메뉴 건너뛰기




Volumn 63, Issue 4, 2002, Pages 317-332

The role of the IGF system in cancer: From basic to clinical studies and clinical applications

Author keywords

Cancer; Epidemiology; Insulin like growth factors

Indexed keywords

ANTIANDROGEN; ANTIESTROGEN; ANTINEOPLASTIC AGENT; RETINOIC ACID; SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN C RECEPTOR; SOMATOSTATIN; TAMOXIFEN; VITAMIN D;

EID: 0036970842     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000066230     Document Type: Review
Times cited : (319)

References (150)
  • 1
    • 0024437318 scopus 로고
    • Insulin-like growth factors; autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments
    • Holly JM, Wass JA: Insulin-like growth factors; autocrine, paracrine or endocrine? New perspectives of the somatomedin hypothesis in the light of recent developments. J Endocrinol 1989;122:611-618.
    • (1989) J Endocrinol , vol.122 , pp. 611-618
    • Holly, J.M.1    Wass, J.A.2
  • 2
    • 0029973924 scopus 로고    scopus 로고
    • Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors
    • Stewart CE, Rotwein P: Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors. Physiol Rev 1996;76:1005-1026.
    • (1996) Physiol Rev , vol.76 , pp. 1005-1026
    • Stewart, C.E.1    Rotwein, P.2
  • 3
    • 0005096726 scopus 로고
    • Tissue concentrations of somatomedin C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action
    • D'Ercole AJ, Stiles AD, Underwood LE: Tissue concentrations of somatomedin C: Further evidence for multiple sites of synthesis and paracrine or autocrine mechanisms of action. Proc Natl Acad Sci USA 1984;81:935-939.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 935-939
    • D'Ercole, A.J.1    Stiles, A.D.2    Underwood, L.E.3
  • 4
    • 0032829933 scopus 로고    scopus 로고
    • Serum insulin-like growth factors and insulin-like growth factor-binding proteins: Clinical implications
    • Rosen CJ: Serum insulin-like growth factors and insulin-like growth factor-binding proteins: Clinical implications. Clin Chem 1999;45:1384-1390.
    • (1999) Clin Chem , vol.45 , pp. 1384-1390
    • Rosen, C.J.1
  • 5
    • 0020579433 scopus 로고
    • Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: Dependence on growth hormone status
    • Schwander JC, Hauri C, Zapf J, Froesch ER: Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: Dependence on growth hormone status. Endocrinology 1983;113:297-305.
    • (1983) Endocrinology , vol.113 , pp. 297-305
    • Schwander, J.C.1    Hauri, C.2    Zapf, J.3    Froesch, E.R.4
  • 6
    • 0020693772 scopus 로고
    • Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via brain
    • Tannenbaum GS, Guyda HJ, Posner BI: Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via brain. Science 1983;220:77-79.
    • (1983) Science , vol.220 , pp. 77-79
    • Tannenbaum, G.S.1    Guyda, H.J.2    Posner, B.I.3
  • 7
    • 0034692430 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor family in cancer development and progression
    • Yu H, Rohan T: Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 2000;92:1472-1489.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, T.2
  • 8
    • 0028127946 scopus 로고
    • Nutritional regulation of the insulin-like growth factors
    • Thissen JP, Ketelslegers JM, Underwood LE: Nutritional regulation of the insulin-like growth factors. Endocr Rev 1994;15:80-101.
    • (1994) Endocr Rev , vol.15 , pp. 80-101
    • Thissen, J.P.1    Ketelslegers, J.M.2    Underwood, L.E.3
  • 9
    • 0033022305 scopus 로고    scopus 로고
    • Age, sex, and smoking are predictors of circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3
    • Kaklamani VG, Linos A, Kaklamani E, Markaki I, Mantzoros C: Age, sex, and smoking are predictors of circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3. J Clin Oncol 1999;17:813-817.
    • (1999) J Clin Oncol , vol.17 , pp. 813-817
    • Kaklamani, V.G.1    Linos, A.2    Kaklamani, E.3    Markaki, I.4    Mantzoros, C.5
  • 10
    • 0032886460 scopus 로고    scopus 로고
    • Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults
    • Kaklamani VG, Linos A, Kaklamani E, Markaki I, Koumantaki Y, Mantzoros CS: Dietary fat and carbohydrates are independently associated with circulating insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 concentrations in healthy adults. J Clin Oncol 1999;17:3291-3298.
    • (1999) J Clin Oncol , vol.17 , pp. 3291-3298
    • Kaklamani, V.G.1    Linos, A.2    Kaklamani, E.3    Markaki, I.4    Koumantaki, Y.5    Mantzoros, C.S.6
  • 11
    • 0034042317 scopus 로고    scopus 로고
    • Hormones and diet: Low insulin-like growth factor-I but normal bioavailable androgens in vegan men
    • Allen NE, Appleby PN, Davey GK, Key TJ: Hormones and diet: Low insulin-like growth factor-I but normal bioavailable androgens in vegan men. Br J Cancer 2000;83:95-97.
    • (2000) Br J Cancer , vol.83 , pp. 95-97
    • Allen, N.E.1    Appleby, P.N.2    Davey, G.K.3    Key, T.J.4
  • 14
    • 0032127906 scopus 로고    scopus 로고
    • Insulin-like growth factor II (IGF-II)
    • O'Dell SD, Day IN: Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol 1998;30:767-771.
    • (1998) Int J Biochem Cell Biol , vol.30 , pp. 767-771
    • O'Dell, S.D.1    Day, I.N.2
  • 15
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker J, Liu JP, Robertson EJ, Efstratiadis A: Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993;75:73-82.
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 16
    • 0026879641 scopus 로고
    • Insulin-like growth factor binding proteins: Gene structure and expression
    • Rechler MM, Brown AL: Insulin-like growth factor binding proteins: Gene structure and expression. Growth Regul 1992;2:55-68.
    • (1992) Growth Regul , vol.2 , pp. 55-68
    • Rechler, M.M.1    Brown, A.L.2
  • 17
    • 0033407392 scopus 로고    scopus 로고
    • Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure
    • Frystyk J, Ivarsen P, Skjaerbaek C, Flyvbjerg A, Pedersen EB, Orskov H: Serum-free insulin-like growth factor I correlates with clearance in patients with chronic renal failure. Kidney Int 1999;56:2076-2084.
    • (1999) Kidney Int , vol.56 , pp. 2076-2084
    • Frystyk, J.1    Ivarsen, P.2    Skjaerbaek, C.3    Flyvbjerg, A.4    Pedersen, E.B.5    Orskov, H.6
  • 18
    • 0032755560 scopus 로고    scopus 로고
    • Pharmacokinetics of insulin-like growth factor I in hypopituitarism: Correlation with binding proteins
    • Mauras N, Quarmby V, Bloedow DC: Pharmacokinetics of insulin-like growth factor I in hypopituitarism: Correlation with binding proteins. Am J Physiol 1999;277:E579-E584.
    • (1999) Am J Physiol , vol.277
    • Mauras, N.1    Quarmby, V.2    Bloedow, D.C.3
  • 20
    • 0033386955 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-3 is partially responsible for high-serum-induced apoptosis in PC-3 prostate cancer cells
    • Rajah R, Khare A, Lee PD, Cohen P: Insulin-like growth factor-binding protein-3 is partially responsible for high-serum-induced apoptosis in PC-3 prostate cancer cells. J Endocrinol 1999;163:487-494.
    • (1999) J Endocrinol , vol.163 , pp. 487-494
    • Rajah, R.1    Khare, A.2    Lee, P.D.3    Cohen, P.4
  • 21
    • 0029076713 scopus 로고
    • Physiological role of the insulin-like growth factor binding proteins
    • Zapf J: Physiological role of the insulin-like growth factor binding proteins. Eur J Endocrinol 1995;132:645-654.
    • (1995) Eur J Endocrinol , vol.132 , pp. 645-654
    • Zapf, J.1
  • 22
    • 0023735546 scopus 로고
    • Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex
    • Baxter RC: Characterization of the acid-labile subunit of the growth hormone-dependent insulin-like growth factor binding protein complex. J Clin Endocrinol Metab 1988;67:265-272.
    • (1988) J Clin Endocrinol Metab , vol.67 , pp. 265-272
    • Baxter, R.C.1
  • 23
    • 0034094498 scopus 로고    scopus 로고
    • Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse
    • Boisclair YR, Hurst KR, Ueki I, Tremblay ML, Ooi GT: Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse. Pediatr Nephrol 2000;14:562-566.
    • (2000) Pediatr Nephrol , vol.14 , pp. 562-566
    • Boisclair, Y.R.1    Hurst, K.R.2    Ueki, I.3    Tremblay, M.L.4    Ooi, G.T.5
  • 24
    • 0031442972 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions
    • Rajaram S, Baylink DJ, Mohan S: Insulin-like growth factor-binding proteins in serum and other biological fluids: Regulation and functions. Endocr Rev 1997;18:801-831.
    • (1997) Endocr Rev , vol.18 , pp. 801-831
    • Rajaram, S.1    Baylink, D.J.2    Mohan, S.3
  • 25
    • 0029829202 scopus 로고    scopus 로고
    • Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix
    • Arai T, Busby W Jr, Clemmons DR: Binding of insulin-like growth factor (IGF) I or II to IGF-binding protein-2 enables it to bind to heparin and extracellular matrix. Endocrinology 1996;137:4571-4575.
    • (1996) Endocrinology , vol.137 , pp. 4571-4575
    • Arai, T.1    Busby W., Jr.2    Clemmons, D.R.3
  • 26
    • 0025925050 scopus 로고
    • Presence of IDF45 (mIGFBP-3) binding sites on chick embryo fibroblasts
    • Delbe J, Blat C, Desauty G, Harel L: Presence of IDF45 (mIGFBP-3) binding sites on chick embryo fibroblasts. Biochem Biophys Res Commun 1991;179:495-501.
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 495-501
    • Delbe, J.1    Blat, C.2    Desauty, G.3    Harel, L.4
  • 27
    • 0029889690 scopus 로고    scopus 로고
    • Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth factor action
    • Conover CA, Clarkson JT, Bale LK: Factors regulating insulin-like growth factor-binding protein-3 binding, processing, and potentiation of insulin-like growth factor action. Endocrinology 1996;137:2286-2292.
    • (1996) Endocrinology , vol.137 , pp. 2286-2292
    • Conover, C.A.1    Clarkson, J.T.2    Bale, L.K.3
  • 28
    • 0034455565 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity
    • Conover CA, Bale LK, Durham SK, Powell DR: Insulin-like growth factor (IGF) binding protein-3 potentiation of IGF action is mediated through the phosphatidylinositol-3-kinase pathway and is associated with alteration in protein kinase B/AKT sensitivity. Endocrinology 2000;141:3098-3103.
    • (2000) Endocrinology , vol.141 , pp. 3098-3103
    • Conover, C.A.1    Bale, L.K.2    Durham, S.K.3    Powell, D.R.4
  • 29
    • 0028936763 scopus 로고
    • The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene
    • Valentinis B, Bhala A, DeAngelis T, Baserga R, Cohen P: The human insulin-like growth factor (IGF) binding protein-3 inhibits the growth of fibroblasts with a targeted disruption of the IGF-I receptor gene. Mol Endocrinol 1995;9:361-367.
    • (1995) Mol Endocrinol , vol.9 , pp. 361-367
    • Valentinis, B.1    Bhala, A.2    DeAngelis, T.3    Baserga, R.4    Cohen, P.5
  • 30
    • 0034671525 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells
    • Butt AJ, Firth SM, King MA, Baxter RC: Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells. J Biol Chem 2000;275:39174-39181.
    • (2000) J Biol Chem , vol.275 , pp. 39174-39181
    • Butt, A.J.1    Firth, S.M.2    King, M.A.3    Baxter, R.C.4
  • 31
    • 0033972178 scopus 로고    scopus 로고
    • Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells
    • Williams AC, Collard TJ, Perks CM, Newcomb P, Moorghen M, Holly JM, Paraskeva C: Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells. Cancer Res 2000;60:22-27.
    • (2000) Cancer Res , vol.60 , pp. 22-27
    • Williams, A.C.1    Collard, T.J.2    Perks, C.M.3    Newcomb, P.4    Moorghen, M.5    Holly, J.M.6    Paraskeva, C.7
  • 32
    • 0033053127 scopus 로고    scopus 로고
    • Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9
    • Mira E, Manes S, Lacalle RA, Marquez G, Martinez AC: Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9. Endocrinology 1999;140:1657-1664.
    • (1999) Endocrinology , vol.140 , pp. 1657-1664
    • Mira, E.1    Manes, S.2    Lacalle, R.A.3    Marquez, G.4    Martinez, A.C.5
  • 33
    • 0030744864 scopus 로고    scopus 로고
    • The type V transforming growth factor beta receptor is the putative insulin-like growth factor-binding protein 3 receptor
    • Leal SM, Liu Q, Huang SS, Huang JS: The type V transforming growth factor beta receptor is the putative insulin-like growth factor-binding protein 3 receptor. J Biol Chem 1997;272:20572-20576.
    • (1997) J Biol Chem , vol.272 , pp. 20572-20576
    • Leal, S.M.1    Liu, Q.2    Huang, S.S.3    Huang, J.S.4
  • 34
    • 0032937419 scopus 로고    scopus 로고
    • Characterization of insulin-like growth factor binding protein-3 (IGFBP-3) binding to human breast cancer cells: Kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule
    • Yamanaka Y, Fowlkes JL, Wilson EM, Rosenfeld RG, Oh Y: Characterization of insulin-like growth factor binding protein-3 (IGFBP-3) binding to human breast cancer cells: Kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule. Endocrinology 1999;140:1319-1328.
    • (1999) Endocrinology , vol.140 , pp. 1319-1328
    • Yamanaka, Y.1    Fowlkes, J.L.2    Wilson, E.M.3    Rosenfeld, R.G.4    Oh, Y.5
  • 35
    • 0034039896 scopus 로고    scopus 로고
    • Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins
    • Schneider MR, Lahm H, Wu M, Hoeflich A, Wolf E: Transgenic mouse models for studying the functions of insulin-like growth factor-binding proteins. FASEB J 2000;14:629-640.
    • (2000) FASEB J , vol.14 , pp. 629-640
    • Schneider, M.R.1    Lahm, H.2    Wu, M.3    Hoeflich, A.4    Wolf, E.5
  • 36
    • 0029433607 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein proteases: Functional regulators of cell growth
    • Rajah R, Katz L, Nunn S, Solberg P, Beers T, Cohen P: Insulin-like growth factor binding protein proteases: Functional regulators of cell growth. Prog Growth Factor Res 1996;6:273-284.
    • (1996) Prog Growth Factor Res , vol.6 , pp. 273-284
    • Rajah, R.1    Katz, L.2    Nunn, S.3    Solberg, P.4    Beers, T.5    Cohen, P.6
  • 37
    • 0034597897 scopus 로고    scopus 로고
    • Can measurements of IGF-1 and IGFBP-3 improve the sensitivity of prostate-cancer screening?
    • Wolk A, Andersson SO, Mantzoros CS, Trichopoulos D, Adami HO: Can measurements of IGF-1 and IGFBP-3 improve the sensitivity of prostate-cancer screening? Lancet 2000;356:1902-1903.
    • (2000) Lancet , vol.356 , pp. 1902-1903
    • Wolk, A.1    Andersson, S.O.2    Mantzoros, C.S.3    Trichopoulos, D.4    Adami, H.O.5
  • 38
    • 0033136406 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein (IGFBP) proteolysis: Occurrence, identification, role and regulation
    • Maile LA, Holly JM: Insulin-like growth factor binding protein (IGFBP) proteolysis: Occurrence, identification, role and regulation. Growth Horm IGF Res 1999;9:85-95.
    • (1999) Growth Horm IGF Res , vol.9 , pp. 85-95
    • Maile, L.A.1    Holly, J.M.2
  • 39
    • 0032527626 scopus 로고    scopus 로고
    • Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression
    • Butler AA, Blakesley VA, Poulaki V, Tsokos M, Wood TL, Le Roith D, Pouliki V: Stimulation of tumor growth by recombinant human insulin-like growth factor-I (IGF-I) is dependent on the dose and the level of IGF-I receptor expression. Cancer Res 1998;58:3021-3027.
    • (1998) Cancer Res , vol.58 , pp. 3021-3027
    • Butler, A.A.1    Blakesley, V.A.2    Poulaki, V.3    Tsokos, M.4    Wood, T.L.5    Le Roith, D.6    Pouliki, V.7
  • 40
    • 0344734066 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis
    • Werner H, Le Roith D: The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Crit Rev Oncog 1997;8:71-92.
    • (1997) Crit Rev Oncog , vol.8 , pp. 71-92
    • Werner, H.1    Le Roith, D.2
  • 41
    • 0033604523 scopus 로고    scopus 로고
    • The IGF-I receptor in cancer research
    • Baserga R: The IGF-I receptor in cancer research. Exp Cell Res 1999;253:1-6.
    • (1999) Exp Cell Res , vol.253 , pp. 1-6
    • Baserga, R.1
  • 42
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A: Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993;75:59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 43
    • 0029079651 scopus 로고
    • Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein
    • Seely BL, Reichart DR, Staubs PA, Jhun BH, Hsu D, Maegawa H, Milarski KL, Saltiel AR, Olefsky JM: Localization of the insulin-like growth factor I receptor binding sites for the SH2 domain proteins p85, Syp, and GTPase activating protein. J Biol Chem 1995;270:19151-19157.
    • (1995) J Biol Chem , vol.270 , pp. 19151-19157
    • Seely, B.L.1    Reichart, D.R.2    Staubs, P.A.3    Jhun, B.H.4    Hsu, D.5    Maegawa, H.6    Milarski, K.L.7    Saltiel, A.R.8    Olefsky, J.M.9
  • 44
    • 0032898811 scopus 로고    scopus 로고
    • Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses
    • Petley T, Graff K, Jiang W, Yang H, Florini J: Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses. Horm Metab Res 1999;31:70-76.
    • (1999) Horm Metab Res , vol.31 , pp. 70-76
    • Petley, T.1    Graff, K.2    Jiang, W.3    Yang, H.4    Florini, J.5
  • 45
    • 0029026697 scopus 로고
    • Convergent signalling in the action of integrins, neuropeptides, growth factors and oncogenes
    • Rozengurt E: Convergent signalling in the action of integrins, neuropeptides, growth factors and oncogenes. Cancer Surv 1995;24:81-96.
    • (1995) Cancer Surv , vol.24 , pp. 81-96
    • Rozengurt, E.1
  • 46
    • 0025240143 scopus 로고
    • Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells
    • Nolan CM, Kyle JW, Watanabe H, Sly WS: Binding of insulin-like growth factor II (IGF-II) by human cation-independent mannose 6-phosphate receptor/IGF-II receptor expressed in receptor-deficient mouse L cells. Cell Regul 1990;1:197-213.
    • (1990) Cell Regul , vol.1 , pp. 197-213
    • Nolan, C.M.1    Kyle, J.W.2    Watanabe, H.3    Sly, W.S.4
  • 47
    • 0026059613 scopus 로고
    • Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
    • Dennis PA, Rifkin DB: Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor. Proc Natl Acad Sci USA 1991;88:580-584.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 580-584
    • Dennis, P.A.1    Rifkin, D.B.2
  • 48
    • 0031456570 scopus 로고    scopus 로고
    • Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid
    • Kang JX, Li Y, Leaf A: Mannose-6-phosphate/insulin-like growth factor-II receptor is a receptor for retinoic acid. Proc Natl Acad Sci USA 1997;94:13671-13676.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13671-13676
    • Kang, J.X.1    Li, Y.2    Leaf, A.3
  • 49
    • 0027999284 scopus 로고
    • Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene
    • Wang ZQ, Fung MR, Barlow DP, Wagner EF: Regulation of embryonic growth and lysosomal targeting by the imprinted Igf2/Mpr gene. Nature 1994;372:464-467.
    • (1994) Nature , vol.372 , pp. 464-467
    • Wang, Z.Q.1    Fung, M.R.2    Barlow, D.P.3    Wagner, E.F.4
  • 51
    • 0000479445 scopus 로고
    • Hypophysectomy in treatment of disseminated breast cancer
    • Ray BS, Pearson OH: Hypophysectomy in treatment of disseminated breast cancer. Surg Clin North Am 1962;12:419-433.
    • (1962) Surg Clin North Am , vol.12 , pp. 419-433
    • Ray, B.S.1    Pearson, O.H.2
  • 52
    • 0024539364 scopus 로고
    • Effect of tamoxifen on plasma insulin-like growth factor I in patients with breast cancer
    • Colletti RB, Roberts JD, Devlin JT, Copeland KC: Effect of tamoxifen on plasma insulin-like growth factor I in patients with breast cancer. Cancer Res 1989;49:1882-1884.
    • (1989) Cancer Res , vol.49 , pp. 1882-1884
    • Colletti, R.B.1    Roberts, J.D.2    Devlin, J.T.3    Copeland, K.C.4
  • 54
    • 0024550730 scopus 로고
    • Analysis of insulin-like growth factor I gene expression in malignancy: Evidence for a paracrine role in human breast cancer
    • Yee D, Paik S, Lebovic GS, Marcus RR, Favoni RE, Cullen KJ, Lippman ME, Rosen N: Analysis of insulin-like growth factor I gene expression in malignancy: Evidence for a paracrine role in human breast cancer. Mol Endocrinol 1989;3:509-517.
    • (1989) Mol Endocrinol , vol.3 , pp. 509-517
    • Yee, D.1    Paik, S.2    Lebovic, G.S.3    Marcus, R.R.4    Favoni, R.E.5    Cullen, K.J.6    Lippman, M.E.7    Rosen, N.8
  • 55
  • 57
    • 0026746298 scopus 로고
    • Expression of IGF-I and IGF-II mRNA in breast tissue
    • Paik S: Expression of IGF-I and IGF-II mRNA in breast tissue. Breast Cancer Res Treat 1992;22:31-38.
    • (1992) Breast Cancer Res Treat , vol.22 , pp. 31-38
    • Paik, S.1
  • 58
    • 0028330135 scopus 로고
    • Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cells
    • Lee AV, Darbre P, King RJ: Processing of insulin-like growth factor-II (IGF-II) by human breast cancer cells. Mol Cell Endocrinol 1994;99:211-220.
    • (1994) Mol Cell Endocrinol , vol.99 , pp. 211-220
    • Lee, A.V.1    Darbre, P.2    King, R.J.3
  • 59
    • 0031560899 scopus 로고    scopus 로고
    • Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas
    • Wu HK, Squire JA, Catzavelos CG, Weksberg R: Relaxation of imprinting of human insulin-like growth factor II gene, IGF2, in sporadic breast carcinomas. Biochem Biophys Res Commun 1997;235:123-129.
    • (1997) Biochem Biophys Res Commun , vol.235 , pp. 123-129
    • Wu, H.K.1    Squire, J.A.2    Catzavelos, C.G.3    Weksberg, R.4
  • 61
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D, Roberts CT Jr: Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995;16:143-163.
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts C.T., Jr.4
  • 63
    • 0030067106 scopus 로고    scopus 로고
    • Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells
    • Huynh H, Yang X, Pollak M: Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells. J Biol Chem 1996;271:1016-1021.
    • (1996) J Biol Chem , vol.271 , pp. 1016-1021
    • Huynh, H.1    Yang, X.2    Pollak, M.3
  • 64
    • 0025635904 scopus 로고
    • Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells
    • Stewart AJ, Johnson MD, May FE, Westley BR: Role of insulin-like growth factors and the type I insulin-like growth factor receptor in the estrogen-stimulated proliferation of human breast cancer cells. J Biol Chem 1990;265:21172-21178.
    • (1990) J Biol Chem , vol.265 , pp. 21172-21178
    • Stewart, A.J.1    Johnson, M.D.2    May, F.E.3    Westley, B.R.4
  • 65
    • 0032496157 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse
    • Richards RG, Walker MP, Sebastian J, DiAugustine RP: Insulin-like growth factor-1 (IGF-1) receptor-insulin receptor substrate complexes in the uterus. Altered signaling response to estradiol in the IGF-1(m/m) mouse. J Biol Chem 1998;273:11962-11969.
    • (1998) J Biol Chem , vol.273 , pp. 11962-11969
    • Richards, R.G.1    Walker, M.P.2    Sebastian, J.3    DiAugustine, R.P.4
  • 66
    • 0034680761 scopus 로고    scopus 로고
    • The potentiation of estrogen on IGF-I action in MCF-7 human breast cancer cells includes cell cycle components
    • Dupont J, Karas M, Le Roith D: The potentiation of estrogen on IGF-I action in MCF-7 human breast cancer cells includes cell cycle components. J Biol Chem 2000;275:35893-35901.
    • (2000) J Biol Chem , vol.275 , pp. 35893-35901
    • Dupont, J.1    Karas, M.2    Le Roith, D.3
  • 67
    • 0027955102 scopus 로고
    • Analysis of the IGF-II receptor gene copy number in breast carcinoma
    • Hebert E, Herbelin C, Bougnoux P: Analysis of the IGF-II receptor gene copy number in breast carcinoma. Br J Cancer 1994;69:120-124.
    • (1994) Br J Cancer , vol.69 , pp. 120-124
    • Hebert, E.1    Herbelin, C.2    Bougnoux, P.3
  • 69
    • 0032800850 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling
    • Pandini G, Vigneri R, Costantino A, Frasca F, Ippolito A, Fujita-Yamaguchi Y, Siddle K, Goldfine ID, Belfiore A: Insulin and insulin-like growth factor-I (IGF-I) receptor overexpression in breast cancers leads to insulin/IGF-I hybrid receptor overexpression: Evidence for a second mechanism of IGF-I signaling. Clin Cancer Res 1999;5:1935-1944.
    • (1999) Clin Cancer Res , vol.5 , pp. 1935-1944
    • Pandini, G.1    Vigneri, R.2    Costantino, A.3    Frasca, F.4    Ippolito, A.5    Fujita-Yamaguchi, Y.6    Siddle, K.7    Goldfine, I.D.8    Belfiore, A.9
  • 70
    • 0033603879 scopus 로고    scopus 로고
    • The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin
    • Guvakova MA, Surmacz E: The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin. Exp Cell Res 1999;251:244-255.
    • (1999) Exp Cell Res , vol.251 , pp. 244-255
    • Guvakova, M.A.1    Surmacz, E.2
  • 71
    • 0027496222 scopus 로고
    • Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media
    • Pratt SE, Pollak MN: Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media. Cancer Res 1993;53:5193-5198.
    • (1993) Cancer Res , vol.53 , pp. 5193-5198
    • Pratt, S.E.1    Pollak, M.N.2
  • 72
    • 0033573204 scopus 로고    scopus 로고
    • Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells
    • Perks CM, Bowen S, Gill ZP, Newcomb PV, Holly JM: Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells. J Cell Biochem 1999;75:652-664.
    • (1999) J Cell Biochem , vol.75 , pp. 652-664
    • Perks, C.M.1    Bowen, S.2    Gill, Z.P.3    Newcomb, P.V.4    Holly, J.M.5
  • 73
    • 0027199617 scopus 로고
    • Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition
    • Oh Y, Muller HL, Lamson G, Rosenfeld RG: Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition. J Biol Chem 1993;268:14964-14971.
    • (1993) J Biol Chem , vol.268 , pp. 14964-14971
    • Oh, Y.1    Muller, H.L.2    Lamson, G.3    Rosenfeld, R.G.4
  • 74
    • 0032516239 scopus 로고    scopus 로고
    • Down-regulation of T1A12/mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas
    • Burger AM, Zhang X, Li H, Ostrowski JL, Beatty B, Venanzoni M, Papas T, Seth A: Down-regulation of T1A12/mac25, a novel insulin-like growth factor binding protein related gene, is associated with disease progression in breast carcinomas. Oncogene 1998;16:2459-2467.
    • (1998) Oncogene , vol.16 , pp. 2459-2467
    • Burger, A.M.1    Zhang, X.2    Li, H.3    Ostrowski, J.L.4    Beatty, B.5    Venanzoni, M.6    Papas, T.7    Seth, A.8
  • 75
    • 0032835343 scopus 로고    scopus 로고
    • A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype
    • van Golen KL, Davies S, Wu ZF, Wang Y, Bucana CD, Root H, Chandrasekharappa S, Strawderman M, Ethier SP, Merajver SD: A novel putative low-affinity insulin-like growth factor-binding protein, LIBC (lost in inflammatory breast cancer), and RhoC GTPase correlate with the inflammatory breast cancer phenotype. Clin Cancer Res 1999;5:2511-2519.
    • (1999) Clin Cancer Res , vol.5 , pp. 2511-2519
    • Van Golen, K.L.1    Davies, S.2    Wu, Z.F.3    Wang, Y.4    Bucana, C.D.5    Root, H.6    Chandrasekharappa, S.7    Strawderman, M.8    Ethier, S.P.9    Merajver, S.D.10
  • 76
    • 0028804261 scopus 로고
    • Proliferation of cultured human prostate cancer cells is inhibited by insulin-like growth factor (IGF) binding protein-1: Evidence for an IGF-II autocrine growth loop
    • Figueroa JA, Lee AV, Jackson JG, Yee D: Proliferation of cultured human prostate cancer cells is inhibited by insulin-like growth factor (IGF) binding protein-1: Evidence for an IGF-II autocrine growth loop. J Clin Endocrinol Metab 1995;80:3476-3482.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3476-3482
    • Figueroa, J.A.1    Lee, A.V.2    Jackson, J.G.3    Yee, D.4
  • 77
    • 0027407639 scopus 로고
    • Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1
    • Pietrzkowski Z, Mulholland G, Gomella L, Jameson BA, Wernicke D, Baserga R: Inhibition of growth of prostatic cancer cell lines by peptide analogues of insulin-like growth factor 1. Cancer Res 1993;53:1102-1106.
    • (1993) Cancer Res , vol.53 , pp. 1102-1106
    • Pietrzkowski, Z.1    Mulholland, G.2    Gomella, L.3    Jameson, B.A.4    Wernicke, D.5    Baserga, R.6
  • 78
    • 0029826841 scopus 로고    scopus 로고
    • Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium
    • Tennant MK, Thrasher JB, Twomey PA, Drivdahl RH, Birnbaum RS, Plymate SR: Protein and messenger ribonucleic acid (mRNA) for the type 1 insulin-like growth factor (IGF) receptor is decreased and IGF-II mRNA is increased in human prostate carcinoma compared to benign prostate epithelium. J Clin Endocrinol Metab 1996;81:3774-3782.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3774-3782
    • Tennant, M.K.1    Thrasher, J.B.2    Twomey, P.A.3    Drivdahl, R.H.4    Birnbaum, R.S.5    Plymate, S.R.6
  • 83
    • 0029593458 scopus 로고
    • Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues
    • Jarrard DF, Bussemakers MJ, Bova GS, Isaacs WB: Regional loss of imprinting of the insulin-like growth factor II gene occurs in human prostate tissues. Clin Cancer Res 1995;1:1471-1478.
    • (1995) Clin Cancer Res , vol.1 , pp. 1471-1478
    • Jarrard, D.F.1    Bussemakers, M.J.2    Bova, G.S.3    Isaacs, W.B.4
  • 84
    • 0027152122 scopus 로고
    • Insulin-like growth factor I: Action and receptor characterization in human prostate cancer cell lines
    • Iwamura M, Sluss PM, Casamento JB, Cockett AT: Insulin-like growth factor I: Action and receptor characterization in human prostate cancer cell lines. Prostate 1993;22:243-252.
    • (1993) Prostate , vol.22 , pp. 243-252
    • Iwamura, M.1    Sluss, P.M.2    Casamento, J.B.3    Cockett, A.T.4
  • 85
    • 0032877615 scopus 로고    scopus 로고
    • Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor
    • Chott A, Sun Z, Morganstern D, Pan J, Li T, Susani M, Mosberger I, Upton MP, Bubley GJ, Balk SP: Tyrosine kinases expressed in vivo by human prostate cancer bone marrow metastases and loss of the type 1 insulin-like growth factor receptor. Am J Pathol 1999;155:1271-1279.
    • (1999) Am J Pathol , vol.155 , pp. 1271-1279
    • Chott, A.1    Sun, Z.2    Morganstern, D.3    Pan, J.4    Li, T.5    Susani, M.6    Mosberger, I.7    Upton, M.P.8    Bubley, G.J.9    Balk, S.P.10
  • 86
    • 0030960834 scopus 로고    scopus 로고
    • Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cells
    • Plymate SR, Bae VL, Maddison L, Quinn LS, Ware JL: Reexpression of the type 1 insulin-like growth factor receptor inhibits the malignant phenotype of simian virus 40 T antigen immortalized human prostate epithelial cells. Endocrinology 1997;138:1728-1735.
    • (1997) Endocrinology , vol.138 , pp. 1728-1735
    • Plymate, S.R.1    Bae, V.L.2    Maddison, L.3    Quinn, L.S.4    Ware, J.L.5
  • 87
    • 0028113415 scopus 로고
    • Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor
    • Culig Z, Hobisch A, Cronauer MV, Radmayr C, Trapman J, Hittmair A, Bartsch G, Klocker H: Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor. Cancer Res 1994;54:5474-5478.
    • (1994) Cancer Res , vol.54 , pp. 5474-5478
    • Culig, Z.1    Hobisch, A.2    Cronauer, M.V.3    Radmayr, C.4    Trapman, J.5    Hittmair, A.6    Bartsch, G.7    Klocker, H.8
  • 88
    • 0031984805 scopus 로고    scopus 로고
    • Reduction of ventral prostate weight by finasteride is associated with suppression of insulin-like growth factor I (IGF-I) and IGF-I receptor genes and with an increase in IGF binding protein 3
    • Huynh H, Seyam RM, Brock GB: Reduction of ventral prostate weight by finasteride is associated with suppression of insulin-like growth factor I (IGF-I) and IGF-I receptor genes and with an increase in IGF binding protein 3. Cancer Res 1998;58:215-218.
    • (1998) Cancer Res , vol.58 , pp. 215-218
    • Huynh, H.1    Seyam, R.M.2    Brock, G.B.3
  • 89
    • 0030027259 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate
    • Tennant MK, Thrasher JB, Twomey PA, Birnbaum RS, Plymate SR: Insulin-like growth factor-binding protein-2 and -3 expression in benign human prostate epithelium, prostate intraepithelial neoplasia, and adenocarcinoma of the prostate. J Clin Endocrinol Metab 1996;81:411-420.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 411-420
    • Tennant, M.K.1    Thrasher, J.B.2    Twomey, P.A.3    Birnbaum, R.S.4    Plymate, S.R.5
  • 90
    • 0029836795 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding proteins (IGFBP)-4, -5, and -6 in the benign and malignant human prostate: IGFBP-5 messenger ribonucleic acid localization differs from IGFBP-5 protein localization
    • Tennant MK, Thrasher JB, Twomey PA, Birnbaum RS, Plymate SR: Insulin-like growth factor-binding proteins (IGFBP)-4, -5, and -6 in the benign and malignant human prostate: IGFBP-5 messenger ribonucleic acid localization differs from IGFBP-5 protein localization. J Clin Endocrinol Metab 1996;81:3783-3792.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3783-3792
    • Tennant, M.K.1    Thrasher, J.B.2    Twomey, P.A.3    Birnbaum, R.S.4    Plymate, S.R.5
  • 91
    • 0033562985 scopus 로고    scopus 로고
    • Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer
    • Sprenger CC, Damon SE, Hwa V, Rosenfeld RG, Plymate SR: Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) is a potential tumor suppressor protein for prostate cancer. Cancer Res 1999;59:2370-2375.
    • (1999) Cancer Res , vol.59 , pp. 2370-2375
    • Sprenger, C.C.1    Damon, S.E.2    Hwa, V.3    Rosenfeld, R.G.4    Plymate, S.R.5
  • 92
    • 0033306866 scopus 로고    scopus 로고
    • Androgen receptor up-regulates insulin-like growth factor binding protein-5 (IGFBP-5) expression in a human prostate cancer xenograft
    • Gregory CW, Kim D, Ye P, D'Ercole AJ, Pretlow TG, Mohler JL, French FS: Androgen receptor up-regulates insulin-like growth factor binding protein-5 (IGFBP-5) expression in a human prostate cancer xenograft. Endocrinology 1999;140:2372-2381.
    • (1999) Endocrinology , vol.140 , pp. 2372-2381
    • Gregory, C.W.1    Kim, D.2    Ye, P.3    D'Ercole, A.J.4    Pretlow, T.G.5    Mohler, J.L.6    French, F.S.7
  • 93
    • 0028834170 scopus 로고
    • IGF-binding proteins in human prostate tumor cells: Expression and regulation by 1,25-dihydroxyvitamin D3
    • Drivdahl RH, Loop SM, Andress DL, Ostenson RC: IGF-binding proteins in human prostate tumor cells: Expression and regulation by 1,25-dihydroxyvitamin D3. Prostate 1995;26:72-79.
    • (1995) Prostate , vol.26 , pp. 72-79
    • Drivdahl, R.H.1    Loop, S.M.2    Andress, D.L.3    Ostenson, R.C.4
  • 94
    • 0027326228 scopus 로고
    • Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: Correlation with serum prostate-specific antigen
    • Kanety H, Madjar Y, Dagan Y, Levi J, Papa MZ, Pariente C, Goldwasser B, Karasik A: Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: Correlation with serum prostate-specific antigen. J Clin Endocrinol Metab 1993;77:229-233.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 229-233
    • Kanety, H.1    Madjar, Y.2    Dagan, Y.3    Levi, J.4    Papa, M.Z.5    Pariente, C.6    Goldwasser, B.7    Karasik, A.8
  • 95
    • 0030972216 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism
    • Rajah R, Valentinis B, Cohen P: Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem 1997;272:12181-12188.
    • (1997) J Biol Chem , vol.272 , pp. 12181-12188
    • Rajah, R.1    Valentinis, B.2    Cohen, P.3
  • 96
    • 0030923679 scopus 로고    scopus 로고
    • Insulin-like growth factors and their binding proteins in human colonocytes: Preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers
    • Michell NP, Langman MJ, Eggo MC: Insulin-like growth factors and their binding proteins in human colonocytes: Preferential degradation of insulin-like growth factor binding protein 2 in colonic cancers. Br J Cancer 1997;76:60-66.
    • (1997) Br J Cancer , vol.76 , pp. 60-66
    • Michell, N.P.1    Langman, M.J.2    Eggo, M.C.3
  • 97
    • 0032924170 scopus 로고    scopus 로고
    • Differential autocrine regulation of intestine epithelial cell proliferation and differentiation by insulin-like growth factor (IGF) system components
    • Jehle PM, Fussgaenger RD, Blum WF, Angelus NK, Hoeflich A, Wolf E, Jungwirth RJ: Differential autocrine regulation of intestine epithelial cell proliferation and differentiation by insulin-like growth factor (IGF) system components. Horm Metab Res 1999;31:97-102.
    • (1999) Horm Metab Res , vol.31 , pp. 97-102
    • Jehle, P.M.1    Fussgaenger, R.D.2    Blum, W.F.3    Angelus, N.K.4    Hoeflich, A.5    Wolf, E.6    Jungwirth, R.J.7
  • 98
    • 0029145670 scopus 로고
    • Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells
    • Remacle-Bonnet M, Garrouste F, el Atiq F, Marvaldi J, Pommier G: Cell polarity of the insulin-like growth factor system in human intestinal epithelial cells. Unique apical sorting of insulin-like growth factor binding protein-6 in differentiated human colon cancer cells. J Clin Invest 1995;96:192-200.
    • (1995) J Clin Invest , vol.96 , pp. 192-200
    • Remacle-Bonnet, M.1    Garrouste, F.2    El Atiq, F.3    Marvaldi, J.4    Pommier, G.5
  • 99
    • 0034032010 scopus 로고    scopus 로고
    • Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways
    • Remacle-Bonnet MM, Garrouste FL, Heller S, Andre F, Marvaldi JL, Pommier GJ: Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathways. Cancer Res 2000;60:2007-2017.
    • (2000) Cancer Res , vol.60 , pp. 2007-2017
    • Remacle-Bonnet, M.M.1    Garrouste, F.L.2    Heller, S.3    Andre, F.4    Marvaldi, J.L.5    Pommier, G.J.6
  • 100
    • 0032170035 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I
    • Akagi Y, Liu W, Zebrowski B, Xie K, Ellis LM: Regulation of vascular endothelial growth factor expression in human colon cancer by insulin-like growth factor-I. Cancer Res 1998;58:4008-4014.
    • (1998) Cancer Res , vol.58 , pp. 4008-4014
    • Akagi, Y.1    Liu, W.2    Zebrowski, B.3    Xie, K.4    Ellis, L.M.5
  • 101
    • 0027327503 scopus 로고
    • Insulinlike growth factors and binding proteins in colon cancer
    • Singh P, Rubin N: Insulinlike growth factors and binding proteins in colon cancer. Gastroenterology 1993;105:1218-1237.
    • (1993) Gastroenterology , vol.105 , pp. 1218-1237
    • Singh, P.1    Rubin, N.2
  • 102
    • 0026778874 scopus 로고
    • Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line
    • Remacle-Bonnet MM, Culouscou JM, Garrouste FL, Rabenandrasana C, Marvaldi JL, Pommier GJ: Expression of type I, but not type II insulin-like growth factor receptor on both undifferentiated and differentiated HT29 human colon carcinoma cell line. J Clin Endocrinol Metab 1992;75:609-616.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 609-616
    • Remacle-Bonnet, M.M.1    Culouscou, J.M.2    Garrouste, F.L.3    Rabenandrasana, C.4    Marvaldi, J.L.5    Pommier, G.J.6
  • 103
    • 0026504138 scopus 로고
    • Characterization of insulinlike growth factor I receptors in human colon cancer
    • Guo YS, Narayan S, Yallampalli C, Singh P: Characterization of insulinlike growth factor I receptors in human colon cancer. Gastroenterology 1992;102:1101-1108.
    • (1992) Gastroenterology , vol.102 , pp. 1101-1108
    • Guo, Y.S.1    Narayan, S.2    Yallampalli, C.3    Singh, P.4
  • 105
    • 0023473304 scopus 로고
    • Presence of somatomedin receptors on primary human breast and colon carcinomas
    • Pollak MN, Perdue JF, Margolese RG, Baer K, Richard M: Presence of somatomedin receptors on primary human breast and colon carcinomas. Cancer Lett 1987;38:223-230.
    • (1987) Cancer Lett , vol.38 , pp. 223-230
    • Pollak, M.N.1    Perdue, J.F.2    Margolese, R.G.3    Baer, K.4    Richard, M.5
  • 106
    • 0028084175 scopus 로고
    • Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs
    • Singh P, Dai B, Yallampalli C, Xu Z: Expression of IGF-II and IGF-binding proteins by colon cancer cells in relation to growth response to IGFs. Am J Physiol 1994;267:G608-G617.
    • (1994) Am J Physiol , vol.267
    • Singh, P.1    Dai, B.2    Yallampalli, C.3    Xu, Z.4
  • 107
    • 0025775536 scopus 로고
    • Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein
    • Culouscou JM, Shoyab M: Purification of a colon cancer cell growth inhibitor and its identification as an insulin-like growth factor binding protein. Cancer Res 1991;51:2813-2819.
    • (1991) Cancer Res , vol.51 , pp. 2813-2819
    • Culouscou, J.M.1    Shoyab, M.2
  • 108
    • 0029776419 scopus 로고    scopus 로고
    • Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: Implications of IGF-I receptor gene activation by hepatitis B virus X gene product
    • Kim SO, Park JG, Lee YI: Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: Implications of IGF-I receptor gene activation by hepatitis B virus X gene product. Cancer Res 1996;56:3831-3836.
    • (1996) Cancer Res , vol.56 , pp. 3831-3836
    • Kim, S.O.1    Park, J.G.2    Lee, Y.I.3
  • 109
    • 0032493107 scopus 로고    scopus 로고
    • The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4
    • Lee YI, Lee S, Lee Y, Bong YS, Hyun SW, Yoo YD, Kim SJ, Kim YW, Poo HR: The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4. Oncogene 1998;16:2367-2380.
    • (1998) Oncogene , vol.16 , pp. 2367-2380
    • Lee, Y.I.1    Lee, S.2    Lee, Y.3    Bong, Y.S.4    Hyun, S.W.5    Yoo, Y.D.6    Kim, S.J.7    Kim, Y.W.8    Poo, H.R.9
  • 110
    • 0029664980 scopus 로고    scopus 로고
    • Hepatitis C virus replication is associated with expression of transforming growth factor-alpha and insulin-like growth factor-II in cirrhotic livers
    • Tanaka S, Takenaka K, Matsumata T, Mori R, Sugimachi K: Hepatitis C virus replication is associated with expression of transforming growth factor-alpha and insulin-like growth factor-II in cirrhotic livers. Dig Dis Sci 1996;41:208-215.
    • (1996) Dig Dis Sci , vol.41 , pp. 208-215
    • Tanaka, S.1    Takenaka, K.2    Matsumata, T.3    Mori, R.4    Sugimachi, K.5
  • 111
    • 0030060967 scopus 로고    scopus 로고
    • Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins
    • Kleinman D, Karas M, Danilenko M, Arbell A, Roberts CT, Le Roith D, Levy J, Sharoni Y: Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction in IGF binding proteins. Endocrinology 1996;137:1089-1095.
    • (1996) Endocrinology , vol.137 , pp. 1089-1095
    • Kleinman, D.1    Karas, M.2    Danilenko, M.3    Arbell, A.4    Roberts, C.T.5    Le Roith, D.6    Levy, J.7    Sharoni, Y.8
  • 112
    • 0032515581 scopus 로고    scopus 로고
    • Childhood energy intake and adult mortality from cancer: The Boyd Orr Cohort Study
    • Frankel S, Gunnell DJ, Peters TJ, Maynard M, Davey Smith G: Childhood energy intake and adult mortality from cancer: The Boyd Orr Cohort Study. BMJ 1998;316:499-504.
    • (1998) BMJ , vol.316 , pp. 499-504
    • Frankel, S.1    Gunnell, D.J.2    Peters, T.J.3    Maynard, M.4    Davey Smith, G.5
  • 113
    • 0030727705 scopus 로고    scopus 로고
    • Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice
    • Dunn SE, Kari FW, French J, Leininger JR, Travlos G, Wilson R, Barrett JC: Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice. Cancer Res 1997;57:4667-4672.
    • (1997) Cancer Res , vol.57 , pp. 4667-4672
    • Dunn, S.E.1    Kari, F.W.2    French, J.3    Leininger, J.R.4    Travlos, G.5    Wilson, R.6    Barrett, J.C.7
  • 114
    • 0031759850 scopus 로고    scopus 로고
    • Mortality and cancer incidence in acromegaly: A retrospective cohort study
    • United Kingdom Acromegaly Study Group
    • Orme SM, McNally RJ, Cartwright RA, Belchetz PE: Mortality and cancer incidence in acromegaly: A retrospective cohort study. United Kingdom Acromegaly Study Group. J Clin Endocrinol Metab 1998;83:2730-2734.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 2730-2734
    • Orme, S.M.1    McNally, R.J.2    Cartwright, R.A.3    Belchetz, P.E.4
  • 116
    • 0030896613 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia
    • Ho PJ, Baxter RC: Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia. Clin Endocrinol (Oxf) 1997;46:333-342.
    • (1997) Clin Endocrinol (Oxf) , vol.46 , pp. 333-342
    • Ho, P.J.1    Baxter, R.C.2
  • 117
    • 0035111828 scopus 로고    scopus 로고
    • Levels of insulin-like growth factor I (IGF-I) and IGF binding proteins 2 and 3 in serial postoperative serum samples and risk of prostate cancer recurrence
    • Yu H, Nicar MR, Shi R, Berkel HJ, Nam R, Trachtenberg J, Diamandis EP: Levels of insulin-like growth factor I (IGF-I) and IGF binding proteins 2 and 3 in serial postoperative serum samples and risk of prostate cancer recurrence. Urology 2001;57:471-475.
    • (2001) Urology , vol.57 , pp. 471-475
    • Yu, H.1    Nicar, M.R.2    Shi, R.3    Berkel, H.J.4    Nam, R.5    Trachtenberg, J.6    Diamandis, E.P.7
  • 118
    • 0035092756 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in benign prostatic hyperplasia and prostate cancer
    • Khosravi J, Diamandi A, Mistry J, Scorilas A: Insulin-like growth factor I (IGF-I) and IGF-binding protein-3 in benign prostatic hyperplasia and prostate cancer. J Clin Endocrinol Metab 2001;86:694-699.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 694-699
    • Khosravi, J.1    Diamandi, A.2    Mistry, J.3    Scorilas, A.4
  • 120
    • 0031840476 scopus 로고    scopus 로고
    • Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast
    • Bohlke K, Cramer DW, Trichopoulos D, Mantzoros CS: Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast. Epidemiology 1998;9:570-573.
    • (1998) Epidemiology , vol.9 , pp. 570-573
    • Bohlke, K.1    Cramer, D.W.2    Trichopoulos, D.3    Mantzoros, C.S.4
  • 122
    • 0028812792 scopus 로고
    • Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early- and late-stage breast cancer: Mutual relationship and possible correlations with patients' hormonal status
    • Favoni RE, de Cupis A, Perrotta A, Sforzini S, Amoroso D, Pensa F, Miglietta L: Insulin-like growth factor-I (IGF-I) and IGF-binding proteins blood serum levels in women with early- and late-stage breast cancer: Mutual relationship and possible correlations with patients' hormonal status. J Cancer Res Clin Oncol 1995;121:674-682.
    • (1995) J Cancer Res Clin Oncol , vol.121 , pp. 674-682
    • Favoni, R.E.1    De Cupis, A.2    Perrotta, A.3    Sforzini, S.4    Amoroso, D.5    Pensa, F.6    Miglietta, L.7
  • 123
    • 0033061542 scopus 로고    scopus 로고
    • Serum IGF-binding protein-6 and prostate specific antigen in breast cancer
    • Kaulsay KK, Ng EH, Ji CY, Ho GH, Aw TC, Lee KO: Serum IGF-binding protein-6 and prostate specific antigen in breast cancer. Eur J Endocrinol 1999;140:164-168.
    • (1999) Eur J Endocrinol , vol.140 , pp. 164-168
    • Kaulsay, K.K.1    Ng, E.H.2    Ji, C.Y.3    Ho, G.H.4    Aw, T.C.5    Lee, K.O.6
  • 124
    • 0033531765 scopus 로고    scopus 로고
    • Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3
    • Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, Stampfer MJ: Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst 1999;91:620-625.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 620-625
    • Ma, J.1    Pollak, M.N.2    Giovannucci, E.3    Chan, J.M.4    Tao, Y.5    Hennekens, C.H.6    Stampfer, M.J.7
  • 125
    • 0033750859 scopus 로고    scopus 로고
    • Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer
    • Renehan AG, Jones J, Potten CS, Shalet SM, O'Dwyer ST: Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer. Br J Cancer 2000;83:1344-1350.
    • (2000) Br J Cancer , vol.83 , pp. 1344-1350
    • Renehan, A.G.1    Jones, J.2    Potten, C.S.3    Shalet, S.M.4    O'Dwyer, S.T.5
  • 129
    • 0028009695 scopus 로고
    • Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer
    • Karasik A, Menczer J, Pariente C, Kanety H: Insulin-like growth factor-I (IGF-I) and IGF-binding protein-2 are increased in cyst fluids of epithelial ovarian cancer. J Clin Endocrinol Metab 1994;78:271-276.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 271-276
    • Karasik, A.1    Menczer, J.2    Pariente, C.3    Kanety, H.4
  • 130
    • 0030752414 scopus 로고    scopus 로고
    • Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: Correlation with cancer antigen 125 and tumor-associated trypsin inhibitor
    • Flyvbjerg A, Mogensen O, Mogensen B, Nielsen OS: Elevated serum insulin-like growth factor-binding protein 2 (IGFBP-2) and decreased IGFBP-3 in epithelial ovarian cancer: Correlation with cancer antigen 125 and tumor-associated trypsin inhibitor. J Clin Endocrinol Metab 1997;82:2308-2313.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2308-2313
    • Flyvbjerg, A.1    Mogensen, O.2    Mogensen, B.3    Nielsen, O.S.4
  • 131
    • 0030728566 scopus 로고    scopus 로고
    • Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer
    • Evans JD, Eggo MC, Donovan IA, Bramhall SR, Neoptolemos JP: Serum levels of insulin-like growth factors (IGF-I and IGF-II) and their binding protein (IGFBP-3) are not elevated in pancreatic cancer. Int J Pancreatol 1997;22:95-100.
    • (1997) Int J Pancreatol , vol.22 , pp. 95-100
    • Evans, J.D.1    Eggo, M.C.2    Donovan, I.A.3    Bramhall, S.R.4    Neoptolemos, J.P.5
  • 132
    • 0031064912 scopus 로고    scopus 로고
    • Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery
    • Lee DY, Yang DH, Kang CW, Kim SJ, Joo CU, Cho SC, Kim JS: Serum insulin-like growth factors (IGFs) and IGF binding protein (IGFBP)-3 in patients with gastric cancer: IGFBP-3 protease activity induced by surgery. J Korean Med Sci 1997;12:32-39.
    • (1997) J Korean Med Sci , vol.12 , pp. 32-39
    • Lee, D.Y.1    Yang, D.H.2    Kang, C.W.3    Kim, S.J.4    Joo, C.U.5    Cho, S.C.6    Kim, J.S.7
  • 134
    • 0033585421 scopus 로고    scopus 로고
    • Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis
    • Yu H, Spitz MR, Mistry J, Gu J, Hong WK, Wu X: Plasma levels of insulin-like growth factor-I and lung cancer risk: A case-control analysis. J Natl Cancer Inst 1999;91:151-156.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 151-156
    • Yu, H.1    Spitz, M.R.2    Mistry, J.3    Gu, J.4    Hong, W.K.5    Wu, X.6
  • 135
    • 0033174947 scopus 로고    scopus 로고
    • Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients
    • Lee DY, Kim SJ, Lee YC: Serum insulin-like growth factor (IGF)-I and IGF-binding proteins in lung cancer patients. J Korean Med Sci 1999;14:401-404.
    • (1999) J Korean Med Sci , vol.14 , pp. 401-404
    • Lee, D.Y.1    Kim, S.J.2    Lee, Y.C.3
  • 136
    • 0033065792 scopus 로고    scopus 로고
    • Decreased serum levels of insulin-like growth factor (IGF)-I in patients with lung cancer: Temporal relationship with growth hormone (GH) levels
    • Mazzoccoli G, Giuliani A, Bianco G, De Cata A, Balzanelli M, Carella AM, La Viola M, Tarquini R: Decreased serum levels of insulin-like growth factor (IGF)-I in patients with lung cancer: Temporal relationship with growth hormone (GH) levels. Anticancer Res 1999;19:1397-1399.
    • (1999) Anticancer Res , vol.19 , pp. 1397-1399
    • Mazzoccoli, G.1    Giuliani, A.2    Bianco, G.3    De Cata, A.4    Balzanelli, M.5    Carella, A.M.6    La Viola, M.7    Tarquini, R.8
  • 137
    • 0027179283 scopus 로고
    • Relationship between carbohydrate metabolism and serum insulin-like growth factor system in postmenopausal women: Comparison of endometrial cancer patients with healthy controls
    • Rutanen EM, Stenman S, Blum W, Karkkainen T, Lehtovirta P, Stenman UH: Relationship between carbohydrate metabolism and serum insulin-like growth factor system in postmenopausal women: Comparison of endometrial cancer patients with healthy controls. J Clin Endocrinol Metab 1993;77:199-204.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 199-204
    • Rutanen, E.M.1    Stenman, S.2    Blum, W.3    Karkkainen, T.4    Lehtovirta, P.5    Stenman, U.H.6
  • 138
    • 0030843850 scopus 로고    scopus 로고
    • Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer
    • Ayabe T, Tsutsumi O, Sakai H, Yoshikawa H, Yano T, Kurimoto F, Taketani Y: Increased circulating levels of insulin-like growth factor-I and decreased circulating levels of insulin-like growth factor binding protein-1 in postmenopausal women with endometrial cancer. Endocr J 1997;44:419-424.
    • (1997) Endocr J , vol.44 , pp. 419-424
    • Ayabe, T.1    Tsutsumi, O.2    Sakai, H.3    Yoshikawa, H.4    Yano, T.5    Kurimoto, F.6    Taketani, Y.7
  • 139
    • 0025168534 scopus 로고
    • Cell proliferation in carcinogenesis
    • Cohen SM, Ellwein LB: Cell proliferation in carcinogenesis. Science 1990;249:1007-1011.
    • (1990) Science , vol.249 , pp. 1007-1011
    • Cohen, S.M.1    Ellwein, L.B.2
  • 142
    • 0032981091 scopus 로고    scopus 로고
    • Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro
    • Csernus VJ, Schally AV, Kiaris H, Armatis P: Inhibition of growth, production of insulin-like growth factor-II (IGF-II), and expression of IGF-II mRNA of human cancer cell lines by antagonistic analogs of growth hormone-releasing hormone in vitro. Proc Natl Acad Sci USA 1999;96:3098-3103.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3098-3103
    • Csernus, V.J.1    Schally, A.V.2    Kiaris, H.3    Armatis, P.4
  • 143
    • 0031393588 scopus 로고    scopus 로고
    • The potential role of somatostatin analogues in breast cancer treatment
    • Pollak M: The potential role of somatostatin analogues in breast cancer treatment. Yale J Biol Med 1997;70:535-539.
    • (1997) Yale J Biol Med , vol.70 , pp. 535-539
    • Pollak, M.1
  • 145
    • 0032569831 scopus 로고    scopus 로고
    • Tamoxifen in the treatment of breast cancer
    • Osborne CK: Tamoxifen in the treatment of breast cancer. N Engl J Med 1998;339:1609-1618.
    • (1998) N Engl J Med , vol.339 , pp. 1609-1618
    • Osborne, C.K.1
  • 146
    • 0029995770 scopus 로고    scopus 로고
    • Controlling IGF-receptor function: A possible strategy for tumor therapy
    • Baserga R: Controlling IGF-receptor function: A possible strategy for tumor therapy. Trends Biotechnol 1996;14:150-152.
    • (1996) Trends Biotechnol , vol.14 , pp. 150-152
    • Baserga, R.1
  • 148
    • 15644378537 scopus 로고    scopus 로고
    • The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer
    • Miller WH Jr: The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer. Cancer 1998;83:1471-1482.
    • (1998) Cancer , vol.83 , pp. 1471-1482
    • Miller W.H., Jr.1
  • 150
    • 0027434075 scopus 로고
    • Does growth hormone increase the risk of malignancies?
    • Ritzen EM: Does growth hormone increase the risk of malignancies? Horm Res 1993;39:99-101.
    • (1993) Horm Res , vol.39 , pp. 99-101
    • Ritzen, E.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.