Development of serum-free medium supplemented with hydrolysates for the production of therapeutic antibodies in CHO cell cultures using design of experiments

Applied Microbiology and Biotechnology

Volumn 83, Issue 4, 2009, Pages 639-648

  Kim, Sung Hyun ^a   Lee, Gyun Min ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Antibody; CHO cells; Hydrolysates; Serum free medium; Statistical design

Indexed keywords

ANTIBODY CONCENTRATION; ANTIBODY PRODUCTION; CELL LINES; CHO CELLS; EFFICIENT METHOD; HIGH GROWTH; HYDROLYSATES; MIXTURE RATIO; POSITIVE EFFECTS; PROGRAM DESIGN; SERUM-FREE MEDIUM; STATISTICAL ANALYSIS; STATISTICAL DESIGN; THERAPEUTIC ANTIBODIES; WHEAT GLUTEN;

ANIMAL CELL CULTURE; BODY FLUIDS; CELL CULTURE; CELL MEMBRANES; DESIGN OF EXPERIMENTS; GROWTH KINETICS; MIXTURES;

ANTIBODIES;

GLUTEN; PROTEIN HYDROLYSATE; SOYBEAN PROTEIN;

ANTIBODY; EXPERIMENTAL DESIGN; HYDROLYSIS; RECOMBINATION; SERUM; STATISTICAL ANALYSIS; WHEAT;

ANIMAL CELL; ANTIBODY PRODUCTION; ARTICLE; CELL GROWTH; CELL LINE; CELL SUSPENSION; CHO CELL; COMPUTER PROGRAM; CONTROLLED STUDY; CULTURE MEDIUM; NONHUMAN;

ANIMALS; ANTIBODIES; CHO CELLS; CRICETINAE; CRICETULUS; CULTURE MEDIA, SERUM-FREE; IMMUNOLOGIC FACTORS; PEPTONES; RECOMBINANT PROTEINS;

ANIMALIA; TRITICUM AESTIVUM;

EID: 67349115980     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-1903-1     Document Type: Article

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