Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 23, 2010, Pages 6915-6919

  Krug, Martin ^a   Erlenkamp, German ^a   Sippl, Wolfgang ^a   Schächtele, Christoph ^b   Totzke, Frank ^b   Hilgeroth, Andreas ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b PROQINASE GMBH   (Germany)

Author keywords

Drug discovery; Growth factor; Inhibitors; Receptor; Structure activity relationships

Indexed keywords

4 BENZYLAMINO 1 AZA 9 OXAFLUORENE DERIVATIVE; CASEIN KINASE; CISPLATIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; ETOPOSIDE; FLUORENE DERIVATIVE; IRINOTECAN; MELPHALAN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZYLAMINES; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG DISCOVERY; HUMANS; PROTEIN BINDING; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, IGF TYPE 1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 78149280763     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.10.004     Document Type: Article

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