Crystal structure of bisphosphorylated igf-1 receptor kinase: Insight into domain movements upon kinase activation

Structure

Volumn 9, Issue 10, 2001, Pages 955-965

  Pautsch, Alexander ^a   Zoephel, Andreas ^b   Ahorn, Horst ^b   Spevak, Walter ^b   Hauptmann, Rudolf ^b   Nar, Herbert ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

Author keywords

Cancer; Crystal structure; Growth factor receptor; IGF 1; Protein tyrosine kinase

Indexed keywords

ADENOSINE TRIPHOSPHATE DERIVATIVE; INSULIN RECEPTOR KINASE; LIGAND; PROTEIN TYROSINE KINASE; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR KINASE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BINDING; HUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

ADENYLYL IMIDODIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, IGF TYPE 1; SUBSTRATE SPECIFICITY;

EID: 0034793734     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00655-4     Document Type: Article

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