메뉴 건너뛰기




Volumn 110, Issue 5, 2013, Pages 1255-1271

An 'omics approach towards CHO cell engineering

Author keywords

Bioengineering; Chinese hamster ovary cells; Glycomics; Metabolic engineering

Indexed keywords

BIOPHARMACEUTICAL PRODUCTS; CHINESE HAMSTER OVARY CELLS; GLYCOMICS; HUMAN GROWTH HORMONE; INDUSTRIAL PRODUCTION; METABOLIC PATHWAYS; SUSPENSION CULTURES; TECHNIQUES AND TOOLS;

EID: 84875517609     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24841     Document Type: Review
Times cited : (103)

References (174)
  • 3
    • 74849109669 scopus 로고    scopus 로고
    • A DIGE approach for the assessment of differential expression of the CHO proteome under sodium butyrate addition: Effect of Bcl-x(L) overexpression
    • Baik JY, Lee GM. 2010. A DIGE approach for the assessment of differential expression of the CHO proteome under sodium butyrate addition: Effect of Bcl-x(L) overexpression. Biotechnol Bioeng 105: 358-367. http://www.ncbi.nlm.nih.gov/pubmed/19739093
    • (2010) Biotechnol Bioeng , vol.105 , pp. 358-367
    • Baik, J.Y.1    Lee, G.M.2
  • 4
    • 33645573249 scopus 로고    scopus 로고
    • Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin
    • Baik JY, Lee MS, An SR, Yoon SK, Joo EJ, Kim YH, Park HW, Lee GM. 2006. Initial transcriptome and proteome analyses of low culture temperature-induced expression in CHO cells producing erythropoietin. Biotechnol Bioeng 93: 361-371. http://www.ncbi.nlm.nih.gov/pubmed/16187333
    • (2006) Biotechnol Bioeng , vol.93 , pp. 361-371
    • Baik, J.Y.1    Lee, M.S.2    An, S.R.3    Yoon, S.K.4    Joo, E.J.5    Kim, Y.H.6    Park, H.W.7    Lee, G.M.8
  • 5
    • 0037146826 scopus 로고    scopus 로고
    • High-throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein-GFP fusion protein
    • DOI: 10.1002/bit.10424
    • Bailey CG, Tait AS, Sunstrom NA. 2002. High-throughput clonal selection of recombinant CHO cells using a dominant selectable and amplifiable metallothionein-GFP fusion protein. Biotechnol Bioeng 80: 670-676. DOI: 10.1002/bit.10424
    • (2002) Biotechnol Bioeng , vol.80 , pp. 670-676
    • Bailey, C.G.1    Tait, A.S.2    Sunstrom, N.A.3
  • 6
    • 13544257263 scopus 로고    scopus 로고
    • Transient gene expression in suspension HEK-293 cells: Application to large-scale protein production
    • Baldi L, Muller N, Picasso S, Jacquet R, Girard P, Thanh HP, Derow E, Wurm FM. 2005. Transient gene expression in suspension HEK-293 cells: Application to large-scale protein production. Biotechnol Prog 21: 148-153. http://www.ncbi.nlm.nih.gov/pubmed/15903252
    • (2005) Biotechnol Prog , vol.21 , pp. 148-153
    • Baldi, L.1    Muller, N.2    Picasso, S.3    Jacquet, R.4    Girard, P.5    Thanh, H.P.6    Derow, E.7    Wurm, F.M.8
  • 7
    • 0035918616 scopus 로고    scopus 로고
    • Characterization of the stability of recombinant protein production in the GS-NS0 expression system
    • Barnes LM, Bentley CM, Dickson AJ. 2001. Characterization of the stability of recombinant protein production in the GS-NS0 expression system. Biotechnol Bioeng 73: 261-270. http://www.ncbi.nlm.nih.gov/pubmed/11283909
    • (2001) Biotechnol Bioeng , vol.73 , pp. 261-270
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 8
    • 78651507094 scopus 로고    scopus 로고
    • Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7
    • Barron N, Kumar N, Sanchez N, Doolan P, Clarke C, Meleady P, O'Sullivan F, Clynes M. 2011. Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7. J Biotechnol 151: 204-211. http://www.ncbi.nlm.nih.gov/pubmed/21167223
    • (2011) J Biotechnol , vol.151 , pp. 204-211
    • Barron, N.1    Kumar, N.2    Sanchez, N.3    Doolan, P.4    Clarke, C.5    Meleady, P.6    O'Sullivan, F.7    Clynes, M.8
  • 9
    • 84875522581 scopus 로고    scopus 로고
    • MicroRNAs as potential engineering targets for improvement of CHO cell production Phenotypes. In: Jenkins N, Barron N, Alves P, editors. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Vol. 5, p -. Netherlands.
    • Barron N, Kumar N, Sanchez N, Gammell P, Clynes M. 2012. MicroRNAs as potential engineering targets for improvement of CHO cell production Phenotypes. In: Jenkins N, Barron N, Alves P, editors. Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), Dublin, Ireland, June 7-10, 2009. Vol. 5, p 3-11. Netherlands.
    • (2012) , pp. 3-11
    • Barron, N.1    Kumar, N.2    Sanchez, N.3    Gammell, P.4    Clynes, M.5
  • 11
    • 14744283551 scopus 로고
    • High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker
    • Bebbington CR, Renner G, Thomson S, King D, Abrams D, Yarranton GT. 1992. High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker. Nat Biotechnol 10: 169-175.
    • (1992) Nat Biotechnol , vol.10 , pp. 169-175
    • Bebbington, C.R.1    Renner, G.2    Thomson, S.3    King, D.4    Abrams, D.5    Yarranton, G.T.6
  • 12
    • 83555176235 scopus 로고    scopus 로고
    • Exploring the effect of mild hypothermia on CHO cell productivity
    • Becerra S, Berrios J, Osses N, Altamirano C. 2012. Exploring the effect of mild hypothermia on CHO cell productivity. Biochem Eng J 60: 1-8. http://www.sciencedirect.com/science/article/pii/S1369703×11002804
    • (2012) Biochem Eng J , vol.60 , pp. 1-8
    • Becerra, S.1    Berrios, J.2    Osses, N.3    Altamirano, C.4
  • 14
    • 0036422427 scopus 로고    scopus 로고
    • The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein
    • Benton T, Chen T, McEntee M, Fox B, King D, Crombie R, Thomas TC, Bebbington C. 2002. The use of UCOE vectors in combination with a preadapted serum free, suspension cell line allows for rapid production of large quantities of protein. Cytotechnology 38: 43-46. http://www.ncbi.nlm.nih.gov/pubmed/19003085
    • (2002) Cytotechnology , vol.38 , pp. 43-46
    • Benton, T.1    Chen, T.2    McEntee, M.3    Fox, B.4    King, D.5    Crombie, R.6    Thomas, T.C.7    Bebbington, C.8
  • 16
    • 79955597234 scopus 로고    scopus 로고
    • Design of experiment in CHO and HEK transient transfection condition optimization
    • Bollin F, Dechavanne V, Chevalet L. 2011. Design of experiment in CHO and HEK transient transfection condition optimization. Protein Expr Purif 78: 61-68. http://www.sciencedirect.com/science/article/pii/S1046592811000465
    • (2011) Protein Expr Purif , vol.78 , pp. 61-68
    • Bollin, F.1    Dechavanne, V.2    Chevalet, L.3
  • 18
    • 0034446598 scopus 로고    scopus 로고
    • Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting
    • Borth N, Zeyda M, Kunert R, Katinger H. 2000. Efficient selection of high-producing subclones during gene amplification of recombinant Chinese hamster ovary cells by flow cytometry and cell sorting. Biotechnol Bioeng 71: 266-273. http://www.ncbi.nlm.nih.gov/pubmed/11291036
    • (2000) Biotechnol Bioeng , vol.71 , pp. 266-273
    • Borth, N.1    Zeyda, M.2    Kunert, R.3    Katinger, H.4
  • 19
    • 35548990601 scopus 로고    scopus 로고
    • Selection methods for high-producing mammalian cell lines
    • Browne SM, Al-Rubeai M. 2007. Selection methods for high-producing mammalian cell lines. Trends Biotechnol 25: 425-432. http://www.ncbi.nlm.nih.gov/pubmed/17659798
    • (2007) Trends Biotechnol , vol.25 , pp. 425-432
    • Browne, S.M.1    Al-Rubeai, M.2
  • 20
    • 23844433927 scopus 로고    scopus 로고
    • Animal cell cultures: Recent achievements and perspectives in the production of biopharmaceuticals
    • Butler M. 2005. Animal cell cultures: Recent achievements and perspectives in the production of biopharmaceuticals. Appl Microbiol Biotechnol 68: 283-291. http://www.ncbi.nlm.nih.gov/pubmed/15834715
    • (2005) Appl Microbiol Biotechnol , vol.68 , pp. 283-291
    • Butler, M.1
  • 22
    • 84859882580 scopus 로고    scopus 로고
    • Construction of BAC-based physical map and analysis of chromosome rearrangement in Chinese hamster ovary cell lines
    • DOI: 10.1002/bit.24347
    • Cao Y, Kimura S, Itoi T, Honda K, Ohtake H, Omasa T. 2012. Construction of BAC-based physical map and analysis of chromosome rearrangement in Chinese hamster ovary cell lines. Biotechnol Bioeng 109: 1357-1367. DOI: 10.1002/bit.24347
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1357-1367
    • Cao, Y.1    Kimura, S.2    Itoi, T.3    Honda, K.4    Ohtake, H.5    Omasa, T.6
  • 24
    • 80054026314 scopus 로고    scopus 로고
    • A review of the mammalian unfolded protein response
    • Chakrabarti A, Chen AW, Varner JD. 2011. A review of the mammalian unfolded protein response. Biotechnol Bioeng 108: 2777-2793. http://www.ncbi.nlm.nih.gov/pubmed/21809331
    • (2011) Biotechnol Bioeng , vol.108 , pp. 2777-2793
    • Chakrabarti, A.1    Chen, A.W.2    Varner, J.D.3
  • 26
    • 0242551376 scopus 로고    scopus 로고
    • Development of recombinant Chinese hamster ovary cell lines producing human thrombopoietin or its analog
    • Chung JY, Ahn HK, Lim SW, Sung YH, Koh YW, Park SK, Lee GM. 2003. Development of recombinant Chinese hamster ovary cell lines producing human thrombopoietin or its analog. J Microb Biotechnol 13: 759-766.
    • (2003) J Microb Biotechnol , vol.13 , pp. 759-766
    • Chung, J.Y.1    Ahn, H.K.2    Lim, S.W.3    Sung, Y.H.4    Koh, Y.W.5    Park, S.K.6    Lee, G.M.7
  • 29
    • 84862207929 scopus 로고    scopus 로고
    • Expanding the chemical palate of cells by combining systems biology and metabolic engineering
    • Curran KA, Alper HS. 2012. Expanding the chemical palate of cells by combining systems biology and metabolic engineering. Metab Eng 14: 289-297. http://www.sciencedirect.com/science/article/pii/S1096717612000493
    • (2012) Metab Eng , vol.14 , pp. 289-297
    • Curran, K.A.1    Alper, H.S.2
  • 30
    • 84655161863 scopus 로고    scopus 로고
    • Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: A study of Chinese hamster ovary cells producing a recombinant monoclonal antibody
    • Dahodwala H, Nowey M, Mitina T, Sharfstein ST. 2012. Effects of clonal variation on growth, metabolism, and productivity in response to trophic factor stimulation: A study of Chinese hamster ovary cells producing a recombinant monoclonal antibody. Cytotechnology 64: 27-41. http://www.ncbi.nlm.nih.gov/pubmed/21822681
    • (2012) Cytotechnology , vol.64 , pp. 27-41
    • Dahodwala, H.1    Nowey, M.2    Mitina, T.3    Sharfstein, S.T.4
  • 31
    • 84862688366 scopus 로고    scopus 로고
    • Glycosaminoglycan polysaccharide biosynthesis and production: Today and tomorrow
    • DeAngelis PL. 2012. Glycosaminoglycan polysaccharide biosynthesis and production: Today and tomorrow. Appl Microbiol Biotechnol 94: 295-305. http://www.ncbi.nlm.nih.gov/pubmed/22391966
    • (2012) Appl Microbiol Biotechnol , vol.94 , pp. 295-305
    • DeAngelis, P.L.1
  • 33
    • 77954457415 scopus 로고    scopus 로고
    • Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol
    • Dietmair S, Timmins NE, Gray PP, Nielsen LK, Krömer JO. 2010. Towards quantitative metabolomics of mammalian cells: Development of a metabolite extraction protocol. Anal Biochem 404: 155-164. http://www.sciencedirect.com/science/article/pii/S0003269710002836
    • (2010) Anal Biochem , vol.404 , pp. 155-164
    • Dietmair, S.1    Timmins, N.E.2    Gray, P.P.3    Nielsen, L.K.4    Krömer, J.O.5
  • 34
    • 84859240257 scopus 로고    scopus 로고
    • Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines
    • Doolan P, Barron N, Kinsella P, Clarke C, Meleady P, O'Sullivan F, Melville M, Leonard M, Clynes M. 2012. Microarray expression profiling identifies genes regulating sustained cell specific productivity (S-Qp) in CHO K1 production cell lines. Biotechnol J 7: 516-526. http://www.ncbi.nlm.nih.gov/pubmed/22147654
    • (2012) Biotechnol J , vol.7 , pp. 516-526
    • Doolan, P.1    Barron, N.2    Kinsella, P.3    Clarke, C.4    Meleady, P.5    O'Sullivan, F.6    Melville, M.7    Leonard, M.8    Clynes, M.9
  • 35
    • 77951555640 scopus 로고    scopus 로고
    • Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines
    • Doolan P, Meleady P, Barron N, Henry M, Gallagher R, Gammell P, Melville M, Sinacore M, McCarthy K, Leonard M, Charlebois T, Clynes M. 2010. Microarray and proteomics expression profiling identifies several candidates, including the valosin-containing protein (VCP), involved in regulating high cellular growth rate in production CHO cell lines. Biotechnol Bioeng 106: 42-56. http://www.ncbi.nlm.nih.gov/pubmed/20091739
    • (2010) Biotechnol Bioeng , vol.106 , pp. 42-56
    • Doolan, P.1    Meleady, P.2    Barron, N.3    Henry, M.4    Gallagher, R.5    Gammell, P.6    Melville, M.7    Sinacore, M.8    McCarthy, K.9    Leonard, M.10    Charlebois, T.11    Clynes, M.12
  • 36
    • 79952198533 scopus 로고    scopus 로고
    • Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines
    • Dorai H, Ellis D, Keung YS, Campbell M, Zhuang M, Lin C, Betenbaugh MJ. 2010. Combining high-throughput screening of caspase activity with anti-apoptosis genes for development of robust CHO production cell lines. Biotechnol Prog 26: 1367-1381. http://dx.doi.org/10.1002/btpr.426
    • (2010) Biotechnol Prog , vol.26 , pp. 1367-1381
    • Dorai, H.1    Ellis, D.2    Keung, Y.S.3    Campbell, M.4    Zhuang, M.5    Lin, C.6    Betenbaugh, M.J.7
  • 37
    • 65549153512 scopus 로고    scopus 로고
    • Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture
    • Dorai H, Kyung YS, Ellis D, Kinney C, Lin C, Jan D, Moore G, Betenbaugh MJ. 2009. Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture. Biotechnol Bioeng 103: 592-608. http://dx.doi.org/10.1002/bit.22269
    • (2009) Biotechnol Bioeng , vol.103 , pp. 592-608
    • Dorai, H.1    Kyung, Y.S.2    Ellis, D.3    Kinney, C.4    Lin, C.5    Jan, D.6    Moore, G.7    Betenbaugh, M.J.8
  • 38
    • 0029154557 scopus 로고
    • Glycobiology: More functions for oligosaccharides
    • Dwek RA. 1995. Glycobiology: More functions for oligosaccharides. Science 269: 1234-1235. http://www.ncbi.nlm.nih.gov/pubmed/7652569
    • (1995) Science , vol.269 , pp. 1234-1235
    • Dwek, R.A.1
  • 39
    • 0032247499 scopus 로고    scopus 로고
    • Biological importance of glycosylation
    • Dwek RA. 1998. Biological importance of glycosylation. Dev Biol Stand 96: 43-47. http://www.ncbi.nlm.nih.gov/pubmed/9890515
    • (1998) Dev Biol Stand , vol.96 , pp. 43-47
    • Dwek, R.A.1
  • 40
    • 57049182407 scopus 로고    scopus 로고
    • Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1
    • Eisele F, Wolf DH. 2008. Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. FEBS Lett 582: 4143-4146. http://www.ncbi.nlm.nih.gov/pubmed/19041308
    • (2008) FEBS Lett , vol.582 , pp. 4143-4146
    • Eisele, F.1    Wolf, D.H.2
  • 41
    • 0035997376 scopus 로고    scopus 로고
    • Order out of chaos: Assembly of ligand binding sites in heparan sulfate
    • Esko JD, Selleck SB. 2002. Order out of chaos: Assembly of ligand binding sites in heparan sulfate. Annu Rev Biochem 71: 435-471. http://www.ncbi.nlm.nih.gov/pubmed/12045103
    • (2002) Annu Rev Biochem , vol.71 , pp. 435-471
    • Esko, J.D.1    Selleck, S.B.2
  • 42
    • 84856187603 scopus 로고    scopus 로고
    • Glycosylation mutants of cultured cells
    • Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors., 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press.
    • Esko JD, Stanley P. 2009. Glycosylation mutants of cultured cells. In: Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Bertozzi CR, Hart GW, Etzler ME, editors. Essentials of Glycobiology, 2nd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press.
    • (2009) Essentials of Glycobiology
    • Esko, J.D.1    Stanley, P.2
  • 43
    • 2142854239 scopus 로고
    • Animal cell mutants defective in glycosaminoglycan biosynthesis
    • Esko JD, Stewart TE, Taylor WH. 1985. Animal cell mutants defective in glycosaminoglycan biosynthesis. Proc Natl Acad Sci USA 82: 3197-3201. http://www.ncbi.nlm.nih.gov/pubmed/3858816
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 3197-3201
    • Esko, J.D.1    Stewart, T.E.2    Taylor, W.H.3
  • 44
    • 0033136786 scopus 로고    scopus 로고
    • Characterization of protein-glycolipid recognition at the membrane bilayer
    • Evans SV, Roger MacKenzie C. 1999. Characterization of protein-glycolipid recognition at the membrane bilayer. J Mol Recognit 12: 155-168. http://www.ncbi.nlm.nih.gov/pubmed/10398406
    • (1999) J Mol Recognit , vol.12 , pp. 155-168
    • Evans, S.V.1    Roger MacKenzie, C.2
  • 45
    • 79961023951 scopus 로고    scopus 로고
    • Regulation of Rad51 function by phosphorylation
    • Flott S, Kwon Y, Pigli YZ, Rice PA, Sung P, Jackson SP. 2011. Regulation of Rad51 function by phosphorylation. EMBO Rep 12: 833-839. http://www.ncbi.nlm.nih.gov/pubmed/21738226
    • (2011) EMBO Rep , vol.12 , pp. 833-839
    • Flott, S.1    Kwon, Y.2    Pigli, Y.Z.3    Rice, P.A.4    Sung, P.5    Jackson, S.P.6
  • 46
    • 75649140253 scopus 로고    scopus 로고
    • A GFP-based method facilitates clonal selection of transfected CHO cells
    • DOI: 10.1002/biot.200800264
    • Freimark D, Jerome V, Freitag R. 2010. A GFP-based method facilitates clonal selection of transfected CHO cells. Biotechnol J 5: 24-31. DOI: 10.1002/biot.200800264
    • (2010) Biotechnol J , vol.5 , pp. 24-31
    • Freimark, D.1    Jerome, V.2    Freitag, R.3
  • 47
    • 84862201602 scopus 로고    scopus 로고
    • Effect of process parameters and product-host-interaction on hVEGFA-production by recombinant Chinese hamster ovary cells
    • Freimark D, Jérôme V, Freitag R. 2012. Effect of process parameters and product-host-interaction on hVEGFA-production by recombinant Chinese hamster ovary cells. Biotechnol Prog 28: 762-772. http://dx.doi.org/10.1002/btpr.1524
    • (2012) Biotechnol Prog , vol.28 , pp. 762-772
    • Freimark, D.1    Jérôme, V.2    Freitag, R.3
  • 48
    • 84864439768 scopus 로고    scopus 로고
    • Targeted gene knockout by direct delivery of zinc-finger nuclease proteins
    • Gaj T, Guo J, Kato Y, Sirk SJ, Barbas CF. 2012. Targeted gene knockout by direct delivery of zinc-finger nuclease proteins. Nat Methods 9: 805-807. http://www.nature.com/nmeth/journal/v9/n8/full/nmeth.2030.html
    • (2012) Nat Methods , vol.9 , pp. 805-807
    • Gaj, T.1    Guo, J.2    Kato, Y.3    Sirk, S.J.4    Barbas, C.F.5
  • 49
    • 34250307966 scopus 로고    scopus 로고
    • Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells
    • Gammell P, Barron N, Kumar N, Clynes M. 2007. Initial identification of low temperature and culture stage induction of miRNA expression in suspension CHO-K1 cells. J Biotechnol 130: 213-218. http://www.ncbi.nlm.nih.gov/pubmed/17570552
    • (2007) J Biotechnol , vol.130 , pp. 213-218
    • Gammell, P.1    Barron, N.2    Kumar, N.3    Clynes, M.4
  • 51
    • 21344449323 scopus 로고    scopus 로고
    • Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines
    • Girod PA, Zahn-Zabal M, Mermod N. 2005. Use of the chicken lysozyme 5′ matrix attachment region to generate high producer CHO cell lines. Biotechnol Bioeng 91: 1-11. http://www.ncbi.nlm.nih.gov/pubmed/15889435
    • (2005) Biotechnol Bioeng , vol.91 , pp. 1-11
    • Girod, P.A.1    Zahn-Zabal, M.2    Mermod, N.3
  • 52
    • 0016175381 scopus 로고
    • On the mechanism of erythropoietin-induced differentiation
    • Goldwasser E, Kung CK-H, Eliason J. 1974. On the mechanism of erythropoietin-induced differentiation. J Biol Chem 249: 4202-4206.
    • (1974) J Biol Chem , vol.249 , pp. 4202-4206
    • Goldwasser, E.1    Kung, C.-H.2    Eliason, J.3
  • 53
    • 0033571986 scopus 로고    scopus 로고
    • Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: A study using the tetracycline-inducible system in human cancer cells
    • Gopalkrishnan RV, Christiansen KA, Goldstein NI, DePinho RA, Fisher PB. 1999. Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: A study using the tetracycline-inducible system in human cancer cells. Nucleic Acids Res 27: 4775-4782. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC148778/
    • (1999) Nucleic Acids Res , vol.27 , pp. 4775-4782
    • Gopalkrishnan, R.V.1    Christiansen, K.A.2    Goldstein, N.I.3    DePinho, R.A.4    Fisher, P.B.5
  • 55
    • 3142514373 scopus 로고    scopus 로고
    • The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus
    • de Graffenried CL, Bertozzi CR. 2004. The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus. Curr Opin Cell Biol 16: 356-363. http://www.ncbi.nlm.nih.gov/pubmed/15261667
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 356-363
    • de Graffenried, C.L.1    Bertozzi, C.R.2
  • 56
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham FL, van der Eb AJ. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52: 456-467. http://www.ncbi.nlm.nih.gov/pubmed/4705382
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    van der Eb, A.J.2
  • 57
    • 35548983052 scopus 로고    scopus 로고
    • Advancing mammalian cell culture engineering using genome-scale technologies
    • Griffin TJ, Seth G, Xie H, Bandhakavi S, Hu WS. 2007. Advancing mammalian cell culture engineering using genome-scale technologies. Trends Biotechnol 25: 401-408. http://www.ncbi.nlm.nih.gov/pubmed/17681628
    • (2007) Trends Biotechnol , vol.25 , pp. 401-408
    • Griffin, T.J.1    Seth, G.2    Xie, H.3    Bandhakavi, S.4    Hu, W.S.5
  • 63
    • 3943056897 scopus 로고    scopus 로고
    • Role of glycosylation in development
    • Haltiwanger RS, Lowe JB. 2004. Role of glycosylation in development. Annu Rev Biochem 73: 491-537. http://www.ncbi.nlm.nih.gov/pubmed/15189151
    • (2004) Annu Rev Biochem , vol.73 , pp. 491-537
    • Haltiwanger, R.S.1    Lowe, J.B.2
  • 64
    • 0033735527 scopus 로고    scopus 로고
    • The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells
    • Hammill L, Welles J, Carson GR. 2000. The gel microdrop secretion assay: Identification of a low productivity subpopulation arising during the production of human antibody in CHO cells. Cytotechnology 34: 27-37. http://www.ncbi.nlm.nih.gov/pubmed/19003378
    • (2000) Cytotechnology , vol.34 , pp. 27-37
    • Hammill, L.1    Welles, J.2    Carson, G.R.3
  • 65
    • 84862778524 scopus 로고    scopus 로고
    • Profiling conserved microRNA expression in recombinant CHO cell lines using illumina sequencing
    • Hammond S, Swanberg JC, Polson SW, Lee KH. 2012. Profiling conserved microRNA expression in recombinant CHO cell lines using illumina sequencing. Biotechnol Bioeng 109: 1371-1375. http://www.ncbi.nlm.nih.gov/pubmed/22189905
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1371-1375
    • Hammond, S.1    Swanberg, J.C.2    Polson, S.W.3    Lee, K.H.4
  • 66
    • 0027112084 scopus 로고
    • Glucose-limited chemostat culture of Chinese hamster ovary cells producing recombinant human interferon-gamma
    • Hayter PM, Curling EM, Baines AJ, Jenkins N, Salmon I, Strange PG, Tong JM, Bull AT. 1992. Glucose-limited chemostat culture of Chinese hamster ovary cells producing recombinant human interferon-gamma. Biotechnol Bioeng 39: 327-335. http://www.ncbi.nlm.nih.gov/pubmed/18600949
    • (1992) Biotechnol Bioeng , vol.39 , pp. 327-335
    • Hayter, P.M.1    Curling, E.M.2    Baines, A.J.3    Jenkins, N.4    Salmon, I.5    Strange, P.G.6    Tong, J.M.7    Bull, A.T.8
  • 67
    • 34247181579 scopus 로고    scopus 로고
    • A novel RNA silencing vector to improve antigen expression and stability in Chinese hamster ovary cells
    • Hong WW, Wu SC. 2007. A novel RNA silencing vector to improve antigen expression and stability in Chinese hamster ovary cells. Vaccine 25: 4103-4111. http://www.ncbi.nlm.nih.gov/pubmed/17428585
    • (2007) Vaccine , vol.25 , pp. 4103-4111
    • Hong, W.W.1    Wu, S.C.2
  • 68
    • 34147179033 scopus 로고    scopus 로고
    • An efficient and targeted gene integration system for high-level antibody expression
    • Huang Y, Li Y, Wang YG, Gu X, Wang Y, Shen BF. 2007. An efficient and targeted gene integration system for high-level antibody expression. J Immunol Methods 322: 28-39. http://www.ncbi.nlm.nih.gov/pubmed/17350648
    • (2007) J Immunol Methods , vol.322 , pp. 28-39
    • Huang, Y.1    Li, Y.2    Wang, Y.G.3    Gu, X.4    Wang, Y.5    Shen, B.F.6
  • 69
    • 79952202624 scopus 로고    scopus 로고
    • Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment
    • Huang Y-M, Hu W, Rustandi E, Chang K, Yusuf-Makagiansar H, Ryll T. 2010. Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment. Biotechnol Prog 26: 1400-1410. http://dx.doi.org/10.1002/btpr.436
    • (2010) Biotechnol Prog , vol.26 , pp. 1400-1410
    • Huang, Y.-M.1    Hu, W.2    Rustandi, E.3    Chang, K.4    Yusuf-Makagiansar, H.5    Ryll, T.6
  • 70
    • 84859926395 scopus 로고    scopus 로고
    • A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells
    • DOI: 10.1002/bit.24490
    • Jadhav V, Hackl M, Hernandez BortJA, Wieser M, Harreither E, Kunert R, Borth N, Grillari J. 2012. A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells. Biotechnol Bioeng 109: 1376-1385. DOI: 10.1002/bit.24490
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1376-1385
    • Jadhav, V.1    Hackl, M.2    Hernandez, B.3    Wieser, M.4    Harreither, E.5    Kunert, R.6    Borth, N.7    Grillari, J.8
  • 72
    • 41849140828 scopus 로고    scopus 로고
    • Recombinant protein therapeutics from Cho Cells-20 years and counting. CHO Consortium: SBE Special Edition: -.
    • Jayapal KP, Wlaschin KF, Hu W-S, Yap MGS. 2007. Recombinant protein therapeutics from Cho Cells-20 years and counting. CHO Consortium: SBE Special Edition: 40-47.
    • (2007) , pp. 40-47
    • Jayapal, K.P.1    Wlaschin, K.F.2    Hu, W.-S.3    Yap, M.G.S.4
  • 73
    • 0029837484 scopus 로고    scopus 로고
    • Getting the glycosylation right: Implications for the biotechnology industry
    • Jenkins N, Parekh RB, James DC. 1996. Getting the glycosylation right: Implications for the biotechnology industry. Nat Biotechnol 14: 975-981.
    • (1996) Nat Biotechnol , vol.14 , pp. 975-981
    • Jenkins, N.1    Parekh, R.B.2    James, D.C.3
  • 74
    • 82355176018 scopus 로고    scopus 로고
    • Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells
    • Jeon M, Yu D, Lee G. 2011. Combinatorial engineering of ldh-a and bcl-2 for reducing lactate production and improving cell growth in dihydrofolate reductase-deficient Chinese hamster ovary cells. Appl Microbiol Biotechnol 92: 779-790. http://dx.doi.org/10.1007/s00253-011-3475-0
    • (2011) Appl Microbiol Biotechnol , vol.92 , pp. 779-790
    • Jeon, M.1    Yu, D.2    Lee, G.3
  • 75
    • 66149104098 scopus 로고    scopus 로고
    • Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells
    • Jeong YT, Choi O, Son YD, Park SY, Kim JH. 2009. Enhanced sialylation of recombinant erythropoietin in genetically engineered Chinese-hamster ovary cells. Biotechnol Appl Biochem 52: 283-291. http://www.ncbi.nlm.nih.gov/pubmed/18590515
    • (2009) Biotechnol Appl Biochem , vol.52 , pp. 283-291
    • Jeong, Y.T.1    Choi, O.2    Son, Y.D.3    Park, S.Y.4    Kim, J.H.5
  • 76
    • 42549114735 scopus 로고    scopus 로고
    • Sodium butyrate stimulates monoclonal antibody over-expression in CHO cells by improving gene accessibility
    • Jiang Z, Sharfstein ST. 2008. Sodium butyrate stimulates monoclonal antibody over-expression in CHO cells by improving gene accessibility. Biotechnol Bioeng 100: 189-194. http://www.ncbi.nlm.nih.gov/pubmed/18023047
    • (2008) Biotechnol Bioeng , vol.100 , pp. 189-194
    • Jiang, Z.1    Sharfstein, S.T.2
  • 77
    • 83655201267 scopus 로고    scopus 로고
    • Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells
    • Jing Y, Borys M, Nayak S, Egan S, Qian Y, Pan S-H, Li ZJ. 2012a. Identification of cell culture conditions to control protein aggregation of IgG fusion proteins expressed in Chinese hamster ovary cells. Process Biochem 47: 69-75.
    • (2012) Process Biochem , vol.47 , pp. 69-75
    • Jing, Y.1    Borys, M.2    Nayak, S.3    Egan, S.4    Qian, Y.5    Pan, S.-H.6    Li, Z.J.7
  • 78
    • 84859638862 scopus 로고    scopus 로고
    • A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures
    • Jing Y, Qian Y, Ghandi M, He A, Borys MC, Pan SH, Li ZJ. 2012b. A mechanistic study on the effect of dexamethasone in moderating cell death in Chinese Hamster Ovary cell cultures. Biotechnol Prog 28: 490-496. http://www.ncbi.nlm.nih.gov/pubmed/22140034
    • (2012) Biotechnol Prog , vol.28 , pp. 490-496
    • Jing, Y.1    Qian, Y.2    Ghandi, M.3    He, A.4    Borys, M.C.5    Pan, S.H.6    Li, Z.J.7
  • 81
    • 27744540773 scopus 로고    scopus 로고
    • Dynamics of single cell property distributions in Chinese hamster ovary cell cultures monitored and controlled with automated flow cytometry
    • Kacmar J, Srienc F. 2005. Dynamics of single cell property distributions in Chinese hamster ovary cell cultures monitored and controlled with automated flow cytometry. J Biotechnol 120: 410-420. http://www.ncbi.nlm.nih.gov/pubmed/16144728
    • (2005) J Biotechnol , vol.120 , pp. 410-420
    • Kacmar, J.1    Srienc, F.2
  • 82
    • 33746888249 scopus 로고    scopus 로고
    • Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation
    • Kaneko Y, Nimmerjahn F, Ravetch JV. 2006. Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science 313: 670-673. http://www.sciencemag.org/content/313/5787/670.abstract
    • (2006) Science , vol.313 , pp. 670-673
    • Kaneko, Y.1    Nimmerjahn, F.2    Ravetch, J.V.3
  • 83
  • 84
    • 0022100495 scopus 로고
    • Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells
    • Kaufman RJ, Wasley LC, Spiliotes AJ, Gossels SD, Latt SA, Larsen GR, Kay RM. 1985. Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells. Mol Cell Biol 5: 1750-1759. http://www.ncbi.nlm.nih.gov/pubmed/4040603
    • (1985) Mol Cell Biol , vol.5 , pp. 1750-1759
    • Kaufman, R.J.1    Wasley, L.C.2    Spiliotes, A.J.3    Gossels, S.D.4    Latt, S.A.5    Larsen, G.R.6    Kay, R.M.7
  • 85
    • 0346094306 scopus 로고    scopus 로고
    • Improved recombinant gene expression in CHO cells using matrix attachment regions
    • Kim JM, Kim JS, Park DH, Kang HS, Yoon J, Baek K, Yoon Y. 2004. Improved recombinant gene expression in CHO cells using matrix attachment regions. J Biotechnol 107: 95-105. http://www.ncbi.nlm.nih.gov/pubmed/14711493
    • (2004) J Biotechnol , vol.107 , pp. 95-105
    • Kim, J.M.1    Kim, J.S.2    Park, D.H.3    Kang, H.S.4    Yoon, J.5    Baek, K.6    Yoon, Y.7
  • 86
    • 84856389498 scopus 로고    scopus 로고
    • CHO cells in biotechnology for production of recombinant proteins: Current state and further potential
    • Kim JY, Kim YG, Lee GM. 2012a. CHO cells in biotechnology for production of recombinant proteins: Current state and further potential. Appl Microbiol Biotechnol 93: 917-930. http://www.ncbi.nlm.nih.gov/pubmed/22159888
    • (2012) Appl Microbiol Biotechnol , vol.93 , pp. 917-930
    • Kim, J.Y.1    Kim, Y.G.2    Lee, G.M.3
  • 87
    • 84862798518 scopus 로고    scopus 로고
    • Differential in-gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: Osmoprotective effect of glycine betaine addition
    • Kim JY, Kim Y-G, Lee GM. 2012b. Differential in-gel electrophoresis (DIGE) analysis of CHO cells under hyperosmotic pressure: Osmoprotective effect of glycine betaine addition. Biotechnol Bioeng 109: 1395-1403. http://dx.doi.org/10.1002/bit.24442
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1395-1403
    • Kim, J.Y.1    Kim, Y.-G.2    Lee, G.M.3
  • 88
    • 0008451224 scopus 로고    scopus 로고
    • Clonal variability within dihydrofolate reductase-mediated gene amplified Chinese hamster ovary cells: Stability in the absence of selective pressure
    • Kim NS, Kim SJ, Lee GM. 1998. Clonal variability within dihydrofolate reductase-mediated gene amplified Chinese hamster ovary cells: Stability in the absence of selective pressure. Biotechnol Bioeng 60: 679-688. http://dx.doi.org/10.1002/(SICI)1097-0290(19981220)60:6<679::AID-BIT5>3.0.CO;2-Q
    • (1998) Biotechnol Bioeng , vol.60 , pp. 679-688
    • Kim, N.S.1    Kim, S.J.2    Lee, G.M.3
  • 89
    • 33846643485 scopus 로고    scopus 로고
    • Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin
    • Kim SH, Lee GM. 2007. Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin. Appl Microbiol Biotechnol 74: 152-159. http://www.ncbi.nlm.nih.gov/pubmed/17086415
    • (2007) Appl Microbiol Biotechnol , vol.74 , pp. 152-159
    • Kim, S.H.1    Lee, G.M.2
  • 90
    • 67349115980 scopus 로고    scopus 로고
    • Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments
    • Kim S, Lee G. 2009. Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments. Appl Microbiol Biotechnol 83: 639-648. http://dx.doi.org/10.1007/s00253-009-1903-1
    • (2009) Appl Microbiol Biotechnol , vol.83 , pp. 639-648
    • Kim, S.1    Lee, G.2
  • 91
    • 0037212982 scopus 로고    scopus 로고
    • Construction of engineered CHO strains for high-level production of recombinant proteins
    • Kito M, Itami S, Fukano Y, Yamana K, Shibui T. 2002. Construction of engineered CHO strains for high-level production of recombinant proteins. Appl Microbiol Biotechnol 60: 442-448. http://www.ncbi.nlm.nih.gov/pubmed/12466885
    • (2002) Appl Microbiol Biotechnol , vol.60 , pp. 442-448
    • Kito, M.1    Itami, S.2    Fukano, Y.3    Yamana, K.4    Shibui, T.5
  • 92
    • 67649518193 scopus 로고    scopus 로고
    • Methodological aspects of measuring absolute values of membrane potential in human cells by flow cytometry
    • Klapperstuck T, Glanz D, Klapperstuck M, Wohlrab J. 2009. Methodological aspects of measuring absolute values of membrane potential in human cells by flow cytometry. Cytometry A 75: 593-608.
    • (2009) Cytometry A , vol.75 , pp. 593-608
    • Klapperstuck, T.1    Glanz, D.2    Klapperstuck, M.3    Wohlrab, J.4
  • 93
    • 84875512625 scopus 로고    scopus 로고
    • Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment-Comparative transcriptome analysis with CHO cDNA microarrays
    • Klausing S, Kramer O, Noll T. 2011. Bioreactor cultivation of CHO DP-12 cells under sodium butyrate treatment-Comparative transcriptome analysis with CHO cDNA microarrays. BMC Proc 5(Suppl 8): P98. http://www.ncbi.nlm.nih.gov/pubmed/22373269
    • (2011) BMC Proc , vol.5 , Issue.SUPPL 8
    • Klausing, S.1    Kramer, O.2    Noll, T.3
  • 94
    • 38949167537 scopus 로고    scopus 로고
    • Proteomic profiling of secreted proteins from CHO cells using Surface-Enhanced Laser desorption ionization time-of-flight mass spectrometry
    • Kumar N, Maurya P, Gammell P, Dowling P, Clynes M, Meleady P. 2008. Proteomic profiling of secreted proteins from CHO cells using Surface-Enhanced Laser desorption ionization time-of-flight mass spectrometry. Biotechnol Prog 24: 273-278. http://www.ncbi.nlm.nih.gov/pubmed/18163642
    • (2008) Biotechnol Prog , vol.24 , pp. 273-278
    • Kumar, N.1    Maurya, P.2    Gammell, P.3    Dowling, P.4    Clynes, M.5    Meleady, P.6
  • 95
    • 84860441179 scopus 로고    scopus 로고
    • Flow-cytometry and cell sorting: An efficient approach to investigate productivity and cell physiology in mammalian cell factories
    • Kumar N, Borth N. 2012. Flow-cytometry and cell sorting: An efficient approach to investigate productivity and cell physiology in mammalian cell factories. Methods 56: 366-374. http://www.sciencedirect.com/science/article/pii/S1046202312000515
    • (2012) Methods , vol.56 , pp. 366-374
    • Kumar, N.1    Borth, N.2
  • 96
    • 34250647014 scopus 로고    scopus 로고
    • Using cell engineering and omic tools for the improvement of cell culture processes
    • Kuystermans D, Krampe B, Swiderek H, Al-Rubeai M. 2007. Using cell engineering and omic tools for the improvement of cell culture processes. Cytotechnology 53: 3-22. http://www.ncbi.nlm.nih.gov/pubmed/19003186
    • (2007) Cytotechnology , vol.53 , pp. 3-22
    • Kuystermans, D.1    Krampe, B.2    Swiderek, H.3    Al-Rubeai, M.4
  • 98
    • 33644500399 scopus 로고    scopus 로고
    • Employing epigenetics to augment the expression of therapeutic proteins in mammalian cells
    • Kwaks TH, Otte AP. 2006. Employing epigenetics to augment the expression of therapeutic proteins in mammalian cells. Trends Biotechnol 24: 137-142. http://www.ncbi.nlm.nih.gov/pubmed/16460822
    • (2006) Trends Biotechnol , vol.24 , pp. 137-142
    • Kwaks, T.H.1    Otte, A.P.2
  • 99
    • 51849111124 scopus 로고    scopus 로고
    • Generation of high-level stable transgene expressing human embryonic stem cell lines using chinese hamster elongation factor-1α promoter system
    • Kwok-Keung Chan K, Meiyun Wu S, Morin Nissom P, Oh SKW, Choo ABH. 2008. Generation of high-level stable transgene expressing human embryonic stem cell lines using chinese hamster elongation factor-1α promoter system. Stem Cells Dev 17: 825-836. http://www.ncbi.nlm.nih.gov/pubmed/18788934
    • (2008) Stem Cells Dev , vol.17 , pp. 825-836
    • Kwok-Keung Chan, K.1    Meiyun Wu, S.2    Morin Nissom, P.3    Oh, S.K.W.4    Choo, A.B.H.5
  • 100
    • 84860434525 scopus 로고    scopus 로고
    • Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry
    • Lee JS, Lee GM. 2012. Monitoring of autophagy in Chinese hamster ovary cells using flow cytometry. Methods 56: 375-382. http://www.ncbi.nlm.nih.gov/pubmed/22142658
    • (2012) Methods , vol.56 , pp. 375-382
    • Lee, J.S.1    Lee, G.M.2
  • 101
    • 84861440312 scopus 로고    scopus 로고
    • Systems metabolic engineering of microorganisms for natural and non-natural chemicals
    • Lee JW, Na D, Park JM, Lee J, Choi S, Lee SY. 2012. Systems metabolic engineering of microorganisms for natural and non-natural chemicals. Nat Chem Biol 8: 536-546. http://dx.doi.org/10.1038/nchembio.970
    • (2012) Nat Chem Biol , vol.8 , pp. 536-546
    • Lee, J.W.1    Na, D.2    Park, J.M.3    Lee, J.4    Choi, S.5    Lee, S.Y.6
  • 102
    • 70350512964 scopus 로고    scopus 로고
    • A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells
    • Legmann R, Schreyer HB, Combs RG, McCormick EL, Russo AP, Rodgers ST. 2009. A predictive high-throughput scale-down model of monoclonal antibody production in CHO cells. Biotechnol Bioeng 104: 1107-1120. http://dx.doi.org/10.1002/bit.22474
    • (2009) Biotechnol Bioeng , vol.104 , pp. 1107-1120
    • Legmann, R.1    Schreyer, H.B.2    Combs, R.G.3    McCormick, E.L.4    Russo, A.P.5    Rodgers, S.T.6
  • 103
    • 84858617893 scopus 로고    scopus 로고
    • Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance
    • Li J, Wong CL, Vijayasankaran N, Hudson T, Amanullah A. 2012. Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance. Biotechnol Bioeng 109: 1173-1186. http://dx.doi.org/10.1002/bit.24389
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1173-1186
    • Li, J.1    Wong, C.L.2    Vijayasankaran, N.3    Hudson, T.4    Amanullah, A.5
  • 104
    • 33749435598 scopus 로고    scopus 로고
    • RNAi suppression of Bax and Bak enhances viability in fed-batch cultures of CHO cells
    • Lim SF, Chuan KH, Liu S, Loh SO, Chung BY, Ong CC, Song Z. 2006. RNAi suppression of Bax and Bak enhances viability in fed-batch cultures of CHO cells. Metab Eng 8: 509-522. http://www.ncbi.nlm.nih.gov/pubmed/16860584
    • (2006) Metab Eng , vol.8 , pp. 509-522
    • Lim, S.F.1    Chuan, K.H.2    Liu, S.3    Loh, S.O.4    Chung, B.Y.5    Ong, C.C.6    Song, Z.7
  • 105
    • 79961021060 scopus 로고    scopus 로고
    • Profiling highly conserved microrna expression in recombinant IgG-producing and parental Chinese hamster ovary cells
    • Lin N, Davis A, Bahr S, Borgschulte T, Achtien K, Kayser K. 2011. Profiling highly conserved microrna expression in recombinant IgG-producing and parental Chinese hamster ovary cells. Biotechnol Prog 27: 1163-1171. http://www.ncbi.nlm.nih.gov/pubmed/21692195
    • (2011) Biotechnol Prog , vol.27 , pp. 1163-1171
    • Lin, N.1    Davis, A.2    Bahr, S.3    Borgschulte, T.4    Achtien, K.5    Kayser, K.6
  • 106
    • 61449171129 scopus 로고    scopus 로고
    • Lessons learned from the contamination of heparin
    • Liu H, Zhang Z, Linhardt RJ. 2009. Lessons learned from the contamination of heparin. Nat Prod Rep 26: 313-321. http://www.ncbi.nlm.nih.gov/pubmed/19240943
    • (2009) Nat Prod Rep , vol.26 , pp. 313-321
    • Liu, H.1    Zhang, Z.2    Linhardt, R.J.3
  • 107
    • 79957977463 scopus 로고    scopus 로고
    • Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein
    • Lu H, Wang X, Li T, Urvalek AM, Yu L, Li J, Zhu J, Lin Q, Peng X, Zhao J. 2011. Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein. J Biol Chem 286: 20335-20344. http://www.ncbi.nlm.nih.gov/pubmed/21518760
    • (2011) J Biol Chem , vol.286 , pp. 20335-20344
    • Lu, H.1    Wang, X.2    Li, T.3    Urvalek, A.M.4    Yu, L.5    Li, J.6    Zhu, J.7    Lin, Q.8    Peng, X.9    Zhao, J.10
  • 108
    • 70350136377 scopus 로고    scopus 로고
    • A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism
    • Ma N, Ellet J, Okediadi C, Hermes P, McCormick E, Casnocha S. 2009. A single nutrient feed supports both chemically defined NS0 and CHO fed-batch processes: Improved productivity and lactate metabolism. Biotechnol Prog 25: 1353-1363. http://dx.doi.org/10.1002/btpr.238
    • (2009) Biotechnol Prog , vol.25 , pp. 1353-1363
    • Ma, N.1    Ellet, J.2    Okediadi, C.3    Hermes, P.4    McCormick, E.5    Casnocha, S.6
  • 109
    • 69149086474 scopus 로고    scopus 로고
    • Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells
    • Majors BS, Betenbaugh MJ, Pederson NE, Chiang GG. 2009. Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells. Biotechnol Prog 25: 1161-1168. http://dx.doi.org/10.1002/btpr.192
    • (2009) Biotechnol Prog , vol.25 , pp. 1161-1168
    • Majors, B.S.1    Betenbaugh, M.J.2    Pederson, N.E.3    Chiang, G.G.4
  • 110
    • 77956886210 scopus 로고    scopus 로고
    • A high-throughput method for quantification of glycoprotein sialylation
    • Markely LRA, Ong BT, Hoi KM, Teo G, Lu MY, Wang DIC. 2010. A high-throughput method for quantification of glycoprotein sialylation. Anal Biochem 407: 128-133. http://www.sciencedirect.com/science/article/pii/S0003269710004902
    • (2010) Anal Biochem , vol.407 , pp. 128-133
    • Markely, L.R.A.1    Ong, B.T.2    Hoi, K.M.3    Teo, G.4    Lu, M.Y.5    Wang, D.I.C.6
  • 111
    • 34250625244 scopus 로고    scopus 로고
    • Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes
    • Meleady P. 2007. Proteomic profiling of recombinant cells from large-scale mammalian cell culture processes. Cytotechnology 53: 23-31. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267616
    • (2007) Cytotechnology , vol.53 , pp. 23-31
    • Meleady, P.1
  • 112
    • 84864067310 scopus 로고    scopus 로고
    • Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells
    • Meleady P, Gallagher M, Clarke C, Henry M, Sanchez N, Barron N, Clynes M. 2012a. Impact of miR-7 over-expression on the proteome of Chinese hamster ovary cells. J Biotechnol 160(3-4): 251-262. http://www.ncbi.nlm.nih.gov/pubmed/22445466
    • (2012) J Biotechnol , vol.160 , Issue.3-4 , pp. 251-262
    • Meleady, P.1    Gallagher, M.2    Clarke, C.3    Henry, M.4    Sanchez, N.5    Barron, N.6    Clynes, M.7
  • 115
    • 79960570244 scopus 로고    scopus 로고
    • Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: Proteome analysis of the molecular basis for a process-related phenotype
    • Meleady P, Doolan P, Henry M, Barron N, Keenan J, O'Sullivan F, Clarke C, Gammell P, Melville M, Leonard M, Clynes M. 2011. Sustained productivity in recombinant Chinese Hamster Ovary (CHO) cell lines: Proteome analysis of the molecular basis for a process-related phenotype. BMC Biotechnol 11: 78. http://www.biomedcentral.com/1472-6750/11/78
    • (2011) BMC Biotechnol , vol.11 , pp. 78
    • Meleady, P.1    Doolan, P.2    Henry, M.3    Barron, N.4    Keenan, J.5    O'Sullivan, F.6    Clarke, C.7    Gammell, P.8    Melville, M.9    Leonard, M.10    Clynes, M.11
  • 116
    • 80051471205 scopus 로고    scopus 로고
    • Development and characterization of a Chinese hamster ovary cell-specific oligonucleotide microarray
    • Melville M, Doolan P, Mounts W, Barron N, Hann L, Leonard M, Clynes M, Charlebois T. 2011. Development and characterization of a Chinese hamster ovary cell-specific oligonucleotide microarray. Biotechnol Lett 33: 1773-1779. http://www.ncbi.nlm.nih.gov/pubmed/21547514
    • (2011) Biotechnol Lett , vol.33 , pp. 1773-1779
    • Melville, M.1    Doolan, P.2    Mounts, W.3    Barron, N.4    Hann, L.5    Leonard, M.6    Clynes, M.7    Charlebois, T.8
  • 117
    • 44949158950 scopus 로고    scopus 로고
    • Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells
    • Mohan C, Kim Y-G, Koo J, Lee GM. 2008. Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells. Biotechnol J 3: 624-630. http://dx.doi.org/10.1002/biot.200700249
    • (2008) Biotechnol J , vol.3 , pp. 624-630
    • Mohan, C.1    Kim, Y.-G.2    Koo, J.3    Lee, G.M.4
  • 118
    • 84860461854 scopus 로고    scopus 로고
    • Apoptosis and autophagy cell engineering
    • Al-Rubeai M, editor. Vol. 6. Netherlands: Springer
    • Mohan C, Kim Y-G, Lee GM. 2009. Apoptosis and autophagy cell engineering. In: Al-Rubeai M, editor. Cell line development. Vol. 6. Netherlands: Springer. p 195-216.
    • (2009) Cell line development , pp. 195-216
    • Mohan, C.1    Kim, Y.-G.2    Lee, G.M.3
  • 120
    • 45049085323 scopus 로고    scopus 로고
    • MicroRNAs as targets for engineering of CHO cell factories
    • Muller D, Katinger H, Grillari J. 2008. MicroRNAs as targets for engineering of CHO cell factories. Trends Biotechnol 26: 359-365. http://www.ncbi.nlm.nih.gov/pubmed/18471912
    • (2008) Trends Biotechnol , vol.26 , pp. 359-365
    • Muller, D.1    Katinger, H.2    Grillari, J.3
  • 121
    • 48649107131 scopus 로고    scopus 로고
    • The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells
    • Nam JH, Zhang F, Ermonval M, Linhardt RJ, Sharfstein ST. 2008. The effects of culture conditions on the glycosylation of secreted human placental alkaline phosphatase produced in Chinese hamster ovary cells. Biotechnol Bioeng 100: 1178-1192. http://www.ncbi.nlm.nih.gov/pubmed/18553404
    • (2008) Biotechnol Bioeng , vol.100 , pp. 1178-1192
    • Nam, J.H.1    Zhang, F.2    Ermonval, M.3    Linhardt, R.J.4    Sharfstein, S.T.5
  • 122
    • 33748438957 scopus 로고    scopus 로고
    • RNA interference of sialidase improves glycoprotein sialic acid content consistency
    • Ngantung FA, Miller PG, Brushett FR, Tang GL, Wang DI. 2006. RNA interference of sialidase improves glycoprotein sialic acid content consistency. Biotechnol Bioeng 95: 106-119. http://www.ncbi.nlm.nih.gov/pubmed/16673415
    • (2006) Biotechnol Bioeng , vol.95 , pp. 106-119
    • Ngantung, F.A.1    Miller, P.G.2    Brushett, F.R.3    Tang, G.L.4    Wang, D.I.5
  • 123
    • 79957904069 scopus 로고    scopus 로고
    • In vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells
    • Nicolette J, Diehl M, Sonders P, Bryce S, Blomme E. 2011. In vitro micronucleus screening of pharmaceutical candidates by flow cytometry in Chinese hamster V79 cells. Environ Mol Mutagen 52: 355-362. http://www.ncbi.nlm.nih.gov/pubmed/20963813
    • (2011) Environ Mol Mutagen , vol.52 , pp. 355-362
    • Nicolette, J.1    Diehl, M.2    Sonders, P.3    Bryce, S.4    Blomme, E.5
  • 125
    • 0028798520 scopus 로고
    • Immunogenicity of N-glycolylneuraminic acid-containing carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells
    • Noguchi A, Mukuria CJ, Suzuki E, Naiki M. 1995. Immunogenicity of N-glycolylneuraminic acid-containing carbohydrate chains of recombinant human erythropoietin expressed in Chinese hamster ovary cells. J Biol Chem 117: 59-62. http://jb.oxfordjournals.org/content/117/1/59
    • (1995) J Biol Chem , vol.117 , pp. 59-62
    • Noguchi, A.1    Mukuria, C.J.2    Suzuki, E.3    Naiki, M.4
  • 127
    • 77950881484 scopus 로고    scopus 로고
    • Cell engineering and cultivation of Chinese hamster ovary (CHO) cells
    • Omasa T, Onitsuka M, Kim WD. 2010. Cell engineering and cultivation of Chinese hamster ovary (CHO) cells. Curr Pharm Biotechnol 11: 233-240. http://www.ncbi.nlm.nih.gov/pubmed/20210750
    • (2010) Curr Pharm Biotechnol , vol.11 , pp. 233-240
    • Omasa, T.1    Onitsuka, M.2    Kim, W.D.3
  • 128
    • 77954203178 scopus 로고    scopus 로고
    • Array-based analysis of secreted glycoproteins for rapid selection of a single cell producing a glycoprotein with desired glycosylation
    • Park S, Kim W, Kim Y, Son YD, Lee S-C, Kim E, Kim SH, Kim JH, Kim H-S. 2010. Array-based analysis of secreted glycoproteins for rapid selection of a single cell producing a glycoprotein with desired glycosylation. Anal Chem 82: 5830-5837. http://dx.doi.org/10.1021/ac100992n
    • (2010) Anal Chem , vol.82 , pp. 5830-5837
    • Park, S.1    Kim, W.2    Kim, Y.3    Son, Y.D.4    Lee, S.-C.5    Kim, E.6    Kim, S.H.7    Kim, J.H.8    Kim, H.-S.9
  • 129
    • 0024431691 scopus 로고
    • Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation
    • Paulson JC, Colley KJ. 1989. Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation. J Biol Chem 264: 17615-17618.
    • (1989) J Biol Chem , vol.264 , pp. 17615-17618
    • Paulson, J.C.1    Colley, K.J.2
  • 130
    • 78650204558 scopus 로고    scopus 로고
    • Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting
    • Pichler J, Galosy S, Mott J, Borth N. 2011. Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting. Biotechnol Bioeng 108: 386-394. http://dx.doi.org/10.1002/bit.22946
    • (2011) Biotechnol Bioeng , vol.108 , pp. 386-394
    • Pichler, J.1    Galosy, S.2    Mott, J.3    Borth, N.4
  • 131
    • 77954076709 scopus 로고    scopus 로고
    • Intraclonal protein expression heterogeneity in recombinant CHO cells
    • Pilbrough W, Munro TP, Gray P. 2009. Intraclonal protein expression heterogeneity in recombinant CHO cells. PLoS ONE 4: e8432. http://dx.doi.org/10.1371/journal.pone.0008432
    • (2009) PLoS ONE , vol.4
    • Pilbrough, W.1    Munro, T.P.2    Gray, P.3
  • 132
    • 0032552221 scopus 로고    scopus 로고
    • Antisense strategies for glycosylation engineering of Chinese hamster ovary (CHO) cells
    • Prati EG, Scheidegger P, Sburlati AR, Bailey JE. 1998. Antisense strategies for glycosylation engineering of Chinese hamster ovary (CHO) cells. BiotechnolBioeng 59(4): 445-450. http://www.ncbi.nlm.nih.gov/pubmed/10099358
    • (1998) BiotechnolBioeng , vol.59 , Issue.4 , pp. 445-450
    • Prati, E.G.1    Scheidegger, P.2    Sburlati, A.R.3    Bailey, J.E.4
  • 133
    • 0000291202 scopus 로고
    • A rapid method for viable cell titration and clone production with hela cells in tissue culture: The use of X-irradiated cells to supply conditioning factors
    • Puck TT, Marcus PI. 1955. A rapid method for viable cell titration and clone production with hela cells in tissue culture: The use of X-irradiated cells to supply conditioning factors. Proc Natl Acad Sci USA 41: 432-437. http://www.ncbi.nlm.nih.gov/pubmed/16589695
    • (1955) Proc Natl Acad Sci USA , vol.41 , pp. 432-437
    • Puck, T.T.1    Marcus, P.I.2
  • 134
    • 0019863416 scopus 로고
    • Co-expression and amplification of dihydrofolate reductase cDNA and the Escherichia coli XGPRT gene in Chinese hamster ovary cells
    • Ringold G, Dieckmann B, Lee F. 1981. Co-expression and amplification of dihydrofolate reductase cDNA and the Escherichia coli XGPRT gene in Chinese hamster ovary cells. J Mol Appl Genet 1: 165-175. http://www.ncbi.nlm.nih.gov/pubmed/6180118
    • (1981) J Mol Appl Genet , vol.1 , pp. 165-175
    • Ringold, G.1    Dieckmann, B.2    Lee, F.3
  • 135
    • 84862204695 scopus 로고    scopus 로고
    • Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures
    • Rouiller Y, Périlleux A, Marsaut M, Stettler M, Vesin M-N, Broly H. 2012. Effect of hydrocortisone on the production and glycosylation of an Fc-fusion protein in CHO cell cultures. Biotechnol Prog 28: 803-813. http://dx.doi.org/10.1002/btpr.1530
    • (2012) Biotechnol Prog , vol.28 , pp. 803-813
    • Rouiller, Y.1    Périlleux, A.2    Marsaut, M.3    Stettler, M.4    Vesin, M.-N.5    Broly, H.6
  • 136
    • 2942709860 scopus 로고    scopus 로고
    • High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene
    • Running Deer J, Allison DS. 2004. High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-1alpha gene. Biotechnol Prog 20: 880-889. http://www.ncbi.nlm.nih.gov/pubmed/15176895
    • (2004) Biotechnol Prog , vol.20 , pp. 880-889
    • Running Deer, J.1    Allison, D.S.2
  • 137
    • 58149460015 scopus 로고    scopus 로고
    • Effective quenching processes for physiologically valid metabolite profiling of suspension cultured mammalian cells
    • Sellick CA, Hansen R, Maqsood AR, Dunn WB, Stephens GM, Goodacre R, Dickson AJ. 2009. Effective quenching processes for physiologically valid metabolite profiling of suspension cultured mammalian cells. Anal Chem 81: 174-183. http://pubs.acs.org/doi/abs/10.1021/ac8016899
    • (2009) Anal Chem , vol.81 , pp. 174-183
    • Sellick, C.A.1    Hansen, R.2    Maqsood, A.R.3    Dunn, W.B.4    Stephens, G.M.5    Goodacre, R.6    Dickson, A.J.7
  • 138
    • 84862784156 scopus 로고    scopus 로고
    • Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture
    • Selvarasu S, Ho YS, Chong WP, Wong NS, Yusufi FN, Lee YY, Yap MG, Lee DY. 2012. Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture. Biotechnol Bioeng 109: 1415-1429. http://www.ncbi.nlm.nih.gov/pubmed/22252269
    • (2012) Biotechnol Bioeng , vol.109 , pp. 1415-1429
    • Selvarasu, S.1    Ho, Y.S.2    Chong, W.P.3    Wong, N.S.4    Yusufi, F.N.5    Lee, Y.Y.6    Yap, M.G.7    Lee, D.Y.8
  • 139
    • 37549043566 scopus 로고    scopus 로고
    • In pursuit of a super producer-alternative paths to high producing recombinant mammalian cells
    • Seth G, Charaniya S, Wlaschin KF, Hu WS. 2007. In pursuit of a super producer-alternative paths to high producing recombinant mammalian cells. Curr Opin Biotechnol 18: 557-564. http://www.ncbi.nlm.nih.gov/pubmed/18082393
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 557-564
    • Seth, G.1    Charaniya, S.2    Wlaschin, K.F.3    Hu, W.S.4
  • 140
    • 0027339137 scopus 로고
    • Carbohydrates in cell recognition
    • Sharon N, Lis H. 1993. Carbohydrates in cell recognition. Sci Am 268: 82-89. http://www.ncbi.nlm.nih.gov/pubmed/7678182
    • (1993) Sci Am , vol.268 , pp. 82-89
    • Sharon, N.1    Lis, H.2
  • 141
    • 77957123642 scopus 로고    scopus 로고
    • Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures
    • Shen D, Kiehl TR, Khattak SF, Li ZJ, He A, Kayne PS, Patel V, Neuhaus IM, Sharfstein ST. 2010. Transcriptomic responses to sodium chloride-induced osmotic stress: A study of industrial fed-batch CHO cell cultures. Biotechnol Prog 26: 1104-1115. http://www.ncbi.nlm.nih.gov/pubmed/20306541
    • (2010) Biotechnol Prog , vol.26 , pp. 1104-1115
    • Shen, D.1    Kiehl, T.R.2    Khattak, S.F.3    Li, Z.J.4    He, A.5    Kayne, P.S.6    Patel, V.7    Neuhaus, I.M.8    Sharfstein, S.T.9
  • 142
    • 80053916832 scopus 로고    scopus 로고
    • A high-throughput automated platform for the development of manufacturing cell lines for protein therapeutics
    • Shi S, Condon RG, Deng L, Saunders J, Hung F, Tsao YS, Liu Z. 2011. A high-throughput automated platform for the development of manufacturing cell lines for protein therapeutics. J Vis Exp (55): e3010
    • (2011) J Vis Exp , vol.55
    • Shi, S.1    Condon, R.G.2    Deng, L.3    Saunders, J.4    Hung, F.5    Tsao, Y.S.6    Liu, Z.7
  • 143
    • 79951694132 scopus 로고    scopus 로고
    • Meganucleases and other tools for targeted genome engineering: Perspectives and challenges for gene therapy
    • Silva G, Poirot L, Galetto R, Smith J, Montoya G, Duchateau P, Paques F. 2011. Meganucleases and other tools for targeted genome engineering: Perspectives and challenges for gene therapy. Curr Gene Ther 11: 11-27. http://www.hubmed.org/display.cgi?uids=21182466
    • (2011) Curr Gene Ther , vol.11 , pp. 11-27
    • Silva, G.1    Poirot, L.2    Galetto, R.3    Smith, J.4    Montoya, G.5    Duchateau, P.6    Paques, F.7
  • 144
    • 25444435396 scopus 로고    scopus 로고
    • Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins
    • Sinclair AM, Elliott S. 2005. Glycoengineering: The effect of glycosylation on the properties of therapeutic proteins. J Pharm Sci 94: 1626-1635. http://www.ncbi.nlm.nih.gov/pubmed/15959882
    • (2005) J Pharm Sci , vol.94 , pp. 1626-1635
    • Sinclair, A.M.1    Elliott, S.2
  • 145
    • 79960209555 scopus 로고    scopus 로고
    • Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes
    • Son Y-D, Jeong YT, Park S-Y, Kim JH. 2011. Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes. Glycobiology 21: 1019-1028. http://www.ncbi.nlm.nih.gov/pubmed/21436238
    • (2011) Glycobiology , vol.21 , pp. 1019-1028
    • Son, Y.-D.1    Jeong, Y.T.2    Park, S.-Y.3    Kim, J.H.4
  • 146
    • 29044436756 scopus 로고    scopus 로고
    • Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin
    • Sung YH, Hwang SJ, Lee GM. 2005. Influence of down-regulation of caspase-3 by siRNAs on sodium-butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin. Metab Eng 7: 457-466. http://www.ncbi.nlm.nih.gov/pubmed/16169764
    • (2005) Metab Eng , vol.7 , pp. 457-466
    • Sung, Y.H.1    Hwang, S.J.2    Lee, G.M.3
  • 147
    • 35549010214 scopus 로고    scopus 로고
    • Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin
    • Sung YH, Lee JS, Park SH, Koo J, Lee GM. 2007. Influence of co-down-regulation of caspase-3 and caspase-7 by siRNAs on sodium butyrate-induced apoptotic cell death of Chinese hamster ovary cells producing thrombopoietin. Metab Eng 9: 452-464. http://www.ncbi.nlm.nih.gov/pubmed/17892962
    • (2007) Metab Eng , vol.9 , pp. 452-464
    • Sung, Y.H.1    Lee, J.S.2    Park, S.H.3    Koo, J.4    Lee, G.M.5
  • 148
    • 84875515777 scopus 로고    scopus 로고
    • LDH-C can be differentially expressed during fermentation of CHO cells
    • Szperalski B, Jung C, Shao Z, Kantardjieff A, Hu WS. 2011. LDH-C can be differentially expressed during fermentation of CHO cells. BMC Proc 5(Suppl 8): P107. http://www.ncbi.nlm.nih.gov/pubmed/22373157
    • (2011) BMC Proc , vol.5 , Issue.SUPPL 8
    • Szperalski, B.1    Jung, C.2    Shao, Z.3    Kantardjieff, A.4    Hu, W.S.5
  • 149
    • 84868134349 scopus 로고    scopus 로고
    • The characterization and quantitation of glycomic changes in CHO cells during a bioreactor campaign
    • Tep S, Hincapie M, Hancock WS. 2012. The characterization and quantitation of glycomic changes in CHO cells during a bioreactor campaign. Biotechnol Bioeng 109: 3007-3017. http://www.ncbi.nlm.nih.gov/pubmed/22752974
    • (2012) Biotechnol Bioeng , vol.109 , pp. 3007-3017
    • Tep, S.1    Hincapie, M.2    Hancock, W.S.3
  • 150
    • 0025214337 scopus 로고
    • The role of carbohydrate in recombinant human erythropoietin
    • Tsuda E, Kawanishi G, Ueda M, Masuda S, Sasaki R. 1990. The role of carbohydrate in recombinant human erythropoietin. Eur J Biochem 188: 405-411. http://www.ncbi.nlm.nih.gov/pubmed/2156701
    • (1990) Eur J Biochem , vol.188 , pp. 405-411
    • Tsuda, E.1    Kawanishi, G.2    Ueda, M.3    Masuda, S.4    Sasaki, R.5
  • 152
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. 2006. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20: 515-524. http://www.ncbi.nlm.nih.gov/pubmed/16510870
    • (2006) Genes Dev , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 154
    • 0035370656 scopus 로고    scopus 로고
    • A flow cytometry technique for measuring chromosome-mediated gene transfer
    • Vanderbyl S, MacDonald N, de Jong G. 2001. A flow cytometry technique for measuring chromosome-mediated gene transfer. Cytometry 44: 100-105. http://www.ncbi.nlm.nih.gov/pubmed/11378859
    • (2001) Cytometry , vol.44 , pp. 100-105
    • Vanderbyl, S.1    MacDonald, N.2    de Jong, G.3
  • 155
    • 0027318961 scopus 로고
    • Biological roles of oligosaccharides: All of the theories are correct
    • Varki A. 1993. Biological roles of oligosaccharides: All of the theories are correct. Glycobiology 3: 97-130. http://www.ncbi.nlm.nih.gov/pubmed/8490246
    • (1993) Glycobiology , vol.3 , pp. 97-130
    • Varki, A.1
  • 156
    • 0031976097 scopus 로고    scopus 로고
    • Factors controlling the glycosylation potential of the Golgi apparatus
    • Varki A. 1998. Factors controlling the glycosylation potential of the Golgi apparatus. Trends Cell Biol 8: 34-40. http://www.ncbi.nlm.nih.gov/pubmed/9695806
    • (1998) Trends Cell Biol , vol.8 , pp. 34-40
    • Varki, A.1
  • 157
    • 77956690413 scopus 로고    scopus 로고
    • Biopharmaceutical benchmarks 2010
    • Walsh G. 2010. Biopharmaceutical benchmarks 2010. Nat Biotechnol 28: 917-924. http://www.ncbi.nlm.nih.gov/pubmed/20829826
    • (2010) Nat Biotechnol , vol.28 , pp. 917-924
    • Walsh, G.1
  • 158
    • 33749860977 scopus 로고    scopus 로고
    • Post-translational modifications in the context of therapeutic proteins
    • Walsh G, Jefferis R. 2006. Post-translational modifications in the context of therapeutic proteins. Nat Biotechnol 24: 1241-1252. http://www.ncbi.nlm.nih.gov/pubmed/17033665
    • (2006) Nat Biotechnol , vol.24 , pp. 1241-1252
    • Walsh, G.1    Jefferis, R.2
  • 159
    • 0025222679 scopus 로고
    • Position effects on eukaryotic gene expression
    • Wilson C, Bellen HJ, Gehring WJ. 1990. Position effects on eukaryotic gene expression. Annu Rev Cell Biol 6: 679-714. http://www.ncbi.nlm.nih.gov/pubmed/2275824
    • (1990) Annu Rev Cell Biol , vol.6 , pp. 679-714
    • Wilson, C.1    Bellen, H.J.2    Gehring, W.J.3
  • 160
    • 34547518231 scopus 로고    scopus 로고
    • Engineering cell metabolism for high-density cell culture via manipulation of sugar transport
    • Wlaschin KF, Hu W-S. 2007. Engineering cell metabolism for high-density cell culture via manipulation of sugar transport. J Biotechnol 131: 168-176. http://www.ncbi.nlm.nih.gov/pubmed/17662499
    • (2007) J Biotechnol , vol.131 , pp. 168-176
    • Wlaschin, K.F.1    Hu, W.-S.2
  • 162
    • 33744455813 scopus 로고    scopus 로고
    • Targeting early apoptotic genes in batch and fed-batch CHO cell cultures
    • Wong DC, Wong KT, Nissom PM, Heng CK, Yap MG. 2006a. Targeting early apoptotic genes in batch and fed-batch CHO cell cultures. Biotechnol Bioeng 95: 350-361. http://www.ncbi.nlm.nih.gov/pubmed/16894638
    • (2006) Biotechnol Bioeng , vol.95 , pp. 350-361
    • Wong, D.C.1    Wong, K.T.2    Nissom, P.M.3    Heng, C.K.4    Yap, M.G.5
  • 163
    • 33646029110 scopus 로고    scopus 로고
    • Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells
    • Wong NS, Yap MG, Wang DI. 2006b. Enhancing recombinant glycoprotein sialylation through CMP-sialic acid transporter over expression in Chinese hamster ovary cells. Biotechnol Bioeng 93: 1005-1016. http://www.ncbi.nlm.nih.gov/pubmed/16432895
    • (2006) Biotechnol Bioeng , vol.93 , pp. 1005-1016
    • Wong, N.S.1    Yap, M.G.2    Wang, D.I.3
  • 164
    • 67349211749 scopus 로고    scopus 로고
    • RNA interference technology to improve recombinant protein production in Chinese hamster ovary cells
    • Wu SC. 2009. RNA interference technology to improve recombinant protein production in Chinese hamster ovary cells. Biotechnol Adv 27: 417-422. http://www.ncbi.nlm.nih.gov/pubmed/19289164
    • (2009) Biotechnol Adv , vol.27 , pp. 417-422
    • Wu, S.C.1
  • 165
    • 50049104724 scopus 로고    scopus 로고
    • Short hairpin RNA targeted to dihydrofolate reductase enhances the immunoglobulin G expression in gene-amplified stable Chinese hamster ovary cells
    • Wu SC, Hong WW, Liu JH. 2008. Short hairpin RNA targeted to dihydrofolate reductase enhances the immunoglobulin G expression in gene-amplified stable Chinese hamster ovary cells. Vaccine 26: 4969-4974. http://www.ncbi.nlm.nih.gov/pubmed/18602963
    • (2008) Vaccine , vol.26 , pp. 4969-4974
    • Wu, S.C.1    Hong, W.W.2    Liu, J.H.3
  • 166
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • Wurm FM. 2004. Production of recombinant protein therapeutics in cultivated mammalian cells. Nat Biotechnol 22: 1393-1398. http://www.ncbi.nlm.nih.gov/pubmed/15529164
    • (2004) Nat Biotechnol , vol.22 , pp. 1393-1398
    • Wurm, F.M.1
  • 168
    • 4644245850 scopus 로고    scopus 로고
    • Establishment of FUT8 knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity
    • Yamane-Ohnuki N, Kinoshita S, Inoue-Urakubo M, Kusunoki M, Iida S, Nakano R, Wakitani M, Niwa R, Sakurada M, Uchida K, Shitara K, Satoh M. 2004. Establishment of FUT8 knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody-dependent cellular cytotoxicity. Biotechnol Bioeng 87: 614-622. http://www.ncbi.nlm.nih.gov/pubmed/15352059
    • (2004) Biotechnol Bioeng , vol.87 , pp. 614-622
    • Yamane-Ohnuki, N.1    Kinoshita, S.2    Inoue-Urakubo, M.3    Kusunoki, M.4    Iida, S.5    Nakano, R.6    Wakitani, M.7    Niwa, R.8    Sakurada, M.9    Uchida, K.10    Shitara, K.11    Satoh, M.12
  • 169
    • 41249093488 scopus 로고    scopus 로고
    • Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment
    • Yee JC, de Leon Gatti M, Philp RJ, Yap M, Hu WS. 2008a. Genomic and proteomic exploration of CHO and hybridoma cells under sodium butyrate treatment. Biotechnol Bioeng 99: 1186-1204. http://www.ncbi.nlm.nih.gov/pubmed/17929327
    • (2008) Biotechnol Bioeng , vol.99 , pp. 1186-1204
    • Yee, J.C.1    de Leon Gatti, M.2    Philp, R.J.3    Yap, M.4    Hu, W.S.5
  • 170
    • 56749148174 scopus 로고    scopus 로고
    • Quality assessment of cross-species hybridization of CHO transcriptome on a mouse DNA oligo microarray
    • Yee JC, Wlaschin KF, Chuah SH, Nissom PM, Hu W-S. 2008b. Quality assessment of cross-species hybridization of CHO transcriptome on a mouse DNA oligo microarray. Biotechnol Bioeng 101: 1359-1365. http://www.ncbi.nlm.nih.gov/pubmed/18814282
    • (2008) Biotechnol Bioeng , vol.101 , pp. 1359-1365
    • Yee, J.C.1    Wlaschin, K.F.2    Chuah, S.H.3    Nissom, P.M.4    Hu, W.-S.5
  • 171
    • 0035957848 scopus 로고    scopus 로고
    • Development of stable cell lines for production or regulated expression using matrix attachment regions
    • Zahn-Zabal M, Kobr M, Girod PA, Imhof M, Chatellard P, de Jesus M, Wurm F, Mermod N. 2001. Development of stable cell lines for production or regulated expression using matrix attachment regions. J Biotechnol 87: 29-42. http://www.ncbi.nlm.nih.gov/pubmed/11267697
    • (2001) J Biotechnol , vol.87 , pp. 29-42
    • Zahn-Zabal, M.1    Kobr, M.2    Girod, P.A.3    Imhof, M.4    Chatellard, P.5    de Jesus, M.6    Wurm, F.7    Mermod, N.8
  • 172
    • 33751010743 scopus 로고    scopus 로고
    • CHO glycosylation mutants: Proteoglycans
    • Zhang L, Lawrence R, Frazier BA, Esko JD. 2006. CHO glycosylation mutants: Proteoglycans. Methods Enzymol 416: 205-221. http://www.ncbi.nlm.nih.gov/pubmed/17113868
    • (2006) Methods Enzymol , vol.416 , pp. 205-221
    • Zhang, L.1    Lawrence, R.2    Frazier, B.A.3    Esko, J.D.4
  • 173
    • 79955540196 scopus 로고    scopus 로고
    • Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases
    • Zhou M, Crawford Y, Ng D, Tung J, Pynn AFJ, Meier A, Yuk IH, Vijayasankaran N, Leach K, Joly J, Snedecor B, Shen A. 2011. Decreasing lactate level and increasing antibody production in Chinese Hamster Ovary cells (CHO) by reducing the expression of lactate dehydrogenase and pyruvate dehydrogenase kinases. J Biotechnol 153: 27-34. http://www.sciencedirect.com/science/article/pii/S0168165611001143
    • (2011) J Biotechnol , vol.153 , pp. 27-34
    • Zhou, M.1    Crawford, Y.2    Ng, D.3    Tung, J.4    Pynn, A.F.J.5    Meier, A.6    Yuk, I.H.7    Vijayasankaran, N.8    Leach, K.9    Joly, J.10    Snedecor, B.11    Shen, A.12
  • 174
    • 84862541940 scopus 로고    scopus 로고
    • Mammalian cell protein expression for biopharmaceutical production
    • Zhu J. 2012. Mammalian cell protein expression for biopharmaceutical production. Biotechnol Adv 30: 1158-1170. http://www.ncbi.nlm.nih.gov/pubmed/21968146
    • (2012) Biotechnol Adv , vol.30 , pp. 1158-1170
    • Zhu, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.