., et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 59:1999;99-106
-
(1999)
Cancer Res.
, vol.59
, pp. 99-106
-
-
Fong, T.A.1
Shawver, L.K.2
Sun, L.3
Tang, C.4
App, H.5
Powell, T.J.6
-
138
-
-
0036279804
-
Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics
-
Zhu Z., Bohlen P., Witte L. Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics. Curr. Cancer Drug Targets. 2:2002;135-156
-
(2002)
Curr. Cancer Drug Targets
, vol.2
, pp. 135-156
-
-
Zhu, Z.1
Bohlen, P.2
Witte, L.3
-
139
-
-
0035282940
-
The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-KIT) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
-
Smolich B.D., Yuen H.A., West K.A., Giles F.J., Albitar M., Cherrington J.M. The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-KIT) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood. 97:2001;1413-1421
-
(2001)
Blood
, vol.97
, pp. 1413-1421
-
-
Smolich, B.D.1
Yuen, H.A.2
West, K.A.3
Giles, F.J.4
Albitar, M.5
Cherrington, J.M.6
-
140
-
-
0038327794
-
Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma
-
Kuenen B.C., Tabernero J., Baselga J., Cavalli F., Pfanner E., Conte P.F., et al. Efficacy and toxicity of the angiogenesis inhibitor SU5416 as a single agent in patients with advanced renal cell carcinoma, melanoma, and soft tissue sarcoma. Clin. Cancer Res. 9:2003;1648-1655
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1648-1655
-
-
Kuenen, B.C.1
Tabernero, J.2
Baselga, J.3
Cavalli, F.4
Pfanner, E.5
Conte, P.F.6
-
141
-
-
0037087585
-
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors
-
Kuenen B.C., Rosen L., Smit E.F., Parson M.R., Levi M., Ruijter R., et al. Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors. J. Clin. Oncol. 20:2002;1657-1667
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 1657-1667
-
-
Kuenen, B.C.1
Rosen, L.2
Smit, E.F.3
Parson, M.R.4
Levi, M.5
Ruijter, R.6
-
142
-
-
0033883776
-
SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors
-
Laird A.D., Vajkoczy P., Shawver L.K., Thurnher A., Liang C., Mohammadi M., et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. Cancer Res. 60:2000;4152-4160
-
(2000)
Cancer Res.
, vol.60
, pp. 4152-4160
-
-
Laird, A.D.1
Vajkoczy, P.2
Shawver, L.K.3
Thurnher, A.4
Liang, C.5
Mohammadi, M.6
-
143
-
-
0035866334
-
Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms
-
Shaheen R.M., Tseng W.W., Davis D.W., Liu W., Reinmuth N., Vellagas R., et al. Tyrosine kinase inhibition of multiple angiogenic growth factor receptors improves survival in mice bearing colon cancer liver metastases by inhibition of endothelial cell survival mechanisms. Cancer Res. 61:2001;1464-1468
-
(2001)
Cancer Res.
, vol.61
, pp. 1464-1468
-
-
Shaheen, R.M.1
Tseng, W.W.2
Davis, D.W.3
Liu, W.4
Reinmuth, N.5
Vellagas, R.6
-
145
-
-
0034282515
-
Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model
-
Drevs J., Hofmann I., Hugenschmidt H., Wittig C., Madjar H., Muller M., et al. Effects of PTK787/ZK 222584, a specific inhibitor of vascular endothelial growth factor receptor tyrosine kinases, on primary tumor, metastasis, vessel density, and blood flow in a murine renal cell carcinoma model. Cancer Res. 60:2000;4819-4824
-
(2000)
Cancer Res.
, vol.60
, pp. 4819-4824
-
-
Drevs, J.1
Hofmann, I.2
Hugenschmidt, H.3
Wittig, C.4
Madjar, H.5
Muller, M.6
-
146
-
-
0034655182
-
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration
-
Wood J.M., Bold G., Buchdunger E., Cozens R., Ferrari S., Frei J., et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60:2000;2178-2189
-
(2000)
Cancer Res.
, vol.60
, pp. 2178-2189
-
-
Wood, J.M.1
Bold, G.2
Buchdunger, E.3
Cozens, R.4
Ferrari, S.5
Frei, J.6
-
147
-
-
0037102369
-
ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
-
Wedge S.R., Ogilvie D.J., Dukes M., Kendrew J., Chester R., Jackson J.A., et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res. 62:2002;4645-4655
-
(2002)
Cancer Res.
, vol.62
, pp. 4645-4655
-
-
Wedge, S.R.1
Ogilvie, D.J.2
Dukes, M.3
Kendrew, J.4
Chester, R.5
Jackson, J.A.6
-
148
-
-
0032771840
-
The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma
-
Miknyoczki S.J., Chang H., Klein-Szanto A., Dionne C.A., Ruggeri B.A. The Trk tyrosine kinase inhibitor CEP-701 (KT-5555) exhibits significant antitumor efficacy in preclinical xenograft models of human pancreatic ductal adenocarcinoma. Clin. Cancer Res. 5:1999;2205-2212
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 2205-2212
-
-
Miknyoczki, S.J.1
Chang, H.2
Klein-Szanto, A.3
Dionne, C.A.4
Ruggeri, B.A.5
-
149
-
-
0033563119
-
Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)
-
George D.J., Dionne C.A., Jani J., Angeles T., Murakata C., Lamb J., et al. Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555). Cancer Res. 59:1999;2395-2401
-
(1999)
Cancer Res.
, vol.59
, pp. 2395-2401
-
-
George, D.J.1
Dionne, C.A.2
Jani, J.3
Angeles, T.4
Murakata, C.5
Lamb, J.6
-
150
-
-
0037115405
-
ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases
-
Carlomagno F., Vitagliano D., Guida T., Ciardiello F., Tortora G., Vecchio G., et al. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res. 62:2002;7284-7290
-
(2002)
Cancer Res.
, vol.62
, pp. 7284-7290
-
-
Carlomagno, F.1
Vitagliano, D.2
Guida, T.3
Ciardiello, F.4
Tortora, G.5
Vecchio, G.6
-
151
-
-
0013102301
-
CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
-
Kelly L.M., Yu J.C., Boulton C.L., Apatira M., Li J., Sullivan C.M., et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell. 1:2002;421-432
-
(2002)
Cancer Cell
, vol.1
, pp. 421-432
-
-
Kelly, L.M.1
Yu, J.C.2
Boulton, C.L.3
Apatira, M.4
Li, J.5
Sullivan, C.M.6
-
152
-
-
0038204144
-
SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
-
O'Farrell A.M., Abrams T.J., Yuen H.A., Ngai T.J., Louie S.G., Yee K.W., et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 101:2003;3597-3605
-
(2003)
Blood
, vol.101
, pp. 3597-3605
-
-
O'Farrell, A.M.1
Abrams, T.J.2
Yuen, H.A.3
Ngai, T.J.4
Louie, S.G.5
Yee, K.W.6
-
153
-
-
0037441745
-
The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
-
Spiekermann K., Dirschinger R.J., Schwab R., Bagrintseva K., Faber F., Buske C., et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and
-
(2003)
Blood
, vol.101
, pp. 1494-1504
-
-
Spiekermann, K.1
Dirschinger, R.J.2
Schwab, R.3
Bagrintseva, K.4
Faber, F.5
Buske, C.6
-
154
-
-
0036595143
-
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
-
Weisberg E., Boulton C., Kelly L.M., Manley P., Fabbro D., Meyer T., et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 1:2002;433-443
-
(2002)
Cancer Cell
, vol.1
, pp. 433-443
-
-
Weisberg, E.1
Boulton, C.2
Kelly, L.M.3
Manley, P.4
Fabbro, D.5
Meyer, T.6
-
155
-
-
0036624916
-
A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
-
Levis M., Allebach J., Tse K.F., Zheng R., Baldwin B.R., Smith B.D., et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 99:2002;3885-3891
-
(2002)
Blood
, vol.99
, pp. 3885-3891
-
-
Levis, M.1
Allebach, J.2
Tse, K.F.3
Zheng, R.4
Baldwin, B.R.5
Smith, B.D.6
-
156
-
-
0034424220
-
Src inhibitors: Drugs for the treatment of osteoporosis, cancer or both?
-
Susva M., Missbach M., Green J. Src inhibitors: drugs for the treatment of osteoporosis, cancer or both? Trends Pharmacol. Sci. 21:2000;489-495
-
(2000)
Trends Pharmacol. Sci.
, vol.21
, pp. 489-495
-
-
Susva, M.1
Missbach, M.2
Green, J.3
-
157
-
-
70349762849
-
A new class of small-molecule therapeutics for osteolytic bone metastasis: Discovery of novel bone-targeted src tyrosine kinase inhibitors having potent in vitro and in vivo activities [abstract no. 977]
-
Sawyer T.K., Shakespeare W., Wang Y., Metcalf R., Sundaramoorthi T., Keenen R. A new class of small-molecule therapeutics for osteolytic bone metastasis: discovery of novel bone-targeted src tyrosine kinase inhibitors having potent in vitro and in vivo activities [abstract no. 977]. Proc. ASCO. 22:2003
-
(2003)
Proc. ASCO
, vol.22
-
-
Sawyer, T.K.1
Shakespeare, W.2
Wang, Y.3
Metcalf, R.4
Sundaramoorthi, T.5
Keenen, R.6
-
158
-
-
3042694304
-
The novel small molecule drug SU-MI-2 induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase [abstract no. 1005]
-
Sattler M., Pride B.Y., Gramlich J.L., Chu S.C., Quinnan L.A., Ma P., et al. The novel small molecule drug SU-MI-2 induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase [abstract no. 1005]. Proc. AACR. 44:2003
-
(2003)
Proc. AACR
, vol.44
-
-
Sattler, M.1
Pride, B.Y.2
Gramlich, J.L.3
Chu, S.C.4
Quinnan, L.A.5
Ma, P.6
-
161
-
-
3042588613
-
Mechanism of resistance to epidermal growth factor receptor inhibitor ZD1839: A role for inhibiting phosphorylation of EGFR at Tyr 1068 [abstract no. 1001]
-
Koizumi F., Taguchi F., Shimoyama T., Saijo N., Nishio K. Mechanism of resistance to epidermal growth factor receptor inhibitor ZD1839: a role for inhibiting phosphorylation of EGFR at Tyr 1068 [abstract no. 1001]. Proc. AACR. 44:2003
-
(2003)
Proc. AACR
, vol.44
-
-
Koizumi, F.1
Taguchi, F.2
Shimoyama, T.3
Saijo, N.4
Nishio, K.5
-
162
-
-
3042554629
-
Acquired resistance to geftinib ('Iressa', ZD1839) in breast cancer cells result from increased IGF1-R signalling and generates cross-resistance to trastuzumab
-
The Netherlands: Amsterdam. Vol.; abstract no. O.22
-
Jones H.E., Gee J.M.W., Taylor K.M., Barrow D., Wakeling A., Guy S., et al. Acquired resistance to geftinib ('Iressa', ZD1839) in breast cancer cells result from increased IGF1-R signalling and generates cross-resistance to trastuzumab. 2nd international symposium on signal transduction modulators in cancer therapy:2003;Amsterdam, The Netherlands. Vol.; abstract no. O.22
-
(2003)
2nd International Symposium on Signal Transduction Modulators in Cancer Therapy
-
-
Jones, H.E.1
Gee, J.M.W.2
Taylor, K.M.3
Barrow, D.4
Wakeling, A.5
Guy, S.6
-
163
-
-
3042542255
-
Molecular mechanisms of resistance to the HER1/EGFR tyrosine kinase inhibitor erlotinib HCI in human cell lines [abstract no. 762]
-
Soler-Perez R., Ling Y.H., Lia M., Kroog G., Dai Q., Haigentz M. Molecular mechanisms of resistance to the HER1/EGFR tyrosine kinase inhibitor erlotinib HCI in human cell lines [abstract no. 762]. Proc. ASCO. 22:2003
-
(2003)
Proc. ASCO
, vol.22
-
-
Soler-Perez, R.1
Ling, Y.H.2
Lia, M.3
Kroog, G.4
Dai, Q.5
Haigentz, M.6
-
164
-
-
0037106374
-
Mechanisms and future directions for angiogenesis-based cancer therapies
-
Scappaticci F.A. Mechanisms and future directions for angiogenesis-based cancer therapies. J. Clin. Oncol. 20:2002;3906-3927
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 3906-3927
-
-
Scappaticci, F.A.1
-
165
-
-
0345184913
-
Opportunities and challenges in the development of kinase inhibitor therapy for cancer
-
Sawyers C.L. Opportunities and challenges in the development of kinase inhibitor therapy for cancer. Genes Dev. 17:2003;2998-3010
-
(2003)
Genes Dev.
, vol.17
, pp. 2998-3010
-
-
Sawyers, C.L.1
-
166
-
-
0035839867
-
Translocations involving anaplastic lymphoma kinase (ALK)
-
Duyster J., Bai R.Y., Morris S.W. Translocations involving anaplastic lymphoma kinase (ALK). Oncogene. 20:2001;5623-5637
-
(2001)
Oncogene
, vol.20
, pp. 5623-5637
-
-
Duyster, J.1
Bai, R.Y.2
Morris, S.W.3
-
167
-
-
0033535530
-
Novel mutations of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt L., Junker K., Nakaigawa N., Kinjerski T., Weirich G., Miller M., et al. Novel mutations of the MET proto-oncogene in papillary renal carcinomas. Oncogene. 18:1999;2343-2350
-
(1999)
Oncogene
, vol.18
, pp. 2343-2350
-
-
Schmidt, L.1
Junker, K.2
Nakaigawa, N.3
Kinjerski, T.4
Weirich, G.5
Miller, M.6
-
168
-
-
0032894774
-
RET proto-oncogene in the development of human cancer
-
Eng C. RET proto-oncogene in the development of human cancer. J. Clin. Oncol. 17:1999;380-393
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 380-393
-
-
Eng, C.1
-
170
-
-
0033178762
-
The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
-
Shimizu A., O'Brien K.P., Sjoblom T., Pietras K., Buchdunger E., Collins V.P., et al. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB. Cancer Res. 59:1999;3719-3723
-
(1999)
Cancer Res.
, vol.59
, pp. 3719-3723
-
-
Shimizu, A.1
O'Brien, K.P.2
Sjoblom, T.3
Pietras, K.4
Buchdunger, E.5
Collins, V.P.6
-
171
-
-
0038670241
-
Mutational analysis of the tyrosine kinome in colorectal cancers
-
Bardelli A., Parsons D.W., Silliman N., Ptak J., Szabo S., Saha S., et al. Mutational analysis of the tyrosine kinome in colorectal cancers. Science. 300:2003;949
-
(2003)
Science
, vol.300
, pp. 949
-
-
Bardelli, A.1
Parsons, D.W.2
Silliman, N.3
Ptak, J.4
Szabo, S.5
Saha, S.6
-
172
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang J.C., Haworth L., Sherry R.M., Hwu P., Schwartzentruber D.J., Topalian S.L., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N. Engl. J. Med. 349:2003;427-434
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
Hwu, P.4
Schwartzentruber, D.J.5
Topalian, S.L.6
-
173
-
-
0036682301
-
Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
-
Nagar B., Bornmann W.G., Pellicena P., Schindler T., Veach D.R., Miller W.T., et al. Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571). Cancer Res. 62:2002;4236-4243
-
(2002)
Cancer Res.
, vol.62
, pp. 4236-4243
-
-
Nagar, B.1
Bornmann, W.G.2
Pellicena, P.3
Schindler, T.4
Veach, D.R.5
Miller, W.T.6
-
174
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah N.P., Nicoll J.M., Nagar B., Gorre M.E., Paquette R.L., Kuriyan J., et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2:2002;117-125
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
Nicoll, J.M.2
Nagar, B.3
Gorre, M.E.4
Paquette, R.L.5
Kuriyan, J.6
-
175
-
-
10744232328
-
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
-
Branford S., Rudzki Z., Walsh S., Parkinson I., Grigg A., Szer J., et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood. 102:2003;276-283
-
(2003)
Blood
, vol.102
, pp. 276-283
-
-
Branford, S.1
Rudzki, Z.2
Walsh, S.3
Parkinson, I.4
Grigg, A.5
Szer, J.6
-
176
-
-
0036014978
-
Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia
-
Gorre M.E., Sawyers C.L. Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia. Curr. Opin. Hematol. 9:2002;303-307
-
(2002)
Curr. Opin. Hematol.
, vol.9
, pp. 303-307
-
-
Gorre, M.E.1
Sawyers, C.L.2
-
177
-
-
0037459344
-
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL
-
Azam M., Latek R.R., Daley G.Q. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell. 112:2003;831-843
-
(2003)
Cell
, vol.112
, pp. 831-843
-
-
Azam, M.1
Latek, R.R.2
Daley, G.Q.3
|